광중합기 종류에 따른 복합레진과 콤포머의 미세누출에 관한 연구

박창후,최남기,양규호,김선미 대한소아치과학회 2006 大韓小兒齒科學會誌 Vol.33 No.3

전립선암 환자의 검체에서 Neuroendocrine Cell Differentiation의 의의

박창후,박창면,김한권,강길현,송재석,박종연 대한비뇨의학회 2008 Investigative and Clinical Urology Vol.49 No.7

Purpose: The neuroendocrine cell(NEC) is one of the constitutional cells found in the prostate gland; these cells secret neurotransmitters. These neuroendocrine products have been associated with prostate cancer progression. We evaluated the significance of neuroendocrine differentiation(NED) in radical prostatectomy specimens. Materials and Methods: We studied 45 patients who underwent bilateral pelvic lymphadenectomy and radical prostatectomy. The patients were classified into three groups according to their pathological stage. Group A included cases with organ confined tumors, Group B local advanced tumors and Group C cases had any T stage and lymph node metastasis. The cellular expression of chromogranin A in matched samples from the same patients was evaluated by immunohistochemical staining using commercially available monoclonal antibodies. Results: Sixteen(35.6%) tumors had chromogranin A stained cells. Chromogranin A immunoreactivity was greatest in cases with lymph node involvement(75.0%) compared to those with primary prostate cancer(5.9% in group A and 37.5% in group B). Pathologically advanced tumors or tumors with the highest histological grades were associated with increased NED. The median staining score was 0 in Group A, 0 in Group B and 1 in Group C. The logistic regression analysis the odds ratio for group C cases showed a relative risk of 32.07(95% CI: 2.783-369.416) for NED compared to Group A. An increased prostate-specific antigen(PSA) and Gleason score were also associated with the NED. Conclusions: The degree of NEC immunohistochemical staining using the chromogranin A monoclonal antibody was marginally useful for predicting the outcome in prostate cancer patients after radical prostatectomy, especially in node positive patients. However, it is important to determine a therapeutic plan for patients with low PSA and internal organ metastasis. Purpose: The neuroendocrine cell(NEC) is one of the constitutional cells found in the prostate gland; these cells secret neurotransmitters. These neuroendocrine products have been associated with prostate cancer progression. We evaluated the significance of neuroendocrine differentiation(NED) in radical prostatectomy specimens. Materials and Methods: We studied 45 patients who underwent bilateral pelvic lymphadenectomy and radical prostatectomy. The patients were classified into three groups according to their pathological stage. Group A included cases with organ confined tumors, Group B local advanced tumors and Group C cases had any T stage and lymph node metastasis. The cellular expression of chromogranin A in matched samples from the same patients was evaluated by immunohistochemical staining using commercially available monoclonal antibodies. Results: Sixteen(35.6%) tumors had chromogranin A stained cells. Chromogranin A immunoreactivity was greatest in cases with lymph node involvement(75.0%) compared to those with primary prostate cancer(5.9% in group A and 37.5% in group B). Pathologically advanced tumors or tumors with the highest histological grades were associated with increased NED. The median staining score was 0 in Group A, 0 in Group B and 1 in Group C. The logistic regression analysis the odds ratio for group C cases showed a relative risk of 32.07(95% CI: 2.783-369.416) for NED compared to Group A. An increased prostate-specific antigen(PSA) and Gleason score were also associated with the NED. Conclusions: The degree of NEC immunohistochemical staining using the chromogranin A monoclonal antibody was marginally useful for predicting the outcome in prostate cancer patients after radical prostatectomy, especially in node positive patients. However, it is important to determine a therapeutic plan for patients with low PSA and internal organ metastasis.

타일화된 항공 라이다 데이터로부터의 재귀적 건물영역 추출 기법

박창후 ( Chang-hoo Park ),김유성 ( Yoo-sung Kim ) 한국정보처리학회 2011 한국정보처리학회 학술대회논문집 Vol.18 No.1

타일로 분할된 항공 라이다 데이터로 부터 데이터마이닝 기법을 이용한 지표면 분류 결과에 따라 건물을 포함하는 타일에 대해 적용할 건물영역 추출 기법을 제안한다. 본 기법은 재귀적 경계점 추출 알고리즘과 경계점 연결을 통해 경계선을 형성하고 경계선을 타일의 외벽과 연결해 건물영역의 외곽을 추출한다. 제안된 기법으로 추출된 건물 영역을 실제 항공사진과 비교하여 제시하고 재귀적 경계점 추출 알고리즘의 실행시간을 단축시키기 위해 사용된 지형정보 인덱스의 실행시간 단축 효과 분석이 제시된다.

경직장 전립샘 생검의 양성 및 악성에서 전립선암 관련 지표인자들에 대하여 무증상 만성염증이 미치는 영향

박창후(Chang Hoo Park),김성진(Sung Jin Kim),박창면(Chang Myeon Park),김한권(Han Kwon Kim),박종연(Jong Yeon Park) 대한비뇨기종양학회 2009 대한비뇨기종양학회지 Vol.7 No.2

한국인에서 전립선암으로 호르몬치료를 받는 환자의 대사성 변화

박창후(Chang Hoo Park),성기택(Gi Teck Sung),김세영(Sea Young Kim),김성진(Sung Jin Kim),홍성우(Sungwoo Hong),김종원(Jongwon Kim),박창면(Chang Myon Park),김한권(Han Kwon Kim),박종연(Jong Yeon Park) 대한비뇨기종양학회 2010 대한비뇨기종양학회지 Vol.8 No.2

Purpose: In men with prostate cancer, Androgen deprivation therapy shows a variety of well recognized metabolic alteration. But it is not known in Korean men with prostate cancer. To better characterize the metabolic effects of androgen deprivation therapy in Korean men, we evaluated the changes in fat thickness, bone mineral density (BMD), body mass index (BMI), and levels of hemoglobin (Hb) and cholesterol. Materials and Methods: From December 2002 to December 2008, 148 Korean men treated with leuprolide depot and bicalutamide for prostate cancer and 100 healthy subjects were investigated included change from baseline to month 12 in fat thickness, bone mineral density (BMD), body mass index (BMI), and levels of hemoglobin (Hb) and cholesterol. Fat thickness was estimated from subcutaneous fat thickness at T10 level through CT or MRI image. We also compared them with data from healthy subjects. Results: The mean fat thickness was significantly increased by 22.9% from baseline (16.6mm) to month 12 (20.4mm) in men with prostate cancer (p<0.001). The BMD was significantly decreased by 4.2% from 0.95 to 0.91 (p<0.001). The BMI was significantly increased by 4.8% from 23.0kg/m² to 24.1kg/m² 43 (p<0.001). The hemoglobin level was significantly decreased. In contrast, the cholesterol levels did not change significantly. The patients with prostate cancer had significant changes in fat thickness, BMD, and BMI, compared with healthy subjects (p<0.005, respectively). But there are no significant changes in hemoglobin and cholesterol levels. Conclusions: Our results show that Korean men with prostate cancer have increased abdominal subcutaneous fat and BMI and have decreased BMD during androgen deprivation therapy. These increases the risk of bone fracture and obesity related complication. Therefore, BMD will be checked periodically and carry out exercise program to prevention obesity during androgen deprivation therapy.

여성 단순 급성 신우신염 환자에서 당뇨 및 당화혈색소가 치료 경과에 미치는 영향

배민호,박창후,조영삼,주관중,권칠훈,박흥재 대한요로생식기감염학회 2015 Urogenital Tract Infection Vol.10 No.1

Purpose: We investigated potential difference in the clinical features of hospitalized female acute pyelonephritis (APN) patients with and without diabetes mellitus (DM). The additional purpose of the study was to determine whether HbA1c has a role in predicting clinical outcome in terms of morbidity compared with those considered to have normal glycemic control in female APN patients with DM.Materials and Methods: Among the female patients who received inpatients care due to APN from January 2011 to December 2013, 282 patients (86 with DM and 196 without DM) were selected and their medical records were analyzed. Laboratory results (white blood cell, blood urea nitrogen, serum creatinine, fasting plasma glucose, HbA1c) were dichotomized. Primary outcomes for comparison between the groups of patients with or without DM were early clinical response rate and length of in-hospital stay. Subgroup analysis was also performed in DM patients according to HbA1c status (<6.5%, ≥6.5%).Results: In multivariate logistic regression analysis, DM was not found to show independent association with poor early clinical response or longer hospital stay. HbA1c was the common risk factor of poor early clinical response (odds ratio [OR] 4.88, 95% confidence interval [CI] 1.61-14.8) and longer hospital stay (OR 4.20 95% CI 1.52-11.60) in APN patients with DM.Conclusions: Strict glucose control may be more important prognostic factor than presence or absence of DM in APN patients. As a marker of prolonged hospitalization and poor early clinical response, HbA1c can complement the present clinical and laboratory parameters used as guide in the proper treatment of DM patients with APN.

항공 라이다 데이터를 이용한 동적 가변 윈도우 기반 지형 분류 기법

성철웅,이성규,박창후,이호준,김유성,Sung, Chul-Woong,Lee, Sung-Gyu,Park, Chang-Hoo,Lee, Ho-Jun,Kim, Yoo-Sung 대한공간정보학회 2010 한국공간정보학회지 Vol.18 No.5

본 논문에서는 항공 라이다 데이터를 이용하여 지형의 유형을 분류하는 과정에서 지형의 특성에 따라 지형 분류의 판정 단위를 가변적으로 변화시키는 동적 가변 윈도우 기반 지형 분류 기법을 제안한다. 제안된 동적 가변 윈도우 기반 지형 분류 기법에서는 지형의 특성과 반복 패턴에 따라 지형 분류의 판정 단위를 가변적으로 결정하여 지형 분류에 소요되는 시간을 감소시키고자 하였다. 또한, 본 논문에서는 실험을 통하여 동적 가변 윈도우 기반 지형 분류 기법의 시간효율과 정확도를 분석하고 최적의 최대 판정 윈도우 크기를 제시하였다. 실험 결과에 따르면 제안된 동적 가변 윈도우 기반 지형 분류 기법은 고정 윈도우 크기를 이용하는 기법과 유사한 정도의 정확성을 유지하면서도 빠른 지형 분류가 가능한 것으로 판명되었다. In this paper, a dynamic variable window-based topographical classification method is proposed which has the changeable classification units depending on topographical properties. In the proposed scheme, to im prove the classification efficiency, the unit of topographical classification can be changeable dynamically according to the topographical properties and repeated patterns. Also, in this paper, the classification efficiency and accuracy of the proposed method are analyzed in order to find an optimal maximum decision window-size through the experiment. According to the experiment results, the proposed dynamic variable window-based topographical classification method maintains similar accuracy but remarkably reduce computing time than that of a fixed window-size based one, respectively.

Management of Severe Bilateral Ureteropelvic Junction Obstruction in Neonates with Prenatally Diagnosed Bilateral Hydronephrosis

김종원,홍성우,박창후,박홍주,김건석 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.9

Purpose: The management of prenatally detected bilateral ureteropelvic junction obstruction (UPJO) remains controversial. We attempted to develop a treatment plan for patients with severe bilateral UPJO. Materials and Methods: We evaluated the records of 13 patients with prenatally diagnosed grade 3 or more bilateral hydronephrosis that led to the postnatal diagnosis of severe bilateral UPJO. Ultrasonography and 99mtechnetium mercaptoacetyltriglycine (99mTc-MAG3) renal scans were performed within 1 month. Four renal units had grade 3 and 22 had grade 4 hydronephrosis. All 13 patients were managed by unilateral pyeloplasty, and the patients’ mean age was 3 months. At 1 month postoperatively, we decided whether delayed surgery in the opposite renal unit was necessary according to the findings of ultrasonography and 99mTc-MAG3 scans. Results: Of 13 patients, 11 underwent initial pyeloplasty on renal units with more severe hydronephrosis or lower relative renal function (RRF) on 99mTc-MAG3 scans. The remaining 2 patients simultaneously underwent percutaneous nephrostomy on renal units with a lower RRF and initial pyeloplasty on renal units with a higher RRF. In 5 patients, contralateral hydronephrosis had spontaneously improved at 1 month postoperatively, and 8 patients underwent delayed contralateral pyeloplasty at 2 months postoperatively. Conclusions: In children with severe bilateral UPJO, the non-operated renal units with grade 3 and some with grade 4 hydronephrosis improved spontaneously after unilateral pyeloplasty. Therefore, delayed pyeloplasty of the opposite side should be considered at 1 month following initial pyeloplasty. Purpose: The management of prenatally detected bilateral ureteropelvic junction obstruction (UPJO) remains controversial. We attempted to develop a treatment plan for patients with severe bilateral UPJO. Materials and Methods: We evaluated the records of 13 patients with prenatally diagnosed grade 3 or more bilateral hydronephrosis that led to the postnatal diagnosis of severe bilateral UPJO. Ultrasonography and 99mtechnetium mercaptoacetyltriglycine (99mTc-MAG3) renal scans were performed within 1 month. Four renal units had grade 3 and 22 had grade 4 hydronephrosis. All 13 patients were managed by unilateral pyeloplasty, and the patients’ mean age was 3 months. At 1 month postoperatively, we decided whether delayed surgery in the opposite renal unit was necessary according to the findings of ultrasonography and 99mTc-MAG3 scans. Results: Of 13 patients, 11 underwent initial pyeloplasty on renal units with more severe hydronephrosis or lower relative renal function (RRF) on 99mTc-MAG3 scans. The remaining 2 patients simultaneously underwent percutaneous nephrostomy on renal units with a lower RRF and initial pyeloplasty on renal units with a higher RRF. In 5 patients, contralateral hydronephrosis had spontaneously improved at 1 month postoperatively, and 8 patients underwent delayed contralateral pyeloplasty at 2 months postoperatively. Conclusions: In children with severe bilateral UPJO, the non-operated renal units with grade 3 and some with grade 4 hydronephrosis improved spontaneously after unilateral pyeloplasty. Therefore, delayed pyeloplasty of the opposite side should be considered at 1 month following initial pyeloplasty.

항공 라이다 데이터를 이용한 동적 윈도우 크기 기반 지형 분류 기법의 성능 분석

성철웅,이성규,박창후,김유성,이호준 한국정보과학회 2010 데이타베이스 연구 Vol.26 No.3

In this paper, we report a performance evaluation result of dynamic window-size topographical classification methods which use decision windows of dynamic variable sizes for topographical classification depending on topographical properties. As the dynamic window-size topographical classification schemes, two schemes have been proposed: reducible window-size topographical classification scheme and extendible window-size one. Since these two schemes have different policies for dynamically changing window sizes for classifications, they may produce different results with respect to the classification accuracy and the classification time efficiency. Therefore, in this paper the performance of these two dynamic window-size topographical classification methods is compared with respect to the classification time and the classification accuracy. According to the experiment result, the reducible dynamic window-size topographical classification method can classify land's classes fast by 33.4% and accurately by 0.9% than the extendible window-size one. It is expected that the reducible dynamic window-size topographical classification method can be used for real-time land monitoring systems. 동적 윈도우 크기 기반 지형 분류 기법은 지형의 특성에 따라 지형의 유형을 분류하는데 사용하는 판정 윈도우의 크기를 변화시키는 방법이다. 동적 윈도우 크기 기반 지형 분류 기법은 초기 윈도우의 크기에 따라 축소형 동적 윈도우 크기 기반 지형분류 기법과 확장형 동적 윈도우 크기 기반 지형 분류 기법으로 나눌 수 있으며윈도우 크기를 변화시키는 방법이 다르기 때문에 동일한 지형의 유형을 분류하여도 정확도와 소요시간이 다를 수 있다. 따라서 본 논문에서는 이와 같은 두 가지 동적 윈도우 크기 기반 지형 분류 기법의 분류에 소요되는 시간과 정확도를 분석하였다. 실험결과에 따르면 축소형 동적 윈도우 크기 기반 지형 분류 기법이 확장형 동적 윈도우 크기 기반 지형 분류 기법보다 평균적으로 33.4%정도 빠르고 0.9%정도 보다 정확하게 지형의 유형을 분류 하는 것으로 판명되었다. 이러한 축소형 동적 윈도우 크기 기반 지형 분류 기법을 이용하여 재해의 피해지 조사 등과 같이 빠른 지형 분류 결과가 필요한 실시간 국토 모니터링 시스템을 개발할 수 있다.

항공 라이다 데이터를 이용한 동적 가변 윈도우 기반 지형 분류 기법

성철웅,이성규,박창후,이호준,김유성 대한공간정보학회 2010 Spatial Information Research Vol.18 No.5

In this paper, a dynamic variable window-based topographical classification method is proposed which has the changeable classification units depending on topographical properties. In the proposed scheme, to improve the classification efficiency, the unit of topographical classification can be changeable dynamically according to the topographical properties and repeated patterns. Also, in this paper, the classification efficiency and accuracy of the proposed method are analyzed in order to find an optimal maximum decision window-size through the experiment. According to the experiment results, the proposed dynamic variable window-based topographical classification method maintains similar accuracy but remarkably reduce computing time than that of a fixed window-size based one, respectively. 본 논문에서는 항공 라이다 데이터를 이용하여 지형의 유형을 분류하는 과정에서 지형의 특성에 따라 지형 분류의 판정 단위를 가변적으로 변화시키는 동적 가변 윈도우 기반 지형 분류 기법을 제안한다. 제안된 동적 가변 윈도우 기반 지형 분류 기법에서는 지형의 특성과 반복 패턴에 따라 지형 분류의 판정 단위를 가변적으로 결정하여 지형 분류에 소요되는 시간을 감소시키고자 하였다. 또한, 본 논문에서는 실험을 통하여 동적 가변 윈도우 기반 지형 분류 기법의 시간효율과 정확도를 분석하고 최적의 최대 판정 윈도우 크기를 제시하였다. 실험 결과에 따르면 제안된 동적 가변 윈도우 기반 지형 분류 기법은 고정 윈도우 크기를 이용하는 기법과 유사한 정도의 정확성을 유지하면서도 빠른 지형 분류가 가능한 것으로 판명되었다.