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성인형 호흡장애 증후군 ( ARDS ) 환자에서 혈중 모체 ( Complement ) 의 변화
김완동(Wan Dong Kim),김영선(Young Sun Kim),조성우(Sung Woo Cho),권순구(Sun Ku Kwon),정연태(Yun Tae Jung),김용훈(Yong Hun Kim),박춘식(Choon Sik Park) 대한내과학회 1989 대한내과학회지 Vol.37 No.3
N/A We previously reported that patients with ARDS had some serum factors which enhance neutrophil functions in terms of adherence and oxygen radical formation partly through complement activation, In this study, we measured complement C3, C4, C3a and C5a in the serum of patients with ARDS to search for the relation between the change of complement concentration and clinical sequence and the pathogenesis of ARDS. The results were as follows: 1) Although the concentration of C3 was lower in ARDS compared to normal controls, no difference was found between the two groups in the case of C4, 2) The concentrations of C3 and C5a were increased in the ARDS group. 3) The concentrations of C3a and C5a were increased in the ARDS group. In conclusion, in the serum of patients with ARDS, activated fragments of complement were found and the complement may be activated through an alternative pathway.
조성원,김완동,김진홍,심찬섭 순천향대학교 1988 논문집 Vol.11 No.3
Clinical Studies were made at the Soonchunhyang University Hospital on 144 cases of primary hepatocellular carcinoma of the liver from Jan. 1983 to Dec. 1987. The results were as follows: 1) The average age was 55.7 years and the ratio of male to female was 3.1:1. 2) The chief complaints on admission were abodominal pain in 59..0%, epigastric discomfort in 58.3%, fatigability in 58.3%, anorexia in 55.65%, weight loss in 45.8%, weight loss in 45.8%, nausea and vomiting in 21.5, % and hematemesis in 12.5% in order of frequency. Physical examination showed hepatomegaly in 64.6%, jaundice in 49.3%, ascites in 46.5%, edema in 20.1%, and fever in 17.4% in order of frequency. 3) Liver function tests revealed hypoalbuminemia in 68.3%, globulin elevation in 90.8%, SGPT elevation in 69.7%, SGOT/SGPT ratio was 2.19. 4) Clonorchis sinensis infestation was found din 4.9% of the cases. 5) The incidence of positive serum HBsAg, Anti-HBs, Anti-HBc, and HBeAg was 57.5%, 22.0%, 86.1%, and 21.1%, respectively. 6) Alpha-fetoprotein(AFP) was positive in 50.8%. The incidence of positive HBsAg was 66.0% in hepatoma with positive AFP, and 45.7% in hepatoma with negative AFP, respectively. 7) The presence of space occupying lesion could be demonstrated by ultrasonogram in 90.5%:52.6% in the right lobe, 57.4% in increased echogenecity, 59.3% in solitary type. 8) The presence of space occupying lesion could be demonstrated by liver scanning in 85.0%, by computed-tomogram in all of 19 cases, and by hepatic angiogram in 4 of 5 cases, respectively. 9) The site of metastasis revealed lung in 39.3%, lymph node in 28.6%, intraperitoneal organ in 17.9%, bone in 10.7% and peritoneum in 3.6% in order of frequency. 10) Of 25 cases of death, 22 cases(88%) were died within 3 months after diagnosis and 23 cases(92%) within 6 months after diagnosis.
김진홍,김용일,심찬섭,조성원,김완동 대한소화기내시경학회 1988 Clinical Endoscopy Vol.8 No.2
A 60-year-old woman has experienced of right upper quadrant abdominal discomfort. This partient took cholecytectomy due to gall stone 15 years ago. At that time microscopic finding the neck of gallbladder showed well differentiated papillary adenocarcinoma confined to superficial part of musele layer. 3 years before admission she took T-tube drainage due to obstructive jaundice. The microscopic finding af distal common bile duct showed well differentiated adenocarcinoma. Recently she complained of pain and discomfort on T-tube site and so we perforrned endoscopic retrograde biliary drainage after removal of T-tube. The computed tomogram showed no mass in liver or lymph node enlargement. 4 months after procedure of ERBD; we changed to the new catheter for the prevention of cloggiag of prosthesis. We report here a case of longterm survival over 15 years after the diagnosis of cancer of extrahepatic bile duct.