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원형질체 융합 및 핵전이에 의한 새로운 담자균류의 개발에 관한 연구(II) - 융합균사체의 항암성분이 생쥐의 면역세포에 미치는 영향 -
문철,김채균,윤종명,심미자,김하원,최응칠,김병각,Moon, Chul,Kim, Chae-Kyun,Yoon, Jong-Myung,Shim, Mi-Ja,Kim, Ha-Won,Choi, Eung-Chil,Kim, Byong-Kak 한국생약학회 1996 생약학회지 Vol.27 No.3
The antitumor components of the protoplast fusants of Lentinula edodes and Ganoderma lucidum were examined for immunological activity to elucidate the mechanism of their antitumor activity. They did not show any direct cytotoxicity against tumor cells. But being examined for immunopotentiation activity, they increased the number of colonies in the bone marrow stem cells to 3.0 times. They also increased the activities of the acid phosphatase in activated macrophages to 2.1 times and the secretion of nitric oxide in RAW 264.7 to 2.2 times, respectively. They activated the components of the alternative complement pathway. In humoral immunity. they increased the activities of the alkaline phosphatase in differentiated B cells to 1.6 times and the number of plaque forming cells to 1.8 times, respectively. In cellular immunity, they restored the depressed response of delayed type hypersensitivity in tumor bearing mice to normal level.
원형질체 융합 및 핵전이에 의한 새로운 담자균류의 개발에 관한 연구(I) - 융합균사체의 항암성분 -
문철,윤종명,김채균,김하원,최응칠,김병각,Moon, Chul,Yoon, Jong-Myung,Kim, Chae-Kyun,Kim, Ha-Won,Choi, Eung-Chil,Kim, Byong-Kak 한국생약학회 1996 생약학회지 Vol.27 No.3
To find pharmacologically active hybrids among the inter-order protoplast fusants of Lentinula edodes and Ginoderma lucidam the antitumor test was performed and the fusant P22 was selected among them. The hot water and alkaline extracts from the cultured mycelia of P22 were purified and separated into four fractions by DEAE-cellulose anion exchange chromatography. When a dose of 20 mg/kg/day of each fractions was injected into ICR mice by i.p., the tumor inhibition ratio of Fr. IV against solid sarcoma 180 was the higher than any other fraction. Fr. IV was a protein-bound polysaccharide which was composed of 69. 12% polysacchafide and 9.76% protein and the molecular weight of Fr. IV was $6.7{\times}10^4$ dalton.
조선희,박광영,김채균,김완영,이연식,변윤섭 한국공업화학회 2002 한국공업화학회 연구논문 초록집 Vol.2002 No.0
We reported that the antibacterial activity of poly(styrene-alt-maleic anhydride)-4-amjnophenol conjugate was satisfactory, but any significant antifungal activity was not observed from the polymer. Quaternary ammonium salts have been reported to exhibit good antifungal activities. Thus, in this study, poly(methyl methacrylate-co-4-vinylbenzyl chloride) (poly(MMA-co-VBC)) was reacted with N,N-dimethylamino-3-phenol (DMAP) to obtain a conjugate, poly(MMA-co-VBC)-DMAP. The antimicrobial activity as well as the thermal property of the polymer will be presented in detail.
고영길,박광영,김채균,김완영,이연식,변윤섭 한국공업화학회 2002 한국공업화학회 연구논문 초록집 Vol.2002 No.0
Pentachlorophenol (PCP) has been known to be a strong antibacterial agent and powerful pesticide. Quaternary ammonium salts have been reported to exhibit excellent antifungal activities. We observed that the antifungal activity of polymers containing PCP as pendant was not satisfactory even though the antibacterial activity was very strong. In this study, poly(methyl methacrylate-co-4-vinylbenzyl chloride) (poly(MMA-co-VBC)) was reacted with PCP and N,N-dimethylamine (DMA) to obtain poly(MMA-co-VBC)-PCP and poly(MMA-co-VBC)-DMA, respectively. The base polymer was also reacted with both PCP and DMA at the same time to obtain poly(MMA-co-VBC)-PCP-DMA. The polymers were characterized In terms of the antimicrobial acticity and the thermal property.