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류미선,김은영 조선대학교 의학연구소 2013 The Medical Journal of Chosun University Vol.38 No.2
XX male syndrome is a genetic disease associated with gender dysplasia and characterized by a spectrum of clinical presentations, which range from ambiguous to normal male genitalia. The incidence of XX male syndrome is about 1 per 20,000- 25,000. The majority of XX males with SRY gene have normal genitalia, whereas most SRY-negative cases have ambiguous genitalia. Here, we report a case of a SRY-negative XX male with ambiguous genitalia.
실신을 주소로 방문한 소아 환자의 원인질환에 대한 임상적 고찰
류미선,이재희,김은영,노영일,양은석,문경래,박영봉 조선대학교 의학연구소 2013 The Medical Journal of Chosun University Vol.38 No.3
Syncope is a common symptom, with 15% to 25% of children and adolescents experiencing at least one syncopal episode by young adulthood. In most cases, syncope is a symptom of benign diseases however may be a symptom of severe cardiac disease that results in sudden death. The purpose of this study is to analyze the etiologies and clinical characteristics of syncope in children and adolescents. We retroprospectively analyzed 51 patients with syncope. A total of 51 patients were included in the study and the ratio of males to female was 1: 1.04. The mean patient age was 12.7±3.1 years. Abrupt standing was the most common state of patients with syncopal attack. The etiologies of syncope were noncardiac syncope (60.7%), cardiac syncope (2%), neuropsychiatric syncope (25.5%), and unknown (11.8%). Abnormality of the head-up tilt test was more common in noncardiac syncope than the others [38.7% (12/31) vs 5% (1/20) (p=0.007)]. Further, EEG is a useful diagnostic test for neuropychiatric syncope [41.6% (5/12) vs 2.7% (1/36) (p=0.002)]. Therefore, detailed history taking and physical examinations were useful tools to diagnose the etiology of sycope. The head-up tilt test is an effective diagnostic test in noncardiac syncope and EEG is a valuable test in neuropychiatric syncope, especially in seizure.
茵陳五苓散약침이 DEN으로 유발된 흰쥐의 간암에 미치는 영향
류미선,김성필,김재홍,류혜선,윤여충,신정철 대한침구의학회 2011 대한침구의학회지 Vol.28 No.5
Objectives : Inchinohryungsan has been used for treatment of hepatobiliary diseases. This study was designed to investigate the effect of Inchinohryungsan pharmacopuncture on hepatocellular carcinoma in rats. Sprague Dawley(SD) rats of the control and experimental groups received intraperitoneal injection of 50 ㎎/㎏ DEN, weekly for 12 weeks. Methods : Rats were divided into 5 groups. Normal group was not induced hepatocellular carcinoma and not treated. Control group was induced hepatocellular carcinoma and injected with Inchinohryungsan pharmacopuncture into the root of tail. Experimental groups were induced hepatocellular carcinoma. BL group was injected with Inchinohryungsan pharmacopuncture into the BL_(18) and LR_(14), BG group was injected into the BL_(19) and GB_(24) and CSC group was injected into the CV_(12), ST_(25) and CV_4. Thereafter, the changes of the body weight, the liver weight and the weight of liver/100g body weight, WBC, neutrophil, lymphocyte and the activities of AST, ALT, ALP, LDH, AFP and SOD were measured. And gross anatomy, light and electron microscopy were performed. Results : The significant results were as follows,1. The activities of LDH were significantly decreased in CSC group compared with control group. 2. The activities of AFP were significantly decreased in the BL, BG, CSC groups compared with control group. 3. The activities of SOD were increased in the BL, BG, CSC groups compared with control group and CSC group was significantly increased than normal group. 4. According to the gross anatomical observation, the control and BL, BG, CSC groups showed multi-nodular hepatocellular carcinoma. But the size and numbers of the hepatocellular carcinoma in experimental groups were smaller than control group. 5. The numbers of hepatic p53 positive cells were decreased in the BL, BG groups compared with control group. 6. According to the light and electron microscopical observation, the BL, BG and CSC groups were mildly improved than control group in morphological and histopathological changes. Conclusions : These results suggested that Inchinohryungsan pharmacopuncture may have some effects on hepatocellular carcinoma induced by DEN in rats.
足三里(ST36)․腎兪(BL23)에 대한 당귀약침이 Freund’s Adjuvant로 유발된 白鼠의 관절염에 미치는 영향
류미선,윤여충,김재홍 대한침구의학회 2010 대한침구의학회지 Vol.27 No.5
Objectives : The purpose of this study is to investigate that effect of Angelica gigas NAKAI pharmacopuncture(AGN-Ph) by concentration at ST36(足三里) and BL23(腎兪) in Freund’s adjuvant rats. Methods : The experimental model of arthritis was induced by injection of Freund’s adjuvant into Sprague Dawley(SD) rats. After arthritis was induced, AGN-Ph was injected by concentration at ST36 and BL23 of rats every other day for 6 times. Thereafter, edema rate, body weight, IFN-γ, TNF-α, hematologic assay were measured. Results : The results were as follows,1. After 3 times AGN-Ph treatment, the mean of edema rate was significantly decreased in AGN-Ph group 3 than control group. And after 6 times AGN-Ph treatment, the mean of edema rate was significantly decreased in AGN-Ph group 1, 2, 3 than control group. 2. The mean of body weight was significantly increased in AGN-Ph group 1, 3 than control group and saline group. 3. The mean of IFN-γ was significantly increased in AGN-Ph group 3 than control group. 4. The mean of TNF-α was significantly increased in saline group than control group. But the mean of TNF-α in AGN-Ph group 2, 3 showed no significance compared with control group’s. 5. In hematologic assay, levels of WBC, RBC, Hemoglobin, Hematocrit showed no significance in all groups. Conclusions : These results are suggest that the Angelica gigas NAKAI pharmacopuncture(AGN-Ph) at ST36 and BL23 has a suppressing inflammation effect on Freund’s adjuvant arthritis in rats.
슬링치료를 병행하여 한의학적 치료를 시행한 파열형 요추 추간판 탈출증 환자 5례에 대한 임상적 고찰
류미선,위준,방성필,이지은,천혜선,강성인,이중철,윤여충,김재홍 대한침구의학회 2009 대한침구의학회지 Vol.26 No.5
Objectives : A ruptured disc is a condition in which part or all of the nucleus pulposus is forced through a weakened part of the disc, resulting in back pain and leg pain caused by nerve root irritation. In this report, we investigated the effect of oriental medicine treatment in parallel with sling exercise therapy on ruptured intervertebral lumbar disc patients. Methods : The patients who have ruptured disc were treated by oriental medicine treatment in parallel with sling exercise therapy. The patients’ symptoms were assessed by visual analogue scale(VAS) and revised oswestry disability questionnaire(RODQ) every week. Results : In all cases, chief complain such as lumbago, radicular pain and paresthesia were improved after above treatment. VAS score and RODQ score of all cases were decreased. Conclusions : There were usually thought to need operation in ruptured disc. But conservative treatment such as oriental medicine treatment in parallel with sling exercise therapy is helpful to improve the symptoms of the ruptured intervertebral lumbar disc except the emergency state.
K-ALSFRS-R과 ALSSS로 평가한 근위축성 측삭 경화증 2례 증례보고
류미선,위준,방성필,이지은,김재홍,윤여충 대한침구의학회 2009 대한침구의학회지 Vol.26 No.1
Objectives : Amyotrophic Lateral Sclerosis(ALS) is a progressive disease that causes degeneration of the motor neurons of the brain and spinal cord. The purpose of this case study is to improvement of oriental mediacl treatment on ALS. Methods : The patients were treated by acupuncture, moxibustion, cupping therapy, herbal medication, physical treatment. To determine the effects of Oriental medical treatment, we evaluated weekly used by Korean version of Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (K-ALSFRS-R), Amyotrophic Lateral Sclerosis Severity Scale(ALSSS). Results : Symptoms such as cervical and shoulder pain, knee pain, cold sweating, insomnia etc were improved after above treatment. But K-ALSFRS-R and ALSSS were no improvement after above treatment. Conclusions : The Oriental medical treatment is effective on local symptoms of ALS, but there were no functional improvement of ALS in this case study. It is necessary to have more examination about ALS.