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박순현,전현재 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
색소는 가시광선의 특정 파장부분을 선택적으로 흡수하는 물질로 우리 생활의 전반에 걸쳐 사용되고 있으며 최근 디스플레이 장치를 비롯한 전자장치의 발달과 함께 다양한 응용이 전개되고 있다. 본 발표에서는 다양한 색소 중 염료를 중심으로 기본적인 지식과 역사, 응용분야 등을 살펴보고, 그 중 특히 디스플레이 장치를 비롯한 전자소재용 색소의 최근 개발동향에 대해 소개하고자 한다.
Graves’ Disease that Developed Shortly after Surgery for Thyroid Cancer
유혜민,박순현,이재민,박강서 대한내분비학회 2013 Endocrinology and metabolism Vol.28 No.3
Graves’ disease is an autoimmune disorder that may present with various clinical manifestations of hyperthyroidism. Patients with Graves’ disease have a greater number of thyroid nodules and a higher incidence of thyroid cancer compared with patients with normal thyroid activity. However, cases in which patients are diagnosed with recurrence of Graves’ disease shortly after partial thyroidectomy for thyroid cancer are very rare. Here we report a case of hyperthyroid Graves’ disease that occurred after partial thyroidectomy for papillary thyroid cancer. In this case, the patient developed hyperthyroidism 9 months after right hemithyroidectomy, and antithyroglobulin autoantibody and thyroid stimulating hormone receptor stimulating autoantibody were positive. Therefore, we diagnosed Graves’ disease on the basis of the laboratory test results and thyroid ultrasonography findings. The patient was treated with and maintained on antithyroid drugs. The mechanism of the recurrence of Graves’ disease in this patient is still unclear. The mechanism may have been the improper response of the immune system after partial thyroidectomy. To precisely determine the mechanisms in Graves’ disease after partial thyroidectomy, further studies based on a greater number of cases are needed.
전현재,박순현 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
(주)경인양행은 정밀 화학제품의 개발 및 제조를 선도하는 기업이며, 1971년 설립된 이래 근 50년 동안 섬유, 식품, 농업 및 전자제품에 사용하는 염료, 잉크, 정밀 화학제품과 그 재료를 생산해 왔습니다. 그리고 이러한 합성 기술력을 바탕으로 세계 50여 개 국에 염료를 수출하고 있는 글로벌 수출 특화 기업입니다. 현재 인천 광역시 서구 석남동에 본사와 1,2공장을 두고 있으며, 경기도 안산시와 경기도 시흥시에 각각 3공장과 4공장을 두고 있다. 이 외에도 서울 사업소 본관, 서울 사업소 신관, 대구영업소, 부산출장소를 전국 각지에 두고 있다. 또한 그룹은 상장사 경인양행 1곳과 비상장사 9곳(KISCO SHANGHAI, LIANYUNGANG KISCO, 제이엠씨, 다이토키스코, 와이즈켐, KISCO INDIA, KISCO USA, KIMSOY ADANA, RACHADA CHEMICAL)의 계열사가 있다.
한영은,임아진,박순현,장성호,이석호,호원경 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-
AMP-activated protein kinase (AMPK) is a metabolic sensor activated during metabolic stress and it regulates various enzymes and cellular processes to maintain metabolic homeostasis. We previously reported that activation of AMPK by glucose deprivation (GD) and leptin increases KATP currents by increasing the surface levels of KATP channel proteins in pancreatic β-cells. Here, we show that the signaling mechanisms that mediate actin cytoskeleton remodeling are closely associated with AMPK-induced KATP channel trafficking. Using F-actin staining with Alexa 633-conjugated phalloidin, we observed that dense cortical actin filaments present in INS-1 cells cultured in 11mM glucose were disrupted by GD or leptin treatment. These changes were blocked by inhibiting AMPK using compound C or siAMPK and mimicked by activating AMPK using AICAR, indicating that cytoskeletal remodeling induced by GD or leptin was mediated by AMPK signaling. AMPK activation led to the activation of Rac GTPase and the phosphorylation of myosin regulatory light chain (MRLC). AMPK-dependent actin remodeling induced by GD or leptin was abolished by the inhibition of Rac with a Rac inhibitor (NSC23766), siRac1 or siRac2, and by inhibition of myosin II with a myosin ATPase inhibitor (blebbistatin). Immunocytochemistry, surface biotinylation and electrophysiological analyses of KATP channel activity and membrane potentials revealed that AMPK-dependent KATP channel trafficking to the plasma membrane was also inhibited by NSC23766 or blebbistatin. Taken together, these results indicate that AMPK/Rac-dependent cytoskeletal remodeling associated with myosin II motor function promotes the translocation of KATP channels to the plasma membrane in pancreatic β-cells.