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      • KCI등재

        정신분열증 예후에 관한 고찰

        백성욱 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.3

        In order to study the prognostic factors and symptoms which could influence outcome of schizophrenia, the author surveyed 43 schizophrenic patient who met D.S.M-Ⅲ schizophrenic criteria and who could be followed up until Feb. 1982, among 108 schizophrenic patients who had been admitted Busan National University Hospital from Mar. 1976 to Feb. 1980 for the first time. The outcomes were scored by the modified scale and the mean score were analyzed by using T-test(two-tailed) and correlation coefficient. The results were as follows 1. The outcomes were highly significantly better in acute onset, and in proper late onset age and the good premorbid adjustment. 2. The outcome was highly signficantly poor when the premorbid personality was sichizoid. 3. The outcomes were negatively corelated to the number of admissions and significantly poor when the intelligence was below the average. 4. The outcomes were negatively corelated to the duration of discontinuence of medication and total duration of hospitalization. 5. The outcome was highly significantly poor in the patients with emotional blunting while significantly better in the patients with guily feelings. 6. The cutcome was not favorable even when the patients had depressive symptom or positive family history.

      • KCI등재

        홍화자유약침이 CIA 모델 생쥐의 윤활관절막 손상 억제에 미치는 영향

        백성욱,김은정,황지후,윤종화,이승덕,김갑성 대한침구의학회 2012 대한침구의학회지 Vol.29 No.1

        Objectives : The purpose of this study is to observe the inhibitory effects of Chrthami semen oil pharmacopuncture(CSOP) on CIA (collagen-induced arthritis) mice. Materials and Methods : Two types of experiments were conducted: in vitro assay, inhibition of MIF mRNA and TNF-α mRNA expressions in synovial membranes was observed, and in vivo assay, 1 ㎕/㎏ CSOP was injected every day to the left Weizhong (BL40) from day 3 to 21 after induction of CIA, and changes in paw edema, apical surface morphology, neovascularization in synovial membranes, fibrosis, pro-inflammatory cytokines production, Th-1 differentiation, and anti-inflammatory effect were investigated. Results : 1. In synoviocytes of the CIA mice treated with CSOP, MIF mRNA and TNF-α mRNA expressions were down-regulated in a dose-dependent manner. 2. Paw edema of the CIA mice treated with CSOP was diminished. 3. Tissue injury in the synovial membranes, capillary distribution and fibrosis were reduced in CSOP-treated mice. 4. MIF, TNF-α, IL-6, MMP-9 expressions were repressed in CSOP-treated mice during the experiment to observe the inhibitory effect on cytokines production in early stage RA. 5. IL-12 and CD28 were reduced in CSOP-treated mice during the observation of inhibitory effect on Th1 differentiation. 6. PPAR-γ was increased during the experiment to observe the anti-inflammatory effect of CSOP. Conclusions : The results may suggest that administration treatment using Chrthami semen oil pharmacopuncture decreases the inflammatory response on an Animal Model with CIA.

      • KCI등재

        건강보험 빅데이터를 통한 전체 근로자 및 공무원 근로자의 암 발생률 분석

        백성욱,이완형,유기봉,이우리,이원태,김민석,임성실,김지현,최준혁,이경은,윤진하 한국산업보건학회 2022 한국산업보건학회지 Vol.32 No.3

        Objectives: This study aimed to establish a control group based on the big data from National Health Insurance Service. We also presented presented the number of incidences for each cancer, and analyzed the cancer incidence rate among Korean workers. Methods: The cohort definition was separated by ‘baseline cohort’, ‘dynamic cohort’, and ‘fixed- industry cohort’ according to the definition. Cancer incidence was calculated based on the Korean Standard Classification of Disease code. Incidence rate was calculated among the group of all workers and public officials. Based on the study subjects and each cohort definition, the number of observations, incidences, and the incidence rate according to sex and age groups was calculated. The incidence rate was estimated based on the incidence per 100,000 person-year, and 95% confidence intervals calculated according to the Poisson distribution. Results: The result shows that the number of cancer cases in the all-worker group decreases after the age of 55, but the incidence rate tends to increase, which is attributed to the retirement of workers over 55 years old. Despite the specific characteristics of the workers, the trend and figures of cancer incidence revealed in this study are similar to those reported in previous studies of the overall South Korean population. When comparing the incidence rates of all workers and the control group of public officials, the incidence rate of public officials is generally observed to be higher in the age group under the age of 55. On the other hand, for workers aged 60 or older, the incidence rates were 1,065.4 per 100,000 person-year for all workers and 1,023.7 per 100,000 person-year for civil servants. Conclusions: This study analyzed through health insurance data including all workers in Korea, and analyzed the incidence of cancer of workers by sex and age. In addition, further in-depth researches are needed to determine the incidence of cancer by industry.

      • KCI등재

        Effect of Phacoemulsification on Intraocular Pressure in Healthy Subjects and Glaucoma Patients

        백성욱,권순일,박인원,서울 대한의학회 2019 Journal of Korean medical science Vol.34 No.6

        Background: We investigated how cataract surgery might influence long-term intraocular pressure (IOP) change in both healthy subjects and glaucoma patients. Methods: A retrospective analysis of patients who had had clear corneal phacoemulsification with a minimum of 12 months of follow up was performed. Glaucoma patients with medically controlled open-angle glaucoma and healthy subjects with no glaucoma were included in the analysis. The change of IOP after phacoemulsification and factors associated with postoperative IOP change were investigated. Results: In total, 754 eyes of 754 patients, specifically 106 patients with glaucoma and 648 patients with no glaucoma (i.e., healthy subjects) were enrolled. The phacoemulsification effected a reduction of IOP: 1.03 ± 3.72 mmHg in healthy subjects and 1.08 ± 3.79 mmHg in glaucoma patients at postoperative 1 year (P = 0.656). There were negative coefficients of IOP until 1 year of follow up (all P < 0.001), but the IOP change gradually showed a less steeply decreasing slope (correlation coefficient: −0.993), compared with those for 1 week and 1 month of follow up (correlation coefficients: −1.893 and −1.540, respectively). In the multivariate analysis, age and preoperative IOP showed significant associations with postoperative IOP change (regression coefficients: −0.034 and 0.419 respectively, all P < 0.001). Conclusion: Phacoemulsification resulted in IOP reduction, which effect regressed in healthy subjects and glaucoma patients over the course of long-term follow up. Therefore, long-term monitoring of IOP change is needed. In cases of higher preoperative IOP and young patients, phacoemulsification alone is a reliable option for IOP control.

      • KCI등재

        <<傷寒論>> 太陽病 堤綱의 鍼灸學的 分經 및 定證의 運用 方法論에 關한 硏究

        백성욱,손성철,이준범,황민섭,윤종화 대한침구의학회 2005 대한침구의학회지 Vol.29 No.3

        Objective : The following study was undertaken in order to seek the acupuncture operation method of <<Sang Han Lun(傷寒論)>> Liu-Jing-Bian-Zheng(六經辯證). Methods : Based on the documents quoted in <<Sang Hang Za Bing Lun ․ Xu Wen(傷寒雜病論 ․ 序文)>> of "Zhang, Zhong-Jing(張仲景)", the relativity of the theory of Jing-Mai(經脈) and Liu-Jing-Bian-Zheng of convalescence, and from the Liu-Jing-Bing(六經病), the origin and implication that caused Tai-Yang-Bing(太陽病) to form was studied on the basis of acupuncture medicine publications and the commentary writing of <<Sang Han Lun>>. Results 1. <<Sang Han Lun>> Liu-Jing-Bian-Zheng has succeeded and was developed based on Liu-Jing-Fen-Zheng(六經分證) of <<Su Wen ․ Re Lun(素問 ․ 熱論)>>. In addition, the summary of Liu-Jing-Bing became the general principle of Fen-Jing(分經) and Ding-Zheng(定證) that may be applicable to Fenghan(風寒), Wenre(溫熱), Lili(疫癘) and Zabing(雜病). 2. Most commentators of <<Sang Han Lun>> in the Song, Ming and Ching Dynasties of <<Sang Han Lun>> interpreted the Tai-Yang-Bing in physiological and pathological aspects of Rong-Wei(榮衛) as the disease of the bladder meridian that oversees the skin of the human body. 3. From the Liu-Jing-Bing of <<Sang Han Lun>>, the region of acupuncture treatment of Tai-Yang-Bing is treated with the needle from the point of view of Bing-Zheng-Lun-Zhi(辨證論治) with the basis of the important region of acupuncture of the small intestine meridian ․ bladder meridian and governor vessel.

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