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성견에서 골형성단백질이 코팅된 임플란트가 치조골 증대에 미치는 영향
박찬경,김종은,신주희,류재준,허중보,신상완,Park, Chan-Kyung,Kim, Jong-Eun,Shin, Ju-Hee,Ryu, Jae-Jun,Huh, Jung-Bo,Shin, Sang-Wan 대한치과보철학회 2010 대한치과보철학회지 Vol.48 No.3
연구 목적: 이 연구의 목적은 골형성단백질 (recombinant human Bone Morphogenetic Protein-2; rhBMP-2)이 코팅된 임플란트가 치조골 증대에 미치는 영향을 알아보는 것이다. 연구 재료 및 방법: 6마리의 비글견이 실험에 사용되었다. 6개의 8 mm 길이의 임플란트가 발치 후 6개월 이상의 충분한 치유기간이 경과한 비글견의 치조골에 5 mm 깊이로 식립되었다. 각각의 동물에 좌측과 우측의 악궁-분할형으로 임의추출하여 한쪽에는 1.5 ml/mg 농도의 rhBMP-2가 코팅된 임플란트를, 반대편에는 코팅되지 않은 대조군 임플란트를 식립하고 임플란트 주변 골에 round bur를 이용하여 피질골 천공을 시행하였다. 점막골막판막에 이완절개를 시행하여 판막을 접합시키고 봉합하여 임플란트가 피개되도록 하였다. 방사선 사진 촬영은 수술 직후 (기준치), 수술 4주후, 수술 8주 후에 시행하였다. 측정은 각 방사선 사진의 임플란트 덮개나사 최상방에서 변연골까지의 거리를 측정하여 골 형성량을 계산하였다. 수술 직후와 수술 8주 후에 임플란트 안정도 (Implant Stability Quotient value; ISQ value)를 측정하였다. 통계분석을 위해 SPSS software를 사용하여 Man-Whitney ranksum test와 Wilcoxon signed ranksum test를 시행하였다. 통계적 유의수준은P=.05를 기준으로 하였다. 결과: 골형성단백질이 코팅된 임플란트에서 수직 결손부 상방으로 약 0.6 mm의 골 형성이 관찰되었다. 대조군에서는 제한된 양의 골 형성 혹은 골 소실이 일어났다. 각 시기에 따른 실험군과 대조군간의 골 형성량에 유의한 차이가 있었다 (P<.05). ISQ value는 수술 직후에는 실험군과 대조군의 유의한 차이가 없었지만 수술 8주 후에는 실험군에서 대조군 보다 유의하게 높게 증가되었다 (P<.05). 결론: 골형성단백질이 코팅된 임플란트는 완전히 치유된 치조골에서 임상적으로 유의한 골 증대 효과가 있는 것으로 보인다. Purpose: This study was aimed to evaluate the effect of rhPMP-2 coated implants on alveolar ridge augmentation in dogs. Materials and methods: Six Beagle dogs were used in this study. Six 8.0 mm long anodized surface titanium implants were placed 5 mm into the mandibular alveolar ridge following 6 month of healing period after extraction. Each animal received three implants coated with rhBMP-2 and three uncoated control implants using the randomized split-mouth design. Radiographic examinations were undertaken immediately at implant placement (baseline), at weeks 4 and 8 after implant placement. The amount of bone augmentation was evaluated by measuring the distance from the uppermost point of the coverscrew to the marginal bone. Implant Stability Quotient (ISQ) values were measured immediately at implant placement and 8 weeks after implant placement. For the statistical analysis, Man-Whitney ranksum test and Wilcoxon signed rank test of SPSS 12.0 software were used (P=.05). Results: The BMP group exhibited radiographic vertical bone augmentation about $0.6{\pm}0.7$ mm at 8 weeks later while controls showed bone loss about $0.4{\pm}0.6$ mm. There was significant difference among the rhBMP-2 group and controls in bone level change (P<.05). The ISQ values were significantly higher in the BMP-2 group than the control group at 8 weeks later (P<.05), while there was no significant difference at surgery. Conclusion: Within the limitation of this study, the rhBMP-2 coated on anodized implant could stimulate vertical alveolar bone augmentation, which may increase implant stability significantly on completely healed alveolar ridge.
반응표면모델에 의한 철도 차량 대차의 탄성조인트 최적설계
박찬경,이광기,Park, Chan-Gyeong,Lee, Gwang-Gi 대한기계학회 2000 大韓機械學會論文集A Vol.24 No.3
Optimization of the elastic joint of train is performed according to the minimization of ten responses which represent driving safety and ride comfort of train and analyzed by using the each response se surface model from stochastic design of experiments. After the each response surface model is constructed, the main effect and sensitivity analyses are successfully performed by 2nd order approximated regression model as described in this paper. We can get the optimal solutions using by nonlinear programming method such as simplex or interval optimization algorithms. The response surface models and the optimization algorithms are used together to obtain the optimal design of the elastic joint of train. the ten 2nd order polynomial response surface models of the three translational stiffness of the elastic joint (design factors) are constructed by using CCD(Central Composite Design) and the multi-objective optimization is also performed by applying min-max and distance minimization techniques of relative target deviation.
철도차량 동특성 해석을 위한 휠/레일 상호작용의 선형모델링 연구
박찬경(Park Chan-Kyoung),박기준(Park Kee-Jun),박준서(Park Jun-Seo),배대성(Bae Dae-Sung) 한국철도학회 1998 한국철도학회 학술발표대회논문집 Vol.- No.-
A linar numerical model of the wheel-rail interation and the track geometry is developed for multi-body dynamics program. The simulation results are very similar to these of VAMPIRE simulation. This program can be used for the analysis of train dynamic performance.
박찬경(Chan-Kyeong Park),최면(Myeon Choe),주진순(Jin-Soon Ju) 한국식품영양과학회 1993 한국식품영양과학회지 Vol.21 No.6
위암은 모든 한국인에 있어서 발병율이 높은 성인병이며 또한 식이 중 Na 섭취와 관련이 있는 질병으로 알려져 있는바, 본 연구는 건강한 구성원만을 가진 정상 인군과 위암환자가 있는 가족의 구성원을 대상으로(환자 자신은 제외) Na 섭취패턴을 분석하여 비교하고자 하였다. 위암환자 가족의 고추장, 김치류, 국류, 육류반찬류중 Na함량이 정상인 가족에 비해 유의적으로 높고 기타 식품군내 Na 함량도 높아 위암환자 가족군의 Na 섭취량이 많음을 알 수 있었다. 그러나 소변내 Na 배설량은 위암환자 가족군이 오히려 낮은 경향을 보여 장기간의 Na 다량섭취가 인체내 Na 대사에 변화를 가져올 수 있을것으로 생각된다. Purpose of this study was to investigate intake pattern of sodium in the family members of normal and stomach cancer patients, excluding patients themselves. Every food samples that they consumed for 3 days, drinking water, hot pepper paste, soybean paste and soy sauce from the each family were collected for Na analysis. Three days of morning urine from the each subjects was collected for determination of urinary Na excretion. Sodium contents of hot pepper paste, pickles, soups and meats in stomach cancer families were significantly higher than those in normal families. However, urinary sodium excretion between the two groups was not different. This suggests that sodium metabolism in human may be altered with a long-term intake of sodium-rich foods.
박찬경(Park Chan-Kyeong),김상수(Kim Sang-Soo),김기환(Kim Ki-Hwan),김영국(Kim Young-Guk) 한국철도학회 2009 한국철도학회 학술발표대회논문집 Vol.2009 No.11월
The High speed electrical multiple train having a distributed electrical motor system has just been developing to aim the experimental maximum speed at 400㎞/h since August, 2007. This project comes in stage of critical design and so, it needs to take some review and analysis the characteristics of suspensions on the view of design. The vehicle model for dynamic analysis is upgraded from the basic design model with 12 linear dampers, 8 non-linear dampers, 8 bush and 12 shear springs. The non-linear dampers are the secondary yaw dampers and lateral dampers that generally have non-linear characters. The optimization technique is applied to search the proper range of non-linear characteristics for the damper elements to satisfy the curving stability performance at speed 110m/s (about 400km/h). The results shows there are some optimum points according to the variation of characteristics and it would be useful to make a decision to select the proper suspension elements in the precision design that will be done by the manufacturing company.
시험을 통한 한국형 고속전철 차량의 속도에 따른 실내소음 수준 분석
박찬경(Chankyoung Park),박춘수(Chunsu Park),김기환(Kihwan Kim),이억재(Ukjae Lee),나희승(Heeseong Na) 한국철도학회 2004 한국철도학회 학술발표대회논문집 Vol.- No.-
Korean High Speed Train (KHST) designed to operate at 350㎞/h has been tested on KyungBu high speed line since it was developed in 2002. The specification of the interior noise level for high speed train in Korea has been adopted through the contract between KHRC and Korea TGV consortium, not a national specification. But it can not be adopted to KHST designed at 350㎞/h because this has involved up to 300Km/h. Therefor, in this paper, the interior noise level at 350㎞/h are predicted in passenger car using the results at 300Km/h and these results show that the KHST"s interior noise levels are good up to 300Km/h but need to be reduced at 350Km/h in the view point of limit value at 300Km/h of the contract between KHRC and Korea TGV consortium. Also it proposed to make a national specification for the interior noise level to evaluate it in detail at 350Km/h.
일반적인 접촉특성을 이용한 휠/레일 접촉모듈 프로그램 개발에 관한 연구
박찬경(Park Chan-Kyoung),배대성(Bea Dea-Sung),조희제(Cho Hee-Jae),조영걸(Cho Young-Geol) 한국철도학회 2003 한국철도학회 학술발표대회논문집 Vol.- No.-
The railway vehicle is composed of many suspension components, such as 1st springs, 2nd dampers, that have an influence on the dynamic characteristics of high speed train. Also, the wheel/rail shapes and its contact mechanism affect the dynamic behavior of high speed train. but these geometric contact characteristics are nonlinear functions of the wheelset lateral displacement and it do not exact dynamic analysis for high speed train. there is a need to develop a new wheel/rail contact module for dynamic behavior and wheelset model is divided motor box, wheel box and wheel body. This wheel is moved by motor box and constrained by joint. It is almost same a train and its result is more exactly.