Puromycin-induced kidney injury and subsequent regeneration in adult zebrafish

권순일,박혜진,정수민,차진주,차대룡,강영선 한국통합생물학회 2023 Animal cells and systems Vol.27 No.1

Puromycin treatment can cause glomerular injury to the kidney, leading to proteinuria. However,the pathogenesis of acute kidney injury and subsequent regeneration after puromycinadministration in animal models remain unclear. In this work, we examined the characteristicsof kidney injury and subsequent regeneration following puromycin treatment in adult zebrafish. We intraperitoneally injected 100 μg of puromycin into zebrafish; sacrificed them at 1, 3, 5, 7, or14 days post-injection (dpi); and examined the morphological, functional, and molecularchanges in the kidney. Puromycin-treated zebrafish presented more rapid clearance ofrhodamine dextran than control animals. Morphological changes were observed immediatelyafter the puromycin injection (1–7 dpi) and had recovered by 14 dpi. The mRNA production oflhx1a, a renal progenitor marker, increased during recovery from kidney injury. Levels of NFκB,TNFα, Nampt, and p-ERK increased significantly during nephron injury and regeneration, andSirt1, FOXO1, pax2, and wt1b showed an increasing tendency. However, TGF-β1 and smad5production did not show any changes after puromycin treatment. This study provides evidencethat puromycin-induced injury in adult zebrafish kidneys is a potential tool for evaluating themechanism of nephron injury and subsequent regeneration.

체육교습업 입법과정과 의도되지 않은 결과: 리틀야구를 중심으로

권순일,장익영 한국체육정책학회 2023 한국체육정책학회지 Vol.21 No.4

This study aims to examine the legislative and execution processes of Sports Lesson Business and identify unintended consequences that Little League baseball teams involved in Sports Lesson Business have faced. To explore the legislative process of Sports Lesson Business, this study conducted in-depth interviews with 11 representatives or coaches from Little League baseball teams involved in Sports Lesson Business tand one government agency official involved in policy-making, and a literature review of academic papers and reports. The data were analyzed using constant comparative analysis. The research rigor and ethical considerations were continuously validated throughout the data collection and analysis process. Based on this research methodology, the following research findings were obtained. First, the legislative process of Sports Lesson Business unfolded as follows: Similar bills were sequentially introduced by three different Representatives. The process of scrutiny by standing committees and the Legislative and Judiciary Committee skipped the subcommittee review, and there needed to be more scrutiny and a lack of questioning and debate. In summary, examining the legislative process of Sports Lesson Business revealed issues such as a showpiece bill presentation, inadequate review process, and insufficient scrutiny. Secondly, the unintended consequences manifested primarily as commercial activities and varying interpretations by officials. Firstly, unintended consequences related to commercial activities were observed concerning the use of public sports facilities. Due to the lack of specific regulations regarding Sports Lesson Business, officials at the local government level interpret the rights and obligations differently, leading to inconvenience.

목표특성요인이 성과에 미치는 영향에 대한 연구

권순일 신라대학교 2009 경제경영연구 Vol.10 No.2

급냉응고공정에 의한 NiTi 계 박판 형상기억합금의 변태특성 및 집합조직에 관한 연구

권순일,김선진,이규환,신명철 대한금속재료학회 1996 대한금속재료학회 학술대회 개요집 Vol.1996 No.1

2004년 증권 판례의 주요 동향

권순일 한국증권법학회 2005 증권법연구 Vol.6 No.1

자율주행 교통사고 조사체계 수립

권순일,천정환,선치성 대한교통학회 2023 대한교통학회 학술대회지 Vol.89 No.-

자율주행 교통사고 조사체계 수립

권순일,천정환,선치성 대한교통학회 2023 대한교통학회 학술대회지 Vol.89 No.-

TIGGE자료를 이용한 앙상블 예측시스템의 중기예측성능 분석

권순일,박정현,이승우,나득균 한국기상학회 2016 한국기상학회 학술대회 논문집 Vol.2016 No.10

생산유전의 CO₂ 공법 적용성 평가를 위한 평가차트 개발 및 응용

권순일,조현진,하세훈,이원규,양성오,성원모,Kwon, Sunil,Cho, Hyunjin,Ha, Sehun,Lee, Wonkyu,Yang, Sungoh,Sung, Wonmo 한국화학공학회 2007 Korean Chemical Engineering Research(HWAHAK KONGHA Vol. No.

본 연구에서는 회수증진기법 중 하나인 $CO_2$ 공법을 생산유전에 적용할 경우, 적용성 여부를 간단하고 정량적으로 평가할 수 있도록 하기 위한 평가차트를 개발하였다. 이 평가차트는 소스의 이용성, $CO_2$-오일의 혼합도, 저류층 및 오일 특성의 적정성, 주입기법의 평가항목으로 구성되어 있다. 저류층 및 오일의 특성에서 오일 비중, 오일 점성도, 오일 포화도, 저류층 온도 및 투과도의 기본평가항목에 대해서는 점수로 평가되며, $CO_2$ 순도, 저류층 두께 및 경사도 등의 추가평가항목에 대해서는 상 중 하로 구분하여 정량적으로 평가된다. 또한 미서블공법의 주입기법 평가에서는 지층경사, 수직투과성 및 저류층 두께 등에 따라 연속주입공법과 WAG($CO_2$) 공법의 여부가 정성적으로 평가된다. 이와 같이 구성된 평가차트에 대해 $CO_2$ 공법이 성공적으로 수행된 51개 유전의 적용사례를 분석하여 이를 토대로 $CO_2$ 공법이 가능한 추천점수를 설정하였다. 본 연구에서 개발한 평가차트를 국내 기업이 참여중인 스코틀랜드의 캡틴 생산유전과 베네수엘라의 오나도 생산유전에 적용하여 $CO_2$ 공법의 적용 가능성 여부를 평가하였다. 여기서 캡틴 유전은 저류층의 공극률과 투과도가 매우 양호하나, $C_{21+}$ 이상의 무거운 탄화수소 함유량이 54%를 넘는 중질유이다. 따라서 이러한 중질오일은 $CO_2$와 비미서블공법으로 진행되므로 비미서블공법 기준하의 기본평가항목에 대해서만 평가한 결과 비미서블 $CO_2$ 공법이 적정한 것으로 평가되었다. 한편, 베네수엘라의 오나도 유전에 대해서는 최소 미서블압력이 저류층 압력보다 낮게 산출되어 미서블 $CO_2$ 공법이 적용 가능할 것으로 평가되었다. In this study, we present the evaluation chart for assessing the applicability of $CO_2$ flooding method to oil reservoirs. The evaluation chart consists of four categories as source availability, miscibility, applicability and injecting method of miscible flooding. The applicability of reservoir and oil in the chart has basic items of the properties such as oil gravity, viscosity, oil saturation, reservoir temperature and permeability, and these are quantitatively graded. Meanwhile, for additional items of $CO_2$ purity, reservoir thickness and formation dip, they are graded as "highmediumlow". In the case of evaluating the injection method of either continuous injection or WAG ($CO_2$), the qualitative decision will be made according to formation dip, vertical permeability, reservoir thickness, etc. The recommended score in the chart was assigned by utilizing 51 oil producing fields which $CO_2$ flooding is successfully being applied. The evaluation chart developed in this work has been applied to the Captain oil producing field located in Scotland as well as to the Onado oil field of Venezuela, which Korean oil companies have participated in. For the Captain field, the reservoir quality in terms of permeability and porosity is considered to be very excellent to flow the oil. The oil in captain field contains heavier component of $C_{21+}$ as 54%. Therefore, this heavy oil could be immiscibly displaced, hence the evaluating result with the basis of immiscible criteria shows that $CO_2$ immiscible flooding in this field could be properly applied. In the case of Onado oil producing field, since the estimated minimum miscibility pressure is lower than the reservoir pressure, it was assessed that the Onado field would be efficiently conducted for $CO_2$ miscible flooding.

從業員 職務滿足要因에 對한 一考 : L社 工場 從業員을 對象으로

權純一 新羅大學校 1983 論文集 Vol.14 No.-

The primary purpose of this study is to give light on the factors of job satisfaction. So many scholors have studied the factors of job satisfaction, but they couldn't have clearly found out which are the desive factors. Therefore I tried to search for decisive factors through the practical study. The results are as follows: 1. Job satisfaction depends on individual backgrounds. Amang them, marriage, age, seniority, and number of dependents are closely related with job satisfaction. On the other hand, sex and education are hardly related with it. 2. Job satisfaction can be influenced by extrinsic reward. Especially pay is the most influential element for job satisfaction. Promotion chance and rank give a little relationship to job satisfaction especially in case of man. 3. Job satisfaction can be varied according to the characteristics of the job and the private views on the job. Aptitude and autonomy for the job are closely related job satisfaction, but ability and variety for the job are hardly related with job satisfaction. And people in sales department rather than in production department or general affairs feel much more job satisfaction. And also those who make the job itself their own purpose feel much more job satisfaction than others. 4. Job satisfaction can be influenced by the social interaction in the organization: if leadership is employee-oriented, parental, and if the relationship, among employees is based on understanding, they feel much more job satisfaction. Cohesion and life-commitment are also important elements for job satisfaction. The results of this practical study also have the limitation as follows: 1, There are methodological limitations in the practical study itself. The problem is, reliability & objectivity of the study. 2. Another problem can appear when we apply these results to real situation. That is job perfomance.