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ICR마우스에서 phenytoin의 최기형성 및 dimethyl sulfoxide의 항최기형 효과
이재권,이창업,이문한,류판동,조명행,성하정,박진봉,Lee, Jae-kwon,Lee, Chang-eop,Lee, Mun-han,Ryu, Pan-dong,Cho, Myung-haing,Sung, Ha-jung,Park, Jin-bong 대한수의학회 1994 大韓獸醫學會誌 Vol.34 No.4
Phenytoin(PHT), a commonly prescribed anticonvulsant, has been known as a teratogen in experimental animals and human. However, PHT has strain-specific teratogenic effects for mice and human. Dimethyl sulfoxids(DMSO) has been known to antagonize the teratogenic effects of secalonic acid D, a toxic mold metabolite that has similar teratogenic effects to PHT. Therefore, this study was performed to examine the embryopathic effects of PHT in terms of treatment period and the antiteratogenic effect of DMSO in ICR mice. PHT(75mg/kg, BW) was administered intrapetitoneally on day 10, 10-11 and 10-12 of gestation with or without DMSO(2ml/kg, BW), and the fetal malformation was observed on day 18. Major malformation of fetuses treated with PHT on day 10, 10-11 and 10-12 of gestation was cleft palate, and the percentages of fetus with cleft palate were 14.5%, 31.7% and 51.7%, respectively. Also, there was a significant decrease of cleft palate from 51.7% in PHT alone group to 30.8% in PHT plus DMSO group. Our findings suggest that cleft palate is one of major malformation by PHT treatment in ICR mouse and DMSO has strong antiteratogenic effect.
Phenytoin의 태아 구개열 유발과 모체 혈청 Corticosterone 증가에 대한 Dimethyl Sulfoxide 억제 작용
이재권,이창업,이문한,류판동,이영재,성하정,Lee, Jae-Kwon,Lee, Chang-Eop,Lee, Mun-Han,Ryu, Pan-Dong,Lee, Young-Jae,Sung, Ha-Jung 한국독성학회 1992 Toxicological Research Vol.8 No.2
It is well known that phenytoin (PHT), a commonly prescribed anticonvulsant, has teratogenicity in experimental animals and human. The major malformation induced by PHT in mouse is cleft palate. The mechanisms of the embryotoxic effects of PHT are unknown. However, PHT and synthetic glucocorticoids share several features with respect to their teratogenicity, and it was known that PHT increased maternal corticosterone level. Therefore PHT-induced cleft palate may be mediated indirectly by elevated maternal corticosterone. Recently it was reported that secalonic acid Dinduced cleft palate and elevated endogenous corticosterone level, and that such effects were antagonized by DMSO. The purpose of this work was to investigate whether the elevated maternal corticosterone is associated with the teratogenicity of PHT in the ICR mouse fetuses by treatment with PHT or PHT plus DMSO. PHT (74mg/kg, BW) was daily administered intraperitoneally on day 10~12 of gestation with and without DMSO(2ml/kg, BW), and the fetal malformation was observed on day 18. Maternal serum corticosterone and fetal PHT levels were determined by HPLC. The results are summarized as follows. 1)The percentage of cleft palate incidense in fetuses following treatment with PHT on day 10~12 of gestation was 51.7%. 2)There was a significant decrement in the cleft palate incidence in fetuses to 30.8% in the group treated with PHT plus DMSO compared with 51.7% in that with PHT alone. 3) Maternal serum corticosterone levels following treatment with PHT on day 10~12 of gestation increased by 116~343% compared with that of vehicle control. Such effect was antagonized by DMSO. 4)PHT concentration in the fetuses was not affected by DMSO. These results suggest that PHT-induced cleft-palate in fetuses seems to be closely associated with the elevation of maternal corticosterone level.
연구보문 : 유기화합물질 ; Octachlorostyrene의 환경중 노출평가에 관한 연구
김용석 ( Yong Seok Kim ),전용배 ( Yong Bae Jeon ),김태형 ( Tae Hyoung Kim ),성하정 ( Ha Jung Sung ),이규승 ( Kyu Seung Lee ) 한국환경농학회 2009 한국환경농학회지 Vol.28 No.2
옥타클로르스티렌은 환경중에서 잔류성이 높아 쉽게 분해되지 않으며 먹이연쇄상의 생물상에 고농도로 축적될 뿐만 아니라 환경 및 인간에 대한 독성이 매우 높은 물질군으로 알려져 있다. 따라서 본 연구에서는 옥타클로르스티렌에 대한 노출위험 가능성이 있는 오염 우려지역을 설정하여 그 지역의 수질, 토양 및 어류에 대한 옥타클로르스티렌의 잔류량을 조사하기 위해서 잔류분석법을 확립하고 잔류실태를 조사하였다. 그 결과 옥타클로르스티렌의 물에 대한 회수율은 93.1~토양에 대한 회수율은 90.4~94.8%, 어체에 대한 회수율은 81.5~90.2% 이었고 분석법의 검출한계는 물 0.0004 mg L-1이었고, 토양 및 어체는 각각 0.002 mg L-1이었다. 오염 우려지역으로 선정된 울산, 여수, 대전 및 시화공단에서 옥타클로르스티렌의 잔류량은 물, 토양 및 어체의 모든 시료에서 검출한계 미만이었고, 전국 각지의 소각장을 대상으로 실시한 토양시료에서도 옥타클로르스티렌은 검출되지 않았다. 따라서 우리나라는 아직 옥타클로르스티렌이 노출로부터 위험성이 없는 것으로 판단된다. Octachlorostyrene(OCS) has been persisted in environment because it has not been decomposed easily. And, it has been known as highly toxic compounds to the environment and human as well as accumulated as high concentrations in a biota through a food chain. Therefore, OCS was monitored for water, soil and fish sampled from the areas where were able to be contaminated with OCS. The recoveries of octachlorostyrene were 93.1~98.6% in water, 90.4~94.8% in soil and 81.5~90.2% in fish and detection limits were 0.0004 mg L-1 for water, and 0.002 mg kg-1 for soil and fish, respectively. OCS was not detected in water, sediment, soil and fish samples from Ulsan, Yeosu, Daejeon and Sihwa industrial complex and in soil sampled nearby incineration plants in all parts of the country. Accordingly, we estimated that there is no risk from exposure of OCS.