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      • KCI등재

        Clinical and Angiographic Predictors of Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction

        백용수,우성일,박상돈,김수한,이만종,신성희,김대혁,권준,박금수 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.5

        Purpose: We aimed to discover clinical and angiographic predictors of microvascular dysfunction using the index of microcirculatoryresistance (IMR) in patients with ST-segment elevation myocardial infarction (STEMI). Materials and Methods: We enrolled 113 patients with STEMI (age, 56±11 years; 95 men) who underwent primary percutaneous coronary intervention (PCI). The IMR was measured with a pressure sensor/thermistor-tipped guidewire after primary PCI. The patients were divided into three groups based on IMR values: Low IMR [<18 U (12.9±2.6 U), n=38], Mid IMR [18–31 U (23.9±4.0 U), n=38], and High IMR [>31 U (48.1±17.1 U), n=37]. Results: The age of the Low IMR group was significantly lower than that of the Mid and High IMR groups. The door-to-balloon time was <90 minutes in all patients, and it was not significantly different between groups. Meanwhile, the symptom-onset-to-balloon time was significantly longer in the High IMR group, compared to the Mid and Low IMR groups (p<0.001). In the high IMR group, the culprit lesion was found in a proximal location significantly more often than in a non-proximal location (p=0.008). In multivariate regression analysis, age and symptom-onset-to-balloon time were independent determinants of a high IMR (p=0.013 and p=0.003, respectively). Conclusion: Our data suggest that age and symptom-onset-to-balloon time might be the major predictors of microvascular dysfunctionin STEMI patients with a door-to-balloon time of <90 minutes.

      • KCI등재

        증례 : 순환기; 좌심실 후유두근에서 기인한 심장지방종 1예

        백용수 ( Yong Soo Baek ),권준 ( Jun Kwan ),이경희 ( Kyung Hee Lee ),신성희 ( Sung Hee Shin ),박상돈 ( Sang Don Park ),정은선 ( Eun Soen Jeong ),민경선 ( Kyung Sun Min ) 대한내과학회 2010 대한내과학회지 Vol.79 No.1

        심장 지방종은 매우 드문 원발성 심종양으로 무증상으로 우연히 발견되는 경우가 대부분이다. 저자들은 감염성 대장염으로 입원한 환자에서 우연히 발견된 심장 내 종양의 의심 하에 심초음파와 심장자기공명 촬영 및 관상동맥 다절편 단층 촬영을 이용하여 좌심실내 후유두근에서 기인한 심장지방종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Primary cardiac lipoma is a rare, benign, well-encapsulated tumor that is typically composed of mature fat cells. It can occur in any part of the heart, but is mostly found incidentally. Although cardiac lipoma does not require specific treatment in most cases, physicians should pay attention to this entity, which may cause arrhythmias, embolization, compression of the coronary arteries, or obstruct blood flow within the heart. In this report, we present the case of a 70-year-old woman who was admitted with a complaint of infectious colitis and incidentally found to have a cardiac lipoma in the posterior papillary muscle of the left ventricle on the basis of two-dimensional echocardiography and cardiac MRI. Given the patient`s lack of symptoms and normal cardiac function, we recommended observation without surgical exploration. After six months, the patient was in good health and showed no clinical signs or symptoms of cardiac lipoma. (Korean J Med 79:57-61, 2010)

      • KCI등재

        병원에서 사용된 백신양으로 평간한 예방접종 실태

        김정수,백용수,정문현,이진수,오경선 대한감염학회 2008 감염과 화학요법 Vol.40 No.3

        Background : Studies on immunization in Korea mainly focus to the coverage rates in recipients. The attitudes of health-care providers regarding immunization are rarely evaluated. Therefore, to assess the pattern of vaccine administration by health-care personnel, the vaccine consumption in a university hospital was investigated. Materials and Methods : The vaccine consumption in a university hospital during 2 months (September and October) in 2 years (2002 and 2007) was evaluated. September is representative of months when influenza vaccine is not available, whereas October is representative of months when influenza vaccine is available. These monthly data were summarized by departments and vaccines. Results : Vaccine consumption over the 5-year period increased primarily because of the increased use of the influenza and tetanus-diphtheria (Td) vaccines in adults. In 2007, the most frequently administered vaccine during the influenza season was the influenza vaccine, followed by the Td vaccine. In the same year, the Td vaccine was the most frequently administered vaccine during the non-influenza season. Compared to 2002, there was a marked increase in the use of the hepatitis A virus (7-fo1d), Japanese encephalitis (6-fo1d), and pneumococcal polysaccharide (3-fold) Vaccines in 2007; the Td, meningococcal, and pneumococcal protein-conjugated vaccines were not available in 2002. In adults, pneumococcal vaccination was increasingly prescribed concomitant with the increased influenza vaccination: a similar trend was not observed in children. The use of vaccines in most departments was confined to the influenza vaccine, and the majority of Td vaccine was consumed in the emergency department. As compared to the internal medicine and family medicine departments, fewer vaccines were prescribed by the neurology, surgical, and minor specialty departments, especially in the non-influenza season. Conclusion : Although vaccine consumption increased during the 5-year period, the increase was attributed to the increased consumption of the influenza vaccine. Promotion and education regarding the use of non-influenza vaccines are needed. 배경 : 국내에서 백신 사용은 접종을 받은 사람에서만 조사가 되었고, 예방접종 제공자에서 조사가 적었다. 앞으로 백신 접종률을 높이기 위해서는 접종자에 대한 연구도 있어야 하며, 병원 단위에서 백신 사용 양상을 알기 위해 대학병원에서 백신 사용량을 조사하였다. 재료 및 방법 :2002년과 2007년의 9월과 10월에 약제부에서 사용된 백신 양을 조사하였다. 9월은 인플루엔자 백신이 없는 달을 대표하는 달이고 10월은 인플루엔자 예방 접종이 가능한 달을 대표한 것이다. 월별 백신 소모량을 과별, 백신별로 정리를 하였다. 결과 : 2002년에 비해 2007년에는 백신 사용량이 1.6배 증가했으며, 인플루엔자 백신과 Td의 사용 증가가 주요 이유였다. 인플루엔자 백신 접종 시기에는 인플루엔자 백신 사용량이 제일 많았고, 두 번째 많이 사용되는 백신은 2002년에는 B형 간염 백신이었고 2007년에는 Td였다. 성인에 서는 인플루엔자 백신 사용과 함께 폐렴사슬알균 백신 사용량이 늘었지만 소아에서는 이런 경향이 보이지 않았다. 인플루엔자 백신 접종 시기인 10월에는 소아과에서 사용보다 비소아과에서 백신 사용량이 더 많았다. 과별로 보면 대부분 과에서 인플루엔자 백신이 주로 사용되었고, 응급실에서는 Td만이 사용되었다. 신경과와 재활의학과, 외과계열, 소수과에서 사용이 적었다. 결론 : 예방접종이 5년 사이 증가하였으나 인플루엔자 백신에 국한된 양상을 보였다. 인플루엔자 백신과 파상풍-디프테리아 백신뿐만 아니라 다른 백신에 대한 홍보가 필요하다.

      • Treadmill 運動負荷後 血中 Energy源 變化에 關한 硏究

        金有燮,白龍洙 조선대학교 스포츠과학연구소 1990 스포츠科學硏究 Vol.3 No.-

        This study examined the change of Free Fatty Acid, Glucose, Lactic Acid and Triglyceride related to metabolism of Energy Source in the blood during a convalescence stage after Tread-mill Exorcise. The following conclusions were resulted from the experiment with five athletes in Chonnam University and five non-athletes were randomly selected. 1. Free Fatty Acid in athletes group significantly(P<05) decreased at 1 minute after execise in compaison with the rest stage while significantly( P<05) decreased in non-athlets group. And free fatty acid in both two group significantly(P<05) decreased at 10 minutes and 20 minutes after exercise. 2. Glucose in athletes group significantly(P<05) increased at 1 minute and 3 minutes after exercise;however did in non-athletes group only at 1 mi note after exercise. T-test on the change of glucose quantities by the change of time showed significant(P<01) difference in the rest stage : however did insignificant difference. 3. Lactic Acid in both two groups significantly(P<05) increased at 1 minutes comparison with the rest stage;however lactic acid in athletes group significantly(P<05) decreased at 10 minutes and 20 minutes after exercise in comparison with non-athletes group. T-test on the change of quantities by change of time showed significant (P<01) differ-once and a did in the rest stage at 10 minutes and 20 minutes after exercise in athletes group in comparison with non-athletes group. 4. Triglyceride in both two groups increased without significant(P<05) change at 1 minute and 3 minutes after exercise and did at 5 minutes, 10 minutes and 20 minutes. T-test on the change of Triglyceride quantities by the change of time showed insignifi-cant(P<01) between two groups change in both rest and revovery stages.

      • KCI등재후보

        병원에서 사용된 백신양으로 평가한 예방접종 실태

        김정수,백용수,정문현,이진수,오경선 대한감염학회 2008 Infection and Chemotherapy Vol.40 No.3

        Background:Studies on immunization in Korea mainly focus to the coverage rates in recipients. The attitudes of health-care providers regarding immunization are rarely evaluated. Therefore, to assess the pattern of vaccine administration by health-care personnel, the vaccine consumption in a university hospital was investigated. Materials and Methods:The vaccine consumption in a university hospital during 2 months (September and October) in 2 years (2002 and 2007) was evaluated. September is representative of months when influenza vaccine is not available, whereas October is representative of months when influenza vaccine is available. These monthly data were summarized by departments and vaccines. Results:Vaccine consumption over the 5-year period increased primarily because of the increased use of the influenza and tetanus-diphtheria (Td) vaccines in adults. In 2007, the most frequently administered vaccine during the influenza season was the influenza vaccine, followed by the Td vaccine. In the same year, the Td vaccine was the most frequently administered vaccine during the non-influenza season. Compared to 2002, there was a marked increase in the use of the hepatitis A virus (7-fold), Japanese encephalitis (6-fold), and pneumococcal polysaccharide (3-fold) vaccines in 2007; the Td, meningococcal, and pneumococcal protein-conjugated vaccines were not available in 2002. In adults, pneumococcal vaccination was increasingly prescribed concomitant with the increased influenza vaccination; a similar trend was not observed in children. The use of vaccines in most departments was confined to the influenza vaccine, and the majority of Td vaccine was consumed in the emergency department. As compared to the internal medicine and family medicine departments, fewer vaccines were prescribed by the neurology, surgical, and minor specialty departments, especially in the non-influenza season. Conclusion:Although vaccine consumption increased during the 5-year period, the increase was attributed to the increased consumption of the influenza vaccine. Promotion and education regarding the use of non-influenza vaccines are needed. 배 경:국내에서 백신 사용은 접종을 받은 사람에서만 조사가 되었고, 예방접종 제공자에서 조사가 적었다. 앞으로 백신 접종률을 높이기 위해서는 접종자에 대한 연구도 있어야 하며, 병원 단위에서 백신 사용 양상을 알기 위해 대학병원에서 백신 사용량을 조사하였다. 재료 및 방법:2002년과 2007년의 9월과 10월에 약제부에서 사용된 백신 양을 조사하였다. 9월은 인플루엔자 백신이 없는 달을 대표하는 달이고 10월은 인플루엔자 예방접종이 가능한 달을 대표한 것이다. 월별 백신 소모량을 과별, 백신별로 정리를 하였다. 결 과:2002년에 비해 2007년에는 백신 사용량이 1.6배 증가했으며, 인플루엔자 백신과 Td의 사용 증가가 주요 이유였다. 인플루엔자 백신 접종 시기에는 인플루엔자 백신 사용량이 제일 많았고, 두 번째 많이 사용되는 백신은 2002년에는 B형 간염 백신이었고 2007년에는 Td였다. 성인에서는 인플루엔자 백신 사용과 함께 폐렴사슬알균 백신 사용량이 늘었지만 소아에서는 이런 경향이 보이지 않았다. 인플루엔자 백신 접종 시기인 10월에는 소아과에서 사용보다 비소아과에서 백신 사용량이 더 많았다. 과별로 보면 대부분 과에서 인플루엔자 백신이 주로 사용되었고, 응급실에서는 Td만이 사용되었다. 신경과와 재활의학과, 외과계열, 소수과에서 사용이 적었다. 결 론:예방접종이 5년 사이 증가하였으나 인플루엔자 백신에 국한된 양상을 보였다. 인플루엔자 백신과 파상풍-디프테리아 백신뿐만 아니라 다른 백신에 대한 홍보가 필요하다.

      • KCI등재

        성분분류학적 방법에 의한 제주도산 감귤류 과피의 생약학적 연구

        김창민,완숙,용수,고경수,허인옥 한국생약학회 2018 생약학회지 Vol.49 No.2

        The application of 112 samples of Citrus fruit peel, which is commonly cultivated in Korea as crude drug, has been limited due to the absence of criteria concerning chemical constituents and application of itself. In the context, this study is on the analysis of 11 flavonoid compounds. As a result, the flavonoid pattern could be classified into 5 groups. Furthermore, by utilizing this HPLC data, this study could provide a basis for fruit peel applications of not only Citrus unshiu, but also its cultivars, hybrids and some of Citrus plants which has been cultivated in Jeju Island for a long time. Moondan could be used for the same purposes as Chinese Huajuhong, and Poncirus trifoliata of Korean Jisil origin are effective enough, in terms of ingredients and function, compared with C. aurantium. Based on the content and composition of the PMF region in this study, C. unshiu and C. reticulata, as Tanaka System shows, should be considered as different hortcultural speicies. Also, Jikak, which is known as ‘sour orange’ until now, is confirmed as Chosen-daidai, C. tenuissima, that was reported by Tanaka in 1970, and this C. tenuissima could be used for the same purposes as sour orange.

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