대뇌상 진피내 모반에 의한 뇌회상 피부 2예

박영민(Young Min Park),이동원(Dong Won Lee),김진우(Jin Woo Kim),김형옥(Hyung Ok Kim),김정원(Chung Won Kim) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.2

Cutis verticis gyrata(CVG) is an unusual conformation of the scap characterized by the presence of folds and furrows due to thickening of the corium and the subutlneous tissue. In sccordance with etiological factor and associated findings, CVG occurs as primarary disease or secondary to a variety of local or systemic diseases. Cerebriform intradermal nevus(CIN) is a cause of CVG that can usually be recognized clinically and for a certainty histologically. We report two cases of CVG due to CIN. Not only did they have CVG due to CIN on the scalp, but also they had associated congenital nevi on the face and whole boispy, respectively. (Kor J Dermatol 1993; 31(2): 258-263)

국소 평활근종의 양상을 보인 다발성 사구맥관종

류영식 ( Young Sik Ryu ),박영민 ( Young Min Park ),김태윤 ( Tae Yoon Kim ),김형옥 ( Hyung Ok Kim ),김정원 ( Chung Won Kim ),강석진 ( Seok Jin Kang ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5

We report an unusual case of multiple glomangioma showing the histopathologic findings of focal leiomyomatous component. A 23-year-old man complained of multiple, bluish, soft nodules, 0.5 to 2cm in diameter, which were distr ibuted on the back and both upper limbs. Histologic examination revealed some foci composed of spindle-shaped smooth muscle cells with abundant eosinophilic cytoplasm and blunt ended nuclei as well as cells with features intermediate between glomus cells and fully differentiated myocytes. It was confirmed by immunohistochemical and ultrastructural studies. (Kor J Dermatol 1996;34(5): 837-841)

안면부에 발생된 편측성 국한성 다모증 3예

박영민(Young Min Park),김진우(Jin Woo Kim),김형옥(Hyung Ok Kim),김정원(Chung Won Kim) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.4

Hypertrichosis is an overgrowth of hair not localized to the anclro en dependent areas of the skin. It may be congenital or acquired, localized or generalized localized hypertrichosis may occur in some types of pigrnentary nevi, chronic inflammation or irration, topical application of androgen or steroid, & localized myxedema. We report herein three i:ases of unilateral localized hypertrichosis with or without a brownish hyperpigmented patch developing on the face of a male adol scent. There are no known cau:,es of localized hyper trichosis. Histopath logically, it is characterized by increased melaniii pigment in the basal layer of the epidermis & enlarged hair follicles containing coarser liair. Electron microscopic findings show normal size & number of melanosomes in both mela nocytes & keratinocytes. Our cases differ frorn BecLers nevus in both clinical & histopatholcgic characteristics. (Kor J Dermatol 1992;30(4):551-557)

정맥내 감마글로블린으로 호전된 소아 피부근염

박현정 ( Hyun Jeong Park ),박영민 ( Young Min Park ),이종육 ( Jong Yuk Yi ),김태윤 ( Tae Yoon Kim ),김정원 ( Chung Won Kim ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.4

Dermatomyositis is an inflammatory muscular disease of presumed autoimmune origin. Many possible interventions are available to treat patients with these conditions including corticosteroids, immunosuppressive drugs, plasnapheresis, and total body irradiation. But these therapies are not always effective, and they may be associated with certain serious side effects. Recently polyvalent. intravenous gammaglohulin(IVGG) has been tried with success in inflammatory myopathies after failure of traditional treatment. We report a 8-year-old female patient with juvenile dermatomyositis who improved dramatically after alternative IVGG treatment due to side effects of steroid. (Kor J Dermatol 1996;34(4): 656-659)

원발성 위 림프종의 임상연구

황일란(Il Ran Hwang),김정원(Jung Won Kim),박선미(Sun Mi Park),김해련(Hae Ryun Kim),민영일(Young Il Min) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1

N/A Background/Aims: Primary gastric non-Hodgkins lymphoma is rare and represents a minority of 1-7% of all gastric malignancy. Prognosis and early diagnosis remains important. Methods: We analysed clinical and endoscopic findings in 27 patients with primary gastric non-Hodgkins lymphoma between June 1989 and July 1994 at the Asan Medical Center. Results: The prevalence of primary gastric lymphoma occupied 1.2% of all gastric cancers. The most frequent chief complaint was epigastric pain(74%), followed by postprandia] epigastric discomfort (19%), abdominal mass(15%) and gastrointestinal bleeding(11%). Initial endoscopic findings suggested gastric lyrnphoma in 6 cases(22%), advanced gastric cancer in 14 cases(52%) and benign gastric ulcer in 2 cases(7%). The macroscopic type of 15 cases(56%) was ulcerative, while 5(19%) were superficial, 5(19%) giant mucosal fold, and 2(6%) polypoid. Pathologic findings of initial endoscopic biopsy specimens in 18 operated cases were gastric lymphoma in 7 cases, atypical lymphocyte infiltration in 3 cases, adenocarcinoma in 4 cases and ulcer or erosion in 3 cases. Conclusions: A definite diagnosis of primary gastric non-Hodgkins lymphoma was difficu]t to be confirmed by endoscopic examination and biopsy. Recognition of specific endoscopic findings with a high index of suspicions is essential for early diagnosis, and multiple biopsies with/without submucosa are required. (Korean J Gastroenterol 1996;28: 11 - 18)

피부과 외래환자에서 아토피피부염의 상대 빈도와 임상적 특징 및 검사 소견에 관한 연구

박영민,박홍진,김태윤,김정원 ( Young Min Park,Hong Jin Park,Tae Yoon Kim,Chung Won Kim ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.1

Background : Atopic dermatitis(AD) is a common disease, and population-based studies indicate that the frequency of AD has increased substantially during recent decades. However, there have been few studies on the hospital based relative frequency, and clinical and laborat,ory findings of AD in Korea. Objective : The presenl study was aimed to elucidate the relative frequency of AD on the outpatient base, and to investigate the clinical manifestations and immunological laboratory findings. Methods : Our study was designed by analysing outpatients with AD via physical examination, questionnaires and immunological investigations such as skin prick tests, Multi test CMI, and measurernent of eosinophil counts, total IgE, Derrnatophagoides pteronyssinus-specific IgE and eosinophil cationic protein(ECP). Results : The results were as follows : 1. The relat,ive frequen:y of AD on the hospital base in 1995-1996 was 8.6%. 2. The mean age of onset was 3.36 years. 57.3% of the patients had their onset of eczema by the age of 1 year, 65.5% by 2 years and 83% by 5 years. The most common site at the onset was the face followed by antecubital area, popliteal area, neck, and trunk. 3. The predilection site on physical examination were the face, neck, antecubit,al area, popliteal area and trunk in decreesing order. 4. Concomitant allergic rhinitis, keratoconjunctivitis and asthma were present in 2~3.4%, 14.1%, and 9.5% of patients with AD, respect.ively, whereas pure AD was present in 34.1%. 5. Family history of atopy was observed in 60.5% of AD patient.s. 6. The most frequent ninor fea~ture of AD was xerosis followed by perifollicular accentuation, allergic shiner, cheilitis, imitation allergy, palrnar hyperlinearity and molluscum cantagiosum. 7. Seasonal aggravation was found in 86.8% of patients with AD, especially in summer and winter, The rnost significant aggravating factors were wools followed by sweating, heating, dryness, excessive bat.hing and emotional stress. 8. Abnormal levels of .osinophils, total IgE and ECP were seen in 44.8%, 78.9% and 31.7% Of patients with AD, respec.ively. 9. Cell mediated immunty was decreased in 68.2% of patients with AD. 10. Positive reactivity( at least rnore than one alle~rgen) in the skin prick t,est was noted in 76% of pat,ients with AD and the most popular 8 allergens were D. pteronyssinus, D. farinae, cat fur, M4 mixed threshing dust., dog hair, mugwort pollen, H3 tree pollen and birch pollen. 11. The specific IgE aritibodies to D. pteronyssinus(>+1) were found in 72.3% of AD patients and correlated with the r esults of the skin prick test in 76%. Conclusion : The hospi al-based relative frequency of AD investigated in our study tends to be increased. As the clinica featu~res and laboratory findings of AD might be influenced by genetic, environrnental and psychological factors, the systernic evaluation of patients with AD will be needed (Kor J Dermatol 1997;35(1): 96-106)

선천성 이전부 누공 2예

채구석 ( Koo Seog Chae ),박영민 ( Young Min Park ),이종육 ( Jong Yuk Yi ),김태윤 ( Tae Yoon Kim ),김정원 ( Chung Won Kim ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.3

The auricle develops from six auricular tubercles which originate from the mesenchyme of the first and second branchial arch. If a defective fusion of these tubercles occur, a preauricular fistula may be formed. We report two cases of congenital preauricular fistula manifested by soft nodules with external openings on the left preauricular area. Histologically, the fistulas are lined by stratified squamous epithelium, and elastic cartilage. and chronic inflammatory cell infiltration are also present. (Kor J Dermatol 1996;34(3): 450-453)

아토피 피부염 환자에서 Mycophenolate mofetil 의 치료효과

이상욱(Sang Wook Lee),박영민(Young Min Park),김형옥(Hyung Ok Kim),김정원(Chung Won Kim) 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.8

N/A Background : Atopic dermatitis has been thought be a T cell mediated disease and autoimmune response may be responsible for chronicity of typical skin manifestation. Mycophenolate mofetil(MMF), a new immunosuppressive agent can be tried in the treatment of atopic dermatits. Objective : We examined the efficacy and safety of MMF in the treatment of atopic dermatitis in Korean patients. Methods : 7 patients with moderate to severe atopic dermatits were recruited in the treatment of oral MMF 2 g daily for 6 weeks and followed up for another 6 weeks. Severity of atopic dermatitis was measured using SCORAD index. Laboratory examination was performed to check the side effect of MMF during the study. Results : Six of 7 patients finished the treatment courses. After 6 weeks of therapy with MMF, patients` symptoms were improved and mean SCORAD index was significantly reduced from 67.2 15.5 to 28.7±13.5(p<0.01). Significant side effects such as neutropenia, infection, renal toxicity and hepatotoxicity were not observed. During the follow-up period, patients could be managed by topical steroid and oral antihistamine and flare-up was not observed. Conclusion : According to our study, MMF is an effective, safe and well-tolerated immunosuppressive agent in the treatment of moderate to severe atopic dermatitis. MMF is a promising alternative in the treatment of severe atopic dermatitis.

자동차 공장 주철 주조작업 근로자들의 직업성 피부질환

최희창 ( Hee Chang Choe ),박영민 ( Young Min Park ),이준영 ( Jun Young Lee ),김형옥 ( Hyung Ok Kim ),김정원 ( Chung Won Kim ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.5

N/A Background : Many employees working in cast iron foundry process at an automobile production plant suffered from similar dermatoses due to occupational exposure. But data on the occupational dermatoses in foundry workers at an automobile production plant have not been reported in Korea. Objective : The aim of this study was to evaluate the prevalence of dermatoses in relation to occupational exposure in cast iron foundry process at an automobile production plant. Methods : 188 workers working in the foundry process were investigated for the presence of dermatoses using a questionnaire and a dermatological examination. The questionnaire included the past or present history of occupational exposure, dermatoses and atopy and so on. Patch test with Korean standard allergen and additional related allergen was performed in 38 workers who were suspected to have contact dermatitis in relation to occupational exposure. Results : The results are summarized as follows ; 1. The most common 5 dermatoses were dermatophytoses(40), contact dermatitis(18), folliculitis (11), atopic dermatitis(9) and hand eczema(5). 2. The determined risk factors to the skin were hot environmental condition, silica, organic solvent nickel and chrome. 3. The incidence of irritant contact dermatitis was much higher than that of allergic contact dermatitis. 4. The frequency of irritant contact dermatitis was much higher in atopics than in non-atopics. 5. Contact sensitization was found in 6 workers and sensitizing substances were cobalt, nickel, colophony, quinoline mixture and balsam of Peru. Conclusion : Based en these clinical and epidemiological observations, it is suggested that the health and safety educational programs about the occupational dermatoses are needed for workers. (Korean J Dermatol 2003;41(5) : 586~591)

유두상 에크린 한선종 4예

임지현 ( Ji Hyun Lim ),오신택 ( Shin Taek Oh ),김형옥 ( Hyung Ok Kim ),김정원 ( Chung Won Kim ),박영민 ( Young Min Park ),송계용 ( Key Young Song ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.6

Papillary eccrine adenoma is a rare cutaneous tumor which occurs most commonly on the distal portion of extremities as a small solitary nodule. Histopathologically, the tumor consists of multiple dilated or branching tubular structures that are lined by two or more layers of epithelial cells and shows papillary projection into the lumina. Positive staining with S-100 protein, CEA, EMA and keratin in papillary eccrine adenoma is consistent with differentiation toward the secretory epithelium of eccrine sweat gland. Herein we report four cases of papillary eccirine adenoma and review the literature. (Korean J Dermatol 2003;41(6) : 761~765)