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        황색포도구균혈증의 임상적 고찰

        홍화정(Hwa Jeong Hong),이정환(Chung Hwan Lee),박종오(Chong Oh Park),정일우(Il Woo Jung),이승호(Seung Ho Lee),고경식(Kyung Sik Ko),김구엽(Koo Yeop Kim),서환조(Hwan Jo Suh) 대한내과학회 1997 대한내과학회지 Vol.53 No.3

        N/A Objective: Staphylococcus aureus has persisted and is now resurging as an important hospital and community pathogen. Nosocomial infection caused by methicillin-resistant S.aureus(MRSA) is a major problem which may be connected with heavy or prolonged use of antibiotics S.aureus bacteremia caused acute complications, which occasionally resulted in death, and infectious/suppurative complications, which necessitated prolonged antibiotic therapy, sometimes in conjunction with surgery. Therefore, S.aureus bacteremia is a serious medical problem in association with high morbidity and mortality. Methods: 130 patients with S.aureus bacteremia who were admitted in the Kyung Hee University Hospital from January, 1991 to December, 1994 were analyzed retrospectively. We compared the clinical and laboratory characteristics, and antibiotics resistances between MRSA and MSSA bacteremia and also we evaluated risk factors that contribute to fatal outcome in patients with S.aureus bacteremia. Results : 1) of 130cases, 80 were male and 50 were female. The mean age was 44.5±25.1 years. 2) 84(65%) of S.aureus bacteremia were nosocomial and 46(35%) were community-acpuired. The percentage of MRSA stains studied was 55%(71/130) and The percentage of MRSA bacteremia in hospital-acpuired and community-accquired S. aureus bacteremia were 64% (54/84) and 36%(17/46), respectively. Sources of bacteremia were uncertain in 85(65%) with intravascular catheter(20%) and skin wound sites (8%) being the most common sources in remainder(35%) 3) 110(85%) of 130 patients had one or more underlying diseases. Common underlying dieases were cerebrovascular disease(33%), malignancy(17%), Diabetes mellitus(15%), chronic renal failure(8%) and liver cirrhosis(6%). 4) Acute complications occurred in 35 patients and were fatal in 21 5) The risk factors associated with MRSA bacteremia were various severe underlying diseases, vairous invasive procedures, IV catheter-associated infection, hypoalbuminemia, previous use of antibiotics, male sex and old age. 6) The Case fatality rate for patients with S. aureus bacteremia was 18% and those for patients with MRSA and MSSA bactermia were 20% and 12%, respectively. The risk factors that contribute to the increment of mortality rate in patients with S. aureus bacteremia were acute complication, low serum level of total protein, hypoalbuminemia, various invasive procedures and IV catheter-associated infection, 7) In the antibiotic sensitivity test S. aureus was resistant to penicillin in 98.5%, ofloxacin in 73%, cefotaxime in 67%, erythromycin in 58%, aztreonam in 56%, clindamycin in 52%, vancomycin in 0%. 8) In the multiple antibiotic resistance of S. aureus, 43(68%) of MRSA was resistant to more than 10 antibotics, revealing multiply resistant nature of strains, While all but one MSSA was resistant to 1 to 4 antibiotics, one revealing resistance to 8 antibiotics. Conclusion: S. aureus bacteremia is a cause of considerable morbidity and mortality in hospitalized patients who especially, exposed to various risk factors. MRSA revealed higher resistance rate to most antibiotics tested and more marked multiply resistant nature than MSSA. But there was no significant difference in case fatality rate between patients with MRSA and MSSA bacteremia.

      • 한우에서 인공유발된 제2위내 이물의 초음파상

        김명철,변홍섭,박명호,박종오,김종만 충남대학교 수의과대학 동물의과학연구소 1997 動物醫科學硏究誌 Vol.5 No.-

        This study was performed to determine the ultrasonographic appearance of the reticulum in the cattle according to the intake of foreign body. Metal balls, magnets, gravels and rubber were administered to a 13 months old female Korean native cattle. After foreign bodies in the reticulum were ascertained, foreign bodies were observed by ultrasonography. The ultrasonographic values in this study can be used as reference for the diagnosis of foreign body of the reculum in cattle.

      • KCI등재후보

        Salmonella Group B 에 의한 감염성 동맥류 1 예

        이승호,이정환,박종오,서환조,정일우,홍화정,김구엽,최남수 대한내과학회 1997 대한내과학회지 Vol.53 No.6

        We experienced a case of the rupture of infected aortic aneurysm caused by Salmonella group B. A 75-year-old diabetic female patient was admitted with lower back pain and fever. Abdominal CT scan showed the abdominal aneurysm and the abscess of retroperitoneal space. We confirmed the ruptured aortic anecrysm with retroperitoneal abscess by obermter. The blood culture, and the pus obrained by operan yielded growth of Salmonella group B. After oration the patient was recovered completely by anrotics. We report this case with literature

      • Enterobacter 균혈증의 임상양상 및 예후인자에 관한 고찰

        김구엽,서환조,이성배,박종오,최욱선,홍승재,정일우,이희주 대한감염학회 1996 감염 Vol.28 No.5

        목 적 : Enterobacter균은 인체 병원균으로, 기저질환이 있거나 병원에 입원중인 환자들에게 있어서 매우 중요하다. 최근들어, 항생제의 광범위한 사용, 고령층의 증가, 카테터 사용의 증가, 악성 신생물 질환의 증가, 장기이식의 증가 등에 따라 Enterobacter 균혈증이 증가되고 있으며 항생제에 대한 내성도 증가되어 점차 그 중요성이 강조되어지고 있다. 따라서 이의 임상양상 및 예후인자에 대하여 알아보고자 본 연구를 시행하였다. 방 법 : 1990년 1월부터 1994년 12월 까지 경희의대 부속병원에서 Enterobacter 균혈증을 보인 49예의 임상양상 및 치료, 예후와 관련된 인자 등을 후향적으로 조사하였다. 결 과 : 1) 49명 환자의 평균 연령은 39.1세(1일-88세)였고, 남녀비는 1.72:1 이었다. 2) 병원내 감염은 29명(59.1%)이었고, 복합균혈증은 6예(12.2%)였다. 3) 기저질환을 갖고 있었던 경우가 46예(93.8%)였으며, 감염경로로는 호흡기를 통한 경우가 가장 많았다. 4) 임상양상은 고열(75.5%), 백혈구 증가증(46.9%), 혈소판 감소증(34.6%), 그리고 패혈성 쇽(38.7%) 등이었다. 5) 항생제에 대한 감수성은 amikacin 89.9%, ciprofloxacine 87.5%의 감수성을 보였으나, ampicillin 4.2%, cephalothin 6.2%로 강한 내성을 보였다. 5) 15명이 균혈증으로 사망하였으며(30.6%), 사망과 관련된 예후인자로는 폐렴, 패혈성 쇽, 기저질환이 위중하였던 경우에서는 의미있게 높은 사망률을 보였으나(p<0.05), 성별, 병원내감염, 복합균혈증 유무에 따른 차이는 없었다(p>0.05). 결 론 : Enterobacter 균혈증은 기저질환으로 면역기능이 저하된 환자에서 많이 발생하며, 폐렴, 패혈성 쇽이 동반된 경우와 기저질환이 위중한 환자에서 높은 사망율을 보이며, 따라서 이들에 있어 항생제 감수성 결과에 따른 적절한 항생제의 투여가 매우 중요하다. Background : Enterobacter species have emerged as important human pathogens, particularly in hospitalized patients. Recently, the morbidity and mortality associated with Enterobacter bacteremia have increased. sick because popalativn of old ages, neoplasms, use of indwelling catheter, use of antibiotics and organ transplantations have increased, In this study the epidemiologic factors, clinical characteristics, treatment and outcome of 49 patients with Enterobacter bacteremia are reviewed in Kyung-Hee medical center during a 5-year period. Methods : Fourty-nine cases of Enterobacter bacteremia diagnosed from January 1990 to December 1994 in Kyunghee medical center were analysed by their clinical records retrospectively. Results : 1) Male to female ratio was 1.72:1 and mean age was 39.1. 2) Twenty-nine cases were nosocomially acquired; Enterobacter bacteremia six showed polymicrobial infections. 3) Significant underlying conditions were present in 46 patients(93.85%), and the respiratory tract infection was the most common source of bacteremia. 4) Common clinical manifestations were fever(75.5%), leukocytosis(46.9%) and thrombocytopenia(34.6%), and there were no symptom discrimating from or signs bacteremias by other gram negative organisms. 5) In vitro tests showed susceptibility rates of 89.9% to amikacin, 87.5% to ciprofloxacine, 4.2% to ampicillin and 6.2% to cephalothin. 6) Case fatality rate was 30.6% and the mortality was significantly increased with the presence of pneumonia, septic shock or other fatal underlying diseases. Conclusion : This study suggests that Enterobacter bacteremia is common in patients with altered host defenses secondary to serious underlying disease. Appropriate antibiotics are necessary to decrease the morbidity and mortality rates in enterobacter bacteremia with fatal underlying disease.

      • SCOPUSKCI등재

        Depletion Syndrome 을 동반한 직장 융모성 선종

        이승호,김병호,이정일,김효종,장린,장영운,이정환,동석호,박종오,최남수,이원욱 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.1

        Massive secretory diarrhea with pre-renal insufficiency, hyponatremia, hypokalemia and metabolic alkalosis or acidosis is associated with some large villous adenomas of the rectum and is called with depletion syndrome. This characteristic fluid and electrolyte depletion syndrome is caused by secretion of sodium, potassium, and fluid from the tumor. PGE2 formation in the villous adenoma appears to be the cause of fluid secretion by the abnormal tumor epithelium. Surgical removal of villous adenoma is the only promising therapy, In case of inoperability, denial of surgical intervention or just for palliative treatment prior to surgery, the use of PG synthetase inhibitors may facilitate the correction of severe fluid-electrolyte deficits. We reported a case of large villous adenoma of the rectum with depletion syndrome aceompanied by secretory diarrhea and fluid and electrolyte depletion with metabolic alkalosis due to severe vomiting.

      • SCOPUSKCI등재

        외상성 췌장 가성동맥류 1예

        이승호,김병호,이정일,김효종,이성배,홍화정,장린,동석호,장영운,박종오,최욱선 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.3

        In spite of advances in the management of the victim of trauma, the reported incidence of mortality and significant morbidity after pancreatic and/or duodenal injuries is still remained high. The key to treatment is thought to be early, accurate evaluation and proper management according to the degree of injury. We experienced a case of 26-year-old man who had melena after surgery for gun-shot wound of abdomen. In operation, it was noted that duodenum, superior mesenteric artery, and inferior vena cava were lacerated. He was treated by primary suture and drainage. But, 9 months later, hematochezia was developed. Duodenoscopic findings showed buldging mass with blood oozing at the medial side of duodenum second portion. Abdominal CT and angiography revealed pseudoaneurysm of superior mesenteric artery in the pancreas head. The surgery was postponed because severe adhesion between adjacent structures and pseudoaneurysm was suspected. So we decided medical treatment for him and melena was stopped spontaneously. We report this case with a review of literatures.

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