과립세포종양의 압착도말 세포학적 소견 -1예 보고-

성우정,최준혁,Sung, Woo-Jung,Choi, Joon-Hyuk The Korean Society for Cytopathology 2007 대한세포병리학회지 Vol.18 No.2

Granular cell tumor is a rare tumor of the soft tissue and this is characterized by proliferation of large cells with granular appearing eosinophilic cytoplasm. We report the imprint cytologic features of a case of granular cell tumor in the left calf of a 52-year-old woman. Microscopic examination showed moderate cellularity. The tumor cells were arranged both as single cells and in clusters. The cells were large polygonal-shaped and they had small round nuclei with finely granular chromatin and occasionally conspicuous nucleoli. The cytoplasm was abundant eosinophilic and granular. Naked nuclei and spindle-shaped tumor cells were occasionally noted. No mitosis and necrosis were present. The background showed cytoplasmic granular materials. The tumor cells showed positivity for S-100 protein. Ultrastructurally, abundant lysosomes were present in the cytoplasm of the tumor cells.

Glandular papilloma of the lung with malignant transformation

성우정 영남대학교 의과대학 2017 Yeungnam University Journal of Medicine Vol.34 No.2

Glandular papilloma of the lung is one of three histologic types of solitary endobronchial papillomas. It is known as an uncommon benign neoplasm. No malignant glandular papillomas have been reported. Herein, the first case of granular papilloma with malignant transformation is reported. A 74-year-old man with huge right lung mass extended upper and lower lobe was admitted to the hospital complaining of progressive cough and dyspnea. An open lung biopsy was performed. Microscopically, the tumor showed papillary growth pattern with thick fibrovascular cores. The stroma of the fibrovascular cores shown the infiltration of lymphoplasmacytic cells and proliferation of capillaries. The epithelial cells surrounding the papillary fronds were cilliated columnar cells with focal cellar atypia, and frequent mitoses. Suspicious pleural invasion foci were identified. The Ki-67 labeling index was about 24.3% and p53 labeling index was about 31.7%. Glandular papilloma is known as a benign neoplasm, which is lack of atypia and mitosis. In present case, there were several indications of malignant transformation, such as cellular atypia, frequent mitosis, architectural distortion, and pleural invasion. Pathologists must be aware that glandular papilloma can have a changes of malignant transformation. Further studies about disease behavior and molecular characteristics are needed

유방암 환자에서 수술 중 감시림프절 동결절편검사의 유용성과 한계

성우정,김애리,강수환,이수정,황태윤,배영경 한국유방암학회 2009 Journal of breast cancer Vol.12 No.3

Purpose: Intraoperative frozen sectioning (FS) of sentinel lymph nodes (SLNs) is widely used to determine whether total axillary lymph node dissection should be performed in patients with breast cancer. We evaluated the usefulness and limitations of the FS protocol, which has been used in our institution for the intraoperative SLN examination. Methods: We analyzed the FS results of SLNs in 807 invasive breast carcinoma patients who underwent intraoperative SLN biopsy between January 2005 and December 2007. Lymph nodes larger than 5 mm were sliced at 2 mm intervals and all the slices were submitted for FS. The remaining tissue of the SLN was formalin-fixed and paraffin-embedded for permanent sectioning (PS). If the FS result was negative for tumor cells, then immunohistochemical stain for pancytokeratin was performed. The metastatic SLNs were graded according to the AJCC cancer staging manual (6th edition). The results of FS and PS were compared with regard to the pathologic diagnosis. Results: The average number of SLNs was 2.9 per patients. A total of 204 (25.3%) patients were reported to have a metastatic SLN(s) on the FS. Among the 603 patients with negative FS results, 34 (5.6%) patients showed metastasis on the PS. Another 10 (1.7%) patients who had negative results on FS showed isolated tumor cells on the PS or on the cytokeratin immunohistochemistry. Twenty-nine of the 34 (85.3%) false negative cases showed micrometastasis on the PS. Ten (29.4%) false negative results were caused by interpretation errors and 24 (70.6%) were caused by technical problems. Conclusion: The false negative rate of our protocol for FS of a SLN was low. The failure of FS was largely caused by the failure to detect micrometastasis. FS is a reliable method for an intraoperative SLN examination if a very stringent protocol is used.

Epithelioid Trophoblastic Tumor: Clinicopathologic and Immunohistochemical Analysis of Three Cases

성우정,김미진,신형찬,김민경 대한병리학회 2013 Journal of Pathology and Translational Medicine Vol.47 No.1

Epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Here we report on the clinicopathologic and immunohistochemical features of three cases of epithelioid trophoblastic tumor. All three patients were of reproductive age and presented with vaginal bleeding and mild elevation of human chorionic gonadotropin (hCG). All patients underwent a hysterectomy. The tumors consisted of epithelioid intermediate trophoblastic cells that were mononucleated and eosinophilic, or showed clear cytoplasm on microscopic examination. One case presented with a focal choriocarcinoma component. Immunohistochemically, the tumors displayed diffuse positivity for cytokeratin 18, E-cadherin, epidermal growth factor receptor, and p53 and focal positivity for p63 and hCG. However, expression of α-inhibin and placental alkaline phosphatase was almost negative. Tests for human placental lactogen and epithelial membrane antigen were also negative in all cases.

Mature Cystic Teratoma of the Fallopian Tube - A Brief Case Report -

성우정,김준모,김미진 대한병리학회 2011 Journal of Pathology and Translational Medicine Vol.45 No.3

Mature cystic teratomas of the fallopian tube are unusual, being almost incidentally identified. Here we describe a case of mature cystic teratoma arising in the fallopian tube, in a 44-year-old female. The mass was found during a regular checkup without complication. Microscopically, components from each germ layer were identified.

Diagnostic Importance of Recognition of Calcareous Corpuscles and Larva Part in the Diagnosis of Sparganosis by Fine Needle Aspiration Cytology: Reports of Three Cases of Mammary Sparganosis

성우정,박석주,배영경,김미진 대한병리학회 2011 Journal of Pathology and Translational Medicine Vol.45 No.5

Sparganosis of the breast is an uncommon disease. Cytological granulomatous inflammation is a common feature of sparganosis. The presence of larval fragments is necessary for a definitive diagnosis of sparganosis in a cytological specimen. However, calcareous corpuscles entrapped in necrotic debris can be very diagnostic for sparganosis in endemic areas. We experienced three cases of mammary sparganosis diagnosed by fine needle aspiration cytology before surgical excision. Two cases showed numerous calcareous corpuscles associated with necrotic debris thought to be degenerated parasitic bodies. The remaining case revealed a few degenerative calcareous corpuscles and parasitic bodies. The presence of calcareous corpuscles and/or degenerative parasitic bodies can be an aid in the differential diagnosis between sparganosis and other forms of granulomatous mastitis, particularly in endemic areas of sparganosis.

허혈성 급성 신부전증 실험쥐에 투여한 지방유래 줄기세포의 역할

성우정 ( Woo Jung Sung ),김용진 ( Yong Jin Kim ),박용훈 ( Yong Hoon Park ),김극준 ( Keuk Jun Kim ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.5

Purpose: The aim of this study is to explore the role of human adipose tissue-derived adult stem cells (ASCs) in repair of acute ischemic renal injury. Methods: Acute ischemic tubular necrosis was induced in Spraque-Dawley rats (n=15) by clamping bilateral renal pedicles for 40 minutes. Before releasing the clamps, iron labeled stem cells (1×106/0.3 mL) were directly injected to one side of renal cortex and phosphate-buffered saline (PBS) injections were done as a control to the opposite kidney. The examination on both kidney was done after 2 and 4 weeks (n=5 each). The evaluation of the degree of tubular necrosis and the location of stem cells was done by light and electron microscopically. Results: The rats were all alive without rejection. Morphologically, recovery rate was increased up to about 20% in ASCs injection group in 2 weeks-group (p<0.001). Few Prussian-blue positive cells were demonstrated in 2 weeks-group and more cells were present in 4 weeks-group. The cells which were positively stained in Prussian-blue stain were mainly located in peritubular spaces. Electron microscopically, fine iron granules with electron density were found in the cytoplasm of peritubular endothelial cells. Conclusion: As a result, the endothelial cells might be differentiated from injected ASCs. It seems that stem cells help repairing the tubular epithelium in acute renal failure model, not by tubulogenesis but by vasculogenesis. This outcome suggests that the possibility of therapeutic use of ASCs without immunosuppression of recipients in acute ischemic renal injury.

A Fibroma with Cystic Change Developing in an Accessory Ovary - A Brief Case Report -

김애리,성우정,김미진 대한병리학회 2011 Journal of Pathology and Translational Medicine Vol.45 No.3

Accessory ovaries are rare entities defined as small portions of ovarian tissue situated near, and connected to, the normally placed ovary. Tumors arising in accessory ovaries are extremely rare. In particular, a fibroma arising from an accessory ovary has not been reported in the literature. We describe such a case with a fibroma developing in an accessory ovary. A 53-year-old multiparous woman presented with abdominal pain for 2 months. Pelvic computed tomography revealed 11.0×8.0×6.0 cm sized cystic mass with a thick septal wall in right adnexa. The preoperative diag­nosis was a borderline ovarian tumor. Furthermore, a laparotomy showed a cystic mass connect­ed to the right ovary by stalk. The bilateral eutopic ovaries were completely normal. Histologically, an accessory ovary was replaced by a fibroma accompanied by extensive cystic change.

Primary Pulmonary Glomus Tumor, Diagnosed byPreoperative Needle Biopsy: Report of One Case andLiterature Review

김미진,성우정 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.1

Glomus tumors commonly occur in dermal and subcutaneous tissue in the subungal region of a finger. Some glomus tumors occur extracutaneously, including lung. Only 15 cases of primary pulmonary glomus tumor have been described in literature. In this report, we describe a case of primary pulmonary glomus tumor, which is the first case diagnosed before surgical resection. A 51-year-old man underwent a needle biopsy of a well defined coin-like mass in left lower lobe of the lung on chest radiography. Microscopic examination revealed a tumor composed of perivascularly arranged round to ovoid epithelioid cells with abundant eosinophilic cytoplasm. Tumor cells are immunoreactive for smooth muscle actin and vimentin, but negative for desmin, cytokeratin (AE1/AE3), chromogranin, or synaptophysin. A diagnosis of glomus tumor was then made. The lung mass was resected by wedge resection after being diagnosed by preoperative lung needle biopsy. Although primary pulmonary glomus tumor is rare, most cases follows a benign course. For proper treatment of the patient, glomus tumor should be considered as a differential diagnosis of solitary lung mass.

Pleomorphic Adenoma of the Trachea: A Case Report

박기성,성우정 대한병리학회 2013 Journal of Pathology and Translational Medicine Vol.47 No.4