아토피성 피부로 건조함을 가진 대상자에 대한 왕지네로부터 분리한 펩타이드 Scolopendrasin-I 함유 기능성 화장품의 기능성 및 안전성을 평가하기 위한 임상적 연구

박혜수,김태준,박신용,김희택 대한한방안이비인후피부과학회 2019 한방안이비인후피부과학회지 Vol.32 No.3

Objectives : The purpose of this study is to confirm the efficacy and safety of “Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans” on dry skin due to mild atopic dermatitis. Methods : A total of 24 patients who visited Semyung Oriental Medical Center from November 1st, 2018 to December 20th, 2018 were included in the study. In this study, the patients were treated with Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans. For 4 weeks of gross examination, instrumental assessment were made before and after the study to evaluate how well the products for treatment group in recovering the dry skin barriers by mild atopic dermatitis. Results : 1. In the primary endpoint, Skin Hydration showed a statistically significant increase in treatment group in baseline, 2 weeks and 4 weeks. 2. In the primary endpoint, Transepidermal Water Loss(TEWL) showed a statistically significant decrease in treatment group between Baseline and 4 weeks. 3. In the secondary endpoint, Skin pH showed a statistically significant decrease in treatment group between baseline and 4 weeks. 4. To evaluate the safety of the products for the human body, Adverse events, SCORAD Index Assessment were conducted; There were no severe adverse events during this study. And SCORAD Index showed a statistically significant decrease in treatment group in baseline, 2 weeks and 4 weeks. Therefore, it is suggested that products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that “Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans” should be effective for dry skin due to mild atopic dermatitis.

아토피성 피부로 건조함을 가진 대상자에 대한 환삼덩굴추출물 함유 기능성 화장품의 유효성 및 안전성을 평가하기 위한 임상적 연구

박혜수,김용민,김희택 대한한방안이비인후피부과학회 2019 한방안이비인후피부과학회지 Vol.32 No.2

Objectives : The purpose of this study is to confirm the Efficacy and Safety of “Functional cosmetics containing Humulus japonicus Extract” on dry skin due to mild atopic dermatitis. Methods : A total of 48 patients who visited Semyung Oriental Medical Center from March 20th, 2018 to July 5th, 2018 were included in the study. In this study, the patients were treated with Functional cosmetics containing Humulus japonicus Extract and positive control group. For 6 weeks of gross examination, instrumental assessment were made before and after the study to evaluate how well the products for treatment group with positive control products for control group in recovering the dry skin barriers by mild atopic dermatitis. Results : 1. In the primary endpoint, Skin Hydration showed a statistically significant increase and Transepidermal Water Loss(TEWL) showed a statistically significant decrease in treatment group between Baseline and 6 weeks. 2. In the secondary endpoint, Skin Hydration showed a statistically significant increase in treatment group between Baseline and 3 weeks, but TEWL showed no statistical significance. 3. In the secondary endpoint, Skin Hydration showed a statistically significant increase in treatment group between 3 weeks and 6 weeks, but TEWL showed no statistical significance. 4. In the secondary endpoint, Change of Skin Hydration and TEWL between treatment and control group showed a statistical significance in 6 weeks. 5. In the secondary endpoint, Change of Skin Hydration of 1㎝ below the medial aspect of the elbow between treatment and control group showed a statistical significance in 3 weeks. 6. In the secondary endpoint, Change of Skin Hydration between treatment and control group showed a statistical significance in 3 weeks and 6 weeks except Center between the medial aspect of the elbow and the wrist in 3 weeks, and Change of TEWL between treatment and control group showed a statistical significance in 6 weeks. 7. To evaluate the safety of the products for the human body, Adverse events, EASI Score, Itching Symptoms Assessment, vital sign check were conducted; There were no severe adverse events during this study. And both experimental group and control group showed no abnormal level. Therefore, it is suggested that products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that “Functional cosmetics containing Humulus japonicus Extract” should be effective for dry skin due to mild atopic dermatitis.

인삼 사포닌 분획이 콩 발아시의 당 신생반응에 미치는 영향 ( The Effect of Ginseng Saponin on Gluconeogenesis at the Early Phase of Germinating Soybean Sprout )

박혜수,곽한식,주충노 고려인삼학회 1985 Journal of Ginseng Research Vol.9 No.2

차동기어 메커니즘을 사용한 4 족 보행용 저관성 로봇 다리

박혜수,서정욱 제어로봇시스템학회 2021 제어로봇시스템학회 국내학술대회 논문집 Vol.2021 No.6

The Effects of Cardioplegic Solutions on the Energy Source of the Guinea Pig Heart

박혜수,박소라,이영호,김인숙,서창국,강복순,Park, Hye-Soo,Park, So-Ra,Lee, Young-Ho,Kim, In-Sook,Suh, Chang-Kook,Kang, Bok-Soon The Korean Physiological Society 1989 대한생리학회지 Vol.23 No.1

The changes in adenosine triphosphate (ATP), creatine phosphate (CP) and lactic acid (LA) contents of guinea pig hearts were studied during the cardioplegia and recovery phase. 1) ATP and CP contents in cardiac ventricular tissue were decreased during the cardioplegia, regardless of $Ca^{2+}$ concentration in the cardioplegic solutions, and CP contents were recovered with the reperfusion of normal Tyrode solution faster than those of ATP. And there were no significant differences in the recovery of CP contents with different concentration of $Ca^{2+}$ in the cardioplegic solutions tested, while the recovery of ATP contents was faster with 15 mM $K^{+}$, 0.1 mM $Ca^{2+}$ cardioplegic solutions. 2) LA contents were increased during the cardioplegia and decreased with the reperfusion of normal Tyrode solution. 3) The more recovery time (up to 3 hrs), the more CP contents were recovered with the reperfusion of normal Tyrode solution faster than those of ATP. And LA contents were decreased as the duration of recovery time. These results suggest that $Ca^{2+}$ and $K^{+}$ concentration in the cardioplegic solution is one of the major factors influencing the recovery of cardiac tissue from the cardioplegia. 심근정지용액의 조성이 심근정지 및 심근정지 후 회복기의 에너지원에 미치는 영향을 조사하기 위해 guinea pig 심실 균질액에서 adenosine triphosphate (ATP), creatine phosphate (CP) 및 lactic acid (LA)의 변화를 관찰하여 다음과 같은 결과를 얻었다. 1) ATP 및 CP 양은 심근정지동안은 감소하고 회복기에는 다시 증가하였으며, 심근정지 후 정상용액으로 30분간 회복시켰을 때에는 ATP 양의 회복이 CP에 비해 느린것을 알 수 있었다. 2) LA 양은 심근정지동안은 증가하고 회복기에는 다시 감소하였다. 3) 심근정지 후 회복시간을 길게할수록 ATP 및 CP 양의 회복은 증가하였으며 CP 양이 더 많이 회복되었다. 4) LA 양도 회복시간을 길게할수록 감소하였다. 이상의 결과를 종합하여 볼 때, 심근정지용액의 $Ca^{2+}$ 및 $K^{+}$ 농도는 심근정지후 회복시 심근세포의 에너지원인 ATP, CP 및 lactic acid 양에 영향을 미친다고 생각된다. 이 연구 결과를 토대로 심근세포내 $Na^{+}$과 $H^{+}$ 활성도 변화 및 심근세포의 산증(acidosis)에 관한 연구를 첨가하면 심근정지시의 심근보호기전을 규명하는데 도움이 될 것으로 생각된다.

the poet series 2016-02 silk, wool, 13×13inch, 2016

박혜수 서울여자대학교 조형연구소 2016 조형연구 Vol.22 No.-

‘초등과학교육학회지의 과학교육 및 STEAM 교육 연구 동향 분석

박혜수,공영태 한국초등과학교육학회 2017 한국초등과학교육학회 학술대회 Vol.72 No.-

Angelica gigas 에탄올 추출물의 Hyaluronic acid 합성 효과에 대한 실험적 연구

박혜수,하헌용,김희택 대한한방안이비인후피부과학회 2018 한방안이비인후피부과학회지 Vol.31 No.1

Objectives : Hyaluronic acid(HA) is a mucopolysaccharide, occuring naturally in living organisms. It is one of the most hydrophilic molecules, so it has been known as being related to skin hydration and skin aging. The purpose of this study is to examine the effects of Angelica gigas(A. gigas) ethanol extract on hyaluronic acid synthesis. Methods : To determine cytotoxicity and hyaluronic acid synthase 2 gene expression, hyaluronic acid production in HaCaT cells, MTT assay and RT-PCR ELISA was used. Results : There were no cytotoxicity in 50㎍/㎖ concentration A. gigas extract in MTT assay. Hyaluronic acid synthase 2(HAS2) gene expression was increased by all treated concentration A. gigas extract. Hyaluronic acid production was higher than control group in 50㎍/㎖ & 100㎍/㎖ concentration A. gigas extract. Conclusions : Hyaluronic acid production was increased by A. gigas extracts. Therefore, We suggest that A. gigas can make a contribution to the moisturizing effect on human skin.

패션 브랜드 샤넬의 스토리스케이핑

박혜수,박선희 한국패션디자인학회 2016 한국패션디자인학회지 Vol.16 No.1

본 연구는 패션 브랜드 샤넬(Chanel)의 스토리스케이핑(Storyscaping)에 관한 연구 논문이다. 연구의 목적은 첫째, 현대 사회와 브랜드의 마케팅에 있어서 중요시되는 감성 커뮤니케이션인 브랜드 스토리스케이핑에 관한 개념과 특징을 중점적으로 살펴보고, 둘째, 패션 브랜드 샤넬의 마케팅 전반에 스며들어 있는 스토리스케이핑에 관한 사례 분석을 통해 그 특징과 가치를 규명하고자 한다. 구체적으로 본 연구의 사례는 예술적 영감 표현의 브랜드 감성을 전시로 보여주는 문화 샤넬전(Culture Chanel), 샤넬 공방 장인들의 특별함을 보여주고 선정 도시의 문화와 역사 속에 샤넬 브랜드의 정신이 흡수되도록 스토리를 전개하는 공방 컬렉션(Chanel Métiers d'Art Show), 다양한 스토리 라인을 주제로 디지털 매체를 활용하여 브랜드 감성을 공유하는 패션 필름(fashion film)으로 나누어 분석하였다. 마지막으로, 연구의 분석으로 얻어진 샤넬 브랜드가 추구하는 감성 커뮤니케이션의 가치를 패션 문화 마케팅의 다양한 분야에서 활용하는 데 그 목적이 있다. 본 연구는 문헌 고찰을 통한 이론적 연구와 사례 분석을 통한 실증적 연구를 병행하였다. 이론적 배경과 사례를 토대로 얻어진 스토리스케이핑의 특징은 감성적 공유, 스토리의 투명성, 몰입과 상호 작용에 의한 경험 공간의 구축으로 체계화 시킬 수 있었다. 또한 패션 브랜드 샤넬의 스토리스케이핑은 인물, 장소, 사건을 스토리의 중심에 두고 전개하고 있다는 사실을 확인할 수 있었으며, 하나의 사건은 또 다른 사건을 생산하며 브랜드와 대중이 상호 교류하고 공감하는데 있어서 관계 형성을 유도한다는 사실을 확인하였다. 샤넬 브랜드의 스토리스케이핑은 다양한 측면에서 소비자의 참여를 유도하며 브랜드 공유의 문화를 창출하고 결과적으로 브랜드 가치를 상승시키며 브랜드 고유의 패션 문화를 형성하고 있다. 또한 현대 사회의 미디어 콘텐츠와 맞물려 자발적으로 확산되며 타 브랜드와는 차별화된 관계를 구축하고 있다. This research focuses on the value of storyscaping case studies of fashion brand, ‘chanel’. There are three objectives for this research. Firstly, it is to investigate the concepts and characteristics of brand, story and storyscaping, which plays an important role today in brand marketing. Secondly, it is to examine characteristics and values of fashion brand Chanel’s communicating method of emotional communication through analyzing fashion brand Chanel's storyscaping case studies. The specific case studies of this research are Culture-Chanel, Chanel Meteriers d’Art Show, and fashion film. Culture Chanel is the exhibition that expresses artistic inspirations of Chanel brand’s emotion, Meteriers d’Art Show is a fashion show that shows up Chanel atelier artisan’s specificity. It is a collection with a story aiming for fashion brand Chanel’s spirit to be absorbed into the selected city’s culture and history. And fashion film is sharing brand sensibilities through a variety of digital media. Lastly, it is to understand the use-value of storyscaping and the effectiveness of communication through emotional perception in a fashion brand -marketing environment where many competing global fashion brands co-exit. This research combined a theoretical study through literature review with an objective study through case analysis. The results of this research indicate that characteristic of storyscaping was emotional sharing, story's clarity, and construction of experience space by immersion and interaction. And the characteristics of Chanel's storyscaping were analyzed as figure-centered, location-centered, and event-centered. In addition, the one event produced another event. and they derived relationships by interaction and empathy. Chanel's storyscaping included public participation and created Chanel's own culture. As a result, Chanel established distinctive relationships that differentiate from the other brands with media contents.

코스피·코스닥상장 중소기업의 R&D 비용 및 R&D 자산화와 기업 부실의 관계

박혜수,김민서 한국경영교육학회 2018 경영교육연구 Vol.33 No.1

[Purpose]The purpose of this study is to analyze the relationship between R&D and distress risk of Korean listed SMEs. [Methodology]According to previous studies, it is becoming increasingly necessary to develop various indices for the prediction of corporation distress because the distress level of domestic SMEs is intensifying. Also, R&D considers both approaches, cost approach and asset approach. For the empirical analysis, 1,067 KOSPI and KOSDAQ listed SMEs' financial data and industrial R&D data were collected and the hypothesis was verified through the Hazard analysis. [Findings]The result of Hazard analysis show that R&D expenditures cause higher SME's distress risk than capitalized R&D. And the simulation of Hazard analysis shows that the group with high R&D expenditures has a higher distress risk than the middle group. [Implications]As financial distress rate of domestic SMEs are continuously increasing, in-depth study of various indicators such as R&D is required. The results of this study can be used to prevent the loss of the national economy and improve the efficiency by predicting the corporate distress in the early stage and constructing a national system in which SMEs can preemptively defend themselves. [연구목적]그 동안 R&D 관련 연구는 대부분 기업가치 및 성과에 영향을 미치는 주요 요인으로 연구되어져 왔으나 본 연구에서는 국내 상장 중소기업을 대상으로 기업의 R&D 정보를 활용해 부실위험과의 관계에 대해 분석하였다. [연구방법]선행연구를 검토한 결과, 국내 중소기업의 부실화가 심화되고 있어 부실예측에 대한 다양한 지표를 개발하는 연구의 필요성이 증가하고 있으며 R&D는 비용접근법과 자산접근법의 두 가지 접근방법이 모두 논의되어야함을 확인하였다. 실증분석을 위하여 2007년부터 2016년까지 코스피·코스닥상장 중소기업 1,067개의 기업 재무데이터 및 산업별 R&D 통계 데이터를 수집하였으며, Hazard 분석을 통해 가설을 검증하였다. [연구결과]Hazard 분석 결과, 자산화된 R&D에 비해 R&D 비용은 중소기업의 부실위험을 높였다. 또한 심층분석을 위한 시뮬레이션에서 R&D 비용이 높은 그룹은 중간 그룹 대비 높은 부실위험을 가지는 것으로 분석되었다. [연구의 시사점]국내 중소기업의 부실화는 지속적으로 증가하고 있기 때문에 R&D 지표와 같은 다양한 부실예측 지표에 대한 심층 연구가 요구된다. 이와 같은 연구결과는 조기에 기업 부실을 예측하여 기업이 스스로 선제적 방어를 할 수 있는 시스템을 구축하는데 활용되어 국가경제의 손실을 막고 효율성을 높일 수 있을 것이다.