급성 호흡기 감염으로 입원한 소아 환자에서 Chlamydia pneumoniae의 임상 양상: Mycoplasma pneumoniae와의 비교

성재진 ( Jae Jin Sung ),김은진 ( Eun Jin Kim ),선용한 ( Yong Han Sun ),전인상 ( In Sang Jeon ),차한 ( Hann Tchah ),류일 ( Eell Ryoo ),손동우 ( Dong Woo Son ),조혜경 ( Hye Kyung Cho ),조혜정 ( Hye Jung Cho ),김나연 ( Na Yeon Kim 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.5

Purpose: Chlamydia pneumoniae is a common intracellular bacterial pathogen and plays an important role in acute respiratory infections. The purpose of this study was to investigate clinical presentations of C. pneumoniae in children with acute respiratory infections. Methods: We examined the medical records of pediatric patients (age<18 years) admitted with acute respiratory infections of C. pneumoniae to Gachon University Gil Medical Center between March 1, 2011 and August 31, 2014. We compared the clinical features of C. pneumoniae infection with that of Mycoplasma pneumoniae infection. Results: We confirmed acute respiratory infections of C. pneumoniae in 110 patients out of 2,156 patients (5.1%) admitted with acute respiratory infections. The mean age was 37.2±30.1 months. More than half of them (54.5%) had coinfection. C. pneumoniae infection had mild and subacute courses. The mean duration of symptoms prior to admission was 8.5±13.8 days. There were remarkable seasonal variations and prevalence was higher in December and April (P=0.03 and P=0.02, respectively). Although rhinorrhea and pharyngeal injection were more common in C. pneumoniae infection (P<0.05), clinical signs and symptoms were similar between C. pneumoniae and M. pneumoniae. Extrapulmonary manifestations such as skin lesion, Gastrointestinal symptoms, hepatitis, and neurologic symptoms were common (41.0%) in C. pneumoniae infection and, had similar incidence in M. pneumoniae infection. Conclusion: C. pneumoniae is an important infectious agent of acute respiratory infections in children. Clinical pictures of C. pneumoniae are similar to M. pneumoniae, even in extrapulmonary manifestations. C. pneumoniae should be taken into consideration in differential diagnosis of acute respiratory infection in children. (Allergy Asthma Respir Dis 2015;3:346-351)

Hepatitis associated with Mycoplasma pneumoniae infection in Korean children: a prospective study

김규원,성재진,차한,Eell Ryoo,조혜경,선용한,조강호,손동우,전인상,김윤미 대한소아청소년과학회 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.6

Purpose: Mycoplasma pneumoniae (MP) infection is a major cause of respiratory infection in school-aged children. Extrapulmonary manifestations of MP infection are common, but liver involvement has been rarely reported. The aim of this study was to determine the clinical characteristics of MP-associated hepatitis. Methods: This prospective study included 1,044 pediatric patients with MP infection diagnosed serologically with MP IgM at one medical center from January 2006 to December 2012. Eighty of these patients had elevated levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), each greater than 50 IU/L, without any other specific liver disorder and were compared with the 964 children without liver disorders. Results: In total, 7.7% of patients with MP infection had a diagnosis of hepatitis, especially in fall and winter. The ratio of male to female patients was 1.7:1, and the mean age of the patients was 5 years and 5 months. The most common symptoms were cough, fever, and sputum. Anorexia was the most common gastrointestinal symptom, followed by nausea/vomiting, diarrhea, and abdominal pain. Mean levels of AST and ALT were 100.65 IU/L and 118.73 IU/L, respectively. Serum AST/ALT level was normalized within 7.5 days on average without complications. The mean duration of hospitalization (11.3 days) was longer for children with hepatitis than for those without hepatitis (P=0.034). Conclusion: MP-associated hepatitis is not uncommon and has a relatively good prognosis. Therefore, clinicians should be concerned about liver involvement in MP infection but avoid further unnecessary evaluation of hepatitis associated with MP.

효율적인 관리체계개선을 위한 교량관리 시스템의 개발(Ⅱ) : 교량의 신설 및 보수 우선순위 결정

허택녕,성재진 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

The majority of brides in our infrastructure were constructed in the years of the 1960's to 1970's when the growth of our transportation networks was less of an expansion and more of an explosion. These structures have performed so well, they have been so durable, that most of us, engineers or not, tent to take the bridge for granted. But the life of these structures will reach the stage when they will no longer be so durable, and we will no longer be able to take the bridge for granted. It is though that the rehabilitation and maintenance of them are needed. But the priority determination of rehabilitation and replacement of old bridge and the allocation of the limited funds are no small task. In this study, the bridge maintenance system(BMS) which can allocate the fund for bridge's rehabilitation and replacement are developed with of Visual C++6. Criteria for priority determination of rehabilitation and replacement of old bridges are implemented in the BMS based on literatures and reports. Also, in the BMS, the database which can maintains a record of the elements comprising a bridge and its relative condition and a description of the work that has been done to date on a structures as well as the work that is presently scheduled to be done is built. By the BMS, it is showed that the priority determination of old local bridge in Kyung-Nam area for their rehabilitation and replacement are maded, and the developed BMS is useful in the management of local bridges in Kyung-Nam area.

새로 진단된 결핵 환자의 가족 내 2차 감염 양상 조사

이민현,성재진,은병욱,조혜경 대한소아감염학회 2015 Pediatric Infection and Vaccine Vol.22 No.1

Purpose: The purpose of this study is to investigate secondary infections within the households of newly diagnosed tuberculosis patients. Methods: We collected data on household infections of tuberculosis patients by retrospective review of medical records and telephone surveys. Results: Out of 321 newly diagnosed tuberculosis cases, a total of 253 patients who received telephone surveys were enrolled in this study. Less than 50% of the patients had household contacts screened for tuberculosis infection, and most of the patients were not aware of the necessity of testing. Out of 562 household contacts, there were 8 cases of secondary tuberculosis (1.4%, 8/562) in 7 households. There were 15 cases of latent infection (2.7%, 15/562) in 13 households. Out of 110 child and adolescent household contacts, there were no cases of secondary tuberculosis, and there were 8 cases of latent infection (7.3%) in 7 households, which was 20.5% among child and adolescent contacts screened for tuberculosis infection. In 3 of the cases (13.0%) that had secondary tuberculosis or latent infection in their households, the source of infection was extrapulmonary tuberculosis. There was no correlation between the frequency of household infections and the presence of pulmonary cavities, sputum AFB smear results, and microbiologically confirmed results. Conclusions: For effective investigation of tuberculosis contacts, it is necessary to raise general awareness on the necessity of investigating household contacts, and there should also be a continued assessment on tuberculosis contact investigation since government-supported programs. 목적: 결핵 전파의 주요 원인인 가족 내 2차 감염 관리의 실태를 조사하고 특히 18세 이하 소아청소년에서의 결핵 노출 시의 관리 실태를 분석하는 것이다. 방법: 2011년 10월 1일부터 2012년 9월 30일까지 가천대 길병원에서 결핵균 감염에 의한 질환으로치료받은 환자들을 대상으로 진단을 받은 시기로부터 1년이 지난 시점에 후향적으로 전화 설문 및 의무 기록을 조사하였다. 결과: 총 321명의 연구 대상자들 중 전화 응답이 가능했던 253명의 새로 진단된 결핵 환자들 중에서가족 접촉자에 대한 결핵 감염 여부를 확인하기 위해 검사를 받은 경우는 50% 미만 밖에 되지 않았고, 검사의 필요성에 대한 인식이 부족한 경우가 많았다. 총 562명의 가족 내 접촉자 중 2차 환자가 발생한 경우는 7가족 내 8명(1.4%, 8/562)이었고, 가족 내 잠복결핵감염 환자가 발생한 경우는 13가족 내15명(2.7%, 15/562)이었다. 가족 내 소아∙청소년 접촉자 110명 중 2차 환자는 없었으며 잠복결핵감염은 7가족 내 8명으로 전체 소아∙청소년 접촉자 중에는 7.3%, 검진을 받은 소아∙청소년 접촉자 중에는 20.5%였다. 가족 내에 추가 환자 및 잠복결핵감염자 중 감염원이 폐외 결핵인 경우가 3명(13.0%) 이 있었다. 감염원의 폐공동 존재 여부와 객담 도말 검사 결과 및 미생물학적 확진 여부는 가족 내 접촉자의 감염 여부와는 상관 관계가 없었다. 결론: 효과적인 결핵 접촉자 검진을 위해서 환자의 가족 내 접촉자 검진에 대한 인식의 개선이 필요하며 결핵 접촉자 검진 국가 지원 사업 이후 관리 실태 개선 여부에 대한 평가를 위해 지속적인 조사가 필요하다.

경남지역 지방도상 교량의 외관상태 평가분석에 관한 연구

허택녕(Huh Taik Nyung),성재진(Sung Jae Jin) 대한토목학회 2005 대한토목학회 학술대회 Vol.2005 No.10