황련해독탕(黃連解毒湯) 약침(藥鍼)을 병용한 대상포진(帶狀疱疹) 치험 2례

박수은,김창환,한다님,허연식,Park, Soo-Eun,Kim, Chang-Hwan,Han, Da-Nim,Huh, Yeon-Sik 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.2

Objectives : These 2 case studies were made to evaluate and observe the treatment for the Herpes Zoster through the Hwangryunhaedoktang Herbal Acupuncture. Methods : Clinical observation analysis about 2 cases of Herpes Zoster had been done for the patients of the DongSeo Medical Center. These cases were mainly treated with subcutaneous injection of Hwangryunhaedoktang Herbal Acupuncture at the vesicles. Results : After the treatment, the vesicles were cleared and the pain was decreased. Conclusions : Based on the clinical results, Hwangryunhaedoktang Herbal Acupuncture can be one of a good remedy for Herpes Zoster.

영감강미신하인탕이 Th 2 세포 분화 조절을 통해 알레르기성 비염에 미치는 효과

박수은,홍승욱,Park, Soo-Eun,Hong, Seung-Ug 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.1

Objectives : Younggamgangmisinhayin-tang is clinically used for the treatment of the aller -gic rhinitis. The aim of this study is to investigate the effects of Younggamgangmisinhayin -tang on allergic rhinitis. Methods : The thirty rats were divided into three groups : control group, AR(allergic rhinitis eliciated) group, YT(Younggamgangmisinhayin-tang treated after allergic rhinitis elicitation) group. To induce allergic rhinitis in AR group, YT group rats were sensitized intraperitoneally with 0.1% ovalbumin(OVA) solution 3 times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1% ovalbumin(OVA) solution 3 times at intervals of 2 days. After that time rats in YT group were oral administration treated by Younggamgangmisinhayin-tang for 7days. The change of the amounts of esinophil, PAS, ZO-1, MIP-2, COX-2, IL-4 were observed in each group. Th 2 skewed condition in EL4 cell was induced by using PMA and OPl. Younggamgangmisinhayin-tang was added into EL4 cell by density. And then IL-4 mRNA was observed. Results : In esinophil study YT group was proved significant inhibitary effect. In PAS and ZO-1 YT group were preserved well. In MIP-2, COX-2 study YT group was proved significant inhibitary effect. In IL-4 and IL-4 mRNA study YT group was proved significant inhibitary effect. Conclusion :According to the above results, it is considered that Younggamgangmisinha- yin-tang has inhibitory effects on the allergic rhinitis rat models.

면포를 중심으로 한 순환교대근무 간호사와 주간고정근무 간호사의 피부질환 양태에 관한 연구

옥민근,박수은,김창환,허연식,Ock, Min-Keun,Park, Soo-Eun,Kim, Chang-Hwan,Huh, Yeon-Sik 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.3

Objectives : The purpose of this study is to investigate the differences of skin disease, particularly Acne between the rotating shift work nurses and the nurses on a fixed day schedule. Methods : Questionnaries were distributed to 30 rotating shift work nurses(the rotating group) and 34 nurses on a fixed day schedule(the daytime group). The questionnaris included questions on general health concepts, insomnia skin disease(particularly Acne), gastroenteric trouble, menstrual irregularity. Result : 1. There was significant difference on skin disease(particularly Acne) between two groups. 2. There was no significant relation between Gastroenteric trouble and Acne. But, in particular, there was significant relation between Constipation, Gastritis and Acne. 3. There was no significant relation between menstrual irregularity and Acne. 4. In Acne group, more than 70% felt the necessity of treatment, but only 2.5% used Korean Oriental Medical therapy. Conclusion : Disorder of circadian rhythm affects the skin disease(particularly Acne) more than Gastroenteric trouble and menstrual irregularity. But in this study, the total number of the nurse is not enough. So we need more accurate study about the aspects of skin disease. And about the Acne, publicity of Korean Oriental Medical therapy is required.

동씨침법(董氏鍼法)을 이용한 중풍(中風) 환자의 연하장애(嚥下障碍) 치험 3례(例)

임웅경,박수은,김창환,정경숙,옥민근,Lim, Woong-Kyoung,Park, Soo-Eun,Kim, Chang-Hwan,Jung, Kyung-Suk,Ock, Min-Keun 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3

Objective: This study was performed to evaluate the effect of Dong-Si acupuncture therapy, on the stroke patients with dysphagia. Method: We studied three selected stroke patients with dysphagia who could follow instructions. The patients were treated with Dong-Si acupuncture (Jokch'eonkeum, Jokokeum) with Dong-Qi therapy for two weeks. We evaluated the effects by AHSA scale, VAS and MBI. Results & conclusion: Dysphagia was improved in all of three cases after treatment. But more clinical & scientific trials are expected to follow this study.

구안와사 환자 50례의 스트레스 정도에 관한 임상적 연구

옥민근,허연식,김창환,박수은,Ock, Min-Keun,Huh, Yeon-Sik,Kim, Chang-Hwan,Park, Soo-Eun 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.3

Objective : This study is to explore the various of the stress by perceived by paitents with Bell's palsy Methods : 50 patients who were diagnosed as Bell's palsy were sequentially interviewed and examined Results : The results were as follows 1. The mean average PWI(Psychosocial well-being index, total : score)was $41.58{\pm}17.53$ :Factor I(Social performance and self-confidence) with a mean of $11.18{\pm}8.38$, Fact II( Depression) with a mean of $8.94{\pm}6.26$, Factor III(Sleeping disturbance and anxiety) with a mean $of7.56{\pm}5.20$, Factor IV(General well-being and vatality)with a mean $of9.90{\pm}4.44$ 2. With the respect to the general characteristics of subjects, there were statistically significant differences in the patients's stress perception by sex, having an occupation and the amount of sleeping time. Conclusions : We needed the further study about the relation between stress and Bell's palsy

구안와사(口眼喎斜) 환자 254명에 대한 감리적(臨床的) 고찰(考察)

옥민근,임웅경,김창환,박수은,Ock, Min-Keun,Lim, Woong-Kyoung,Kim, Chang-Hwan,Park, Soo-Eun 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3

Objective: The purpose of this study is to investigate the clinical studies on 254 cases of patient with facial paralysis. Methods: We examined the sex, age, region, month, season, physical condition, attened symptoms, the period before admission, the period of treatment the times of treatment, the point of the recovery Results: 1. The distribution of sex was male 119 cases, female 125 cases(1.032:1). The distribution of age was disclosed that fifty was the most in 53 cases(20.9%) 2. In distribution of the region of facial palsy, the ratio of the male-left was 27.6%(70 cases), female-left was 24.4%(62cases), male-right was 23.2%(59 cases), female-right was 24.8%(63 cases). 3. In distribution of contributing frequence in month, January was the most in number(29 cases, 11.4%), In distribution of contributing number in season winter was the most in number(76 cases, 29.9%). 4. In distribution of physical condition, fatigue(99 cases, 40.0%), stress(66 cases 26.0%), cold exposure(43 cases, 16.9%) were investigated highly than other conditions. 5. In distribution of attended symptoms, stylomastoid pain(91 cases, 35.8%), tears(40 cases 15.7%). taste paralysis(29 cases, 11.4%) were investigated highly than other symptoms. 6. In distribution of the period before admission in descending order the first under the third day was the most number in 92 cases(62.2%), over two weeks 22 cases(14.9%) 7. In distribution of the period of treatment, over eight weeks was the most number in 91 cases(35.8%), under a week in 50 cases(19.7%). In distribution of the times of treatment under five times was the most number in 56 cases(14.2%). 8. In distribution of the point of the recovery, under two weeks was the most number in 77 cases(52%).

Group A-beta Hemolytic Streptococci에 의한 소아 인두편도염에 있어서 Cefdinir의 항균력과 임상적 및 세균학적 효과에 관한 연구

정지영,신선희,안영민,안병문,신영규,배영민,박수은,김종국,이종국,마상혁,장진근,차성호,Chung, Ji-Young,Sin, Seon-Hee,Ahn, Young-Min,Ahn, Byung-Moon,Sin, Young-Gyu,Bae, Young-Min,Park, Soo-Eun,Kim, Jong-Guk,Lee, Jong-Guk,Ma, Saung-Hyuk,Chan 대한소아감염학회 2003 Pediatric Infection and Vaccine Vol.10 No.1

최근 국내 erythromycin 내성률이 증가하는 추세임을 보고하였고 erythromycin의 경우 내성의 증가는 항생제 사용량의 증가와 일치하고 있음을 보고하였다. 그래서 macrolide에 의한 내성균주의 확산을 막고 임상에서 보고되는 penicillin에 의한 치료 실패를 줄이기 위해 A군 연쇄구균 치료에 제일차 약물로 cephalosporin을 고려할 수 있다. Cefdinir의 A군 연쇄구균에 대한 항균력과 인두 편도염에 대한 우수한 임상효과 및 높은 안전성을 미루어 볼 때, Cefdinir는 A군 연쇄구균에 의한 소아 인두 편도염에 유효한 항생제로 사용될 수 있다. Objective : To determine the clinical and bacteriologic efficacy and safety of Cefdinir in acute pharyngitis and pharyngotonsillitis caused by group A beta hemolytic streptococci in pediatric patients. Methods : Children aged 3 through 12 years who visited the hospitals enrolled in this study with signs and symptoms of pharyngitis or pharyngotonsillitis since May to December 2002, were taken throat culture and given Cefdinir(12 mg/kg/day, in three divided doses) for 7 days. Two hundred thirty five patients were enrolled and 90 patients who showed positive culture results were followed up for the signs and symptoms during the treatment to determine clinical efficacy. Follow-up culture were done at the end of the study and bacteriologic efficacy was determined Results : Ninety out of 235 patients who visited the hospitals with the signs and symptoms of pharyngitis showed positive growth on throat culture. Seventy nine patients were clinically and microbiologically assessable. The bacteriologic eradication rates of S. pyogenes were 100% in all the children treated with Cefdinir. Clinical cure rates were not different between less than 7 days-treated group(75%) and just 7 days-treated group(98.6%)(P=0.077). Two patients reported adverse reaction during Cefdinir treatment. Antimicrobial sensitivity of Cefdinir against S. pyogenes was 100% with range of MIC being less than 0.5 ${\mu}g/mL$. Conclusion : It seems that Cefdinir is one of reliable and well-tolerated drugs for the treatment of group A beta hemolytic streptococcal pharyngotonsillitis in children. It needs to be investigated short term efficacy in terms of improving drug compliance and impact of economic point of view. We can recognized that still high rate of the erythromycin resistant group A streptococci in our community should be monitored every year.

2009-2011년에 발생한 신종 인플루엔자 A (H1N1)의 신경학적 양상

김란희(Ran Hee Kim),김영미(Young Mi Kim),박수은(Soo Eun Park),김혜영(Hye Young Kim),이윤진(Yoon Jin Lee),김태형(Tae Hyoung Kim),남상욱(Sang Ook Nam) 대한소아신경학회 2011 대한소아신경학회지 Vol.19 No.1

목적 : 신종 인플루엔자 A (H1N1) 바이러스 감염의 신경학적 합병증의 발생 빈도를 확인하고 임상적 고찰을 시행하였다. 방법 : 2009년 7월부터 2011년 1월까지 부산대학교 병원의 외래, 입원 및 응급실에서 신종 인플루엔자 A (H1N1) RT-PCR로 감염이 확인된 만 18세 이하의 752명 환자의 의무기록을 검토하였다. 이들 중 신경학적 합병증을 보인 환자를 대상으로 인플루엔자의 임상 증상, 신경학적 이상 증상, 검사실소견, 뇌파검사 결과, 신경 방사선학적 검사 소견 등을 조사하였다. 결과 : 15명의 환자가 신경학적 증상을 보였으며 평균 연령은 8.8세이었다. 남아가 10명 (66.7%), 여아가 5명 (33.3%)이었다. 9명 (60)이 경련을 보였고, 2명(13.3%)이 뇌염, 2명(13.3%)가 환시, 1명 (6.7%)이 무균성 수막염, 1명(6.7%)이 현훈을 보였다. 급성 열성 감염의 발생 평균 2일(범위 0-4일)이 경과한 후 신경학적 증상을 보였다. 3명 (20.0%)이 뇌척수액 검사에서 이상 소견을 보였으나 신종인플루엔자 A (H1N1)은 검출되지 않았다. 1명 (6.7%)이 뇌 자기공명검사에서 이상 소견을 보였다. 14명 (93%)이 oseltamivir를 투여 받았다. 모든 환자가 완전히 회복되었으며 신경학적 후유증은 없었다. 결론 : 신종 인플루엔자 A (H1N1)는 대유행 기간 동안 다양한 신경학적 증상을 동반하였다. 소아 신경학을 진료하는 의사는 인플루엔자의 유행시기에 발생하는 신경학적 증상의 감별진단으로 인플루엔자 감염을 반드시 고려해야 하겠다. Purpose : To describe the characteristics and incidence of neurologic complications related to the novel influenza A (H1N1) virus. Methods : We reviewed the medical records of 752 children and adolescence (≤ 18 years of age) who had been diagnosed as novel influenza A (H1N1) infection through positive results of influenza A (H1N1) RT-PCR and hospitalized or visited the outpatient clinic and emergency department of Pusan National University Hospital from July 2009 to January 2011. Results : We identified 15 patients who had experienced a neurologic symptom with a mean age of 8.8 years. There were 10 (66.7%) males and five (33.3%) females. Nine patients (60.0%) presented with seizures, two (13.3%) with decreased mentality, two (13.3%) with visual hallucination, and one (6.7%) with vertigo. The mean duration from onset of respiratory illness to the beginning of neurologic symptoms was 2 days (range: 0-4 days). Three patients (patient 2, 7, and 13) (20.0%) had abnormal results on cerebrospinal fluid analysis; however, novel influenza A (H1N1) was not detected. Further, one patient (6.7%) had abnormal MRI. Antiviral therapy (oseltamivir) was administered to fourteen patients (93%) and all patients recovered fully and had no neurologic sequelae. Conclusion : Novel influenza A (H1N1) was a cause of neurologic symptoms during the outbreak. Pediatricians should consider influenza virus infection in the differential diagnosis for children with neurologic symptoms during an epidemic of influenza.

임신 중 피부질환에 대한 치험 2례

김경혜 ( Kyeong Hye Kim ),정아롱 ( A Rong Jung ),정은아 ( Eun A Jung ),박수은 ( Soo Eun Park ) 대한한방부인과학회 2007 大韓韓方婦人科學會誌 Vol.20 No.1

DTaP 접종력이 없는 3개월 미만 영아의 백일해 3례

서혜경 ( Hyung Kung Seo ),김란희 ( Ran Hee Kim ),김성헌 ( Seong Heon Kim ),김혜영 ( Hye Young Kim ),박수은 ( Soo Eun Park ),박희주 ( Hee Ju Park ),이승주 ( Seung Ju Lee ),김혜정 ( Hye Jung Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.1

저자들은 발작적인 기침증상 및 간헐적으로 동반되는 구토, 청색증이 있는 신생아 및 3개월 미만의 유아에서 백일해균에 대한 배양검사와 PCR로 백일해를 확진하여 치료하였던 환자를 경험하였다. DTaP 접종이 완료되지 않은 신생아와 어린 영유아가 기침 증상이 오랫동안 지속되고 청색증, 호흡곤란이 동반된다면 백일해를 염두해 두어야 한다. 또한 청소년 및 성인에서 영유아로의 백일해 전파를 방지하며 집단 면역을 유지하기 위해 Tdap 백신의 접종을 적극적으로 권장해야 할 것이다. Pertussis is a pediatric infectious disease with one of the highest degrees of infectivity. Although pertussis may cause asymptomatic infections in children and adults with immunity, it can cause life-threatening diseases in newborn babies or infants. We report three cases of pertussis in infants <3 months of age without DTaP immunization who have received symptomatic treatment with the diagnosis of bronchiolitis from other hospitals, and subsequently correctly diagnosed and treated. The patients did not have the characteristic whooping cough, but the main symptoms were episodic cough, intermittent vomiting, and cyanosis. Based on culture results for Bordetella pertussis and PCR, pertussis was diagnosed and treated without any complications. As it is assumed that adults, adolescents, and asymptomatic patients may serve as sources of infection, immunization with Tdap vaccine is recommended to prevent dissemination of pertussis from adolescents and adults to infants, and thus maintain herd immunity. [Pediatr Allergy Respir Dis(Korea) 2011;21:56-60]