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Masticatory Muscle Myositis in a Maltese Dog
강병재,류다은,김용선,이승훈,김완희,권오경 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.3
A 8-year-old, castrated male Maltese with difficulty in opening his mouth was presented. Masticatory musclemyositis (MMM) was diagnosed by 2M antibody test. After treatment of MMM with corticosteroids, range of jawmotion improved and was almost normal at 5 months. In dogs with MMM, early detection and aggressiveimmunosuppressive therapy are required to improve the prognosis.
강병재,류다은,김용선,이승훈,윤대영,김완희,권오경 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.5
Three small-breed dogs with grade IV medial patellar luxation were presented. In all cases, patellar luxationcould not be reduced by conventional surgical techniques. Femoral shortening osteotomy was performed in all dogsto correct patellar luxation. In all the dogs, the clinical condition was remarkably improved, and following surgicalprocedures, no complication or recurrence was presented. Femoral shortening osteotomy is an effective treatment insmall-breed dogs with medial patellar luxation associated with severe skeletal deformity
Effect of canine mesenchymal stromal cells overexpressing heme oxygenase-1 in spinal cord injury
이승훈,김용선,류다은,김아영,조광래,윤용석,최경욱,정태성,김완희,권오경 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.3
Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that modulates the immune response and oxidative stress associated with spinal cord injury (SCI). This study aimed to investigate neuronal regeneration via transplantation of mesenchymal stromal cells (MSCs) overexpressing HO-1. Canine MSCs overexpressing HO-1 were generated by using a lentivirus packaging protocol. Eight beagle dogs with experimentally-induced SCI were divided into GFP-labeled MSC (MSC-GFP) and HO-1-overexpressing MSC (MSC-HO-1) groups. MSCs (1 × 107 cells) were transplanted at 1 week after SCI. Spinal cords were harvested 8 weeks after transplantation, after which histopathological, immunofluorescence, and western blot analyses were performed. The MSC-HO-1 group showed significantly improved functional recovery at 7 weeks after transplantation. Histopathological results showed fibrotic changes and microglial cell infiltration were significantly decreased in the MSC-HO-1 group. Immunohistochemical (IHC) results showed significantly increased expression levels of HO-1 and neuronal markers in the MSC-HO-1 group. Western blot results showed significantly decreased expression of tumor necrosis factor-alpha, interleukin-6, cycloogygenase 2, phosphorylated-signal transducer and activator of transcription 3, and galactosylceramidase in the MSC-HO-1 group, while expression levels of glial fibrillary acidic protein, b3-tubulin, neurofilament medium, and neuronal nuclear antigen were similar to those observed in IHC results. Our results demonstrate that functional recovery after SCI can be promoted to a greater extent by transplantation of HO-1-overexpressing MSCs than by normal MSCs.
강병재,윤대영,류다은,김용선,이승훈,김완희,권오경 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.2
An 8 kg, 9-month-old castrated male Shiba Inu presented with a history of intermittent bilateral hind limblameness. On examination, grade III medial patellar luxation of the bilateral hind limbs was diagnosed. A novel surgicalmethod involving relatively noninvasive tibial tuberosity transposition was used to restore normal alignment of thequadriceps mechanism. The procedure involved an incision on the medial cortical bone of the tibial tuberosity alongthe tibial crest and placement of a cortical screw on the medial side of the tibial crest to laterally transpose the tibialtuberosity. Lameness and patellar luxation of bilateral hind limbs were improved at a 3-month postoperative examination. This technique could be considered an effective treatment for medial patellar luxation in skeletal immature patients.
윤대영,강병재,김용선,이승훈,류다은,김완희,권오경 한국임상수의학회 2015 한국임상수의학회지 Vol.32 No.1
We evaluated outcomes of dogs surgically treated for grade 2 or 3 medial patellar luxation (MPL) with and without trochleoplasty. A retrospective study of 63 dogs with grade 2 or 3 MPL surgically treated with or without trochleoplasty was performed. Results of radiographic evaluation were expressed numerically as degenerative joint disease score and were compared between the groups with and without trochleoplasty. The study included 7 (7/68, 10.3%) cases of reluxation and 1 case of tibial tuberosity transposition implant failure. Reluxation and complications requiring additional surgery were confirmed in 3 cases (3/47, 6.4%) in trochleoplasty group and in 1 case (1/21, 4.8%) in nontrochleoplasty group. The nontrochleoplasty group showed a shorter recovery time than the trochleoplasty group (P < 0·05). There was a significant difference in degenerative joint disease scores over time between the groups, with nontrochleoplasty group having lower scores (P < 0·05). This study suggests that surgical treatment without trochleoplasty results in favorable outcomes compared to treatment with trochleoplasty. It is not mandatory to exclude trochleoplasty when performing surgery for grade 2 or 3 MPL, but we propose that surgical treatment without trochleoplasty is one option when choosing a combination of surgical techniques.
윤대영,강병재,김용선,이승훈,류다은,김완희,권오경 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.4
Composite biological and synthetic grafts with progenitor cells offer an alternative approach to auto- or allografts for fracture repair. This study was conducted to evaluate osteogenesis of autologous serum-derived albumin (ASA) scaffolds seeded with canine adipose tissue-derived mesenchymal stem cells (Ad-MSCs) in a canine segmental bone defect model. ASA scaffold was prepared with canine serum using cross-linking and freeze-drying procedures. Beta-tricalcium phosphate (b-TCP) was mixed at the cross-linking stage. Ad-MSCs were seeded into the scaffold and incubated for one day before implantation. After 16 weeks, the grafts were harvested for histological analysis. The dogs were divided into five groups: control, ASA scaffolds with and without Ad-MSCs, and ASA scaffolds including b-TCP with and without Ad-MSCs. ASA scaffolds with Ad-MSCs had a significantly larger area of increased opacity at the proximal and distal host cortex-implant interfaces in radiographs 16 weeks after implantation compared to the groups with b-TCP (p < 0.05). Histomorphometric analysis showed that ASA scaffolds with Ad-MSCs had significantly greater new bone formation than other groups (p < 0.05). These results suggest that Ad-MSCs seeded into ASA scaffolds enhanced osteogenesis in the bone defect model, but that b-TCP in the ASA scaffold might prevent penetration of the cells required for bone healing.