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Central Antimuscarinic Activity of Imipramine on Micturition Reflex in Anesthetized Rats
Park, Bong-Kee,Sohn, Uy-Dong,Kim, Choong-Young 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.2
Imipramine(IMI)을 마취된 흰쥐의 측뇌실로 투여하여 야기되는 배뇨반사 억제작용이 항무스카린성 작용과 관계가 있는지를 검토하였던 바 아래와 같은 결과를 얻었다. IMI측뇌실로 투여시 배뇨반사가 억제되었으나 정맥이나 복강으로 투여시 별 영향이 없었다. IMI의 억제작용은 atropine과 유사하였다. 배뇨반사의 역치는 IMI와 1-methscoplolamine을 측뇌실로 투여하였을 때 증가되었다. IMI의 억제효과는 carbachol(CCh) 0.01 또는 0.03 ㎍ 처치로 약화되었다. IMI에 의한 배뇨반사 중지효과의 회복이 CCh 투여로 촉진되었으나, hemicholinium-3(HC-3) 처치군에서는 CCh 고용량 투여로서도 회복이 촉진되지 아니하였다. 배뇨반사의 역치는 HC-3 처치군에서 증가되었으나, α-methyl-p-tyrosine이나 p-chlorophenyl-alanine 처치군에서는 변화되지 아니하였다. 배뇨반사에 의한 방광수축의 크기와 횟수가 IMI 단회투여로 감소되었고, 수축기간은 IMI 장기처치로 증가되었다. IMI측뇌실내 투여에 의한 배뇨반사의 중지기간은 단회나 장기처치로 연장되었다. 이러한 결과로 미루어 보아 IMI 측뇌실내 투여로서 배뇨반사에 억제작용을 나타내었으며, 이 억제작용에는 중추의 내인성 및 외인성 무스카린성 기전의 약화가 관여된 것으로 사료된다. We designed to investigate the antimuscarinic effect on the central activity of imipramine (IMI) in distension-induced micturition reflex contraction in urethane-anesthetized female rats. The micturition reflex contraction was inhibited by intracerebroventricular injection (i.c.v.) of IMI, with dose-sensitive manner, not by intravenous or intraperitoneal injection of IMI. This dose-related inhibition of amplitude or frequency of micturition reflex by IMI i.c.v. decreased by carbachol pretreatment of 0.01 or 0.03 ㎍. Atropine i.c.v., similar to IMI, had inhibitory effect. Both IMI and 1-methscopolamine with an increase in dosw elevated the threshold of volume and pressure. The threshold of micturition increased in hemicholinium-3 (HC-3)-, but not in α-methyl-p-tyrosine-, or in p-chlorophenylalanine-treated rat. The period of cessation of bladder contraction in HC-3 rat was more sustained than others. Carbachol i.c.v. facilitated the recovery from the inhibition of IMI in normal rat, but not in HC-3 rt. Acute treatment with IMI resulted in the decrease in amplitude and frequency of bladder contraction, and chronic treatment increased the duration of it. The period of cessation of bladder contractility by IMI i.c.v. was lengthened by acute treatment, with more strength by chronic treatment. These results suggest that IMI exerts inhibitory action through a certain central route on micturition in anesthetized rat, and that the suppression of muscarinic action is involved in the inhibition.
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강영우,박봉기,이상숙,송홍석,박재후,서승연 대한내과학회 1987 대한내과학회지 Vol.33 No.1
Herein we reported a case of sinus histiocytosis with massive lymphadenopathy which was the second in our nation. The patient was 53-year old man with a ten-year clinical course of SHML. Since three years before admission, he was suffered from generalized lymphadenopathy, nasal stuffiness, and multiple dark-reddish colored skin papules. Since 1 month before admission, more progression of nasal stuffiness and lymph node enlargement with persistent frontal headache were developed. Microscopic examination of cervical lymph node and skin tissues revealed characteristic features of SHML: predominant histiocyte infiltration, lymphophagocytosis, plasma cell proliferation. Laboratory examination disclosed anemia, increased erythrocyte sedimentation rate, polyclonal gammopathy and CSF protein of 434 mg/dl with WBC of 63/mm³. We observed a defect in cellular immune function, cutaneous anergy by Multi-CMI skin test. After treatment with vinblastine and prednisolone, improvement of headache, nasal stuffiness, and lymph node enlargement were noted.
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이경민,조희영,박봉기,한형원,배효근,류형국 대한내과학회 1992 대한내과학회지 Vol.43 No.2
Reexpansion edema is a unilateral noncardiogenic pulmonary edema thnt may develop as a complication of reexpansion of collapsed lung. This complication after reexpansion of spontaneous pneumothorax is extremely rare. The possible mechanisms underlying the reexpansion edema are due to multiple factors, increased pulmonary vascular permeability is one of the primary contributing factors. Reexpansion edema is more likely to occur when the duration of collapse is at least three or more days and the extent of pneumthorax is extensive. It is recommended that rapid evacuation of air with application of a large negative intrapleural pressure be avoided. The prognosis of reexpansion edema is relatively good, but occasionally may lead to fatal outcome. We report here a case of reexpansion edema after treatment of spontaneous pneumothorax which presented serious clinical manifestations.
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