Geology of the Danyang Coalfield

金正昭(Jeong So Kim) 대한지질학회 1981 지질학회지 Vol.17 No.2

최근에 설립된 광주지역 중학교의 교과교실제 공간 분석

김정규(Kim, Jeong-Gyu),김정소(Kim, Jeong-So) 한국교육시설학회 2013 敎育施設 Vol.20 No.5

This study was carried out to obtain basic data for architectural plans on the facilities relocation needed in operating the departmentalized classroom system at the latest built middle schools. For this, floor plans of ten middle schools built in Gwangju after 2009 were analyzed about space configuration and area holding state. The process of this study is as follows: (1) To investigate proper area holding state for operating variation type, this study analyzed area of departmentalized classrooms, homebases and teachers' offices. (2) To investigate space configuration for operating variation type, this study analyzed composition of departmentalized classrooms, learning-support facilities and homebases. (3) On the base of those analyses, this study proposed some directions for architectural plans on the facilities relocation.

증례 : 류마티스 ; 류마티스관절염 환자에서 발생한 비정형 대퇴골 골절의 1예

김담 ( Dam Kim ),정소담 ( So Dam Jung ),손창남 ( Chang Nam Son ),최지영 ( Ji Young Choi ),이승훈 ( Seung Hun Lee ),김이석 ( Yee Suk Kim ),성윤경 ( Yoon Kyoung Sung ) 대한내과학회 2014 대한내과학회지 Vol.87 No.2

류마티스관절염 환자에서 질환 자체의 활성도나 질환으로 인한 비스포스포네이트의 장기간 사용 및 PPI, 스테로이드의 사용으로 비정형 대퇴골 골절의 위험도가 높아질 수있으므로 비정형 대퇴골 골절에 대한 많은 연구가 필요하다고 생각하며 대퇴부 통증이 있는 경우 비정형 대퇴골 골절을 염두에 두고 면밀한 진찰과 영상진단을 해야 한다. Atypical femoral fractures are characterized by a subtrochanteric or diaphyseal location. Recent studies have suggested that long-term treatment with bisphosphonates might be associated with the occurrence of atypical femoral fractures. The present report describes a case involving a 60-year-old woman with left buttock pain that was unassociated with trauma. Her hip pain was initially considered to be a symptom of her underlying rheumatoid arthritis, but a plain radiography, bone scintigraphy, and magnetic resonance imaging revealed an insufficiency fracture in the lateral shaft of the left proximal femur. She had been treated with a bisphosphonate for 4.5 years because of a previous vertebral fracture. Her chronic, long-term rheumatoid arthritis and history of bisphosphonate administration were considered to be associated with the development of her atypical femoral fracture. (Korean J Med 2014;87:240-244)

Fusobacterium nucleatum 에 의한 간농양 1 예

정소연(So Yean Jung),정희철(Hee Chul Jung),이창화(Chang Hwa Lee),김남일(Nam Il Kim),김성자(Sung Ja Kim),이구(Goo Lee),서정일(Jeong Il Suh),이창우(Chang Woo Lee),하경임(Gyoung Yim Ha),김한식(Han Sik Kim),양창헌(Chang Heon Yang) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.5

Fusobacterium is a very rare cause of liver abscess. Fusobacteria are anaerobic gram- negative bacilli that are part of normal flora of the oral cavity, the urogenital tract, and the gastrointestinal tract. However, Fusobacterium bacteremia is uncommon, accounting for less than 1% of all bacteremias in adults. Liver abscess due to Fusobacterium nucleatum (F. nucleatum) was reported in patients with AIDS or idiopathic CD4+T lymphocytopenia. We experienced a 54-year-old woman who presented with intermittent fever and generalized weakness for 2 months. Abdominal CT scan revealed an 8 × 10 cm mass in the right hepatic lobe with central low density. Ultrasound-guided aspiration of liver abscess was performed. About 30 mL of greenish-yellow foul-odored pus was aspirated. F. nucleatum was cultured from the aspirated pus. Intravenous administration of antibiotics for 4 weeks and repeated aspiration improved symptoms and decreased size of liver abscess. We report a case of liver abscess due to F. nucleatum in an immunocompetent woman. ( Korean J Gastroenterol 2002; 39: 386-389)

최근에 설립된 광주지역 중학교의 교과교실제 공간 분석

김정규,김정소,Kim, Jeong-Gyu,Kim, Jeong-So 한국교육시설학회 2013 敎育施設 Vol.20 No.5

This study was carried out to obtain basic data for architectural plans on the facilities relocation needed in operating the departmentalized classroom system at the latest built middle schools. For this, floor plans of ten middle schools built in Gwangju after 2009 were analyzed about space configuration and area holding state. The process of this study is as follows: (1) To investigate proper area holding state for operating variation type, this study analyzed area of departmentalized classrooms, homebases and teachers' offices. (2) To investigate space configuration for operating variation type, this study analyzed composition of departmentalized classrooms, learning-support facilities and homebases. (3) On the base of those analyses, this study proposed some directions for architectural plans on the facilities relocation.

양성 골종양의 수술적 치료 후 발생한 골결손에서 시행한 Hydroxyapatite의 조기 결과

정소학,권영호,박영균,김재도,Chung, So-Hak,Kwon, Young-Ho,Park, Young-Gyun,Kim, Jae-Do 대한근골격종양학회 2008 대한골관절종양학회지 Vol.14 No.1

목적: 골종양의 수술적 치료 후 발생한 골결손에 대해 골 대체물의 하나인 Hydroxyapatite ($Bongros^{(R)}$-HA)를 이용하여 치료하고 그 결과를 알아보고자 한다. 대상 및 방법: 2006년 09월부터 2007년 12월까지, 골종양의 수술적 치료 후 발생한 골 결손에 대해 골 대체물의 하나인 Hydroxyapatite를 이용하여 치료하였다. 총 17례의 양성 골종양 환자에서 시행하였으며, 남자 10명, 여자 7명이었고, 평균 연령은 28.5세였다. 양성 골종양의 종류별로 보면 섬유성 이형성증이 8례, 고립성 골 낭종이 5례, 거대 세포종이 4례였다. 부위별로는 근위 대퇴골 6례, 원위 대퇴골 3 례, 근위 경골 3례, 근위 상완골 4례, 골반골 1례였다. 자가골을 함께 사용한 경우가 4례, Hydroxyapatite 단독으로 사용한 경우가 13례였다. 추시 기간은 최단 3 개월에서 최장 15개월로 평균 7.5개월이었다. 주기적인 추시에서 관찰된 단순 방사선 사진에서 Hydroxyapatite의 이식물의 흡수 정도와 골 생성 정도를 술 후 사진과 비교하여 백분율로 표시하여 관찰하였다. 결과: 술 후 평균 4.5 개월에 98% 이상의 흡수율을 관찰할 수 있었고, 술 후 평균 6.2 개월에는 98% 이상의 골 생성을 관찰 할 수 있었다. 골 결손의 양이 적은 겨우 골 형성이 빠른 결과를 보였다(p=0.012). 하지만 그 외 환자의 성별, 나이 그리고 자가골의 첨가 여부에 따른 비교에서 이식물의 흡수율이나 골 생성에 통계학적으로 유의한 차이는 발견할 수 없었으며, 모든 경우에서 최종 추시 시 특이한 합병증은 없었다. 결론: 양성 골종양의 수술적 치료 후 발생한 골 결손의 치료제로서 Hydroxyapatite는 유용할 것으로 사료된다. Purpose: This study was performed to evaluate the efficiency of Hydroxyapatite ($Bongros^{(R)}$-HA) what use for bone defect after operative treatment of benign bone tumor. Materials and Methods: Hydroxyapatite, was used to treat bone defect after operative treatment of benign bone tumor from September, 2006 to December, 2007. A total of 17 benign bone tumor cases (10 males and 7 females) with mean age of 28.5 was observed studied. The diagnoses were fibrous dysplasia in 8 cases, solitary bone cyst in 5 cases, and giant cell tumor in 4 cases. In categorization by location of tumor, there were 6 cases of proximal femur, 3 cases of proximal femur, 3 cases of proximal tibia, 4 cases of proximal humerus, and 1 case of hip bone. Autogenous bone was used with Hydroxyapatite in 4 cases, and only Hydroxyapatite used in 13 cases. Periods of Follow-up were from 3 months to 15 months, and mean period were 7.5 months. Amount of graft resorption and bone formation was observed with compare of post operation radiograph and the difference was shown by percentage. Results: More than 98% bone uptake was observed after mean 4.5 months, and more than 98% bone formation was observed after mean 6.2 months. Lesser bone defect size showed faster bone formation and it was statistically significant result (P=0.012). But other comparative studies on other factors such as sex, age of patients and combination of autogenous bone were no statistically significant differences in graft resorption and bone formation. And there was no significant complications in periods of follow-up. Conclusion: Hydroxyapatite is considered as one of useful method of bone defect after operative treatment of benign bone tumor.

고용량 방사선 조사 후 골육종 세포주(Saos-2)의 아포프토시스 발생

김재도,정소학,홍영기,최장석,Kim, Jae-Do,Chung, So-Hak,Hong, Young-Gi,Choi, Jang-Seok 대한근골격종양학회 1999 대한골관절종양학회지 Vol.5 No.1

A single fraction of 50 Gy extracorporeal irradiation, as a modality of limb-sparing operation, has been used to achieve tumor necrosis in osteosarcoma. Although this modality of radiation therapy preserving the mobility of a joint is commonly practiced, the precise knowledge on the radiobiological response of osteosarcoma cell has remained to be elucidated. We therefore observed whether a single high dose irradiation caused apoptosis in osteosarcoma cells and whether the commitment to apoptosis was associated with cell kinetics. We also investigated radiation dose response along the time course for development of apoptosis following single high dose irradiation. The morphologic change in apoptosis was observed by fluorescence with Hoechst 33258 and the degree and the fraction of cells by flow cytometry. Irradiation of osteosarcoma cells with 10, 30 and 50 Gy resulted in chromatin condensation and apoptotic body formation. The degree of apoptosis in osteosarcoma cells was $29.5{\pm}3.56%$, $39.9{\pm}4.83%$ at 24 and 48 hours after 10 Gy irradiation ; $41.1{\pm}3.93%$, $66.9{\pm}5.21%$ at 24 and 48 hours after 30 Gy irradiation ; and $48.0{\pm}3.69%$, $75.6{\pm}4.65%$ at 24 and 48 hours after 50 Gy irradiation. The fraction of cells in cell-cycle kinetic was $39.2{\pm}4.3%$ in G2/M, $22.1{\pm}4.65%$ in G1 at 24 hours after 10 Gy irradiation ; $51.0{\pm}4.3%$ in G2/M, $20.4{\pm}4.7%$ in G1 at 48 hours after 10 Gy irradiation ; $40.3{\pm}3.9%$ in G2/M, $26.1{\pm}4.7%$ in G1 at 24 hours after 30 Gy irradiation ; $59.2{\pm}3.9%$ in G2/M, $5.9{\pm}5.1%$ in G1 at 48 hours after 30 Gy irradiation ; and $44.3{\pm}4.2%$ in G2/M, $21.1{\pm}3.5%$ in G1 at 24 hours after 50 Gy irradiation. The fraction of cells at 48 hours after 50 Gy irradiation could not be observed because of irradiation induced cell death of most of cells. All values for irradiated cells showed accumulation in G2/M phase and reduction in G1 phase, irrespective of irradiation dose. The results suggest that a single fraction of high dose irradiation with 50 Gy results in accumulation of cells at G2/M phase, leading to apoptosis.

가족보호요인(적응적 평가, 사회적 지지 및 보상적 경험) 효과 검증

정소연(Jung Soyon),김정인(Kim Jeong In) 한국가족학회 2016 가족과 문화 Vol.28 No.2

본 연구는 가족이 경제적 어려움이 가족적응에 미치는 영향, 그리고 가족원의 의료 및 돌봄문제가 가족적응에 미치는 영향 관계에서 가족의 적응적 평가, 사회적지지 및 보상적 경험이 보호요인으로서 기능하는지를 검증하는 것을 목적으로 한다. 이와 같은 연구목적을 위해 구조화된 설문지를 활용하여 서울시 S구의 474가족으로부터 수집된 자료에 대해 위계적 회귀분석을 실행하였다. 이론적으로 가정된 바와 같이, 두 개의 독립 변수들은 가족적응과 부적(-) 관련성을 갖는 것으로 밝혀졌는데, 이는 ‘가족의 경제적 어려움’과 ‘가족원의 의료 및 돌봄 문제’가 가족적응의 위험 요인이라는 것을 의미한다. 또한 적응적 평가, 사회적 지지, 그리고 보상적 경험은 가족 적응과 정적(+) 관련성을 가지고 있음이 확인되었다. 그러나, 경제적 어려움과 가족적응 간 관계에 있어서 세 변수들의 조절적 보호요인효과는 관찰되지 않았다. ‘의료 및 돌봄 문제’와 ‘가족적응’ 간 관계에서, 사회적 지지와 보상적 경험은 조절 효과를 갖는 것으로 밝혀졌지만, 예상과는 달리 이 상호작용항들의 회귀계수가 음수(-)인 것으로 나타났다. 이는 가족 내 의료 및 돌봄문제가 심각한 가족의 경우 사회적 지지와 보상적 경험이 가족적응에 미치는 긍정적 영향력은 가족 내 의료 및 돌봄 문제가 심각하지 않은 가족에 비해 더 약함을 의미한다. 논의에서는 가족정책 및 서비스와 관련한 본 연구의 함의와 연구결과로부터 도출된 실천적 제언이 제시되었다. This study was designed to answer the following four research questions: (1) Are financial difficulties of families negatively associated with family adaptation?: (2) Do adaptive appraisal, social support, and compensatory experience function as family protective factors in the association between financial difficulties and family adaptation?: (3) Are family members’ medical problems and its related caregiving burden negatively related to family adaptation?: and (4) Do adaptive appraisal, social support, and compensatory experience function as family protective factors in the association between medical problemㆍcaregiving burden and family adaptation? The data for this study were collected from 474 families living in S-Gu, Seoul, Korea utilizing structured survey questionnaires. A series of hierarchical multiple regressions, and descriptive statistics were performed. As expected, the two independent variables were found to be negatively associated with family adaptation, indicating that ‘financial difficulties of families’ and ‘family members’ medical problems and related caregiving burden’ are risk factors for family adaptation. Adaptive appraisal, social support, and compensatory experience were also linked positively to family adaptation. However, no moderating protective effects were observed. It implies that adaptive appraisal, social support, and compensatory experience have only compensatory protective effects(main effects) in the relationships. In the association between family association and family members’ medical problem and related caregiving burden,’ social support and compensatory experience were found to have moderating effects but in the opposite direction to those expected. Implications for family services and policies are discussed.

하지에 발생한 악성흑색종 및 편평상피세포암에서 소속 림프절 생검의 의미

김재도,이근우,권영호,정소학,Kim, Jae-Do,Lee, Gun-Woo,Kwon, Young-Ho,Chung, So-Hak 대한근골격종양학회 2010 대한골관절종양학회지 Vol.16 No.2

목적: 사지에 발생된 편평 상피암이나 악성 흑색종에서 술 중 소속 림프절 생검의 의미에 대해 알아보고자 한다. 대상 및 방법: 2005년 9월부터 2009년 1월까지 본원에서 악성 흑색종 또는 편평상피세포암으로 진단된 환자 중, 원발 부위의 광범위 절제술을 시행한 이후 술 후 면역항암화학요법을 시행하고 1년 이상 추시가 가능하였던 악성 흑색종 15예, 편평상피암 10예, 총 25예를 대상으로 하였고, 이 중 소속 림프절 생검을 시행한 군은 10예였다. 평균 연령은 64세였으며, 남자 15예, 여자 10예였다. 결과: 총 25예의 3년 생존율은 100%였고, 3년 무병 생존율는 76%였다. 총 6예에서 전이가 발생하였고, 서혜부 림프절 4예, 슬부 주위 연부조직 1예, 좌측 아킬레스건 1예였다. 소속 림프절 절제술을 시행하지 않았던 15예에서는 평균 생존율은 93.3%였고, 무병 생존율은 73.3%였다. 소속 림프절 절제술을 시행한 10예에서 평균 생존율은 100%였고, 무병 생존율은 90%였다. 술 중 소속 림프절 절제술을 시행한 10예 중 단 1예에서만 조직검사 상 양성 소견을 보였고, 소속 림프절 절제술을 시행하였던 10예 모두에서 추시 상 전이는 없었다. 소속 림프절 절제술 이후 합병증이 발생한 경우는 없었다. 결론: 소속 림프절의 생검 및 절제는 과거의 전 림프절 절제술과 비교하여 간단하고 적은 합병증으로 높은 정확도를 보이며, 종양의 정확한 병기 설정으로 치료 방향을 결정하는 것이 환자의 생존율을 높이는데 도움을 줄 수 있다고 판단된다. Purpose: Sentinel lymph node (SLNB) is the first confronted lymph node from primary lesion of tumor through lymphatic drainage, which is important for determining early metastasis and setting guidelines for treatment. We reported significant of sentinel lymph node biopsy in malignant melanoma (MM) and squamous cell carcinoma (SCC) of lower extremities. Materials and Methods: Twenty-five cases of surgically treatment and being possible for follow up more than 1 year among the patients who were diagnosed as MM and SCC in this institution from Sep. 2005 to Jan. 2009, and 10 cases of them were performed SLNB. Average age was 64 years old, and 15 cases of male and 10 cases of female were in this group. Results: 3 years overall survival rate was 100% and 3 years disease-free survival rate was 76%. Metastasis occurred in total 6 patients, 4 cases of inguinal lymph nodes, 1 case of soft tissue around knee, 1 case of left achilles tendon. In 15 cases of not performing SLNB, overall survival rate was 93.3% and disease-free survival rate was 73.3%. In 10 cases of performing SLNB, overall survival rate was 100% and disease-free survival rate was 90%. And only 1 case showed positive finding in the biopsy, and none of the 10 cases showed metastasis in follow-up. Conclusion: SLNB leads simpler and less complications compared to prior elective lymph node dissection, and shows high degree of accuracy. Throughout the SLNB, setting guidelines for treatment by accurate staging is thought to be helpful for increasing the survival rate in the patient with MM and SCC.

사지구제술에서 언제 재활용 자가골 이식술이 유용한가?

김재도,장재호,조율,김지연,정소학,Kim, Jae-Do,Jang, Jae-Ho,Cho, Yool,Kim, Ji-Youn,Chung, So-Hak 대한근골격종양학회 2008 대한골관절종양학회지 Vol.14 No.2

목적: 악성 근골격계 종양의 치료로 재활용 자가골 이식술을 이용하는 사지구제술에서 종양의 절제 및 재건 방법과 자가골의 재활용 처치 방법에 따라 그 유용성과 임상적 적용에 대하여 후향적 조사를 통하여 알아보고자 한다. 대상 및 방법: 본원에서는 1995년 12월에서 2006년 2월까지 재활용 자가골 이식술을 시행한 58례의 악성 근골격계 종양 환자들을 대상으로 하였다. 나이는 평균 36.5세(5~74세)였고, 성별은 남자가 34례, 여자가 24례였다. 58례 중 47례는 체외 방사선 조사(extracorporeal irradiation)를 시행하였고 11례는 저온 열처리(pasteurization)를 하였다. 재활용 자가골의 절제 및 재건 방법은 조각삽입(fragmentary) 3례, 분절삽입(intercalary) 8례, 골연골 삽입(osteoarticular) 18례, 자가골-종양대치물 복합체(recycling-autograft-prosthesis composite) 23례, 전 관절(total joint) 5례, 아킬레스건(achilles tendon) 1례였다. 결과는 절제 및 재건 방법과 자가골의 재활용 처치 방법에 따라 방사선학적 유합과 기능적인 평가(Musculoskeletal Tumor Society)에 따른 결과를 분석하였고 각각의 합병증에 대하여 조사하였다. 결과: 접합부의 유합은 체외 방사선 조사에서 15.0개월, 저온 열처리에서 12.6개월로 관찰되었다. 절제 방법에 따라 분절삽입 12.8개월, 조각삽입 6.0개월, 자가골-종양대치물 복합체 10.0개월, 골연골 삽입 23.3개월, 전 관절 15.6개월로 관찰되었다. 기능적 결과 점수는 체외 방사선 조사에서 59.6%, 저온 열처리에서 63.5%였고 절제 방법에 따라 분절삽입 60.8%, 조각삽입 65.5%, 자가골-종양대치물 복합체(골반제외) 62.8%, 골연골 삽입 66.0%, 전 관절 이식 66.6%였다. 저온 열처리에서 합병증은 2례(18.1%)로 감염 1례, 비구 돌출 1례가 관찰되었고 체외 방사선 조사에서 22례(46.8%)의 합병증(심부 감염 3례, 불유합 8례, 골절 2례, 성장판 문제 2례, 관절 불안정성 5례, 국소 재발 2례)이 발생하였다. 절제 및 재건 방법에 따라 분절삽입에서 불유합 3례(37.5%), 자가골-종양대치물에서 합병증 9례(50.0%, 불유합 4례, 심부감염 1례, 종양대치물 주위 골절 1례, 성장판 문제 1례, 국소재발 1례, 비구 돌출 1례), 골연골 삽입에서 합병증 6례(33.3%, 심부감염 2례, 불유합 2례, 성장판 문제 1례, 병적 골절 1례), 전 관절 이식에서 합병증 5례(100%, 관절 불안정성 5례), 아킬레스건에서 국소재발 1례(100%)가 발생하였다. 결론: 재활용 자가골 이식술의 유용성은 절제 및 재건 방법에 따라서 조각 및 분절 재건술이 사지의 기능이 우수하고 접합부의 빠른 유합을 보여 가장 좋은 적응증으로 사료되며, 자가골-종양 대치물 복합체의 재건술에서는 절제 후 남은 골이 부족할 때 종양 대치물의 안정성을 위해 고려해 볼 만하다. 자가골의 재활용 처치 방법에서는 저온 열처리법이 체외 방사선 조사법보다 더 우수한 것으로 사료된다. Purpose: To identify which is the best procedure in recycling autograft according to the resection & reconstruction type and recycling methods, and so when the recycling autograft is used in limb salvage surgery. Materials and Methods: We have treated fifty-eight patients (34 male, 24 female; age range 5 to 74 years, mean age 36.5 years), who had the malignant musculoskeletal tumors, with recycling autograft (47 patients with extracoporeal irradiation, 11 patients with pasteurization) from December 1995 to February 2006. The resection and reconstruction type was 3 cases with fragmentary, 8 intercalary, 23 rAPC (recycling-Autograft-Prosthesis composite), 18 osteoarticular, 5 total joint and 1 soft tissue (achilles tendon). The result was evaluated by the radiologic union at junctional site, the functional score by musculoskeletal tumor society score and complications according to the resection & reconstruction type and recycling methods. Results: The junctional union was obtained at 15.0 months in extracoporeal irradiation and 12.6 months in pasteurization. Also the mean radiologic union was shown at 6.0 months in fragmentary, 12.8 months in intercalary, 10 months in rAPC, 23.3 months in osteoarticular and 15.6 months in total joint. The functional score was 65.5% in fragmentary, 60.8% in intercalary, 62.8% in APC (except pelvis), 66.0% in osteoarticular and 66.6% in total joint. We have experienced 1 infection, 1 prutrusio acetabuli in pasteurization (18.1%) and other 22 complications (3 deep infections, 8 nonunions, 2 fractures, 2 epiphyseal problems, 5 joint instabilities, 2 local recurrence) in extracoporeal irradiation (46.8%). Also we have experienced 3 complications (3 nonunions) in intercalary (37.5%), 9 complications (4 nonunions, 1 deep infection, 1 periprosthetic fracture, 1 epiphyseal problem, 1 local recurrence, 1 protrusio acetabuli) in rAPC (50.0%), 6 complications (2 deep infections, 2 nonunions, 1 epiphyseal problem, 1 pathologic fracture) in osteoarticular (33.3%), 5 complications (5 joint instabilities) in total joint (100%) and 1 complication(1 local recurrence) in soft tissue (100%). Conclusion: In our experience, according to the resection & reconstruction type fragmentary and intercalary may have several advantages such as good radiologic and functional result and low rate of complication. And it seems that rAPC was available in case which have no sufficient residual bone stock. Also the pasteurization may have more advantages than that of the extracorporeal irradiation.