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      • SCOPUSKCI등재

        Perifolliculitis Capitis Abscedens et Suffodiens 의 1 예

        변동,김정회,이성제 대한피부과학회 1970 大韓皮膚科學會誌 Vol.8 No.2

        A case of 24 years old male with perifolliculitis capitis abscedens et suffodiens was reported This is, I presume the first case to be reparted in Korea. Clinically, the skin lesions were characterized by tbe multiple confluented indolent abscesses and hypertrophic scars which were developed on the vertex. On these lesions, there were also noticed complete alopecia and several dilated hair follicle orifices plugged by keratinous materials. The regional lymphnodes were not enlarged and the abscesses were proved bacteriologically sterile.

      • High Performance Liquid Chromatography를 이용한 Hemoglobin A1C 측정

        변동,서교일,유명희,김극배 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

        Hemoglobin AIc(HbAlc) has been known to be an index of long-term glycemic control (6-8weeks), and offers several practical advantages for screening of diabetes mellitus and evaluation of effects of treatment. Authors introduced to measure and investigate HbAlc levels by high performance liquid chromatoraphy (HPLC ; LDC Milton Roy, USA), with cation exchange column, Mono S HR 5/5 (Pharmacia). The results were as follows; 1. The mean HbAlc level in normal adult control group (n=50) was 4.13±0.25% (Mean±S.D). 2. Within-run precisions of HbAlc levels measured by HPLC were 4.39±0.01% (Mean±S.D.), 1.41(C.V.) in normal control, and 8.95±0.02% (Mean±S.D.), 1.65(C.V.) in intermittently treated diabetic patients, and 11.02±0.01% (Mean±S.D.) 2.93(C.V.) in untreated diabetic patients. 3. Between-run precision of HbAlc levels measured by HPLC were 4.35±0.01% (Mean±S.D.), 2.76(C.V.) in normal control, and 8.98±0.01% (Mean±S.D.), 1.22(C.V.) in intermittently treated diabetic patients, and 10.95±0.15% (Mean±S.D.), 3.51(C.V.) in untreated patients. 4. The peak level of HbAlc was obtained in about 9 minutes and the whole program could be completed within 17 minutes. 5. Blood specimens could be stored for as long as 8 days at 4℃ without changes of HbAlc levels. These results suggest that the measurement of HbAlc by HPLC using cation exchange column is so accurate, simple and rapid that the clinical use is more wider.

      • 3차원 다양체의 쌍곡 기하학적 구조에 관한 연구

        邊東壽 弘益大學校 科學技術硏究所 1997 科學技術硏究論文集 Vol.8 No.-

        If F is a compact connected oriented surface and Φ: F → F is a diffeomorphism, then we can construct the 3-manifold Fφ. Then Fφis a fiber bundle over S¹. We find the necessary condition that the 3-manifold Fφhas hyperbolic structures.

      • 간 혼수를 동반한 간세포암종 환자의 뇌척수액 Ribonuclease 기질특이성에 관한 연구

        변동일,김동권,이용성,고재경 한양대학교 의과대학 1996 한양의대 학술지 Vol.16 No.1

        Activity of ribonuclease (RNase) was determined with olycytidylate (poly C) and RNA as substrate in the cerebrospinal fluid(CSF) of patients with hepatocellular Carcinoma with coma. RNase and proteins in the CSF of patients with hepatocellular carcinoma were isolated and purified y a DEAE-cellulose column chromatography and high perormance liquid chromatography (HPLC). Substate specificity for the purified RNase activated in the CSF of the cancer patient was determined to evaluate the possible role of the RNase in car5cinogenesis. Activity of RNA measured with poly C and RNA as substrate and ratio of RNA/poly C for the RNase activity in the csf were increased significantly in the hepatocellular carcinoma, but were unchanged in the liver cirrhosis. The positive rate of the RNAse activity in the CSF as a marker for hepatocellular carcinoma was high, suggesting the use of the RNase activity in the CSF as a marker for hepatocellular carcinoma. Proteins and RNases in the CSF of the patient with hepatocellular carcinoma were separated into 7 protein peaks and 5 RNase isozymes(isozyme Ⅰ, Ⅳ-Ⅶ), of which two peak proteins and one RNase isozyme(isozyme Ⅰ) were specific to the hepatocellular carcinoma. The Rnase isozyme Ⅰ purified from the CSF of the cancer patient was a major isozyme of the RNase isozymes isolated, was activated and was higher in ratio of RNA/poly C for the RNase activity, exhibiting more of nonsecretory RNase nature than that from the CSF of the control. The RNase isozyme Ⅰ fraction in the Csf of the patient with hepatorcellular carcinoma was separated by a HPLC into four subpeaks, of which cubpeak Ⅰ-3 exhibited RNase activity. The RNase isozyme Ⅰ (Ⅰ-3) purified from the CSF of the patient with hepatocellular carcinoma showed the highest activity toward poly AC as substrate, the degree of activity being decreased toward poly ACU and C, AU, CI, CIU, CU, RNA, poly U in order. No activity was observed with poly A, G, AG and GU. The substrate specificity toward the RNAse isozyme Ⅰ from the CSF of the cancer patient appeared to be different from that of the control in that relative activity toward RNA, poly U, CI, AC, AU, CIU aand ACU over poly C was higher in the isozyme from the CSF of the cancer patient than in the isozyme from the CSF of the control. The result indicated that the RNASE isozyme Ⅰ from the CSF of the cancer patient was different in nature from the isozyme from the CSF of the control. Observations that in the CSF of the patient with hepatocellular carcinoma with hepatic coma, (1) five RNase isozymes were isolated, (2) of which one isozyme (isozyme Ⅳ) was specific to hepatocellular carcinoma, (3) the RNase isoyzme Ⅰ isolated as a major enzyme was activated and (4) the substrate specficity of the isozyme in the CSF of the cancer patient was different from that in the CSF of the control, suggested that the RNase isozyme Ⅰ in the CSF of the cancer patient might be involved in carcinogenesis processes of hepatocellular carcinoma.

      • KCI등재후보

        掠奪的價格設定과 不當廉賣의 判斷基準

        邊東烈(Byeon Dong-Yeol) 한국법학원 2003 저스티스 Vol.- No.76

        미국 Antitrust Law에서의 약탈적 가격설정 이론이나 판례는 최초에는 대단히 불명확한 개념에 기초함으로써 많은 혼란을 야기하고, 비난도 받아왔으나 Areeda & Turner 이래 점차 경제학적인 분석에 터잡아 합리적인 방향으로 발전하였다. 미국에서의 이론은 비용기초이론, 구조기준이론, 직접적규제이론, 전략적행위 이론 등으로 나누어질 수 있는데, 미국연방대법원은 Matsushita 판결과 Brooke Group 판결을 거치면서 시장구조분석을 1차적으로 시행하여 벌충(recoupment)이 가능한지 여부를 먼저 판단한 다음, 그 단계를 통과한 경우에만 비용-가격 관계를 조사하여 적절한 척도의 비용 미만으로 가격이 설정된 경우에만 약탈적 가격설정을 인정한다는 2단계 이론을 채택하고 있는 것으로 보인다(실제로는 비용-가격 관계의 조사 단계까지 나아가지는 않았다). 이러한 미국에서의 이론이나 판례의 발전은 경쟁촉진 혹은 소비자후생의 증진이라는 Antitrust Law 고유의 관점하에서 이루어진 것이라고 할 수 있다. 이에 반하여 우리 독점규제법상의 부당염매에 대하여는 이론이나 실무상 경쟁법 고유의 목적인 경쟁촉진이나 소비자후생 증진이라는 측면이 상당히 무시되고 있는 것으로 보인다. 그러나 독점규제법이 경쟁법인 이상, 경쟁촉진 혹은 소비자후생의 증진이라는 관점에서 부당염매를 규제하지 않으면 안된다고 할 것이다. 특히, 염매는 경쟁법으로서의 독점규제법이 이상(理想)으로 생각하는 바로 그 현상이며, 너무나 바람직한 현상이기 때문에 원칙적으로 이를 규제할 아무런 이유가 없지만, 오로지 그러한 염매로 인하여 다른 경쟁자가 시장에서 배제되고, 그럼으로써 독점가격이나 경쟁가격 이상의 가격이 유지되어 소비자에게 피해를 주는 경우에만 규제의 정당성이 인정된다고 보아야 할 것이다. 미국에서의 이론과 판례를 참조하여 우리 독점규제법상 부당염매의 판단기준을 제안하여 본다면, 우선 1단계로는 시장구조분석을 통하여 부당염매가 가능할 것 같은 경우를 추려내고, 2단계로 행위기준 특히, 가격-비용 분석을 통하여 부당염매를 확정한 다음, 3단계로 부당염매자의 정당화항변 사유의 존재 여부(항변이 있을 경우에만)를 조사하여 최종적으로 부당염매 여부를 판단하는 것이 타당할 것이라고 생각된다. 시장구조분석에 있어서는 독점기업의 시장점유율(이와 관련하여 해당 산업의 집중도), 생산시설의 제한 여부, 진입장벽 및 재진입장벽의 존재 여부 등을 조사하여 부당염매의 객관적인 성공가능성 여부를 판단하여야 할 것이고, 가격-비용 분석에 있어서는 부당염매자의 염매가격이 평균가변비용 미만인 경우에만 부당염매를 인정하는 것이 타당하다고 생각된다. 한편, 부당염매자의 정당화항변사유로는 경쟁대항가격, 판촉가격의 설정 등을 들 수 있을 것이다. 그리고 독점규제법상 부당염매는 여러 유형으로 나뉘어져 있는데, 부당염매 규제의 목적이 경쟁촉진이나 소비자후생 증진에 있는 이상, 위에서 제안하는 판단기준은 어느 유형의 부당염매에 대하여도 공통적으로 적용하는 것이 타당할 것이다.

      • SCOPUSKCI등재

        Peutz - Jeghers Syndrome 의 2 예

        변동,남용진,설수길 대한피부과학회 1965 大韓皮膚科學會誌 Vol.4 No.1

        Two cases of Feutz-Jeghers Syndrome which showed typical muco-cutaneous pigmentations were reported and the literatures were reviewed. The case 1 was 9 years old boy, who began to have his skin pigmentations 8 years ago but had no gastro-intestinal symptoms No gastro-intestinal polyposis was demonstrable by X-ray r.xamination, but a fetus head sized space was noted in the pelvic area which pressed the small bowel upward. The case 2 was 10 years old girl, who also began to have her skin lesions 8 years ago and had periodic epigactric pain at the intervals of 10 to 14 days for I year which was suggestive of the possibility of the intestinal polyposis But the patient refused X-ray study against medical advice.

      • KCI등재
      • KCI등재

        여성 성기능 장애의 진단에서 외음부 체감각 측정의 유용성과 임상적 의의

        변동,박성재,윤하나,심봉석,홍재엽 대한비뇨의학회 2005 Investigative and Clinical Urology Vol.46 No.6

        Purpose: It is thought that neurological disorders are one of the main causes of organic female sexual dysfunction. However, it is difficult to diagnose due to the lack of measuring tools for assessing genital neural function. Sensory nerve tests on external genitalia is a new challenge for diagnosing female sexual dysfunction. In this study, we aimed to evaluate the clinical significance of the quantitative measurement of the genital sensory threshold in female sexual dysfunction. Materials and Methods: Forty women with complaints of sexual dysfunction were evaluated with physical and vagina examination, serum hormonal tests, routine urinalysis and a questionnaire(the brief index of sexual function for women). A genitosensory analyzer(GAS, Medoc, Israel) was used to quantitative measure the vaginal and clitoral warm, cold and vibratory sensory thresholds. Results: Of the 40 women, an arousal disorder was reported in 40%, orgasmic disorder in 82.5%, sexual pain disorder in 17.5% and a decreased libido in 17.5%. Of the 40 women, 86.4 and 91.2% showed impairment of vaginal cold(A-δ fiber) and warm(unmyelinated C fiber) sensations, respectively. However, the touch and vibratory sensations(A-β fiber) showed relatively lower impairments; vagina and clitoris in 20.0 and 89.2% of the patients, respectively. Conclusions: In this study, most of the patients with sexual problems had significant vaginal and clitoral sensory nerve fiber impairments. The results support the significance of organic origins in female sexual dysfunction and the usefulness of quantitative analysis of genital sensation in diagnosing the etiology.

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