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The Effects of Passive Smoking on Never-smokers with COPD
김웅준,김태형,문지용,박성수,신동호,손장원,김상헌,곽현정,박동원,송준석 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Background: Active smoking is widely acknowledged as the single most important risk factor for COPD. However, it is still controversial that the exposure to secondhand smoking on never-smoker is also a risk factor. In this study, we investigated association of passive smoking exposure to never smokers and occurrence of COPD. Method: This study was based on the data obtained from the Korean National Health and Nutrition Examination Surveys (KNHANES) conducted from 2008 to 2010. Using nationwide stratified random sampling, participants who were aged 40 years or over and available for lung function tests were included in the analysis. Never-smokers were selected and duration of exposure to passive smoking were measured based on the questionnaire of KNHANES. Result: The prevalence of COPD based on Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria was 6.67% (men, 12.96%; women, 5.77%) in never-smokers. We divided the never-smokers with exposure to secondhand smoke into two groups, with COPD and without COPD. The former group was older than the latter (58.84 vs. 52.18, P=0.0002), had higher prevalence of asthma and TB (12.61% vs. 3.14%, P=0.0002; 17.62% vs. 3.79%, P=0.0001, respectively), and had lower income (24.32% vs. 17.62%, P=0.0413). By multivariate logistic regression, secondhand smoke increased the prevalence of COPD but was not statistically significant (OR=1.75, P=0.41). Conclusion: There was no significant difference in prevalence of COPD between the never-smokers with and without exposure to secondhand smoke.
김웅준,김태형,문지용,박성수,신동호,손장원,김상헌,곽현정,박동원,송준석 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Background: Contacts over 35 years old are generally excluded from the treatment of latent tuberculosis infection, because of its high basal tuberculin skin test (TST) positivity and the risk of hepatotoxicity. It is revealed in the previous study con-ducted in Korea, that the risk of latent tuberculosis infection is increased if closely in contact with tuberculosis patients. In this study, based on a previous Korean study, we tried to find the factors significantly increase the risk of latent tuberculosis infection in contacts over 35 years old. Method: 41 contacts of pulmonary tuberculosis patients underwent TST, interferon-gamma release assay (IGRA), and chest radiography. The TST results were considered positive with an induration of 10 mm or more. TST positive or IGRA positive were regarded as latent tuberculosis infection. A standardized questionnaire was used to assess risk factors associated with tuberculosis infection. Result: Latent tuberculosis infection was diagnosed in 31 of 41 contacts of tuberculosis patients (75.6%). There was no differ-ence in the prevalence of latent tuberculosis infection, according to the strength of the contact or contact period. In addition, according to the factors associated with the virulence of the tuberculosis patients, there was no difference in the rate of latent tuberculosis infection. Conclusion: The risk of latent tuberculosis infection seemed not to be significantly increased with the strength of the contact, the contact period, or the virulence factor of tuberculosis patient among contacts over 35 years old in our study.
김웅준 ( Woong Jun Kim ),은창수 ( Chang Soo Eun ),이민규 ( Min Kyu Lee ),민승연 ( Seung Yeon Min ),유연화 ( Yeon Hwa Yoo ),한동수 ( Dong Soo Han ),전용철 ( Yong Cheol Jeon ),손주현 ( Joo Hyun Sohn ) 대한장연구학회 2012 Intestinal Research Vol.10 No.2
A chronic intestinal pseudo-obstruction is a rare disorder and a severe digestive syndrome. It is characterized by deranged gut propulsive motility that resembles a mechanical obstruction, but no obstructive process is present. An intestinal pseudo-obstruction may be classified as acute or chronic; the chronic form may also be classified as idiopathic or secondary to a variety of diseases. Treatment of intestinal pseudo-obstruction involves nutritional, pharmacological, and surgical therapies. Surgery should be limited to patients who are refractory to medical therapy and show a deteriorating course. Despite available medical and surgical interventions, the outcome remains poor. Here, we describe a case of a 54-year-old female with chronic constipation and abdominal distension, who was subsequently found to have segmental aganglionosis. The patient was treated with a subtotal colectomy and ileosigmoidostomy without sequelae. (Intest Res 2012;10:210-214)
증례 : 일과성 뇌허혈과 심근병증으로 발현한 갈색세포종 1예
김웅준 ( Woong Jun Kim ),김해수 ( Hae Su Kim ),김석환 ( Seok Hwan Kim ),신정훈 ( Jeong Hun Shin ),신진호 ( Jin Ho Shin ),김정현 ( Jeong Hyun Kim ),임영효 ( Young Hyo Lim ) 대한내과학회 2012 대한내과학회지 Vol.83 No.2
본 증례에서 환자는 내원 6개월 전 일과성 뇌허혈이 있었고, 흉통을 호소하며 내원하여 심전도 및 심근효소에서 급성관상동맥 증후군이 의심되어 관상동맥조영술을 시행하였으나 관상동맥에는 특이 소견이 없었고, 좌심실 조영술에서 Takotsubo 심근병증 양상으로 나타났다. 내원 6개월 전에 있었던 일과성 뇌허혈 및 Takotsubo 심근병증이 모두 갈색세포종에서 드물게 보일 수 있는 양상이었으며, 발작적인 고혈압, 두통, 심계항진 등의 동반 증상 등으로 갈색세포종을 의심하였고, 복부 전산화단층촬영 및 24시간 요 카테콜라민 검사에서 확인이 되어 수술적 치료로 호전이 된 증례이다. Patients with pheochromocytoma show a variety of clinical symptoms secondary to excessive catecholamine secretion. Major symptoms include hypertension, headache, hyperhidrosis, and palpitation. Stroke and myocardial infarction are known to occur in patients with pheochromocytoma, but the incidence is low. Here, we describe a 45-year-old female with a previous history of transient ischemic attack and a clinical presentation mimicking acute myocardial infarction with transient takotsubo-like myocardial dysfunction. A subsequent diagnostic examination revealed a left adrenal pheochromocytoma. The patient recovered with intensive medical treatment, including alpha- and beta-adrenergic blockade. Follow-up echocardiography revealed normalized cardiac function and wall motion. Thereafter, the patient underwent a laparoscopic left adrenalectomy without complications.
송준석,김웅준,박동원,곽현정,문지용,김상헌,김태형,손장원,윤호주,신동호,박성수 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Background: The therapeutic response in SCLC ptients for 1st line chemotherapy using platinum is closely related with prognosis. So we hypothesize that therapeutic response for chemotherapy using platinum is correlated with SUV-max value in PET-CT which is known to be correlated with prognosis in SCLC patients. Methods: We retrospectively reviewed the medical records of the patients who are diagnosed as SCLC pathologically or cyto-logically in two university hospital from January 2007 to December 2011. We grouped all patients into good-response group and poor-response group. Good-response group is the patients who are platinum-sensitive patients (recurred after 4 month later after finishing chemotherapy using platinum). Poor-response group is the patients who are platinum-resistant patients (recurred before 3 months after finishing chemotherapy using platinum) and progressive disease patients for WHO criteria. We excluded patients who had no PET-CT data or no chemotherapy data. Results: Of the total of 64 screened patients, 24 patients met the enrollment criteria. Good-response group (platinum-sensitive patients) are 10 patients, and poor-response group are 14 patients (platinum-resistant patients are 10 patients, and progressive disease patients are 4 patients). There is no significant association between therapeutic response and SUV-max value in PET-CT. Conclusions: There is no significant association between therapeutic response and SUV-max value in PET-CT. So we conclude that we cannot predict the therapeutic response with SUV-max value in PET-CT.