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금은화의 type I interferon 억제효과 및 기전에 관한 연구
강용구,유익한,김송백,최창민,서윤정,조한백,Kang, Yong-Goo,Ryu, Ik-Han,Kim, Song-Baek,Choi, Chang-Min,Seo, Yun-Jung,Cho, Han-Baek 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.2
Objectives: The purpose of this study was to investigate whether Lonicera japonica(LJ) could inhibit LPS-induced type I IFN production. Methods: To evaluate inhibitory effect of LJ on type I IFN, we examined type I IFN, IRF-1, 7 and IL-10 production on LPS-induced macrophages using real time RT-PCR. Next, we observed the interaction of type I IFN, IRF-1, 7 and IL-10 using IL-10 neutralizing antibody. Finally we examined the activation of STAT-1, 3 using western blot. Results: LJ inhibited Type I IFN expression of mRNA and increased IL-10 expression of mRNA. Also LJ inhibited the level of IRF-1, 7 mRNA and the nuclear translocation of IRF-3. Further more, LJ reduced the activation of STAT-1, 3 which are involved in continuous secretion of immune cytokines. Blockade of IL-10 action caused a significant reduction of type I IFN and IRF-1, 7 than LPS-induced LJ pretreatment. Conclusions: LJ inhibits LPS-induced production of type I IFN by IL-10. This study may provide a clinical basis for anti-inflammatory properties of LJ.
장윤정 ( Yoon Jeong Jang ),김송백 ( Song Baek Kim ),최창민 ( Chang Min Choi ),서윤정 ( Yun Jung Seo ),조한백 ( Han Baek Ch ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.4
Samul-tang and Rhizome of Cyperus rotundus L. have been frequently used in gynecologic disease. The purpose of the present study is to explore the behavioral and neurobiological effects of Samul-tanggahyangbuja (SGH) on ovariectomized rats and to form a basis for clinical treatment. Methods: Ovariectomized rats were repeatedly stressed for over 2 weeks. After orally medicated with SGH (200 or 400 mg/kg/day), the anxiety response was tested using the Elevated Plus Maze (EPM) in rats. The serum levels of estradiol and IL-4, and immunohistochemical changes of IL-4 in the Locus coeruleus (LC) and Paraventricular Nucleus (PVN) were measured. Results:1. In the EPM, SGH 400 mg significantly increased time spent on the open arms and decreased time spent on the closed arms, compared with the control group (p<0.05). 2. SGH tended to increase numbers of crossings in the open and closed arms in the EPM. However, it did not reach statistical significance. 3. SGH significantly increased the serum levels of estradiol compared with the control group (p<0.05). 4. SGH 400 mg significantly increased the serum levels of IL-4 compared with the control group (p<0.05). 5. IL-4 immunoreactivity was reduced in the control group compared with the normal group (p<0.05). However, SGH groups (200 and 400 mg) did not produce any significant effects on levels of IL-4 in the LC and PVN. Conclusions: These results suggest that SGH possesses the anti-depressant and immuno-modulatory effects on ovariectomized rats.
오미백출산이 분만 후 산모의 부종에 미치는 영향 -생화탕과 비교하여-
김건희 ( Gun Hee Kim ),이지현 ( Ji Hyun Lee ),조한백 ( Han Baek Cho ),최창민 ( Chang Min Choi ),김송백 ( Song Baek Kim ) 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.2
Objectives: The aim of this study was to investigate the effect of Omibaekchul-san on postpartum edema in women hospitalized at korean medical postpartum care center in comparison with Saenghwa-tang. Methods: The body composition data was collected from 102 women, who took postpartum care in postpartum care center attached to Won-kwang University Jeonju Korean Medical Hospital, from March 2012 to July 2013. The data was analyzed by Body Composition Analyzer (Inbody 720). Specifically the data was composed of the Extra Cellular Fluid/Total Body Fluid (ECF/TBF), Total Body Water (TBW), Intra Cellular Water (ICW), Extra Cellular Water (ECW), Body Weight, Body Mass Index (BMI), Waist Hip Ratio (WHR), and the ECF/TBF of each body parts such as the upperlimb, lowerlimb and trunk. The body composition was measured twice during 2~8.5 days from childbirth and once again after 7~13.5 days from childbirth by Body Composition Analyzer. Results: The Omibaekchul-san-treated group showed a significant decrease of ECF/TBF, ECW, TBF, Body weight, BMI, ECF/TBF of each body parts and increase of WHR in comparison with the data of the Saenghwa-tang-treated group. In two groups, only the change of ICW was unsignificant. Conclusions: Statistically this study suggests that the Omibaekchul-san will help the quality of life of women who are in postpartum edema.
Ramsay Hunt Syndrome 환자를 대황치자황백병(大黃梔子黃栢餠)과 용담사간탕가미(龍膽瀉肝湯加味)로 치료한 치험1례
임은경,이윤재,황상일,백동기,홍석훈,김송백,윤종민,양경석,최덕화,신선호,Rhim Eun-Kyung,Lee Yun-Jae,Hwang Sang-Il,Baek Dong-Gi,Hong Seok-Hoon,Kim Song-Baeg,Yun Jong-Min,Yang Kyung-Suk,Choi Deok-Hwa,Shin Sun-Ho 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.4
Ramsay Hunt Syndrome is caused by infection of herpes zoster and associated with otalgia, herpetic eruptions, facial palsy, trigerminal pain and cochleovestibular dysfunction such as deafness, tinnitus, vertigo and so on. A 60-year old female, who has tinnitus, peripheral facial palsy, deafness, vertigo, postauricular pain and herpetic eschar, had been admitted to Wonkwang University Oriental Jeonju Medicine Hospital. We treated this patient with Daehwangchijahwangbaeg-byung and Yongdamsagantang-gami, and the patients showed improvement in the symptoms. So we describe the process and contents about the way the patient was cured.
여성 성기능장애의 보완대체의학적 치료에 관한 논문 연구
정영민 ( Young Min Jeong ),김송백 ( Song Baek Kim ),최창민 ( Chang Min Choi ),서윤정 ( Yun Jung Seo ),조한백 ( Han Baek Cho ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.2
Objectives: The aim of this study was to review systemically clinical trials on the trends of studies for Complementary and Alternative Medicine in the treatment of female sexual dysfunction and provide basic resource for future treatment and suggestions for improving research methods. Methods: Through medical website ``Pubmed``, foreign clinical literatures about female sexual dysfunction were searched and domestic clinical literatures about female sexual dysfunction were searched using internet websites ``National assembly library``, ``KISS``, ``RISS``, ``Korean traditional knowledge portal``. Results: Total 19 literatures were selected from January 2000 to June 2012. 15 foreign literatures were selected through medical website and 4 domestic literatures were chosen using internet websites or hand-searching. 5 literatures were published in 2008 and 13 literatures mentioned about age group of patients. FSFI is most common tool for female sexual dysfunction. 9 of 19 literatures were using Herbal medicine for treatment. 5 literatures were about CBT, 6 literatures were about Biofeedback and other one literatures are about Perineal massage. There were 14 Randomized controlled trials and 5 Non-randomized controlled trials. And randomized controlled trials were relatively low in risk of bias than non-randomized controlled trials. Conclusions: Upon these results, in similar future more clinical trials should be done and accumulate Evidence-based literatures.
정현철 ( Hyun Cheol Cheong ),김송백 ( Song Baek Kim ),서윤정 ( Yun Jung Seo ),조한백 ( Han Baek Cho ),최창민 ( Chang Min Choi ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.3
목적: 본 연구에서는 부인과의 흔한 질환인 갱년기 우울증의 모델로 반복적인 스트레스를 가한 난소적출 흰쥐를 설정하고 교감단이 쥐의 항우울 행동과 면역기능에 미치는 영향을 살표보고자 하였다. 방법: 난소적출 흰쥐에 2주간 반복적인 스트레스를 주고, 교감단(100 mg/kg, 400 mg/kg)을 경구 투여한 후 행동검사로 Elevated plus maze, Forced swimming test를 실시하였고, 혈액검사로 혈청 corticosterone, IL-1β와 IL-4의 변화를 측정 하였으며, 뇌내의 IL-1β와 IL-4의 변화를 측정하였다. 결과: 1. Elevated plus maze에서 교감단 100 mg/kg 투여군은 open arms에서의 보낸 시간이 대조군에 비해서 차이가 없었으며, 교감단 400 mg/kg 투여군은 open arms에서 보낸 시간이 대조군에 비하여 증가되었으나 유의성은 없었다. 2. Elevated plus maze에서 교감단 100 mg/kg 투여군은 crossing 횟수가 대조군에 비하여 차이가 없었으며, 교감단 400 mg/kg 투여군은 crossing 횟수가 대조군에 비하여 늘어났으나 유의성은 없었다. 3. Forced swimming test에서 교감단 100 mg/kg, 400 mg/kg 투여군은 각각 대조군에 비해서 immobility 시간이 유의성 있게 감소하였다(p<0.01). 4. Corticosterone 측정에서 교감단 400 mg/kg을 투여한 후 Corticosterone 수준이 유의하게 감소하였다(p<0.05). 5. 혈청내 IL-1β와 IL-4 측정에서 교감단 투여군은 대조군에 비해 유의성 있는 감소나 증가가 관찰되지 않았다. 6. 뇌내 IL-1β와 IL-4 측정에서 교감단 투여군은 대조군에 비해 유의성 있는 감소나 증가가 관찰되지 않았다. 결론: 이상의 결과를 보면 교감단은 난소적출 흰쥐의 우울행동의 완화에 유의성있는 결과를 나타내었으며, 불안 행동검사에서는 유효한 효과가 없었다. 혈청 corticosterone 측정에서 유의성 있는 감소를 나타내어 항우울효과를 나타내었으나, 면역기능에 작용하는 유의성 있는 결과는 관찰되지 않았다. Objectives: In this research, the effect of Gyogam-dan (GGD) on depression and immunity were assessed in ovariectomized rats subjected to repetitive stress. GGD is the prescription consisting of Poria cocos and Cyperi Rhizoma. Methods: Ovariectomized rats were repeatedly stressed over a 2-week period. After GGD (100 or 400 mg/kg) were orally administered, Elevated Plus Maze (EPM) and forced swimming test (FST) were performed to evaluate depressive and anxiety response. As well, the change of corticosterone (CORT) and the change of interleukin-1β (IL-1β) and interleukin-4 (IL-4) in blood serum and in brain were mesured. Results: 1. In the EPM, there were no statistically significant differences among the groups. 2. In the FST, immobility time significantly decreased in rats of each experiment group compared with the control group (p<0.01). 3. Serum CORT level were decreased in 400 mg GGD group (p<0.05). 4. On IL-1β and IL-4 measurement in the serum and brain, there were not significant increase or decrease compared with the control group. Conclusions: These results suggest that GGD is effective to reduce depressionbehavior in ovariectomized rats. However, GGD do not has significant efficacy to reduce anxiety-behavior in EPM test. Measurement of serum CORT level reveals significant decrease and it shows anti-depressant like effect. Results on immunity are not significant.
한방병원 부속 산후조리원을 이용한 산모의 산후 오로 기간과 특징에 관한 고찰
조승희 ( Seung Hee Cho ),김송백 ( Song Baek Kim ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.3
Objectives: The aim of this study was to assess the duration of lochia in women hospitalized at Korean medical postpartum care center and to identify factors that influence duration of lochia. Methods: On the obstetric variables of 315 cases, the duration of lochia was analyzed. In the postpartum care center, the obstetric variables were asked of 315 cases of women, and who examined a body composition. After discharge, women were surveyed for the duration of lochia by telephone. Results: The median duration of lochia was 30 days and the range was 18~53 days. Maternal age, parity and mode of delivery were associated with its duration. So, its duration was longer on women over the age of 35, multipara and women had a Cesarean section. Its duration was correlated with gestational age and BMI before pregnancy, but not neonatal gender, birth weight, maternal BMI change during pregnancy, maternal body weight gain, BMI before delivery. Conclusions: It was 30 days that the median duration of lochia of women who had been got Korean medical postpartum care management, and which was slightly different from previous studies. And it was influenced by maternal age, parity, mood of delivery, gestational age and BMI before pregnancy. In future more studies or surveys for the duration of lochia of women with no treatment, lochial pattern and so on should be done.