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99m Tc - MDP 골스캔에서 골다공증을 시사하는 소견
남대근(Dae Gun Nam),문태건(Tae Geon Moon),김지홍(Ji Hong Kim),손석만(Seok Man Son),김인주(In Ju Kim),김용기(Yong Ki Kim) 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.3
N/A Purpose: Bone scintigraphy with 99mTc-labeled phosphates is one of the most common procedures in evaluation of various skeletal disorders. Metabolic bone diseases show involvement of the whole skeleton and are associated with increased bone turnover and increased uptake of 99mTc-labeled phosphates. In this study, we investigated apparently normal women who were examined with routine bone scintigraphy applied bone densitometry to correlate it with skeletal uptake in bone scan. Materials and Methods: This study includes 79 women who were performed both of bone mineral density(BMD) and bone scintigraphy. We investigated the relation of bone scan findings and BMD of lumbar, femur, radius. Results: Regional BMD were negatively correlated with increased age. Among the bone scintigraphy findings representing metabolic bone disease, uptakes by the long bones, skull and mandible increased with age in women, while that in the costochondral junction decreased; Increased skull and mandible uptakes is associated with decreased BMD, and it has statistically significance. Conclusion: Our results show that increased radionuclide uptake in bone scintigraphy, especially skull and mandible uptake was associated with decreased lumbar, femur BMD in women. So that, increased skull and mandible uptake in women would be a scintigraphic sign of osteopenia or osteoporosis.(Korean J Nucl Med 2001:35:161-167)
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정상 혹은 감소된 혈장 ACTH 를 보이면서 IPSS에 의해 진단된 쿠싱증후군 2예
문태건,남대근,문재현,황지윤,김지홍,안진광,손석만,김인주,김용기,김학진,조용구 대한내과학회 2002 대한내과학회지 Vol.62 No.5
Cushing's syndrome results from prolonged exposure to high levels of glucocorticoid hormones. ACTH-dependent Cushing's syndrome accounts for about 85% of endogenous causes. Autonomous pituitary ACTH secretion, called Cushing's disease, is responsible for 80% of these causes, whereas ectopic ACTH secretion is responsible for 20% of them. Appropriate therapy of patients with Cushing's syndrome depends on accurate diagnosis and classification of the disorder. In addition to the history and clinical evaluation, the laboratory evaluation of a patient with Cushingoid appearance is necessary to establish the diagnosis and determine the cause of hypercortisolism. A major problem in the differential diagnosis of ACTH-dependent Cushing's syndrome is distinguishing Cushing's disease from the ectopic ACTH syndrome. Both entities can have similar clinical and laboratory features. In addition, both pituitary microadenoma and ectopic ACTH-secreting tumors may be radiologically occult. Bilateral inferior petrosal sinus and peripheral vein catheterization with simultaneous collection of samples for measurement of ACTH is one of the most specific tests available to localize the source of ACTH production. We report two cases of Cushing's syndrome diagnosed by inferior petrosal sinus sampling associated with normal or low ACTH levels on routine basal hormone assay. -
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이동현,김지영,박찬원,강대환,문재현,양웅석,송근암,조몽,주형준,공옥녀,남대근 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.4
Congenital hepatic fibrosis(CHF) is a rare development abnormality, which is characterized pathologically by periportal fibrosis with irregularly shaped proliferating bile ducts. In most, if not all. cases CHF is associated with autosomal recessive polycystic kidney disease. Recently, we experienced two cases, confirmed by percutaneous needle liver biopsy, of CHF with polycystic kidney disease. The first patient was a 19-year-old man and presented with hematemesis and hepatosplenomegaly. Esophageal varix was noted by an endoscopic examination and an endoscopic variceal ligation was performed. Abdominal CT scanning revealed innumerable cysts of both kidneys. The patient also had cystic dilation of subarchnoid space in the basal ciatern and posterrior fossa detected through brain MRI. The second patient was a 24-year-old man admitted for an evaluation of splenomegaly. Ha had no esophageal varix but, splenic varix and splenorenal shunt were detected through an abdominal CT scanning. Innumerable renal cysts were also present. The diagnosis of CHF was confirmed in both cases by its typical histologic features. We report these cases with a review of the relevant literatures.
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