한국인 급성 심근경색증 환자에서 좌심실 비대의 형태학적 분류에 따른 임상경과의 차이

김희정 ( Hui Jeong Kim ),정명호 ( Myung Ho Jeong ),윤현주 ( Hyun Ju Yoon ),김용철 ( Yong Cheol Kim ),손석준 ( Seok-joon Sohn ),김민철 ( Min Chul Kim ),심두선 ( Doo Sun Sim ),홍영준 ( Young Joon Hong ),김주한 ( Ju Han Kim ),안영근 대한내과학회 2020 대한내과학회지 Vol.95 No.6

목적: 좌심실의 구조적 변화는 심혈관계 이환율과 사망률의 위험 증가와 관련이 있다고 알려져 있다. 본 연구에서는 급성 심근경색증 환자에서 좌심실 비대와 그 형태적 분류에 따라 임상경과의 차이와 주요심장사건(major adverse cardiac events, MACE)에 미치는 영향을 파악하고자 하였다. 방법: 2014년 1월부터 2015년 10월까지 Korea Acute Myocardial Infarction Registry-National Institute of Health(KAMIR-NIH)에 등록된 환자 중 급성 심근경색증으로 전남대학교병원에 입원한 환자 중에서 관상동맥 중재술을 시술받고 2년 동안 임상 추적 관찰이 되어 분석 가능한 환자 852명(남:여 = 603:249)을 대상으로 하였다. 좌심실의 형태적 구조에 따라 정상군 470명(62.4 ± 12.8세, 남자 389명)과 좌심실비대군 382명(67.1 ± 12.1세, 남자 214명)으로 분류하여, 양군 간의 임상적 특성, 혈액 검사 특성, 심장초음파 및 관상동맥 조영술 소견 및 MACE를 비교·분석하였다. 좌심실 비대군은 좌심실 벽의 상대적 두께(relative wall thickness, RWT)와 좌심실 질량지수(left ventricular mass index, LVMI)에 따라 동심성 재형성군(concentric remodeling; RWT ≥ 0.42, LVMI ≤ 115 g/m² in male, ≤ 95 g/m² in female), 동심성 비대군(concentric hypertrophy; RWT ≥ 0.42, LVMI > 115 g/m² in male, > 95 g/m² in female) 및 편심성 비대군(eccentric hypertrophy; RWT < 0.42, LVMI > 115 g/m² in male, > 95 g/m² in female)으로 세분하여 평가하였다. 결과: 대상 환자를 21 ± 7.8개월간의 임상적 경과 관찰 중에 MACE는 173명(사망 55명, 재발성 심근경색증 26명, 재입원 34명)에서 발생하였다. MACE의 발생은 좌심실 비대군에서 정상군에 비하여 유의하게 높았으며(16.0% vs. 25.5%, p = 0.001), Kaplan-Meier 생존곡선을 이용한 사망률 분석 결과에서 좌심실 비대군이 정상군에 비하여 유의하게 생존율이 낮았다(p = 0.008). 좌심실 비대군의 형태적 분류에 따른 MACE의 분석 결과에서는 편심성 비대에서 MACE의 발생이 유의하게 많았다(동심성 재형성 vs. 동심성 비대 vs. 편심성 비대; 11.2% vs. 15.5% vs. 22.1%, p = 0.046). 결론: 급성 심근경색증 환자에서 좌심실 비대는 불량한 예후와 관련이 있었으며, 좌심실 비대 중 편심성 비대를 동반한 경우에 예후가 가장 불량하였다. 따라서, 한국인 급성심근경색증 환자에서 좌심실 비대를 보이는 경우, 특히 편심성 비대를 동반한 경우에 적극적인 치료가 필요할 것으로 사료되었다. Background/Aims: Left ventricular hypertrophy (LVH) on clinical outcomes in patients with acute myocardial infarction (AMI) is not clear. This study was performed to investigate the effect of abnormal left ventricular geometry on clinical outcomes in Korean patients with AMI. Methods: A total of 852 consecutive patients with AMI were divided into two groups: normal left ventricular geometry (n = 470; 389 males) and LVH (n = 382; 214 males) groups. Major adverse cardiac events (MACEs) were defined as cardiac death, recurrent myocardial infarction, and rehospitalization. Results: During the clinical follow-up period of 21 ± 7.8 months, MACEs developed in 173 patients (20.0%), and the rate was higher in the LVH than normal left ventricular geometry groups (25.5% vs. 16.0%, respectively, p = 0.001). According to Kaplan-Meier survival curves, the MACE-free survival rate was significantly lower in the LVH group than in the left ventricular geometry group (p = 0.008). The rates of MACEs and all-cause mortality differed among the AMI with concentric remodeling, concentric hypertrophy, and eccentric hypertrophy subgroups (11.2% vs. 15.5% vs. 22.1%, respectively, p = 0.046). Eccentric hypertrophy was a predictive factor of MACE according to Cox proportional hazards analysis (hazard ratio 1.804, confidence interval 1.034-3.148, p = 0.038). Conclusions: LVH is a predictor of poor outcomes in patients with AMI, and eccentric hypertrophy is associated with a worse prognosis compared with concentric remodeling and concentric hypertrophy. Therefore, Korean patients with AMI and LVH, especially eccentric hypertrophy, require more careful observation and intensive treatment. (Korean J Med 2020;95:387-397)

증강현실기반 멸종위기동물 에듀테인먼트 콘텐츠 디자인

김희정(Hui-Jeong Kim),전지윤(JiYoon Chun),김현주(Hyun Ju Kim) 한국디지털콘텐츠학회 2020 한국디지털콘텐츠학회논문지 Vol.21 No.1

Effects of Doinsenggitang on Melanin Synthesis and Gene Expression Inhibition in B16F10 Melanoma Cells

Ju-Young Hwang(황주영),Dong-Hee Kim(김동희),Hui-Jung Kim(김희정),Eun-Young Hwang(황은영),Tae-Soon Park(박태순),Jin-Young Lee(이진영),Jun-Ho Son(손준호) 한국생명과학회 2012 생명과학회지 Vol.22 No.3

본 연구는 B16F10 melanoma 세포를 사용하여 도인승기탕의 70% EtOH와 물 추출물의 멜라닌 생합성, tyrosinase 활성, western blotting으로 측정하였다. 도인승기탕 추출물은 농도 의존적으로 멜라닌 생합성과 tyrosinase활성을 저해하였다. 그 결과 도인승기탕 70% 에탄올 추출물이 멜라닌 합성을 40%, tyrosinase는 51% 저해효과를 나타내었다. Western blot을 이용하여 B16F10 melanoma 세포 내에 tyrosinase, TRP-1, TRP-2, MITF의 발현을 억제하는 효과를 관찰하였다. 이상의 결과에 따라 도인승기탕의 70% 에탄올 추출물은 미백 소재로서 가능성을 가지는 것으로 나타났다. This study involved observation of the inhibitory effect of 70% EtOH and water extracts from Doinseunggitang on melanin synthesis, tyrosinase activity, and western blotting using B16F10 melanoma cells. Doinseunggitang extracts inhibited melanin synthesis and tyrosinase activity in a dependent manner. As a result, it was found that Doinseunggitang 70% EtOH extracts inhibit melanin synthesis and tyrosinase activity, respectively, by 40% and 51%. In addition, western blotting analysis showed that 70% EtOH extracts inhibited tyrosinase, MITF, TRP-1, and TRP-2 expression. These results show that 70% ethanol extracts of Doinseunggitang could be developed as a skin whitening material in cosmetics.

The Effect of Metallothionein on the Activity of Enzymes Invelved in Remival of Reactive Oxygen Species

고문주,김희정,Go, Mun Ju,Kim, Hui Jeong Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.4

To show the effects of metallothionein (MT) on the activity of enzymes involved in the removal of reactive oxygen species, MT has been added to the assay systems of superoxide dismutase (SOD), catalase and peroxidase. We have used assay systems of SOD based on NADPH oxidation and nitrite formation from hydroxylammonium chloride as an assay of superoxide breakdown rate. The two assay systems showed different results at the high concentration of MT. MT showed the scavenging of superoxide in the SOD assay system in the presence and absence of SOD. MT added to the SOD assay system behaved as an activator of SOD, but apo-MT behaved as an inhibitor. When MT was added to the assay system in the presence of a fixed amount of SOD, the breakdown rate of superoxide increased. The effects of MT on the decomposition of hydrogen peroxide and the activity of catalase and peroxidase decomposing hydrogen peroxide were evaluated. MT decreased the activities of catalase and peroxidase. We have concluded that the function of MT as an antioxidant might effect the level of superoxide scavenging and not the level of hydrogen peroxide.

만나고 싶었습니다-기획부

조민주,박소연,엄영선,정원묵,김희정,홍지훈,김양희,Jo, Min-Ju,Park, So-Yeon,Eom, Yeong-Seon,Jeong, Won-Muk,Kim, Hui-Jeong,Hong, Ji-Hun,Kim, Yang-Hui 한국과학기술정보연구원 2006 지식정보인프라 Vol.23 No.-

어떤 조직이든 탈 없이 매끈하게 잘 운영되는 조직 뒤에는, 밤낮없이 조직의 구석구석에 기름칠을 하는 조력자들이 있게 마련이다. KISTI를 개원 5년 만에 과학기술계가 깜짝 놀랄 만큼 크고 굳건한 기관으로 성장시킨 이면에는 바로 기획부원들의 보이지 않는 노력이 숨어 있었다.

치과위생사의 그릿이 치위생업무성과에 미치는 영향 : 직무만족과 직무몰입의 매개효과

문상은 ( Sang-eun Moon ),양진주 ( Jin-ju Yang ),이보람 ( Bo-ram Lee ),김희정 ( Hui-jeong Kim ) 한국치위생학회 2022 한국치위생학회지 Vol.22 No.5

Objectives: The purpose of this study was to determine the effects of dental hygienists’ grit, job satisfaction, and job commitment on dental hygiene job performance and the mediating effects of job satisfaction and job commitment on the relationship between grit. Methods: From May 25 to June 13, 2022, the researcher collected and analyzed data from 213 dental hygienists working at dental hospitals and clinics. For the data analysis, SPSS Statistics 21.0 was applied to conduct a t-test, one-way ANOVA, Pearson’s correlation analysis, and hierarchical regression analysis. Results: Grit was in charge of preventive work (scaling) (3.38±0.56, p<0.05), and the lower the stress (3.39±0.57, p<0.05), the higher the grit. Dental hygiene job performance was higher when they worked in Gwangju, Jeolla-do (3.88±0.50, p<0.01), and dental clinics (3.85±0.53, p<0.01). Job satisfaction (3.45±0.49, p<0.05) and job commitment (3.28±0.56, p<0.05) were high, as they had at least a bachelor’s degree. Less job stress was associated with higher job satisfaction (3.71±0.42, p<0.001) and job commitment (3.52±0.65, p<0.001). Job satisfaction and commitment had partial mediating effects on the relationship between dental hygienists’ grit and job performance. Conclusions: It is necessary to develop a program that helps improve grit in dental hygienists to strengthen their psychological resources, job satisfaction, and job commitment.

치과위생사의 코로나19 감염관련 지식, 감염관리 수행 및 사회심리적 건강 관련 연구

문상은 ( Sang-eun Moon ),양진주 ( Jin-ju Yang ),홍선화 ( Sun-Hwa Hong ),이보람 ( Bo-ram Lee ),김희정 ( Hui-jeong Kim ),서가혜 ( Ga-hye Seo ),김은채 ( Eun-chae Kim ) 한국치위생학회 2021 한국치위생학회지 Vol.21 No.5

Objectives: This study aimed to verify the relations of COVID-19 infection-related knowledge, dental infection control performance, and psychosocial health of dental hygienists. Methods: From the data was analyzed through the frequency analysis, t-test, one way ANOVA, and pearson’s correlation analysis with a total of 198 dental hygienists using SPSS Statistics 21.0. Results: The correct answer rate for knowledge about COVID-19 was higher with a bachelor’s degree or higher. Thus, when the level of education was higher, the performance was also high (p<0.01). COVID-19 infection control performance was highly shown in case of high age (4.43) (p<0.05) and the married (4.42) (p<0.01). Infection control performance was high when they had an educational experience of COVID-19 infection control (4.46), and when the infection control guidebooks were equipped in their workplaces (p<0.001). Degree of psychosocial health of research subjects was shown in the order of potential stress (60.6%), high-risk stress (23.7%), and healthy (15.7%). Infection control performance was higher, the psychosocial health was healthy. Conclusions: For the response to COVID-19 infectious disease and the preparation for mutated viruses and new infectious diseases in the future, it would be necessary to establish the concrete measures for establishing the strict infection control system for dental clinics and also enhancing the psychosocial health of dental hygienists.

치주검사와 설문조사를 통한 성인의 구강건강관리행태 및 식이행태와 치주질환과의 관련성

문상은 ( Sang-eun Moon ),홍선화 ( Sun-hwa Hong ),김희정 ( Hui-jeong Kim ),서가혜 ( Ga-hye Seo ),박진아 ( Jin-ah Park ),이지연 ( Ji-yeon Lee ),정주영 ( Ju-yeong Jeong ),최종임 ( Jong-im Choi ),박선미 ( Seon-mi Park ),박진아 ( Jin-a 한국치위생학회(구 한국치위생교육학회) 2020 한국치위생학회지 Vol.20 No.6

Objectives: This study investigated the relevance of dietary behavior and oral management for oral heath in adults to extend the recognition of the importance of food intake in oral health and to provide basic information for oral health management. Methods: A survey and clinical assessment were conducted for 119 adults over 20 years of age. The chi-square test and logistic regression analysis were carried out using SPSS Statistics 20.0. Results: Gingivitis was influenced less when ham and sausage in the sub-area of meat, fish, egg, and bean were consumed once a week rather than the cases when consumed rarely (3.47 times) or when consumed two times or more a week (7.87 times) (p<0.05). Periodontitis was influenced more in the groups of 30s and 40s age than in that of over 50 years of age (14.97 times, 7.73 times) and in the group without drinking experience than in group with that (4.17 times) (p<0.05). Conclusions: The results verified the close relationship between food intake frequency and oral health in patients with periodontitis and gingivitis. Thus, it would be necessary to study the relationship between dietary behavior and oral health continuously.

症例(증례) : 류마티스 곤절염과 동반된 IgA 신병증 1례

고강석 ( Kang Suk Ko ),조양동 ( Yang Tong Cho ),김희정 ( Hui Jung Kim ),이원석 ( Won Seok Lee ),김형일 ( Hyoung Il Kim ),송민주 ( Min Ju Song ),손지연 ( Ji Youn Sohn ),류완희 ( Wan Hee Yoo ),강경표 ( Kyung Pyo Kang ),강명재 ( Myun 전북대학교 의과학연구소 2007 全北醫大論文集 Vol.31 No.2

IgA nephropathy is a common primary glomerulonephritis characterized by the deposition of IgA in glomerular mesangium. At clinical presentation the disorder may be macroscopic hematuria, often recurring in association with viral upper respiratory illness or with microscopic hematuria or proteinuria. Although the cause of primary IgA nephropathy is unknown, IgA nephropathy can be associated with systemic diseases, such as ankylosing spondylitis, Reiters`s syndrome, liver disease, and Sicca syndrome. We report a case of IgA nephropathy associated with rheumatoid arthritis. A 49-year-old woman, who has complaint of multiple joint swelling and pain, was presented with microscopic hematuria and proteinuria. Light microscopy showed mesangial and segmental endocapillary proliferative glomerulonephritis and immunofluorescence microscopy demonstrated segmental positive mesangial stainings for IgA and C3, consistent with IgA nephropathy. Treatment with anti-rheumatic medications and angiotensin converting enzyme inhibitor resulted in gradual disappearance of microscopic hematuria and proteinuria. Therefore, we suggest that IgA nephropathy may be associated with rheumatoid arthritis.

증예(症例) : 만성 폐쇄성 폐질환 환자에서 기관지유래암종으로 오인된 기관지 방선균증 1례

김소영 ( So Young Kim ),최영훈 ( Young Hun Choi ),김국민 ( Kuk Min Kim ),이태환 ( Tae Hwan Lee ),강선미 ( Seon Mi Kang ),이윤재 ( Yoon Jae Lee ),고강석 ( Kang Suk Ko ),김이식 ( Yi Shik Kim ),김재문 ( Jae Moon Kim ),김희정 ( Hui Ju 전북대학교 의과학연구소 2006 全北醫大論文集 Vol.30 No.1

방선균증은 혐기성 그람 양성균인 Actinomyces 속(genus)에 의해서 유발되는 만성 화농성 감염성 질환이다. 기관지 방선균증(endobronchial actinomycosis)은 국내의 적으로 그 빈도가 매우 드문 질환으로 기관지 결핵(endobronchial tuberculosis) 혹은 기관지 유래 암종(bronchogenic carcinoma)으로 잘못 의심되는 경우가 있다. 본 저자들은 50갑년의 흡연력과 만성 폐쇄성 폐질환의 폐암 위험 인자를 가진 65세 남자 환자가 객혈을 주소로 내원하여 흉부 전산화 단층촬영 소견과 기관지 내시경 소견상 기관지 유래 암종이 의증되었던 환자에서 조직 검사를 통해 방선균증으로 진단된 증례를 보고하는 바이다. Endobronchial actinomycosis is a rare disease that presents with endobronchial mass, Endobronchial actinomycosis can be misdiagnosed as endobronchial malignancy such as bronchogenic carcinoma, endobronchial tuberculosis, lipoma, or unresolving pneumonia. We report here a case of endobronchial actinomycosis mimicking bronchogenic carcinoma in patient with chronic obstructive lung disease (COPD). On admission, the patient presented with hemoptysis and had history of COPD. Chest CT finding was endobronchial mass with atelectasis, and fiberoptic bronchoscopy revealed near total obstruction of the left inferior lingular bronchus (LB5) of left upper lobe with an exophytic endobronchial mass. Contrary to fist impression, bronchoscopic biopsy revealed actinomycotic infection involving the bronchus. Intravenous administration of penicillin G followed by oral amoxicillin therapy was done and the mass was markedly decreased thereafter.