황반부종이 동반된 망망분지정맥폐쇄에서 베바시주맙 유리체내주사의 보조치료로써 브롬페낙의 효과

윤종명,조영욱,문종원 대한안과학회 2020 대한안과학회지 Vol.61 No.2

Purpose: To evaluate the effectiveness of 0.1% topical bromfenac as an adjunctive treatment with intravitreal bevacizumab (IVB) injection for branch retinal vein occlusion (BRVO) patients. Methods: We retrospectively evaluated 68 eyes of 68 patients with macular edema (ME) secondary to BRVO who were treated with IVB injection and followed up for at least 12 months. Of the 68 eyes, 38 were treated with IVB combined with 0.1% topical bromfenac and 30 were treated with IVB alone. IVB reinjection was performed in cases of recurrence. The primary outcome measurement was the number of IVB injections. Changes in the best-corrected visual acuity (BCVA) and central foveal thickness (CFT) during the 12-month follow-up were compared. Results: There was no significant difference in the BCVA or CFT between the two groups at the initial and final examinations. However, the number of IVB injections was significantly lower in the 0.1% bromfenac-treated eyes (p < 0.01) than in the control eyes (4.1 ± 0.7 vs. 5.0 ± 0.6 times). Conclusions: Compared to IVB monotherapy, topical bromfenac as an adjunctive treatment with IVB injection of eyes with ME secondary to BRVO did not affect visual outcomes, but it reduced the number of IVB injections. 목적: 망막분지정맥폐쇄로 인한 황반부종에서 베바시주맙 유리체내주사의 보조치료로써 0.1% 브롬페낙 점안액의 효과를 평가하고자 하였다. 대상과 방법: 망막분지정맥폐쇄로 인한 황반부종으로 베바시주맙 유리체내주사 시행 후 12개월 이상 경과 관찰이 가능했던 68명 68안을 대상으로 의무기록을 후향적으로 분석하였다. 0.1% 브롬페낙 점안액을 병용하지 않은 군(30안)과 병용한 군(38안)으로 나누어 치료 12개월 후 최대교정시력 및 중심와두께의 변화, 베바시주맙 유리체내주사 횟수를 비교 분석하였다. 결과: 최대교정시력 및 중심와두께는 두 군 모두에서 통계학적으로 유의한 호전을 보였으며, 12개월째 두 군 간 유의한 차이를 보이지 않았다. 베바시주맙 유리체내주사 횟수는 점안한 군(4.1 ± 0.7)이 점안하지 않은 군(5.0 ± 0.6)에 비해 유의하게 적었다(p<0.01). 결론: 망막분지정맥폐쇄로 인한 황반부종에서 베바시주맙 유리체내주사의 보조치료로써 0.1% 브롬페낙 점안액은 시력예후에는 영향을 미치지 않으나, 주입 횟수를 감소시킬 가능성이 있다.

고식적 치료에 반응하지 않은 욕창 환자에서 음압-이용 흡인 치료법의 효과

복수경,윤종명,조경자,오상향,홍준형,이영진,김윤미 대한재활의학회 2005 Annals of Rehabilitation Medicine Vol.29 No.1

Objective: To evaluate the effect of Vacuum-Assisted Closure (V.A.C.) therapy in stage 3 or 4 pressure ulcers refractory to traditional saline wet gauze dressing. Method: Ten patients who had stage 3 or 4 pressure ulcers which were failed to heal with saline wet gauze dressing over 4 weeks were investigated. We treated these subjects with V.A.C. therapy. The length, width and depth of pressure ulcers were evaluated every week for 3 weeks. Soft tissue biopsy from pressure ulcer was taken before starting V.A.C. therapy and after the scheduled therapy was done. Results: The sizes of length, width and depth in pressure ulcer were significantly decreased after one week of V.A.C. application. And then healthy granulation tissue was formed. The length, width and depth of the pressure ulcer were decreased of 40.2%, 42.7% and 79.8% of their original size. Soft tissue biopsy in pressure ulcers was taken in 4 cases, the number and size of capillaries were more increased and inflammatory cells were decreased. Conclusion: V.A.C. therapy promoted wound healing and revealed favorable histological changes in pressure ulcers refractory to traditional dressing. We suggest that V.A.C. therapy can be used for the effective management of pressure ulcer.

Alternaria에 의한 감염결정각막병증

홍혜진,윤종명,박대진 대한안과학회 2019 대한안과학회지 Vol.60 No.11

Purpose: To report a case of infectious crystalline keratopathy caused by Alternaria in the corneal center. Case summary: A 66-year-old male visited our clinic with right ocular pain and visual loss after corneal trauma caused by a foreign body hitting his right eye while performing farm work 1 month prior to his visit. The patient had no history of corneal surgery and long-term use of topical corticosteroid. A corneal epithelial defect and whitish snowflake margin infiltration around the corneal stroma were observed in the corneal center, but there was an absence of conjunctival injection and anterior segment inflammation. Cultures and a biopsy of the corneal scrapings revealed Alternaria species fungus. The patient was treated with 1% topical voriconazole and 0.5% moxifloxacin, together with oral voriconazole (400 mg/day). After 2 months of treatment, the disease was completely cured, with a minute corneal opacity. Conclusions: We successfully treated a rare case of infectious crystalline keratopathy caused by Alternaria, which has not been previously reported in the Republic of Korea. 목적: 각막 중심에 발생한 Alternaria에 의한 감염결정각막병증 1예를 경험하였기에 이를 보고하고자 한다. 증례요약: 66세 남자 환자가 1개월 전에 밭일 중 우안에 이물이 튀는 각막외상 후에 지속적인 우안 통증과 시력저하로 내원하였다. 각막수술이나 장기간 스테로이드 점안액 사용의 과거력은 없었다. 각막 중심에 상피결손과 각막기질 주위로 백색의 눈송이 모양의 침윤이 보였으나 심한 기질염증은 없었고, 결막충혈이나 전방염증은 관찰되지 않았다. 도말 배양 및 조직검사상 Alternaria 균종이 검출되었다. 1% voriconazole 점안액, 0.5% moxifloxacin 점안액과 경구 vorizonazole (400 mg/day)을 이용하여 2개월간 치료 후 병변 부위에 미세한 각막혼탁을 남기고 완치되었다. 결론: 저자들은 국내에서 보고된 적 없는 Alternaria에 의한 감염결정각막병증 1예를 성공적으로 치험하였기에 이를 보고하는 바이다.

안와연조직염 및 안와농양의 수술적 치료 후 진단된 급성눈물주머니염 1예

허민구,윤종명,곽미선 대한안과학회 2019 대한안과학회지 Vol.60 No.1

Purpose: We report a case of acute dacryocystitis diagnosed with abscess and rupture of lacrimal sac and fistula to posterior orbit during the operation. Case summary: A 71-year-old woman visited our clinic with edema and pain in the eyelid from three days ago. For past four months, there was viscous of the left eye and tears. The patient had severe conjunctival chemosis and hyperemia, compared with the left eyelid edema and redness. Orbital CT scan showed orbital cellulitis, which was followed by systemic antibiotics and steroid therapy. On the 4th day of therapy, orbital abscess formation was observed in orbit MRI and surgical drainage was planned. During surgery, we found rupture of the posterior part of lacrimal sac and fistula to posterior orbit. Pseudomonas aeruginosa was identified in the bacterial cultures, and after the administration of appropriate antibiotics, the disease showed improved progress, and then additional dacryocystorhinostomy was performed. Conclusions: In our case, acute dacryocystitis rarely spread in orbit, which may lead to delayed diagnosis, orbital cellulitis and abscess, resulting in serious complications of vision threat. So, we think that it is necessary to consider surgical treatment more actively in the stage of chronic dacryocysitis. 목적: 안와연조직염을 치료하던 중 경과 악화 및 안와농양이 합병되어 수술 중 발견된 눈물주머니의 농양 및 파열과 뒤쪽 안와로 형성된 샛길을 확인하고 급성 눈물주머니염을 진단하였기에 보고하고자 한다. 증례요약: 71세 여자 환자가 3일 전부터 발생한 눈꺼풀의 부종과 통증을 주소로 내원하였다. 좌안 눈꺼풀부종과 발적에 비해 심한 결막 부종 및 충혈 소견을 보였으며, 안와전산화단층촬영상 안와연조직염 소견이 관찰되어 전신 항생제 및 스테로이드 치료를 하였으나 경과가 악화되었다. 치료 4일째 안와 자기공명영상촬영에서 안와농양이 관찰되어 수술적 배농술을 계획하였고, 수술 중 눈물주머니의 농양과 눈물주머니 뒷부분의 파열 및 안와로 형성된 샛길을 확인하였다. 세균배양검사상 녹농균이 동정되어 적절한 항생제 투여후 호전되었으며, 이후 눈물주머니코안연결술을 시행하였다. 결론: 본 증례와 같이 급성 눈물주머니염이 드물게 안와쪽으로 진행하는 경우에는 진단이 늦어지고 안와연조직염 및 안와농양이 합병되어 시력위협의 중대한 합병증이 발생할 수 있으므로 만성 눈물주머니염 단계에서 보다 적극적으로 수술적 치료를 고려하는 것이 필요하다고 생각된다.

원형질체 융합 및 핵전이에 의한 새로운 담자균류의 개발에 관한 연구(I) - 융합균사체의 항암성분 -

문철,윤종명,김채균,김하원,최응칠,김병각,Moon, Chul,Yoon, Jong-Myung,Kim, Chae-Kyun,Kim, Ha-Won,Choi, Eung-Chil,Kim, Byong-Kak 한국생약학회 1996 생약학회지 Vol.27 No.3

To find pharmacologically active hybrids among the inter-order protoplast fusants of Lentinula edodes and Ginoderma lucidam the antitumor test was performed and the fusant P22 was selected among them. The hot water and alkaline extracts from the cultured mycelia of P22 were purified and separated into four fractions by DEAE-cellulose anion exchange chromatography. When a dose of 20 mg/kg/day of each fractions was injected into ICR mice by i.p., the tumor inhibition ratio of Fr. IV against solid sarcoma 180 was the higher than any other fraction. Fr. IV was a protein-bound polysaccharide which was composed of 69. 12% polysacchafide and 9.76% protein and the molecular weight of Fr. IV was $6.7{\times}10^4$ dalton.

신결핵의 최근동향

이정주,정문기,윤종명 대한신장학회 1989 Kidney Research and Clinical Practice Vol.8 No.1

원형질체 융합 및 핵전이에 의한 새로운 담자균류의 개발에 관한 연구(II) - 융합균사체의 항암성분이 생쥐의 면역세포에 미치는 영향 -

문철,김채균,윤종명,심미자,김하원,최응칠,김병각,Moon, Chul,Kim, Chae-Kyun,Yoon, Jong-Myung,Shim, Mi-Ja,Kim, Ha-Won,Choi, Eung-Chil,Kim, Byong-Kak 한국생약학회 1996 생약학회지 Vol.27 No.3

The antitumor components of the protoplast fusants of Lentinula edodes and Ganoderma lucidum were examined for immunological activity to elucidate the mechanism of their antitumor activity. They did not show any direct cytotoxicity against tumor cells. But being examined for immunopotentiation activity, they increased the number of colonies in the bone marrow stem cells to 3.0 times. They also increased the activities of the acid phosphatase in activated macrophages to 2.1 times and the secretion of nitric oxide in RAW 264.7 to 2.2 times, respectively. They activated the components of the alternative complement pathway. In humoral immunity. they increased the activities of the alkaline phosphatase in differentiated B cells to 1.6 times and the number of plaque forming cells to 1.8 times, respectively. In cellular immunity, they restored the depressed response of delayed type hypersensitivity in tumor bearing mice to normal level.

뇌졸중 환자의 시기에 따른 평균 혈소판 요소의 변화

홍준형,복수경,조경자,오상향,윤종명,이종욱 대한재활의학회 2005 Annals of Rehabilitation Medicine Vol.29 No.1

Objective: Decrease of platelet density by degranulation of activated platelet is well correlated with decrease of mean platelet component (MPC) value. We intended to investigate the change of MPC, mean platelet volume, and platelet count according to the stroke stage and difference between ischemic and hemorrhagic infarction. Method: Thirty eight patients (ischemic stroke 28 men, hemorrhagic stroke 10 men) and twenty age-matched healthy persons were included in this study. They were divided into acute stage group and subacute stage group. Each of them were sampled by venously and investigated about mean platelet component, mean platelet volume, and platelet counts. Results: In ischemic stroke, there was statically (p<0.05) meaningful decrease of MPC value in acute stage (27.5±1.7) compared to control group (28.8±0.9). And MPC value in subacute stage showed meaningful increase (28.1±1.3) compared to acute stage but still remained in statically lower value compared to control value. In hemorrhagic stroke, there was no meaningful difference of MPC value in acute stage group (28.6±2.0) and subacute stage group (27.9±1.1) compared to control group. Conclusion: In ischemic stroke patients, MPC value in acute stage decreased meaningfully and this change might be useful as a landmark in predicting the activity of infarction.

중심 정맥 카테터 제거 후 발생한 뇌 공기 색전증 -증례보고-

복수경,현화진,이영진,윤종명,오상향 대한재활의학회 2007 Annals of Rehabilitation Medicine Vol.31 No.2

급성기 뇌졸중 환자의 입원 시 고혈당증이 임상적 결과에 미치는 영향

오상향,현화진,이영진,남승호,윤종명,복수경 대한재활의학회 2007 Annals of Rehabilitation Medicine Vol.31 No.6