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우리나라 소아 설사에 있어서의 Enteroadherent Escherichia coli의 병원적 역학
김정목,김경희,조양자,서인수,Kim, Jung-Mogg,Kim, Kyung-Hee,Cho, Yaug-Ja,Suh, Inn-Soo 대한미생물학회 1987 大韓微生物學會誌 Vol.22 No.2
Adherence to HEp-2 cells has been proposed as a virulence characteristic of enteropathogenic E. coli (EPEC). The role of the HEp-2 adherent E. coli was evaluated in a group of children with endemic diarrhea admitted to Hanyang University Hospital in Seoul, Korea. HEp-2-adherent E. coli was detected in fecal samples of 59 (59%) of 100 cases and ten (22.7%) of 44 concurrent control children (p<0.0005). Adherence was exhibited by 15 serogroups and subgroups, but within these groups more than one adherence pattern was frequently observed. Of 17 strains belonging to traditional infantile EPEC serogroups, 12(70.6%) gave a positive adherence. Of 45 enterotoxin producing strains, 24 (53.3%) gave a positive adherence. HEp-2-adherent strains that did not belong to classic EPEC serogroups and did not produce heat-stable and/or heat-labile enterotoxins(referred as enteroadherent E. coli, EAEC) was found in 29 (29%) of the patients with diarrhea and in six (13.6%) of the well children (p<0.05). From 22 of the 29 cases, no pathogen other than EAEC was isolated. These findings strongly implicate EAEC as the cause of diarrhea in the children. Our study supports the concept that EAEC may be an important cause of endemic diarrhea in Korean children.
비강내 이상의 유무가 코경유 눈물주머니코안연결술의 성공률에 미치는 영향
김정목,홍욱표,최용준,김성주,Joung Mok Kim,M,D,Wook Pyo Hong,M,D,Yong Jun Choi,M,D,Ph,D,Sung Joo Kim,M,D,Ph,D 대한안과학회 2006 대한안과학회지 Vol.47 No.8
Purpose: To investigate the effect of a nasal cavity abnormality on the success rate of endonasal dacryocystorhinostomy (DCR). Methods: Two hundred seventy eyes of 230 patients who had undergone endonasal DCR from February 2003 to July 2004 were retrospectively analyzed. The patients were classified into three groups after all were preoperatively examined by an otolaryngologist. Group A consisted of patients who had no nasal cavity abnormality; Group B, patients who had a nasal cavity abnormality and who received treatment; and Group C, patients with a nasal cavity abnormality but who received no treatment. Results: The success rate of endonasal DCR were 83.9% in Group A, 87.5% in Group B, and 79.2% in Group C, with no statistical significance among the three groups (p>0.05). Conclusions: The presence of a nasal cavity abnormality did not affect the success rate of endonasal DCR.
유리체강내 트리암시놀론 주사시 용량에 따른 안압상승정도의 비교
김정목,김황기,손용호,Joung Mok Kim,Hwang Ki Kim,Yong Ho Shon 대한안과학회 2006 대한안과학회지 Vol.47 No.12
Purpose: The purpose of this study was to compare the effects of intravitreal injections of 4 mg or 8 mg triamcinolone acetonide(TA) on intraocular pressure (IOP) in macular edema. Methods: This was a retrospective study conducted by reviewing follow-up records for the eyes of 60 patients with macular edema 6 months receiving a intravitreal TA injection. Two groups, A and B, who had received TA injections of either 4 or 8 mg, respectively, were compared. Results: The average pre-injection IOP for group A was 12.8±2.6 mmHg, and the average post-injection IOP at 1 day, 1 week, 1 month, 3 months, and 6 months was 15.0±2.7, 14.6±3.2, 15.3±3.5, 15.8±4.0, and 14.4±2.8 mmHg, respectively. The average pre-injection IOP for group B was 12.5±2.4 mmHg, and the average post-injection IOP at 1 day, 1 week, 1 month, 3 months, and 6 months was 14.9±2.9, 14.3±3.0, 14.7±3.2, 15.2±4.4, and 14.5±4.5 mmHg, respectively. The difference in IOP elevation between the two groups was not statistically significant (p>0.05). Conclusions: There was no statistically significant difference between a 4 mg or 8 mg intravitreal TA injection with respect to IOP elevation.
FM-CW 레이더 거리계의 비트 신호 스펙트럼 상관성을 이용한 고정밀 측정 알고리듬
김정목,임종수,전중창,김태수,심재윤,박위상,Kim, Jeong-Mok,Lim, Zong-Soo,Chun, Joong-Chang,Kim, Tae-Soo,Shim, Jae-Ryun,Park, Wee-Sang 대한전자공학회 2001 電子工學會論文誌-TC (Telecommunications) Vol.38 No.4
본 논문에서는 FM CW 레이더의 원리를 이용한 마이크로파 거리계에서 비트 신호(beat signal)의 스펙트럼 상관도(correlation)를 해석하고, 이를 이용하여 고 정밀도를 실현할 수 있는 거리 측정 알고리듬을 제안한다. 산업 자동화용과 같이 고 정밀도를 요구하는 경우, 거리계에 사용되는 VCO의 주파수 선형도가 매우 우수하여야 한다. 그러나 실제 VCO의 선형도를 높이기 위해서는 고가의 VCO나 복잡한 선형화 회로가 필요하며, 이는 장비 자체의 제작 비용을 높이는 요인이 된다. 거리 차가 충분히 작은 표적물에 대한 두 비트 신호의 주파수 스펙트럼간에는 상관도에서 침투지를 나타내는 주파수 ???V(offset)이 존재하게 되며, 본 논문에서는 이를 바탕으로 일반적인 VCO를 사용하더라도 정밀한 측정을 할 수 있는 상관 알고리듬을 제안한다. 제안된 알고리듬의 타당성을 검증하기 위한 측정 결과를 제시하였다. In this paper, for the microwave level meter based on the FM-CW radar, we analyze the spectrum correlation of beat signals and propose a measurement algorithm using the theory. For industrial applications, level meters must have high precision, which requires a good linearity of VCO. But, in practice, it is very complicated or very expensive to make VCO linear enough to be acceptable in the industrial field. We propose a measurement algorithm using the fact that there exists a peak in the spectrum correlation of beat signals when range difference is sufficiently small. This makes it possible to determine the range difference in a precise manner even using a practical VCO. We present some experimental results to show the validity of this algorithm.
실제 및 시뮬레이션 환경에서의 적대적 공격 기법 연구 동향
김용수(Yongsu Kim),윤영여(Youngyeo Yun),강효은(Hyoeun Kang),김명길(Myeongkil Kim),김호원(Howon Kim) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.2
딥러닝 기술은 지속적인 발전을 통해 실생활에 다양하게 적용되고 있지만, 악의적인 데이터를 주입하여 오작동하게 만드는 적대적 공격에 취약한 것으로 밝혀져 큰 위협이 되고 있다. 특히, 기존 연구에서 발전하여 실제 환경이나 이와 유사한 시뮬레이션 환경에서 딥러닝 모델을 공격할 수 있는 연구가 많이 제안되었다. 본 논문에서는 실제 및 시뮬레이션 환경에서의 적대적 공격 기법 연구 동향을 조사하여, 향후 실생활에 큰 위협이 되는 적대적 공격에 대한 효과적인 방어 연구를 진행하는 데 기여하고자 한다.
한국에서 지역에 따른 Helicobacter pylori 균주 내성
김재연 ( Jae Yeon Kim ),김나영 ( Na Young Kim ),김성중 ( Sung Jung Kim ),백광호 ( Gwang Ho Baik ),김광하 ( Gwang Ha Kim ),김정목 ( Jung Mogg Kim ),남령희 ( Ryoung Hee Nam ),김홍빈 ( Hong Bin Kim ),이동호 ( Dong Ho Lee ),정현채 ( H 대한소화기학회 2011 대한소화기학회지 Vol.57 No.4
Background/Aims: This study was performed to compare the prevalence rates of primary antibiotic resistance in Helicobacter pylori (H. pylori) isolates among different regions of Korea. Methods: H. pylori were isolated from gastric mucosal biopsy specimens of 99 Koreans who lived in Gyeonggi (n=40), Kangwon province (n=40) and Busan (n=19) from April to August in 2008. All the patients had no history of H. pylori eradication therapy. The susceptibilities of the H. pylori isolates to amoxicillin, clarithromycin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin, and moxifloxacin were tested according to the agar dilution method. Results: There was a difference in resistance to clarithromycin in three institutes located among Gyeonggi (32.5%), Kangwon province (12.5%) and Busan (42.1%) by One way ANOVA test (p=0.027) and nonparametric Kruskal Wallis test (p=0.027). However, by post-hoc analysis, there was no statistically significant difference among three regions. Similarly, the other 7 antibiotics (amoxicillin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin) did not show any significant difference. Conclusions: There was no significant regional difference of the primary antibiotic resistance of H. pylori. However, the included patient number might not be enough for this conclusion demanding further evaluations. (Korean J Gastroenterol 2011;57:221-229)
수용성 단백질로 활성화된 호중구에 대한 Rebamipide 의 효과
김주성(Joo Sung Kim),김정목(Jung Mogg Kim),김병관(Byeong Gwan Kim),김상균(Sang Gyun Kim),김지원(Ji Won Kim),김찬규(Chan Gyoo Kim),정현채(Hyun Chae Jung),송인성(In Sung Song) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.1
Background/Aims: Helicobacter pylori (H. pylori) infection induces persistent neutrophil infiltration in gastric mucosa. The expression of cyclooxygenase (COX)-2 and inhibition of apoptosis in the neutrophils could contribute to the pathogenesis of H. pylori infection. Rebamipide, a mucosal protective and ulcer-healing drug, has been known to inhibit neutrophil activation. The aim of this study was to evaluate the effect of rebamipide on the neutrophils activated by Helicobacter pylori water-soluble proteins. Methods: After neutrophils were stimulated with H. pylori water extract (HPWE) or pretreated with rebamipide, the expression of COX-2 mRNA and protein was assessed by quantitative RT-PCR and Western blotting, respectively. Prostaglandin (PG) E2 synthesis was determined by radioimmunoassay. Neutrophil apoptosis was evaluated by cytosolic oligonucleosome-bound DNA ELISA and caspase-3 activity was measured by the detection of p-nitroanilide after cleavage from labeled substrate. Results: Stimulation with HPWE upregulated COX-2 expression and PGE2 secretion, and inhibited neutrophil apoptosis. Rebamipide suppressed PGE2 secretion from neutrophils in a dose-dependent manner. However, rebamipide did not affect neutrophil apoptosis and caspase-3 activity. Conclusions: Rebamipide effectively suppresses PGE2 secretion from neutrophils activated by H. pylori water-soluble proteins. This is another possible mechanism of gastric mucosal protection by rebamipide. (Korean J Gastroenterol 2002;39:13-21)
2003년 우리나라 환자에서 분리한 Helicobacter pylori 균주의 항생제 내성률
김정목 ( Jung Mogg Kim ),김주성 ( Joo Sung Kim ),정현채 ( Hyun Chae Jung ),김나영 ( Na Young Kim ),송인성 ( In Sung Song ) 대한소화기학회 2004 대한소화기학회지 Vol.44 No.3
Background/Aims: Development of antibiotic resistance is a significant clinical problem in the eradication of H. pylori. To select an appropriate regimen, systematic information on antibiotic resistance is mandatory. Thus, we investigated the distribution
감염에 의한 인체 위상피세포로부터의 Inducible Nitric Oxide Synthase 발현 및 Nitric Oxide 생성
김정목(Jung Mogg Kim),김주성(Joo Sung Kim),정현채(Hyun Chae Jung),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.5
Background/Aims: Nitric oxide (NO) is known to be an important regulator of inflammatory response. Our aim was to study the role of inducible nitric oxide synthase (iNOS) expression and NO production in Helicobacter pylori (H. pylori)-infected gastric epithelial cells. Methods: Human gastric epithelial Hs746T cells were infected with H. pylori and iNOS mRNA expression was assessed by quantitative RT-PCR. NO production was assayed by determining nitrite/nitrate levels in culture supernatants. To determine the polarity of NO secretion, Caco-2 cells were cultured in transwell chambers and NO production was measured. Results: iNOS mRNA and NO production were significantly increased in the cells infected with H. pylori. The specific MAP kinase inhibitors decreased H. pylori-induced iNOS and NO up-regulation. After polarized Caco-2 epithelial cells were infected with H. pylori, NO was released predominantly into the apical compartment, and IL-8 was released predominantly into basolateral compartment. The addition of IFN-γ to H. pylori-infected Caco-2 cells showed a synergistically apical and basolateral NO release. Conclusions: These results suggest that apical NO production in H. pylori-infected gastric epithelial cells may influence the bacteria and basolateral production of NO may play a role in the tissue inflammation. (Korean J Gastroenterol 2002; 39: 324-334)