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마우스에 있어서 INAH의 면역독성에 미치는 Pyridoxine의 영향
선우연,김정훈,박찬봉,채병숙,강태욱,안영근 원광대학교 식품약품안전성연구소 1995 食品藥品安全性硏究 Vol.8 No.-
The immunopotenciating effect of pyridoxine on the immunotoxicity of INAH was investigated in ICR mice. ICR male mice were divided 4 groups(10mice/group) and pyridoxine and INAH were administered per oral for 28 days. ICR male were evaluated for changes in immune status as measured by antibody titer, Arthus reaction. delayed type hypersensitivity(DTH), rosette forming cell(RFC). and plaque forming cell(PFC) to sheep red blood cells(S-RBC). To investigate the change of the non-specific immune response, spleen cells of ICR male mice were assayed for natural killer(NK) cell activity against YAC-I lymphoma. Number of leukocytes in peripheral blood and phagocyte activity were measured also. The results were summarized as follows. 1. INAH decreased both humoral and cell-mediated immune responses. the weight ratios of spleen and thymus to body weight, NK cell activity, phagocyt activity, and number of leukocytes. 2. Generally, pyridoxine reduced or removed the decline of both humoral and cell- mediated of immune responses, NK cell activity, phagocyte activity, and number of leukocytes by immunotoxicity of INAH. The above results suggest that pyridoxine enhance both humoral and cell-mediated immune responses to in ICR mice, indicating that pyridoxine may block a immunoglobulin synthesis inhibition of INAH and pyridoxine deficiency.
朴炳哲,文宰奎,朴榮吉,金杏順,安年衡,金度勳,金正勳,安榮根,李相根,鮮于演 圓光大學校 1990 論文集 Vol.24 No.2
食用油脂는 健康維持에 必須的인 營養素이다. 그러나 食用油脂는 脂肪을 構成하는 脂肪酸의 種類와 攝取하는 量에 따라 健康을 保衛하는 必須的인 食品의 成分이 되기도 하고 有害한 影響을 끼칠 수도 있어서 脂質代謝와 關連된 疾病 뿐만아니라 老化를 促進하고, 乳房癌, 大腸癌等의 癌發生과도 關連된 것으로 밝혀져 있다. 本 硏究는 우리生活環境에서 食用으로 接할 수 있는 10種의 油脂에 對한 免疫生物學的인 活性에서 究明한 結果 對照群인 참기름食餌群에 比해 올리브유食用群은 全般的으로 體液性 및 細胞性免疫을 有意性있게 增加시켰으나, 大食細胞의 活性과 末梢循環白血球數는 有意性없는 減少를 보였고, 動物性 油脂인 牛脂食餌群과 植物性 油脂인 옥수수기름食餌群, 들기름食餌群, 米糠油食餌群, 大豆油食餌群, 菜種油食餌群 및 고추씨기름食餌群에서는 全般的으로 體液性 및 細胞性免疫, 大食細胞의 活性 및 末梢循環白血球數를 有意性있게 減少시켰다. This study was performed to investigate the effects of edible oils and fats on the immunobiological responses in ICR male mice. Ten groups of experimental diets, such as sesame oil diet, beef tallow diet, lard oil diet, olive oil diet, corn oil diet, perilla oil diet, rice polishing oil diet, soybeen oil diet, rape seed oil diet, and red pepper seed oil diet were fed adlibitum to the ICR male mice for 27 days. The results of this study were summarized as followings. 1. Both humoral and cellular immune responses, phagocyte activity, and number of leukocytes in sesame oil group were increased. However, the increasing rate of body weight and the weight retios of spleen and thymus to body were generally decreased. 2. Hemagglutination titer(HA) and rosette forming cell(RFC) of the beef tallow group and the lard group were significantly lower than the sesame oil group(P<0.01), but the lard group significantly increased Arthus reaction and delayed type hypersensitivity(DTH)(P<0.01). 3. Arthus reaction, DTH, and RFC of the olive oil group were significantly higher than the sesame oil group(P<0.01). 4. DTH of the corn oil group was significantly higher than the sesame oil group(P<0.01) whereas phagochyte activity was significantly lower(P<0.01). But no statistically significant differences were found between the two groups in the humoral immune response. 5. HA, PFC, DTH, RFC, phagocyte activity, and number of leukocytes of the perilla oil group and the rice polishing oil group were significantly lower than the sesame oil group(P<0.01). 6. Both humoral and cellular immune responses, phagocyte activity, and number of leukocytes of the soybeen oil group, the rape seed oil group, and the red pepper oil group were significantly lower than the sesame oil group(P<0.01).
2.4-Dichlorophenoxyacetic Acid의 毒性에 對한 Ethanol의 影響
安榮根,鮮于演,鄭鍾甲,金正勳 한국환경독성학회 1989 환경독성보건학회지 Vol.4 No.2
The effects of ethanol on the toxicity of 2, 4-Dichlorophenoxyacetic acid in ICR mice were examined. The results were summerized as follows; 1. The LD_(50) of 2.4-dichlorphenoxyacetic acid sodium injected intraperitoneally in mice was approximately 367 mg/kg. When the animals were administered with ethanol, 2ml/kg or 4ml/kg the LD_(50) of 2.4-D sodium were decreased to 338 mg/kg or 32 mg/kg, respectively. 2. In the acute experimental group, spontaneous motor activity in the ANIMEX system exhibited dose-dependent decrease in mice administered with 2.4-D sodium and ethanol. 3. However, in subacute experimental group, spontaneous motor activity in the ANIMEX system exhibited dose-dependent increase in mice treated with ethanol.