Metabotropic Glutamate 수용체와 불안

박영민,이현륭,이승환,Park, Young-Min,Yi, Hyeon-Lyung,Lee, Seung-Hwan 대한불안의학회 2007 대한불안의학회지 Vol.3 No.1

Although treatments of anxiety symptom have been available for decades, the biological basis for anxiety disorders in humans is just beginning to emerge. Recently, there is a growing body of literature suggesting that group II metabotrpic glutamate (mGlu) receptors and group I mGlu receptors are important in the physiological and behavioral sequelae associated with stressful stimuli. Moreover, compounds selective for mGlu receptors, particularly mGlu2/3 and/or mGlu5, have proven as effective as classical anxiolytics in various animal models of anxiety without producing many of the unwanted side effects that are typical of current therapies. This article will focus on the emerging preclinical and clinical data that implicate modulation of the mGlu receptors as a potential anxiolytic strategy.

실리콘관 삽입술에서 관의 고정을 위한 실리콘 시트와 봉합사 사용의 임상적 효과 비교

박영민,구기홍,이지은,이종수,김윤경,Young Min Park,Gi Hong Koo,Ji-Eun Lee,Jong Soo Lee,Yoon Kyung Kim 대한안과학회 2009 대한안과학회지 Vol.50 No.2

Purpose: To compare the clinical outcome of silicone tube intubation according to the tie methods. Methods: Eighty-eight eyes of 87 patients who underwent silicone tube intubation were divided into two groups based on the tie method: a silicone silastic sheet group (Group 1, n=59) and a nylon 6-0 suture knot group (Group 2, n=29). The two groups were compared according to their success rates, recurrence rates and complications. Results: No significant difference was found in the success rate between the two groups (83.0% in Group 1 and 82.7% in Group 2). However, Group 2 showed a significantly higher rate of postoperative complications than Group 1. In Group 1, 5/59 (8.4%) eyes had ocular irritation, 2/59 (3.4%) eyes exhibited tube prolapse, conjunctivitis, corneal erosion, and dacryocystitis and 1/69 (1.6%) eyes had a punctal slit after intubation. In Group 2, 3/29 (10.3%) eyes had ocular irritation, 2/29 (6.9%) eyes exhibited tube prolapse, conjunctivitis, a punctal slit, and dacryocystitis, and 1/29 (3.4%) eyes showed corneal erosion, or a granuloma after intubation. A recurrence of symptomatic tearing was found in 6/59 (10%) eyes in Group 1 and 3/29 (10%) in Group 2. Conclusions: In silicone tube intubation of incomplete NLD obstruction, the usage of silicone silastic sheets to tie both ends of the silicone tube produced a lower complication rate and a higher success rate than that of the suture knot group. Lower tension on the nasolacrimal passage in the silicone silastic sheet group allows for a significantly lower rate of punctal slit development. Therefore, the method of using silicone silasitic sheets can be considered useful in the treatment of NLD obstruction.

Acute-Withdrawal Restless Legs Syndrome Following Abrupt Cessation of Short-Term Tramadol

박영민,Hye Kyeong Park,김린,이헌정,강승걸 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.2

We report a young man who had received tramadol for pain control and experienced an uncomfortable sensation in both legs immediately after tramadol withdrawal that worsened at rest and at night, and which could be relieved only by moving the legs. He suffered from insomnia and paced up and down in his house every night. Readministration of tramadol dramatically resolved his symptoms of restless legs syndrome (RLS), but they reappeared after tramadol withdrawal. Tramadol was therefore replaced with ropinirole, which was discontinued after several weeks, and there was no recurrence of his RLS symptoms. This patient appeared to have developed tramadol- withdrawal-induced RLS, and this case report emphasizes the importance of monitoring for withdrawal-type symptoms like RLS when tramadol intake is being stopped.

20게이지와 23게이지 평면부 유리체절제술 후 각막지형도 변화의 비교

박영민,이지은,엄부섭.Young Min Park. MD. Ji Eun Lee. MD. Boo Sup Oum. MD 대한안과학회 2009 대한안과학회지 Vol.50 No.3

Purpose: To compare the changes in corneal topography between 23 gauge (G) pars plana vitrectomy (PPV) and 20 G PPV. Methods: Forty-three eyes of 42 patients who underwent PPV were divided into 2 groups: 20G PPV (Group I, n=18) and 23 G PPV (Group II, n=25). Both groups were followed up over 3 months postoperatively. ORBSCAN II was performed to compare the corneal topographic change of 20 G PPV and 23 G PPV. Results: In a 5 mm zone, significant postoperative change in the mean corneal surface cylinder was found between the 1st day and the 1st month in Group I, while no significant change was found in Group II. Postoperatively, the increase in the mean corneal surface cylinder in Group I was significantly higher than in Group II between the 1st day and the 1st month. Clinically significant astigmatism, induced by surgery, was found only in Group I one week after the operation. In a 3 mm zone, there was no significant change in the mean corneal surface cylinder in both groups postoperatively. The difference in the mean corneal surface cylinder between the 2 groups at the postoperative periods showed no significant change. Surgically induced astigmatism was significantly higher in Group I than in Group II between the 1st day and the 1st month postoperatively. Conclusions: PPV with the 23 G system is a sutureless transconjunctival surgery, which appears to be more effective due to insignificant corneal surface and astigmatic changes in the early postoperative period.

LCC를 고려한 BOX구조물 뒷채움 재료의 경제성 분석

박영민,김수용,Park, Young-Min,Kim, Soo-Yong 한국건설관리학회 2009 한국건설관리학회 논문집 Vol.10 No.6

경량기포혼합토는 경량성으로 인해 구조물 등에 작용하는 하중이 저감되어 연약지반의 뒷채움 재료로 사용되지만, 일반토사에 비하여 초기시공비용이 많이 소요되어 아직 국내에서는 많이 적용되고 있지 않다. 주로 뒷채움 재료는 초기시공비가 적게 소요되는 일반토사를 사용하고 있으나, 일반토사의 덧씌우기 공법은 횟수가 증가함에 따라 사용연수가 감소된다. 특히 연약지반에 설치된 BOX구조물이나 교대 뒷채움 인근의 단차 발생 시 덧씌우기 공법은 일시적인 대체공법은 가능하지만, 덧씌우기 두께에 대한 하중만큼 추가 하중이 발생하게 되므로 결국 단차에 대한 해결책은 되지 못한다. 따라서 본 연구에서는 BOX구조물 뒷채움 재료인 일반토사와 경량기포혼합토의 두 가지 대안에 대하여 LCC 분석을 실시하고 경제적 측면에서 보다 합리적인 의사결정을 할 수 있는 경제성 분석을 제시하고자 하였다. 그 결과 경량기포혼합토가 일반토사에 비해 초기시공비용은 많이 소요되지만 유지관리 측면에서는 비용이 더 적게 소요되어 경제성을 확보할 수 있는 것으로 분석되었다. The lightweight bubble mixture soil is used for soft ground rear-filling material by applying reduced weight on structure. However, comparing with the general soil, it is not applied in domestic because of initial phase cost of construction. General soil, which has lower initial phase cost is usually used for rear-filling, but the use of overlay method of general soil is reduced as the number of layers increases. Especially box structure placed in soft ground or the overlay method when gap near pier rear-filling can be replaced with temporary alternative method, however, it can't be a solution to gap by generation of extra weight of thickness of overlaying. Therefore, execute LCC analysis of two alternative-the general and the lightweight bubble mixture soils, which are rear-filling material of box structure- and present economical analysis in order to make resonable decision from the economics. As a result, although the lightweight bubble mixture soil takes higher initial phase cost than the general soil, it has been analyzed to procure economical efficiency by having less cost of maintenance.

피부과 외래환자에서 아토피피부염의 상대 빈도와 임상적 특징 및 검사 소견에 관한 연구

박영민,박홍진,김태윤,김정원 ( Young Min Park,Hong Jin Park,Tae Yoon Kim,Chung Won Kim ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.1

Background : Atopic dermatitis(AD) is a common disease, and population-based studies indicate that the frequency of AD has increased substantially during recent decades. However, there have been few studies on the hospital based relative frequency, and clinical and laborat,ory findings of AD in Korea. Objective : The presenl study was aimed to elucidate the relative frequency of AD on the outpatient base, and to investigate the clinical manifestations and immunological laboratory findings. Methods : Our study was designed by analysing outpatients with AD via physical examination, questionnaires and immunological investigations such as skin prick tests, Multi test CMI, and measurernent of eosinophil counts, total IgE, Derrnatophagoides pteronyssinus-specific IgE and eosinophil cationic protein(ECP). Results : The results were as follows : 1. The relat,ive frequen:y of AD on the hospital base in 1995-1996 was 8.6%. 2. The mean age of onset was 3.36 years. 57.3% of the patients had their onset of eczema by the age of 1 year, 65.5% by 2 years and 83% by 5 years. The most common site at the onset was the face followed by antecubital area, popliteal area, neck, and trunk. 3. The predilection site on physical examination were the face, neck, antecubit,al area, popliteal area and trunk in decreesing order. 4. Concomitant allergic rhinitis, keratoconjunctivitis and asthma were present in 2~3.4%, 14.1%, and 9.5% of patients with AD, respect.ively, whereas pure AD was present in 34.1%. 5. Family history of atopy was observed in 60.5% of AD patient.s. 6. The most frequent ninor fea~ture of AD was xerosis followed by perifollicular accentuation, allergic shiner, cheilitis, imitation allergy, palrnar hyperlinearity and molluscum cantagiosum. 7. Seasonal aggravation was found in 86.8% of patients with AD, especially in summer and winter, The rnost significant aggravating factors were wools followed by sweating, heating, dryness, excessive bat.hing and emotional stress. 8. Abnormal levels of .osinophils, total IgE and ECP were seen in 44.8%, 78.9% and 31.7% Of patients with AD, respec.ively. 9. Cell mediated immunty was decreased in 68.2% of patients with AD. 10. Positive reactivity( at least rnore than one alle~rgen) in the skin prick t,est was noted in 76% of pat,ients with AD and the most popular 8 allergens were D. pteronyssinus, D. farinae, cat fur, M4 mixed threshing dust., dog hair, mugwort pollen, H3 tree pollen and birch pollen. 11. The specific IgE aritibodies to D. pteronyssinus(>+1) were found in 72.3% of AD patients and correlated with the r esults of the skin prick test in 76%. Conclusion : The hospi al-based relative frequency of AD investigated in our study tends to be increased. As the clinica featu~res and laboratory findings of AD might be influenced by genetic, environrnental and psychological factors, the systernic evaluation of patients with AD will be needed (Kor J Dermatol 1997;35(1): 96-106)

인간과 하천 3 - [자전거 여행] 하천과 함께 하는 자전거 여행

박영민,Park, Yeong-Min 한국하천협회 2009 하천과 문화 Vol.5 No.3

터보프롭 항공기의 프로펠러 파워효과 해석 및 보정

박영민,정진덕,Park, Youngmin,Chung, Jindeog 항공우주시스템공학회 2015 항공우주시스템공학회지 Vol.9 No.4

During the conceptual design of turboprop aircraft, the power effect driven from rotating propeller is typically obtained from empirical data. In the present paper, propeller power effect was obtained by using unsteady three-dimensional Navier-Stokes solver with $k-{\omega}$ turbulence model for the accurate prediction of turboprop aircraft performance. In order to simulate the relative motion between propeller and fuselage, unsteady sliding mesh method was used. During simulation, three flow conditions such as climb, cruise and descending flight were selected considering the flight envelop of the real turboprop aircraft. For the correction of aerodynamic coefficients, the thrust effect of engine exhaust gas was included based on the engine manufacturer's data. Using the computational results, the correction table for the aerodynamic coefficient of turboprop aircraft was suggested for the performance analysis of turboprop aircraft.

우울증 환자의 주간기분변동과 수면 양상

박영민,김린,서광윤,조숙행,강승걸,윤호경,Park, Young-Min,Kim, Leen,Suh, Kwang-Yoon,Joe, Sook-Haeng,Kang, Seung-Gul,Yoon, Ho-Kyung 대한수면의학회 2001 수면·정신생리 Vol.8 No.1

배 경 : 주간기분변동은 주요 우울장애, 멜랑콜리아 형의 세부진단으로 포함되어 있다. 그러나 현재까지의 연구를 종합해 보면 주간기분변동은 우울증의 고유한 증상인지 수면 양상의 변화와 관련된 현상인지, 혹은 별개의 다른 기전을 갖는 현상인지에 대해서 서로 모순되는 주장들이 혼재되어 있다. 이에 본 연구에서는 우울증의 세부 진단에 따른 주간 기분변동의 유무를 조사하고, 주간기분변동의 유무에 따른 수면 양상의 차이를 비교함으로써 주간기분변동과 수면 양상 사이의 관계를 찾아 보고자 하였다. 방 법 : 입원 혹은 의뢰된 우울장애 환자 62명을 대상으로 하여 주간기분변동은 Visual Analogue Mood Scale로, 수면 양상은 Pittsburgh Sleep Quality Index, 우울증의 심각도는 Hamilton Depression Rating Scale을 이용하여 측정하였다. 주간기분변동이 있는 군과 없는 군으로 나누고 HDRS 총점과 소항목, 그리고 PSQI 총점과 소항목을 변수로 하여 통계적 분석을 시행하였다. 결 과 : 주간기분변동의 빈도는 각각의 진단별로 차이가 없었으며, 주간기분변동이 있는 군과 없는 군으로 나누었을 때 중기 불면증과 수면 시간에 있어서 유의한 차이가 있었다(p<0.05). 또한 멜랑콜리아 형만을 대상으로 주간기분변동이 있는 군과 없는 군을 비교하였을 때 중기 불면증, 수면 시간뿐만 아니라 PSQI 총점, 수면 잠복기, 수면 장애, 주간의 기능 면에서 유의한 차이를 보였다(p<0.05). 결 론 : 주간기분변동은 멜랑콜리아 형의 우울장애 뿐만 아니라, 다른 우울장애에서도 존재하기 때문에 주간기분변동이 멜랑콜리아 형 우울장애의 특유한 증상으로 보기는 어려웠다. 주간기분변동이 있는 군에서 수면의 질이 더 좋은 것으로 나타났는데 이는 수면과 관련될 가능성이 높으며 향후 심도있는 연구가 필요할 것이다. 주간 기분변동은 외부 환경의 영향을 받기 쉬움으로 신뢰성을 높이기 위해서는 측정 기간과 횟수 등의 방법론적 연구도 필요할 것으로 생각된다. Object: Diurnal variation is included in the diagnostic criteria of the major depressive disorder, melancholic specifier. But there has been controversy over whether diurnal variation is an unique depressive symptoms or a symptom related to a change of sleep patterns, or that of another mechanism, when the previous studies are reviewed. We investigated the existence of diurnal variation according to the subtype of depression and whether diurnal variation is charateristic of melancholic depression or not. We also compared sleep variables according to the existence of diurnal variation. Method: We examined diurnal variation, sleep patterns, severity of depression using the Visual Analogue Mood Scale, Pittsburgh Sleep Quality Index, and Hamilton Depression Rating Scale. Patients recorded their mood state on the Visual Analogue Mood Scale twice a day, morning and evening, for diurnal variation. We divided depressive patients into two groups,-diurnal variation group and nondiurnal variation group,-and compared the mood and sleep variables using SPSS. Results: The frequency of diurnal variation is not significantly different among the subtypes of depression. Significant differences between the diurnal variation group and the nondiurnal variation group existed in middle insomnia and sleep time (p<0.05). In melancholic type, al significant difference between the diurnal variation group and the nondiurnal variation group was noticed in PSQI total, sleep latency, sleep disturbances, daytime dysfunction as well as middle insomnia and sleep time (p<0.05). Conclusions: Diurnal variation existed in other types of depression as well as melancholic type. The results showed that diurnal variation was not a specific symptom of melancholic type, and existence of diurnal variation might be related to sleep patterns.

Disciplinary Sport Psychology : 역도 경기에서 선수의 불안감이 Snatch & Jerk Technique 에 미치는 승패 관계

박영민,김정식,이한경,박동근 ( Young Min Park,Jeong Sik Kim,Han Kyung Lee,Dong Kun Park ) 한국체육학회 1996 국제스포츠과학 학술대회 Vol.1996 No.2