http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
조혈모세포 이식 후 Tacrolimus와 연관된 이식관련 혈전미세혈관병증 망막병증 2예
이성택(Seong Taik Lee),김수연(Su Yeun Kim),강용구(Yong Koo Kang),박한상(Han Sang Park),박동호(Dong Ho Park),신재필(Jae Pil Shin) 대한안과학회 2021 대한안과학회지 Vol.62 No.10
목적: 백혈병에서 동종 말초혈액 조혈모세포 이식 후 Tacrolimus와 연관된 이식관련 혈전미세혈관병증에 동반된 망막병증 2예를 보고하고자 한다. 증례요약: 급성골수세포백혈병으로 동종 말초혈액 조혈모세포 이식 후 Tacrolimus를 복용하던 58세 여자가 양안의 시력저하로 내원했다. 우안 시력은 0.5, 좌안은 0.4였고, 안저검사에서 다수의 면화반과 망막출혈을 보였으며 형광안저혈관조영에서 모세혈관 비관류를 보였다. 이식관련 혈전미세혈관병증에 동반된 망막병증이 의심되어 Tacrolimus를 중단하고 혈장분리교환을 시행하였으나 3개월 후 양안에 신생혈관녹내장이 발생하였다. 앞 증례와 유사한 20세 남자가 양안 시력저하로 방문하였다. 우안시력은 0.05, 좌안시력은 0.025였다. 앞의 환자와 유사한 소견을 보여 Tacrolimus를 중단하고 혈장분리교환을 시행하였고 1개월 후 우안 시력은 0.2, 좌안은 0.4로 회복되었다. 결론: 동종 말초혈액 조혈모세포 이식 후 Tacrolimus와 같은 calcineurin 억제제를 복용하는 환자가 시력장애를 호소할 경우 이식관련 혈전미세혈관병증에 동반된 망막병증을 의심해야 하며 조기 진단과 치료가 필요하다. Purpose: We report two cases of tacrolimus-related transplant-associated thrombotic microangiopathy (TA-TMA) retinopathy in leukemia patients who had undergone allogenic peripheral blood stem cell transplantation (PBSCT). Case summary: (Case 1) A 58-year-old woman with a history of PBSCT due to acute myelocytic leukemia and taking tacrolimus was referred to the ophthalmology clinic with visual disturbance. Her visual acuity (VA) was 0.4 in the right eye and 0.5 in the left eye. Multiple cotton wool spots and retinal hemorrhages were found in both eyes on fundus examination. Multiple capillary non-perfusions were seen on fluorescein angiography (FA). Tacrolimus-related TA-TMA retinopathy was suspected. Tacrolimus was discontinued and plasmapheresis was performed. After 3 months, neovascular glaucoma developed and her VA became “counting fingers” at 20 cm in both eyes. (Case 2) A 20-year-old man with a history of PBSCT due to acute lymphocytic leukemia and taking tacrolimus was referred to our clinic because of decreased VA in both eyes. His VA was 0.05 in the right eye and 0.025 in the left eye. Fundus and FA findings were the same as in Case 1, and the patient was suspected to have tacrolimus-related TA-TMA retinopathy. Tacrolimus was discontinued and plasmapheresis was performed. His VA was 0.2 in the right eye and 0.4 in the left eye at 1 month after treatment. Conclusions: It is necessary to consider TA-TMA retinopathy in leukemia patients taking calcineurin inhibitors, such as tacrolimus, who have decreased VA. Early diagnosis and treatment are important. J Korean Ophthalmol Soc 2021;62(10):1428-1434
한국여성에서 조직 미네랄 농도에 따른 생리전증후군의 임상증상
조현희 ( Hyun Hee Cho ),정인철 ( In Chul Jung ),정재은 ( Jae En Jung ),최세경 ( Sae Kyung Choi ),김수연 ( Su Yeun Kim ),김미란 ( Mee Ran Kim ),임용택 ( Yong Taek Lim ),김은중 ( En Jung Kim ),김진홍 ( Jin Hong Kim ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.1
목적: 생리전증후군이란, 황체 후반기에 특정한 정신적, 육체적 증상이 주기적으로 나타나는 질환을 말하며, 발생율은 80%에 이르나 원인은 명확하게 밝혀져 있지 않다. 프로게스테론과 에스트로겐이 체내 미네랄의 균형에 영향을 주기 때문에 생리전증후군 환자들에서 나타나는 프로게스테론의 감소와 에스트로겐이 우세 현상은 조직 내 미네랄의 균형에 이상을 초래할 수 있으며, 이로 인해 생리전증후군의 여러 특이 증상이 유발될 가능성이 있다. 이에 저자는 환자의 조직 미네랄 검사를 통해, 생리전증후군이 있는 환자에서 미네랄 수치와 증상과의 연관성을 알아보고자 본 연구를 시도하였다. 방법: 생리전증후군에 대한 모발검사 연구 지원자는 공고를 통해 모집된 여성을 대상으로 MMDQ 설문지를 작성하도록 하여 총점 10점 이상인 여성 120명으로 대상으로 하였다. 모발을 이용한 조직미네랄 검사는 최근 3주간 염색이나 파마를 하지 않고 3시간 이내에 세정이나 모발관련 제품을 사용하지 않은 상태에서 시행되었으며, 미국 TEI에 분석을 의뢰하였다. 통계분석은 SPSS (Ver. 14.0)를 사용하였다. 결과: 조직 내 마그네슘 농도가 정상인 군의 MMDQ 총점은 비정상인 군보다 유의하게 높았으며 (22.5±17.8 vs. 13.9±11.1), 나트륨 농도가 정상인군의 행동장애 점수는 비정상군보다 유의하게 낮게 나타났다 (2.2±1.7 vs. 3.4±2.2). 또한 구리 농도가 정상인군의 MMDQ 총점은 비정상인 군보다 유의하게 낮았다 (15.7±11.9 vs. 24.9±16.9). 고찰: 조직 내 마그네슘과 구리의 농도에 따라 MMDQ 총점에서 차이를 보였으며, 조직 내 나트륨 농도는 행동장애 점수에 영향을 주는 것으로 나타났다. 그러나 이러한 미네랄 불균형이 생리전증후군의 증상을 악화시키는 원인으로 작용하는지에 대해서는 좀 더 자세한 연구가 필요할 것으로 사료된다. Objective: Premenstrual syndrome (PMS) is a disease with specific psychologic and physical symptoms on luteal phase. Its incidence is variable in 20~80%, but its cause is not definitely proved. Because progesterone and estrogen affect the balance of the body mineral, the alteration of progestorone and estrogen in the patients with PMS may effect the imbalance of tissue mineral, that can induce the specific symptoms of PMS. This study examines the relationship between symptoms of PMS and mineral count by tissue mineral test. Methods: Women who volunteered for the tissue mineral test completed MMDQ questionnaire and checked blood test for Ca, Mg, Na, K, Cu, Zn. The tissue mineral test used the hair not treated within 3 weeks and not washed within 3 hours. The hair was send to TEI for the analysis. We used SPSS (14.0) for statistical analysis. Results: The MMDQ score of the normal Mg group is significantly higher than the high Mg group (22.5±17.8 vs. 13.9±11.1), and the behavioral disorder score of the normal Na group is significantly lower than the low Na group (2.2±1.7 vs. 3.4±2.2). The MMDQ score of the normal Cu group is significantly lower than abnormal group (15.7±11.9 vs. 24.9±16.9). Conclusions: Total score of MMDQ showed difference according to magnesium and copper concentrations in tissue, and scores of behavioral disorder was affected by sodium concentration of tissue. Additional study about cause and effect relationship is required.
김수연,정동선 서울여자대학교 자연과학연구소 2013 자연과학연구논문집 Vol.25 No.-
The mixed fruit and vegetable juices with 15% isomaltooligosaccharide and 0.2% sodium chloride were fermented using co-cultures of Leuconostoc mesenteroides, Lactococcus lactis, and Lactobacillus cellobiosus isolated from Dongchimi. The fermented juices were sterilized by either thermal treatment or ultrafiltration right after centrifugation, and then measured general characteristics such as pH, acidity, vitamin C, free sugar, organic acids contents, and color change during storage at 5°C or 25°C for 8weeks. There was no significant changes in pH, titratable acidity, free sugars and organic acids, but showed an abrupt decrease in vitamin C of the fermented fruit and vegetable juices after thermal treatment or ultrafiltration during storage for 8 weeks at 5°C or 25°C. However, malic acid, glucose and fructose contents were dramatically decreased and acetic acid content was significantly increase during storage at 25°C in untreated fermented juices. Ultrafiltration of the fermented fruit and vegetable juices showed higher lightness and decreased redness and yellowness. In conclusion, it is possible that thermal treatment or ultrafiltration could be proper storage methods for retaining physicochemical qualities of the fermented fruit and vegetable juices.
압축공기내 과습기(壓縮空氣內 過濕氣)로 인한 인공호흡기(人工呼吸器)호기(呼氣)밸브 폐쇄 경험(閉鎖 經驗)
김종래,김진수,김명희,이영석,김수연 대한마취과학회 1990 Korean Journal of Anesthesiology Vol.23 No.1
An air-compressor system takes atmospheric air, and filters, pressurises and dries it, before delivering it to the pipeline as a medical air. Because the air supplied by the air compressor may be used to wentilate patients or to drive surgical tools, its quality and purity must be carefully controlled. Atmospheric air contains a variable amount of water vapour but always more than is specified for medical air. Water vapour must be removed from medical air since it can damage surgical tools and some ventilators and can condense in low-lying parts of the pipeline system. Reeently we have had experience of pneumothorax by pulmonary barotrauma associated with obstruction of the ventilator exhalational valve. As a result of investigating the possible causes, we concluded the cause as high moisture content in the compressed air due to the malfunctioning air drier and filters. Therefore we submit this case report along with discussion and literature reviews.