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좌골신경통을 동반한 측만증 환자에 대한 한방치료와 신발 높이기 병행에 대한 증례연구
방성필,김성필,김진우,류혜선,천혜선,류미선,김재홍,위통순,윤여충,여경찬,정호석 대한침구의학회 2010 대한침구의학회지 Vol.27 No.5
Objectives : The purpose of this study was to investigate the effect of Korean medicine and Shoe Lift for scoliosis with sciatic pain patient. Methods : The patient who has scoliosis and sciatic pain was treated by Korean medicine and Shoe Lift. The patient's symptoms were assessed by Cobb’s angle, correctability, verbal numberical rating scale(VNRS) and revised oswestry disability questionnaire(RODQ) every week. Results : After 18weeks treatment, Cobb’s angle correctability was 34.357%. Patient’s VNRS score and RODQ score were decreased each from 10 to 1 and from 41 to 6. Conclusions : This result suggest that Korean medicine and Shoe Lift were effective treatment on patient for scoliosis with sciatic pain.
環跳(GB30) 草烏藥鍼이 L5 척수신경 결찰에 의한 흰쥐의 동통모델에 미치는 영향
방성필,류미선,김재홍,위통순,윤대환,윤여충,여경찬,정호석 대한침구의학회 2009 대한침구의학회지 Vol.26 No.6
Objectives : The purpose of this study is to examine if Radix Aconiti herbal acupuncture may be effective to the neuropathic pain(mechanical allodynia, cold allodynia) in a rat model of neuropathic pain. Methods : To produce the model of neuropathic pain, under isoflurane 2.5% anesthesia, L5 spinal nerve was ligated by 6-0 silk thread. After neurophathic surgery, the author examined if the animals exhibited the behavioral sign of allodynia. The allodynia was assessed by stimulating the medial malleolus with von frey filament and acetone. Three days after the neuropathic surgery, Radix Aconiti herbal acupuncture was injected at Hwando(GB30) one time per two days for 2 weeks. After that, the author examined the withdrawal response of neuropathic rats' legs by von frey filament and acetone stimulation. And also the author examined c-Fos in the midbrain central gray of neuropathic rats and the change of WBC, RBC, HGB, HCT count in the blood of neuropathic rats. Results : The Radix Aconiti herbal acupuncture injected Hwando(GB30) decreased the withdrawal response of mechanical allodynia that assessed with von frey filament in RA1-GB30, RA2-GB30 group as compared with control group. The Radix Aconiti herbal acupuncture injected Hwando(GB30) decreased the withdrawal response of chemical allodynia(cold allodynia) that assessed with acetone in RA1-GB30, RA2-GB30 group as compared with control group. The Radix Aconiti herbal acupuncture injected Hwando(GB30) showed the significant between control group and RA2-GB30 group in the c-Fos expression. The Radix Aconiti herbal acupuncture injected Hwando(GB30) did not show the significant between control group and RA1-GB30 group, RA2-GB30 group and RA3-GB30 group in the WBC, RBC, HGB, HCT count. Conclusions : We have noticed that Radix Aconiti herbal acupuncture at Hwando(GB30) decreased mechanical allodynia and cold allodynia in the model of neuropathic pain compared with the control group. C-fos expression in the central gray of that group was also decreased compared with the control group. This study can be used as a basic resource on a study and a treatment of pain.
농도 차이에 따른 腎兪(BL23)․大腸兪(BL25) 봉독약침이 백서의 신경병리성 동통모델에 미치는 영향
강수우,방성필,김재홍,위통순,윤여충 대한침구의학회 2010 대한침구의학회지 Vol.27 No.5
Objectives : This study was designed to investigate the effects of bee venom acupuncture at Shinsu(BL23) and Daejangsu(BL25) on neuropathic pain induced by tibial and sural nerve injury in rats. Methods : Neuropathic pain model was made by partial resection of tibial and sural nerve. Three weeks after the neuropathic surgery, bee venom acupuncture was firstly injected at BL23 and BL25, then we measured withdrawal responses induced by von Frey filament and acetone stimulation. Bee venom acupunctures were injected 6times on every 2days. Measurement of withdrawal responses were conducted on the same days. After bee venom acupuncture injection, expression levels of c-Fos, nocieptin and KOR-3 were observed through using immunohistochemistry. Results : In this experiment, bee venom acupunctures at BL23 and BL25 decreased levels of withdrawal responses induced by von Frey filament and acetone stimulation respectively. In addtion, expression levels of c-Fos, nociceptin and KOR-3 in central gray part of brain in rats were decreased by bee venom acupuncture. Conclusions : These results imply that bee venom acupuncture was useful to treat patients with neuropathic pain, and related mechanisms were involved in opioid and their receptors such as nociceptin and KOR-3.