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Sinoatrial Reentrant Tachycardia in a Yorkshire Cross Dog
남소정,현창백 한국임상수의학회 2008 한국임상수의학회지 Vol.25 No.5
An 8-year-old intact male Yorkshire cross dog (7.5 kg of body weight) was referred with the primary complaint of exercise intolerance and occasional syncope. Initial cardiological examination could not identify any abnormalities except mild mitral regurgitation. Exercise stress test revealed chronotrophic incompetence. Furthermore the 1 hr-digital event recording found the sudden onset of paroxysmal sinus tachycaridas (156-172 bpm) lasting few minutes and stopping abruptly. In addition, the tachycardia terminated by vagal maneuver and verapamil administration. Based on this finding, the case was diagnosed as sinoatrial reentrant tachycardia (SART). The dog was treated with diltiazem and enalapril. Although the dog still has exercise intolerance, no syncope has been observed after medication.
Peritoneal Dialysis in Dogs: 20 cases (2006-2008)
남소정,최란,현창백,오원석 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.1
Peritoneal dialysis (PD) is a clinical technique that therapeutically removes toxic solutes from body fluids and normalizes endogenous solutes whose aberrant concentrations disrupt normal physiology. This study retrospectively evaluated clinical outcomes and complications of PD in 20 dogs with renal failure. Blood works (total count of red blood cells (RBC), packed cell volume (PCV), the serum biochemical, and electrolyte values related to renal insufficiency) and complications associated with peritoneal dialysis, and clinical outcomes were recorded before and after PD. Additionally, creatinine reduction ratio (CRR) and urea nitrogen reduction ratio (URR) were calculated for evaluating the efficacy of PD. PD resulted in a significant (p < 0.05) reduction in blood urea nitrogen (BUN) concentration in 19 dogs, while a significant (p < 0.05) reduction in creatinine concentration in 17 dogs. The complications of PD were hypoalbuminemia (12/20, 60%), anemia (10/20, 50%), subcutaneous dialysate leakage (9/ 20, 45%), bacterial peritonitis (6/20, 30%), dialysate retention (5/20, 25%) and limb edema (4/20, 20%). This study demonstrated that PD was effective in reducing the magnitude of azotemia in dogs with renal failure especially in acute phase, although the complication rate was high but manageable.
남소정,현창백 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.2
Patent ductus arteriosus (PDA) is an abnormal shunt between the descending aorta and pulmonary artery through the incompletely closed ductus arteriosus and is the most common congenital heart defect in dogs. Recent human genetic studies found that a the gene mutation in transcription factor AP-2 beta (TFAP2B) was responsible for syndromic cases of PDA. Mutations in the TFAP2B gene are associated with certain congenital cardiac defects in humans that include PDA. In this study, we isolated the entire coding exons of canine TFAP2B gene for genetic screening in dogs with PDA. Analysis of the deduced amino acid sequence suggested that the canine TFAP2B are phylogenetically closer to the human TFAP2B (100% identity in amino acid sequence) than mouse and rat. In cTFAP2B gene screening, one single c.936 + 203G > A base change was found in affected Maltese dogs with PDA. However, further screening found the same base change in one unaffected control dog, suggesting this base change might be polymorphism. No other base changes were found in other dog breeds enrolled in this study. Because the base change was located in the intronic region and found in an unaffected control dog, TFAP2B might not be responsible for familial PDA in Malteses and sporadic cases of other dog breeds, although the gene promoter region should be investigated before reaching to this conclusion. A future study that may take this study further would be to collect more samples and to screen TFAP2B in various breeds of dogs with PDA and other various congenital heart defects.
남소정,이태호,최민구,송임숙 사단법인 한국질량분석학회 2018 Mass spectrometry letters Vol.9 No.2
KPLA-012, a benzopyranyl 1,2,3-triazole compound, is considered a potent HIF-1α inhibitor based on the chemical library screening, and is known to exhibit anti-angiogenetic and anti-tumor progressive effects. The aim of this study was to investigate the pharmacokinetic properties of KPLA-012 in ICR mice and to investigate in vitro characteristics including the intestinal absorption, distribution, metabolism, and excretion of KPLA-012. The oral bioavailability of KPLA-012 was 33.3% in mice. The pharmacokinetics of KPLA-012 changed in a metabolism-dependent manner, which was evident by the low recovery of parent KPLA-012 from urine and feces and metabolic instability in the liver microsomes. However, KPLA-012 exhibited moderate permeability in Caco-2 cells (3.1 × 10 -6 cm/s) and the metabolic stability increased in humans compared to that in mice (% remaining after 1 h; 47.4% in humans vs 14.8% in mice). Overall, the results suggest that KPLA-012 might have more effec- tive pharmacokinetic properties in humans than in mice although further studies on its metabolism are necessary.
Clinical Efficacy of Pimobendan on Dogs with Chronic Mitral Valvular Diseases
남소정,박인철,현창백 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.1
Pimobendan is a recently developed cardiac drug which is useful to control moderate to severe congestive heart failure (CHF) from chronic mitral valvular diseases (CMVI). Because of controversy related to the efficacy and safety of pimobendan in dogs, the optimal efficacy and safety of pimobendan was assessed in 20 dogs with CMVI in this study. Scores for quality of life, respiratory failure, circulatory failure and heart failure were evaluated along with radiographical and echocardiographical assessments for about 2 months period after the addition of pimobendan into the regular cardiac medications. This study proved clear evidence that pimobendan had beneficial therapeutic effects in dogs with advanced CMVI, without particular adverse effects. However, further studies are warranted to address the drug interaction with other cardiac therapeutics and to assess therapeutic effects in CHF from other type of heart diseases in dogs and other animals.
다양한 생산 설비와의 인터페이스를 고려한 설비정보 수집
남소정(So Jeong Nam),이재경(Jai-Kyung Lee),이승우(Sung Woo Lee),박종권(Jong Kweon Park) 대한기계학회 2011 大韓機械學會論文集A Vol.35 No.2
다양한 생산 설비에 따른 설비정보를 MES 등의 생산시스템에 효율적으로 제공하기 위해 설비 정보 수집 시스템은 생산현장의 설비 및 공정특성을 고려한 다양한 설비 인터페이스에 따른 정보수집이 필요하다. 본 연구에서는 생산현장의 다양한 생산 설비의 정보를 수집하기 위해 설비 인터페이스를 통한 설비정보 수집 방법을 제안한다. PLC 기반의 인터페이스, Sensor 기반의 I/O 인터페이스, 작업자 Key-In 에 의한 인터페이스 등 다양한 설비 인터페이스를 통해 생산 현장의 정보를 1 차 수집할 수 있다. 데이터 수집 시스템은 H/W Communication Module 과 Operator Key-In Module 을 이용하여 설비 인터페이스를 통해 수집되는 설비 정보를 2 차 가공하며, 데이터 파서(Data Parser)를 통해 수집 정보의 유연성을 높일 수 있다. There is much information of equipment in shop floor because the manufacturing processes are different as the equipment within the manufacturing process is varied. To provide effective process information to MES and other production systems, the DAS requires an equipment monitoring system that takes into account the characteristics of the equipment on the shop floor. In this study, we proposed some methods for collecting the required information about various equipments on a shop floor. The equipments such as CNC can be interfaced with the DAS by using a PLC-based method and a sensor-based interface board can be used to interface general equipments. The proposed methods can be used to collect information on the shop floor in real-time. Moreover these methods are very adaptive and can be easily modified according to the changes made to the shop floor. The information about a real shop floor acquired by employing these methods is saved in a database and the can be provided to a supervisor and MES so that they are aware of the status of the shop floor.