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신장 이식 환자의 만성 C형 간염에서 인터페론 치료 효과와 합병증
김용균 ( Yong Kyun Kim ),윤혜은 ( Hye Eun Yoon ),김수현 ( Su Hyun Kim ),최범순 ( Bum Soon Choi ),배시현 ( Si Hyun Bae ),최종영 ( Jong Young Choi ),윤승규 ( Seung Kew Yoon ),양철우 ( Chul Woo Yang ),김용수 ( Yong Soo Kim ),김석영 ( 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.6
Purpose : Chronic hepatitis C is a common cause of liver disease in kidney transplant (KT) recipients and lessens the chances of patients and graft survival. We evaluated the efficacy and safety of IFN-αatherapy in KT recipients with chronic hepatitis C. Methods : Ten KT recipients with chronic hepatitis C treated with recombinant IFN-α were enrolled. the patients had stable graft function, serum alanine aminotransferase (ALT) and positive HCV viremia were raised at the start of treatment. Eight patients received IFN alpha 3 million units three times weekly and 3 of them in combination with ribavirin in dose of 600mg daily. Two patients received pegylated INF-αa90 μg once weekly. Results : In 7 patients serum ALT levels were normalized and in 6 patients HCV-RNA became negative at the end of treatment. Five patients had sustained remission (persistently negative HCV-RNA) at the end of the follow-up. One patient relapsed at 15 months after discontinuation of INF. During the course of INF therapy one patient died due to sepsis with bowel perforation. Three patients developed graft dysfunction. In all of them graft function returned with discontinuing of INF and steroid therapy. In of three patients on INF plus ribavirin, hemolytic anemia was developed. After discontinuing of ribavirin hemolytic anemia was recovered and they were treated with INF alone. Conclusion : IFN-α therapy results in good biochemical response and virological clearance in KT recipients with chronic hepatitis C, but in about one third of the patients, the treatment had to do stopped prematurely due to graft dysfunction.
50주년 기념 리뷰 논문 : 품질경영학회 50주년 특별호: 신뢰성 분야 연구 리뷰
성시일 ( Si Il Sung ),김용수 ( Yong Soo Kim ),문병민 ( Byeong Min Mun ),배석주 ( Suk Joo Bae ) 한국품질경영학회 2016 품질경영학회지 Vol.44 No.1
Purpose: This paper reviews the papers on reliability issues which are published in the Journal of the Korean Society for Quality Management (KSQM) since 1965. The literature review is purposed to survey a variety of reliability issues for several categories Methods: We divide all of reliability issues into 9 categories: acceleration test, reliability estimation, system reliability, software reliability, reliability data collection and analysis method, lifetime distribution, maintenance and warranty strategy, reliability applications, and reliability applications to military area Results: Dividing all of papers on reliability published in KSQM for 50 years into 9 categories, we provide a chronological roadmap for individual categories, and summarize the contents and contributions of surveyed papers Conclusion: The review paper is expected to provide future direction to improve reliaiblity theories and applications in manufacturing and service industries