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쥐의 피아조직에서 Nitionl과 Stainless steel의 삽입으로 인한 조직반응에 대한 비교 연구
나춘균,강상균,박희주,김의한 순천향대학교 1994 논문집 Vol.17 No.2
An experimental study was carried out to compare the tissue reaction of nitinol with that of stainless steel. 0.5cm, 27 nitinol wires(A group) and 0.5cm, 27 stainless steel wires(B group) were inserted into the beneath back skin of each 54 white rat and examined for 8 weeks. 3, 5, 7, 10 days, and 2, 3, 4, 6, and 8 weeks after the insertion, 6 rats(3 nitinolinserted rats and 3 stainless steel-inserted rats) were sacrificed and examined to make emphasis on such microscopic points as 1) vascular proliferation 2) type of infiltrated inflammatory cells, 3) proliferation of fibroblasts and collagen 4) the thickness of the membrane surrounding implants and 5) epidermal growth factor reactivity. As a result, the vascular proliferation and fibroblastic and collagen proliferation appeared to be somewhat earlier in the A group than in B group and the thickness of membrane was slight thicker in A group than in B group at an early stage. However, the infiltrated inflammatory cells showed no difference between both A and B groups. The above findings suggested that formation of the granultion tissue appeared somewhat earlier in the A group, but there were no significant meanings on microscopic grounds between them. Insertion in both A and B groups reflected the most intense reactivity of EFG after 3-5 days. The results that the reactivity of EGF was more intense at the periphery of the membrane after 2-3 weeks in bath A and B group were given in that the production of fibroblasts and collagen were revealed chiefly at the periphery of the membrane adjacent to nitinol and stainless steel.
자궁경부 편평상피세포암에서의 CEA의 분포에 관한 연구
양승하,나춘균,강상균 순천향대학교 1990 논문집 Vol.13 No.1
Carcinoembryonic antigen(CEA) isolated from adenocarcinoma of human digestive system and fetal or embryonic gut tissue is one of tumor associated antigen. In recent years, presence of the CEA in various tumors and inflammatory disease has been reported but studies in squamous cell carcinoma of uterine cervix, common malignant tumor in Korea, was rare. Therefore, to understand positive rate of CEA according to cell type of squamous cell carcinoma of uterine cervix the author collected serial 113 cases of formalin fixed, paraffin embedded uterine cervix carcinoma obtained by biopsy and hysterectomy, then performed immunoenzyme histologic reaction by Avidin-Biotin-Complex method using anti-human CEA rabbit serum and analyzed their histologic reaction. Results obtained are as followings 1. CEA positive reaction to anti-CEA antibody was noted in 82 Cases(73%) of the 113 cases with squamous cell carcinoma of uterine cervix. 2. CEA positive reaction to anti-CEAantibody was noted in 25 cases(86%) of 29 cases with large cell, keratinizing type of squamous cell carcinoma of uterine cervix. 3. CEA positive reaction to anti-CEA antibody was noted in 55 cases(72%) of the 76 cases with large cell, nonkeratinizing type of squamous cell carcinoma of uterine cervix. 4. CEA positive reaction to anti-CEA antibody was noted in 2 cases of 8 cases with small cell type of squamous cell carcinoma of uterine cervix.