골수 검사상 양성 혈구 탐식 조직구가 나타난 소아의 임상적 고찰

박진아,박주영,박지민,박샛별,김흥식,전동석,Park, Jin A,Park, Joo Young,Park, Ji Min,Park, Seat Byoul,Kim, Heung Sik,Jeon, Dong Seok 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.8

목 적: 혈구 탐식 조직구 증식증은 양성 질환으로는 드물게 치명율이 높은 질환으로, 발열, 간비장 종대, 림프절 종대 등의 증상이 있고, 검사 소견에서 양성의 혈구 탐식 조직구가 나타난 경우 진단되나 치료가 혼란스러운 경우가 많다. 골수 검사상 양성의 혈구 탐식조직구가 나타난 예들의 임상적 특징을 분석하여 진단 및 치료 방향과 예후 판정에 도움이 되고자 이 연구를 시행하였다. 방 법 : 1995년 1월부터 2001년 11월까지 계명대학교 동산병원에서 골수 검사상 양성의 혈구 탐식 조직구가 나타난 환아 30례를 대상으로, 특징적 임상 증상, 진찰 소견, 혈액 검사 소견, 골수 검사 소견, 치료 방법과 예후에 대하여 임상 기록지를 후향적으로 분석하였다. 또한 골수 도말에서 혈구 탐식 조직구의 수에 따라 a few, some, many로 나누어 환아의 예후와 비교하였다. 결 과 : 골수 검사상 양성 혈구 탐식 조직구를 보인 예들을 분석한 결과 이들의 연령 분포는 2개월에서 15세로, 평균 연령은 5.6세였고, 남녀비는 2.3 : 1로 남아가 많았다. 입원 당시 증상으로는 발열이 가장 많았으며, 호흡기 증상, 위장관 증상 등의 순이었고, 평균 발열 기간은 19.5일이었으며, 진찰 소견은 간비종대, 피부 발진, 림프절 비대 순으로 많았다. 혈액 검사 소견상 백혈구 감소증이 23례(76.7%)로 가장 많았고, 혈소판 감소증이 16례(53.3%), 빈혈이 15례(50.0%), 간기능 검사 이상이 15례(50.0%)로 나타났다. 기저 질환으로 급성 림프구성 백혈병, 악성 림프종 등 면역 저하된 상태가 5례였고, 건강했던 경우가 25례 였으며, 관련 질환의 종류로는 패혈증, 폐렴, 전염성 단핵구증 등의 순이었고, 원인으로는 세균이 많았으며, 바이러스로는 EBV가 4례였고, candida가 1례였다. 골수 도말 소견상 세포 충실도가 정상이 25례(83.3%)였고, 5례(16.7%)에서 감소되어 있었으며, 혈구 탐식 조직구의 수에 따라 분류하였을 때, some이 15례(50.0%), many가 9례(30.0%), a few가 6례(20.0%)이었다. 치료는 보존 요법, 항생제와 항바이러스제, 항진균제, 면역 글로불린, steroid, etoposide, cyclosporine 등의 병용 요법을 시행하였다. 사망율은 30명 중 8명으로 26.7%였으며, 연령이 낮은 군과 혈구 탐식 조직구 수가 some 이상인 경우에 사망률이 높았다. 결 론 : 고열, 간비종대, 범혈구 감소증과 간기능 이상 등의 소견을 보이는 환아에서 조기에 골수 검사를 시행하여 혈구 탐식 조직구가 보일 때, 원인 치료 및 대증 요법과 함께 면역 화학 요법을 시행하는 것이 예후에 도움이 될 것으로 생각되며, 골수 소견과 예후와의 관계는 지속적인 연구 관찰이 필요할 것으로 사료된다. Purpose : The aim of this study is to find a method to diagnose and treat children who showed benign hemophagocytic histiocytes in bone marrow examination. Methods : We analyzed the clinical data of thirty patients retrospectively who showed benign hemophagocytic histiocytes in bone marrow examination from January 1995 to November 2001 at Keimyung University Dong-san Hospital. Bone marrow histiocytes were classified into a few, some, and many according to the number of histiocytes comparing with the white cells. Results : The age of thirty patients ranged from two months to 15 years. The median age was 5.6 years with male predominance(2.3 : 1). The most frequent clinical manifestation was fever; others were respiratory symptom, hepatosplenomegaly, lymphadenopathy and skin rash(in order of frequency). Common laboratory findings were leukopenia, thrombocytopenia, anemia and abnormal liver function test. Infection was present in 30 patients; causative organisms were documented in 15 patients, and bacterial infection was more common. Epstein Barr virus was the cause of infection in four patients. Bone marrow examination showed a few(20.0%), some(75.0%) and many(30.0%) hemophagocytic histiocytes. Combination immunochemotherapy including immunoglobulin, steroids and cyclosporine were helpful in 22 out of 30 patients. The mortality rate was high in young patients who showed some to many hemophagocytic histiocytes. Conclusion : Bone marrow examinations and early detection of histiocytes will be helpful in children who have fever, hepatosplenomegaly and abnormal liver function test. Immunochemotherapy were helpful and further investigation will be needed for the detection of the relationship between the bone marrow findings and prognosis.

신한옥의 평면구성에 따른 공간활용상태에 관한 연구 - 전라남도 신한옥을 중심으로 -

박진아,김수암,Park, Jin-A,Kim, Soo-Am 한국주거학회 2012 한국주거학회 논문집 Vol.23 No.4

Developing the modern design of Hanok and providing support for the commercialization model development in recent years propelled by the New Hanok Support Strategies of the central government in conjunction with the New Hanok revitalization related projects reflecting local goverments. New Hanok revitalization, the rekindling and revaluing of human behaviors and interests in local goverments following the social and cultural changes of the past decades, has emeraged as an increasingly traditional area of concerning in New Hanok planning. In this paper we attempt to this discussion by describing recent projects in New Hanok revitalization in Jeollanam-do Province. Therefore, this study aims to examine the classification of compound knowledges based multidimensional relationship by using Self-Organizing Maps (SOM). SOM is an unsupervised learning neural network model for the analysis of high-dimensional input data. By using SOM, we were able to create a cluster map reflecting the characteristics of the New Hanok. In this case the pattern of the preference data was easily understood by visual analysis. Liking for compound knowledge deduced from this data was classified into 8 categories according to the compound knowledge properties of New Hanok. As a result, a systematic approach for analysis the characteristics of individual family and living environment of New Hanoks and 10 space usage patterns the changes in some aspects of New Hanok.

르 꼬르뷔지에 유토피아적 자연관의 절대적 이데올로기화 과정 연구 -빌라 사보아와 빌라 마이어 옥상정원을 중심으로-

박진아,Park, Jin-A 한국건축역사학회 2004 건축역사연구 Vol.13 No.2

This study is an attempt to prove a relationship between Le Corbusier's utopian attitude towards nature and architectural ideology and ideology by a form of inquiry into sociological interests. That is to find out contradictions and limitations in Le Corbusier's architectural world, namely particularity of his ideology by exploring the base entangled with special interests in the society up until formation of his architectural language. A process of this study is by; 1. Examining of background which affected Le Corbusier's attitude towards nature until the nature became his architectural language; 2. An analysis of Le Corbusier's architectural works. That is, this study's main interest is on formation of Le Corbusier's architectural language by his attitude towards nature which present in residential field especially focused on Villa Meyer and Villa Savoye, two best examples of his villa. 3. This study have a goal to investigate that utopian and ideological conception in architecture of Le Corbusier have a dialectic relationship between them. This goal can be achieved by observing in what ways Le Corbusier's utopian attitude towards nature is expressed in residential architectural language and researching into his inconsistent architectural ideology derived from applying architectural language present in villa to pre-fabricated apartment houses.

파리시 도시지역계획의 지속가능한 개발 핵심전략으로서 '전통수복정책' 연구

박진아,Park, Jin-A 한국건축역사학회 2011 건축역사연구 Vol.20 No.2

France is known to be making particular efforts to maintain its traditional urban architectural culture by diverse measures including the implementation of urban policies. However, France is facing up to the need to pursue modern urbanization in keeping with the requirements of the current times. Thus, this paper examines with what priority France is attempting to reflect in its current urban policies its determination to retain its urban architectural tradition and to recreate its capital city of Paris as a future European hub city. To that end, the paper first seeks to analyze Paris' policies for urban architecture from diachronic perspectives in a bid to determine Paris' urban architectural culture. Second, the study attempts to examine within the purview of the paradigm of contemporary urban architectural designs how Paris is pursuing the two conflicting purposes of the preservation of tradition and modern urbanization through the Paris Local Urbanization Plan (or Plan Local d'Urbanisme [PLU]). First, the findings indicate that Paris is applying the principle of a sustainable development plan in all fields of environment, economy and society. In terms of environmental sustainability, Paris is trying to improve the life quality of its citizens through the establishment of efficient mass transportation systems and the expansion of its green belt areas. In terms of social sustainability, Paris is implementing policies to ensure social diversity through housing policies. Also, in terms of economic sustainability, Paris is trying to expand employment and bolster its urban functions by conserving commercial activities and developing peripheral urban areas. Second, the findings indicate that Paris' policy of recovering its traditions takes priority over that of creating a sustainable city.

러프집합이론을 이용한 한스타일 욕실공간의 구성규칙 추출에 관한 연구

박진아,김수암,Park, Jin-A,Kim, Soo-Am 한국주거학회 2013 한국주거학회 논문집 Vol.24 No.6

Developing a modern Han-style design and providing support for the commercialization development model in recent years has been propelled by the Han-style Support Strategies of the central government in conjunction with Han-style revitalization related projects that reflect the efforts of local governments. Han-style revitalization, the rekindling and revaluing of human behavior and interest in local governments following the social and cultural changes of the past decades, has emerged as an increasingly traditional area of concern in Han-style design. The purpose of the study was to provide a method which clarifies the design rules of the Han-style bathroom based on an evaluation of sensibilities and a rough set theory, and to give the components meaning and to systematize the method. Essentially, the Han-style bathroom design evaluation is a complex multi-criteria decision making process that seeks to improve the effectiveness and objectively of the Han-style bathroom design. Han-style bathroom design can be displayed in a graphical representation in response to input from the evaluation concerning sensibilities. Because the graphical representation is composed of 3D data, it is possible to display the Han-style bathroom design form in any desired perspective and also to perform shading and other operations. With the proposed method, it is possible to obtain a combination of several contributory components which can be referred to as Reducts, Covering Index and Column Score. Han-Style/Non Han-Style Bathroom Designs were identified by the combination of several components.

Inverted labial bow appliance를 이용한 전치부 반대교합 치험례

박진아,박호원,Park, Jin-A,Park, Ho-Won 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.4

III급 부정교합은 유치열기나 혼합치열기에 이미 그 증상을 예측할 수 있을 뿐 아니라 많은 경우 그 증상의 악화를 예방할 수도 있다. III급 부정교합의 원인으로는 단순한 상하악 치아의 위치 이상에 의한 치아 치조성 혹은 기능성 III급 부정교합과 상악골과 하악골의 비정상적 성장발육에 의한 골격성 III급 부정교합으로 나누어 볼 수 있다. 특히 초기의 기능적 III급 부정교합 환자의 경우 방치되면 다양한 환경적 유전적 요소와 함께 골격성 부정교합으로 전이될 수 있고 많은 경우 악골의 비대칭적 성장에 원인이 될 수도 있다. 따라서 이러한 부정교합의 일차적 조기치료는 소아치과 치료영역에서 중요한 관심 분야라 할 수 있다. Inverted labial bow appliance는 통상적인 active plate의 장점과 activator와 같은 양악장치의 장점을 동시에 수용할 수 있는 장치로 상악치아의 개별적인 치아이동이 용이하고 동시에 기능적으로 전방 변위된 하악을 쉽게 정상위치 시킬 수 있는 장치이다. 특히 구호흡 등의 기질적 원인을 가지는 환자나 복잡한 양악장치를 착용하는데 어려움이 있는 협조도가 부족한 환자의 경우 효과적으로 사용할 수 있다. 이러한 장치를 이용하기 위해서는 골격성 III급 부정교합과의 정확한 감별진단이 선행되야 함은 물론이다. 본 증례는 기능성 III급 부정교합으로 진단된 7세 여아에서 Inverted labial bow appliance를 이용하여 전치부 반대교합을 해소한 경우로 치료결과는 상하악 전치부의 치아 치조성 이동에 의해 주로 이루어졌다. The prognosis for class III patients in growing child can be made in mixed dentition and the severity of the symptom is often amenable to early intervention. Class III malocclusion can be classified as functional class lit and skeletal origin. Skeletal Class III malocclusion is usually characterized by overdeveloped mandible, underdeveloped maxilla, but the cause of pseudo class III is most dentoalveolar or functional shift of mandible. The primary goal of early intervention of malocclusion is to supply an environment that is conducive to the development of favorable occlusal relationships and avoiding of worsening of the problems. Inverted labial bow appliance is introduced as an appliance to combine the advantage of active plate and activator. It is undemanding with this appliance to initiate not only dentoalveolar expansion of upper dentition but also to orient the functional retrusion of mandible. With simple design the compliance for patients such as mouth breathing problem can be improved. For successful use of this appliance it is utmost important to make accurate and early diagnosis between pseudo- and skeletal class III malocclusion. This article will demonstrate the use of an Inverted labial bow appliance for early treatment of a functional Class III malocclusion. After 4 month treatment, anterior crossbite was treated and the results were achieved mainly dentoalveolar change of upper and lower anterior teeth.

서울시 터널의 유해대기오염물질 농도변화 특성 분석

박진아,이원영,김진아,김익수,김현수,정종흡,윤중섭,정권,엄석원,Park, Jin-A,Lee, Won-Young,Kim, Jin-A,Kim, Ik-Su,Kim, Hyun-Su,Jeong, Jong-Heup,Yun, Jung-Seop,Jung, Kweon,Eom, Seog-Won 한국환경보건학회 2013 한국환경보건학회지 Vol.39 No.6

Objectives: We analyzed the characteristics of hazardous air pollutants (HAPs) in road tunnels in Seoul. Methods: Particle matter ($PM_{10}$), elemental carbon (EC), organic carbon (OC), and 16 species of polycyclic aromatic hydrocarbons (PAHs) in two road tunnels (NS tunnel and HJ tunnel) were sampled and analyzed from 2007 to 2011. Results: Levels of $PM_{10}$ and carbon ingredients which were mainly emitted from diesel-fueled vehicles showed a declining tendency in both road tunnels. PAHs levels in HJ were declining slightly while PAHs levels in the NS tunnel fluctuated considerably and showed an increasing tendency. Conclusions: These results suggested that the abatement project of diesel vehicle emissions by the Seoul metropolitan government from 2007 has had an impact on the reduction of DVE into the air, though there exist many things to consider for analyses.

과학기술인의 사회적 위상 - 과학기술인에 대한 예우 및 지원 입법 방안

박진아,Park, Jin-A 한국과학기술단체총연합회 2013 과학과 기술 Vol.531 No.-

<송부인전>에서 모함 모티프가 나타나는 양상과 그 의의

박진아 ( Jin A Park ) 택민국학연구원 2014 국학연구론총 Vol.0 No.14

모함 모티프가 한 요소로서 문학 작품에 등장하기 위해서는, 모함하는 편과 모함당하는 편의 위치와 성별로 만들어지는 8가지 유형 중 하나로서 <모함자> <피해자> <판단자> <원인> <형태와 수단> <결과> <극복>이라는 성립 요건을 만족시켜야 한다. 특정 모티프의 성립 조건을 구조적으로 분석하는 것은 창작자뿐 아니라 감상자, 비평자에게도 작품 연구의 도구가 된다. 본고에서는 고소설 <송부인전>에 이를 대입하여 분석하였다. 이로써 <송부인전>에 나타난 모함 모티프는 <원인>이 주인공의 혼전에 있었던 강제 결혼의 무산에 대한 보복이고 <모함자>가 주인공이 속한 집단 바깥에 있는 특이한 양상으로 만들어져 있음을 알게 되었다. 이로써 <송부인전>에 사용된 모함 모티프는, 첫째로 새로운 유형의 모함 모티프 사용, 둘째로 혼사장애 모티프와 신부 수난 모티프의 근대적 변형, 셋째로 근대적 시각의 현실 파악과 대응, 넷째로 중세적 성격에서 탈피한 여주인공의 등장이라는 의의를 갖게 되었다. For appearance in a literature, a slander motif must fulfill a requirements for establishment. That is <Slanderer> <Victim> <Adjudicator> <Sake> <Form and Means> <Results> <Conquest>. It can be a tool for analysis and research to fictionist and reviewer and researcher. In this paper, I analyze on Songbuinjeon to this tool. So I can find that a slander motif in Songbuinjeon has unique form. <Sake> is a revenge for a humiliating failure on a marriage by force that happend before heroine`s marriage. And <Slanderer> is situated in the outside of the heroine`s group. So the slander motif in Songbuinjeon can has four means. First, it can use a new form. Second, it can has a modern transform of the matrimony-hindrance and the suffering bride. Third, it can understand and react to reality from a modern view. Forth, it has the appearance of a heroine who free from a medievalism.

웹 디자인에 있어서 시각 커뮤니케이션을 위한 효과적 레이아옷 연구

박진아(Jin A Park),조열(Youl Cho) 한국기초조형학회 2000 기초조형학연구 Vol.1 No.2

A Society where we are living now is the third wave information society Alvin Toffler says. Especially internet part using computer is being reformed over and over as much as saying the third revolution of telecommunication technology. Information of the most powerful media computer inside turning out to the global network, we are recognizing that it is holding many part of our communication style. Maybe Web(World Wide Web) is its representative example. Over 90% of the web being made as a visual information it feels strong seeing information rather than reading. In the Web like that a graphic image role is being increased as a medium for communication. It can be that by the effect of easy to see magnificent a graphic image huge information`s sea does close relation with our life. In the internet important things of a visual part is that a stimulus and knowledgment of human holding sensitivity are being accomplished 99% which internet has information is a visual information. Especially for digital information accomplishes efficient communication between human and computer it faces to the problem how express information`s content. If users understand a way which watch and translate a visual information, in doing work which contribute a meaning to Web design`s pattern and content, it will elevate probability success. Thus this treatise is not unconditional arrangement of information`s factor but research all expression way under objectivity going to present a concept and direction.