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윤하나 대한남성과학회 2012 The World Journal of Men's Health Vol.30 No.1
Female sexual function is highly complex and deeply influenced by hormonal and non-hormonal factors. As sexual dysfunction becomes a common and important problem for women of all ages with related quality of life issues, we need to understand more about the effect of sex steroid hormones in female sexual function. However, there are limited data about the correlation between the value of sex steroid hormones- testosterone, in particular-and female sexual function. In a certain type of female sexual dysfunction (FSD), hypoactive sexual desire disorder, for example, there is evidence that treatment with androgens or with estrogens is effective. To widen the therapeutic options of hormone replacement therapy in FSD, further research is needed as to the benefits and risks of hormonal treatments in both pre- and post-menopausal women. Although important unanswered questions still exist in hormonal treatment of FSD, new therapeutic strategies are being studied and many ongoing clinical trials are expecting favorable results leading to more successful treatment of FSD.
Effect of Stress on the Expression of Rho-Kinase and Collagen in Rat Bladder Tissue
윤하나,이동현,전계민,윤현석,유재영 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.2
Purpose: We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation. Materials and Methods: A total of 48 female Sprague-Dawley rats were studied in scheduled stress environments for 7, 14, and 28 days; 24 rats were in the control group and 24 rats were in the test (stressed) group. Results: Estrogen decreased significantly whereas testosterone and dopamine increased significantly in the stress group (p<0.05). Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p<0.05). Collagen types I and III in the bladder tissue were significantly higher in rats exposed to stress for 14 days and 28 days (collagen type I in the 14-day group, p<0.01; collagen type I in the 28-day group, p<0.05; collagen type III in the 14-day and 28-day groups, p<0.05). Voiding frequency increased significantly as the duration of stress exposure was prolonged, in addition to a significant decrease in volume per voiding (p<0.05). Conclusions: The changes observed in micturition pattern, factors that contribute to smooth muscle contraction, and relaxation in the female rat bladder support the hypothesis that stress affects bladder stability. Purpose: We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation. Materials and Methods: A total of 48 female Sprague-Dawley rats were studied in scheduled stress environments for 7, 14, and 28 days; 24 rats were in the control group and 24 rats were in the test (stressed) group. Results: Estrogen decreased significantly whereas testosterone and dopamine increased significantly in the stress group (p<0.05). Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p<0.05). Collagen types I and III in the bladder tissue were significantly higher in rats exposed to stress for 14 days and 28 days (collagen type I in the 14-day group, p<0.01; collagen type I in the 28-day group, p<0.05; collagen type III in the 14-day and 28-day groups, p<0.05). Voiding frequency increased significantly as the duration of stress exposure was prolonged, in addition to a significant decrease in volume per voiding (p<0.05). Conclusions: The changes observed in micturition pattern, factors that contribute to smooth muscle contraction, and relaxation in the female rat bladder support the hypothesis that stress affects bladder stability.
윤하나 대한의사협회 2019 대한의사협회지 Vol.62 No.6
Major improvements in health care have allowed people in the modern era to lead longer, healthier, and more active lives. The current generation of over-60s are more active than previous generations at the same age. In South Korea, the elderly population (65 years of age or older) has grown to more than 14% of the general population, meaning that we are already in the era of an ‘aged society’ and are transitioning into a super-aged society. Therefore, health issues in the elderly population cannot be ignored, and should be adequately addressed as soon as possible. Sexual health has become an important issue in the elderly that cannot be neglected, according to studies on sexual attitudes and behavior in older adults. As the quality of health improves in the elderly population, requests for proper sexual education and sexual health-related services have become more common. This pattern of increased sexual activity, partially driven by pharmacological advances in the treatment of sexual dysfunction and hormonal replacement products, has also led to increases in drug use and sexually transmitted infections (STIs). Responses to sexual health and education issues for the elderly currently remain ill-structured, as the significance of these issues is often ignored, largely due to incorrect assumptions about sexuality and sexual health among the elderly. Stronger requirements should be implemented for properly structured education and management systems regarding awareness, risk perception, and preventive strategies for safe sex among the elderly population in Korea.
체외 충격파 쇄석술을 이용한 신결석 치료에서 이뇨제 병용의 효과
윤하나,정우식,박영요 梨花女子大學校 醫科大學 醫科學硏究所 2002 EMJ (Ewha medical journal) Vol.25 No.2
목적 : 저자들은 체외 충격파 쇄석술을 이용하여 요로 결석을 치료할 때 이뇨제를 사용하여 요관 내 요량을 증가시키는 것의 결석 파쇄 효과에 미치는 영향에 대해 알아보고자 하였다. 대상 및 방법 : 대상환자는 요로결석의 치료로서 체외 충격파 쇄석술중 이뇨제를 투여하지 않은 군(A군)과 투여한 군(B군)의 두 군으로 나누어 각 군당 30명의 환자를 택하여 치료결과를 비교 분석하였다. 치료대상은 20대에서 50대의 신 결석 환자로 결석의 크기는 최대 직경 5㎜이상 15㎜ 이내의 범위로 한정하였고, 전향적 무작위 이중 맹검법에 의해 체외 충격파 쇄석술 치료를 시행하였다. A군은 체외 충격파 쇄석술 치료 시 수액주사 500㎖와 위약을 주사하였고, B군은 수액주사 500㎖와 20㎎의 furosemide를 정맥주사 하였다. 치료효과의 균등한 비교를 위해 첫 체외 충격파 쇄석술 시행 3주 후 KUB를 촬영하여 분쇄정도를 비교하였다. 결과 : 대상 환자들의 평균 나이는 A군이 44.5±11.3세, B군이 43.1±11.5세 이었다. 치료 전 결석의 평균 크기는 A군이 9.2±4.8㎜, B군이 8.9±5.1㎜ 이었으며, 두 군 사이에 통계적으로 의미 있는 차이는 없었다.(p>0.05). 치료 3주 후 치료 전과 비교한 KUB에서 A군의 66.7%(20/30명)에서 결석이 파쇄 되었고 26.7%(8/30명)에서만 결석이 완전히 분쇄되어 배출된 반면, B군은 93.3%(28/30명)의 환자에서 결석이 파쇄 되었고 70%(21/30명)에서 완전 분쇄를 보였다(p<0.05). 요중 평균 α2-macroglobulin은 A군에서 치료 전보다 치료 후 75.1±7.3% 상승한 반면 B군은 치료 전에 비해 67.2±9.6% 상승하였으나, 두 군 사이에 통계적 의의는 없었다(p>0.05). Objectives : It is important to improve treatment efficacy in the management of urolithiasis in respect of time saving cost effectiveness. An experimental study reported that optimal fluid act as an interface between stone and urothelium improves fragmentation. We investigated the effect of diuretic usage in the SWL treatment of urolithiasis. Methods : Sixty renal stone patients were selected for the prospective randomized double blind study. Patient in group A were given a placebo injection and patient in group B were given 20㎎ Ⅳ furosemide at the time of SWL treatment. Both groups received standard SWL monotherapy using Modulith SLX2000 lithoclast(Storz^??, Germany). The energy setting, number of shock waves per session were identical in both groups. Treatment results were compared three weeks later after the first SWL treatment. Results : Mean age of the patients was 44.5±11.3 years old in group A, and 43.1±11.5 years old in group B. Mean size of the calculus before treatment were 9.2±4.8, and 8.9±5.1㎜, which did not shown any statistical difference(p>0.05). Three weeks after the treatment, stone fragmentation and stone free rate was significantly higher in group B(p<0.05). Conclusion : This study suggest that administration of furosemide intravenously during SWL improve stone fragmentation and stone free rate.
방광의 만성 질환: 과민성방광과 방광통증증후군/사이질방광염
윤하나 대한의사협회 2021 대한의사협회지 Vol.64 No.11
Background: Overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS) are debilitatingchronic bladder diseases that affect patients’ quality of life. Their etiologies and clinical phenotypes vary, and management strategies should be selected after excluding the possibilities of other pathological conditions with careful consideration of a multidisciplinary integrated approach to ensure optimal success. Current Concepts: OAB is a symptom complex characterized by urinary urgency and frequency and nocturia with or without urge incontinence, and its key symptom is urinary urgency. IC/BPS has symptoms similar to lower urinary tract symptoms (LUTS) associated with OAB but also has distinctly different symptoms, including the key symptom of an unpleasant sensation or pain perceived to be related to the urinary bladder associated with LUTS. Recent studies have revealed that these key symptoms of OAB or IC/BPS are also observed in some patients with other diseases. Patients showing no evidence of bacterial infection on urine culture and experiencing LUTS or pain for more than 6 weeks should be considered as having OAB or IC/BPS. Treatment strategies for OAB and IC/BPS focus on managing LUTS and bothersome pain. Noninvasive management should be considered initially, whereas surgical options should be considered only after conservative treatment failure. Discussion and Conclusion: OAB and IC/BPS symptoms overlap considerably in many patients. A more accurate differentiation of symptoms, including LUTS, would help achieve better treatment outcomes.
윤하나,Youngdong Yoo,서관용,Juneho In,김봉수 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.9
This review covers recent developments in our group regarding the synthesis, characterization and applications of single-crystalline one-dimensional nanostructures based on a wide range of material systems including noble metals, metal silicides and metal germanides. For the single-crystalline one-dimensional nanostructures growth, we have employed chemical vapor transport approach without using any catalysts, capping reagents, and templates because of its simplicity and wide applicability. Au, Pd, and Pt nanowires are epitaxially grown on various substrates, in which the nanowires grow from seed crystals by the correlations of the geometry and orientation of seed crystals with those of as-grown nanowires. We also present the synthesis of numerous metal silicide and germanide 1D nanostructures. By simply varying reaction conditions, furthermore, nanowires of metastable phase, such as Fe5Si3 and Co3Si, and composition tuned cobalt silicides (CoSi, Co2Si, Co3Si) and iron germanides (Fe1.3Ge and Fe3Ge) nanowires are synthesized. Such developments can be utilized as advanced platforms or building blocks for a wide range of applications such as plasmonics, sensings, nanoelectronics, and spintronics.
사회부과 완벽주의와 이상섭식행동의 관계: 인지왜곡을 통한 마른 이상적 체형 내면화의 조절된 매개효과
윤하나,김은정 한국청소년학회 2021 청소년학연구 Vol.28 No.8
The purpose of the current study was to investigate whether cognitive distortion would mediate the relationship between socially prescribed perfectionism and abnormal eating behavior, and if such mediating effect would differ depending on the level of thin-ideal internalization. A total sample of 217 female undergraduate students completed measures assessing for socially prescribed perfectionism, cognitive distortion, abnormal eating behavior and thin-ideal internalization. The data was analyzed using SPSS Macro. The main results were as follows. First, cognitive distortion had a full mediating effect on the relationship between socially prescribed perfectionism and abnormal eating behavior. Second, thin-ideal internalization moderated the association between socially prescribed perfectionism and cognitive distortion. That is, as thin-ideal internalization increased, the effect of socially prescribed perfectionism over cognitive distortion increased. Third, the moderated mediating model was supported in that the mediating effect of cognitive distortion on the relationship between socially prescribed perfectionism and abnormal eating behavior increased as thin-ideal internalization increased. Limitation and future directions were discussed. 본 연구는 여자 대학생을 대상으로 사회부과 완벽주의와 이상섭식행동의 관계에서 섭식관련 인지왜곡이 매개하는지, 마른 이상적 체형 내면화가 이러한 매개효과를 조절하는지 알아보기 위해 SPSS를 활용하여 조절된 매개모형을 분석하였다. 217명의 여자 대학생을 대상으로 사회부과 완벽주의, 섭식관련 인지왜곡, 이상섭식행동, 마른 이상적 체형의 내면화를 측정하였다. 그 결과, 첫째, 인지왜곡은 사회부과 완벽주의와 이상섭식행동 간의 관계를 완전 매개하였다. 둘째, 사회부과 완벽주의와 이상섭식행동의 관계에서 마른 이상적 체형의 내면화의 조절효과가 나타났다. 즉, 마른 이상적 체형에 대한 사회문화적 기준을 내면화할수록 사회부과 완벽주의가 이상섭식행동에 미치는 영향이 증가하였다. 셋째, 조절된 매개효과가 나타났는데, 마른 이상적 체형의 내면화 수준이 높은 사람은 사회부과 완벽주의 수준이 높을수록 인지왜곡을 발달시켜 이상섭식행동에 취약해지지만, 내면화 수준이 낮은 사람은 사회부과 완벽주의 수준이 높더라도 인지왜곡을 발달시키지 않아 이상섭식행동에 취약하지 않다는 것이다. 끝으로 본 연구의 의의, 제한점 및 후속연구를 위한 제언에 대해 논의하였다.