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기관지천식 환자의 기관지분비물내 총 IgE 항체치 연구에서 유도객담검사의 유용성
김상돈,서창희,김희연,남동호,박해심 (Sang Don Kim,Chang Hee Suh,Hee Yeon Kim,Dong Ho Nahm,Hae Sim Park) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.2
Background: IgE antibodies have been considered to play an important role in the pathogenesis of atapic asthma. However, there have been only few studies on the role of IgE in airway secretion in the pathogenesis of bronchial asthma. This might be partly due to difficulty in sampling of airway seceretion from asthmatic patients. Recently, sputum induction method by inhalation of nebulized hypertonic saline was developed, and proved to be valid and useful method for obtaining airway secretion from asthmatic patients for studying air- way inflammation. %jective and method: To evaluate the usefulness of sputum induction method for studying IgE antibodies in airway secretion from atopic asthmatic patients, total IgE levels in induced sputum from 54 atopic asthmatics were measured by enzyme-linked immunosorbent assay(ELISA) and tried to find an association with sputum eosinophilia. Result: Total IgE levels in induced sputum were significantly higher in atopic asthmatic patients(1.27+82.066 IU/ml) than in controls(0.203+0.291 IUgmP)(p<0.05). In atopic asthmatic patients, total IgE levels in induced sputum were not significantly different between patients with and without sputum eosinophilia(>5% of 200 counted leukocytes). There was a significant correlation of total IgE levels between induced sputum and serum in atopic asthmatic patients(r=0.60, p<0.05). Total IgE levels in induced sputum(1.278+ 2.066) were significantly higher than saliva sample(0.504 + 1.111 IU/ml) from atopic asthmatic patients(p<0.05). Conclusion '. These results suggest that total IgE levels are increased in the induced sputum of atopic asthmat,ic patients and sputum induction method is a useful tool for study- ing IgE antibodies in airway secretion from asthmatic patients.
Pyrolytic characteristics of Jatropha seedshell cake in thermobalance and fluidized bed reactors
김상돈,Sung Won Kim,Dong Kyoo Park 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.5
Pyrolytic kinetic parameters of Jatropha seedshell cake (JSC) were determined based on reaction mechanism approach under isothermal condition in a thermobalance reactor. Avrami-Erofeev reaction model represents the pyrolysis conversion of JSC waste well with activation energy of 36.4 kJ mol−1 and frequency factor of 9.18 s−1. The effects of reaction temperature, gas flow rate and feedstock particle size on the products distribution have been determined in a bubbling fluidized bed reactor. Pyrolytic bio-oil yield increases up to 42 wt% at 500 oC with the mean particle size of 1.7 mm and gas flow rate higher than 3Umf, where the maximum heating value of bio-oil was obtained. The pyrolytic bio-oil is characterized by more oxygen, lower HHVs, less sulfur and more nitrogen than petroleum fuel oils. The pyrolytic oil showed plateaus around 360 oC in distribution of components’ boiling point due to high yields of fatty acid and glycerides.
파종성 악성 핍지신경교종 환자에서 시행한 뇌실내 Methotrexate의 효과 - 증례보고 -
김상돈,정용구,김세훈,임동준,조태형,이훈갑,서중근,이기찬,Kim, Sang-Don,Chung, Yong-Gu,Kim, Se-Hoon,Lim, Dong-Jun,Cho, Tae-Hyung,Lee, Hoon-Gap,Suh, Jung-Keun,Lee, Ki-Chan 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.7
Oligodendrogiomas account for about 4 per cent of intracranial gliomas and surgery is known to be an essential first step to establish an accurate diagnosis and when oligodendrogliomas recur with or without anaplastic features after initial resection, radiation and chemotherapy consisting of the administration of procarbazine, lomustine, and vincristine are usually indicated. We report our experience of an excellent result with intraventricular methotrexate chemotherapy for a patient with disseminated anaplastic oligodendroglioma. A 29-year-old male patient presented with diplopia and headache for two months. MRI showed a irregular, faintly enhanced mass in the posterior fossa. The hisotological diagnosis was an anaplaplastic oligodendroglioma and he was treated with chemotherapy of PCV regimen and radiotherapy followed by surgery. CSF dissemination was revealed by a follow-up MRI during the period. Intraventricular methotrexate(0.175mg/kg) was given twice a week for 4 weeks through ommaya reservoir and the size of the multiple tumors was decreased significantly on follow-up MRI. This case report suggests that an aggressive treatment involving intravent-ricular chemotherapy may be helpful even when anaplastic oligodendrogliomas disseminates to leptomeninges.
보문 : XAD 및 FT-IR을 이용한 영산강수계 광주시 유역 자연유기물질의 분포특성 연구
이동진 ( Dong Jin Lee ),전강민 ( Kang Min Chon ),김상돈 ( Sang Don Kim ),정수정 ( Soo Jung Jung ),이경희 ( Kyung Hee Lee ),황태희 ( Tae Hee Hwang ),임병진 ( Byung Jin Lim ),조재원 ( Jae Weon Cho ) 한국하천호수학회(구 한국육수학회) 2011 생태와 환경 Vol.44 No.4
This study investigated the characteristics of natural organic matter (NOM) with tXAD resin and FT-IR in the Yeongsan river system of Gwangju region. NOM fractionation by XAD 8/4 resins was used to classify hydrophobic and hydrophilic substances. FTIR was applied to classify functional groups in the structure of NOM. In the XAD investigation, most of the four site-samples were mainly hydrophilic substances. In March, hydrophilic substances were dominant in the Gwangju 1 site (GJ-1), while hydrophilic substances were dominant for the other sites. In May, samples of all four sites were hydrophilic with a vigorous activity of microorganism due to increasing temperatures. The October results were very similar with those from March. In the FT-IR investigation, most of the broad and large peaks were assigned to the aliphatic group, particularly the OH group, C-H, C-H2, C-H3, and C-O alcohol group. All were related to hydrophilic substances. Other peaks showed the aromatic group, particularly the C=O (Ketone) Group. As a result, there is an identification of NOM in the Yeongsan river system composing mainly of hydrophilic substances and functional groups (OH, C-H etc.) of the aliphatic compound.
한국 폐경 여성에서 호르몬 대체요법시 치료 제제에 따른 유방 치밀도의 변화
이동윤 ( Dong Yun Lee ),김상돈 ( Sang Don Kim ),최영식 ( Young Sik Choi ),지병철 ( Byung Chul Jee ),구승엽 ( Seung Yup Ku ),서창석 ( Chang Suk Suh ),최영민 ( Young Min Choi ),김정구 ( Jung Gu Kim ),문신용 ( Shin Yong Moon ),김석현 대한폐경학회 2003 대한폐경학회지 Vol.9 No.3
목적 : 본 연구는 한국 폐경 여성에서 호르몬 대체요법과 연관된 유방 치밀도의 변화를 평가하기 위하여 시행되었다. 연구 대상 및 방법 : 본 연구에서는 호르몬 대체요법을 시행 받은 폐경 여성 294명을 대상으로 치료 제제에 따라 매일 tibolone 2.5 mg을 투여 받은 군(n=119), conjugated equine estrogen(CEE) 0.625 mg/medroxyprogesterone(MPA) 2.5 mg으로 지속적 병합요법을 시행 받은 군(n=93), CEE 0.625 mg으로 단독요법을 시행 받은 군(n=40) 및 raloxifene 30 mg을 투여 받은 군(n=42)으로 대변하였으며, 호르몬 대체요법을 시행 받지 않은 폐경 여성 36명을 대조군으로 설정하였다. 대상 여성에서 유방촬영술(mammography)을 호르몬 치료 시작 전과 치료 1년 후에 각각 시행한 후 유방 치밀도(breast density)의 변화를 후향적으로 각 군에서 비교 관찰하였다. 결과 : 대상 여성의 연령, 분만력, 폐경 연령, 폐경 후 기간, 체중, 신장 및 체질량지수(BMI)는 각 군간에 통계학적으로 유의한 차이가 없었다. 호르몬 대체요법 1년 후 유방촬영술에서 관찰된 유방 치밀도의 증가는 지속적 병합요법군에서 25.8%(24/93)로서 tibolonerns의 11.8%(14/119), raloxifene군의 2.4%(1/42)에 비하여 각각 유의하게 높았다(p<0.05). 결론 : 본 연구 결과 호르몬 대체요법을 시행 받은 폐경 여성에서 관찰된 유방 치밀도의 변화는 치료 제제에 따라 상이하다는 것을 확인하였으며, 특히 progestogen을 이용한 지속적 병합요법이 유방 치밀도 변화에 중요한 영향을 미치는 것으로 사료된다. Objective : This study was performed to evaluate the mammographic changes in breast density that were associated with hormone replacement therapy(HRT) in Korean postmenopausal women. Materials and Methods : In this retrospective study, 294 postmenopausal women were classified as the four groups according to the regimen of HRT; a daily treatment of tibolone 2.5 mg(n=119), conjugated equine estrogen(CEE) 0.625 mg/medroxyprogeserone(MPA) 2.5 mg(n=93), CEE 0.625 mg only(n=40) or raloxifene 60 mg(n=42), and they were compared with the control group of postmenopausal non-HRT users(n=36). Mammography was performed at baseline and after 1 year of treatment, and the incidence of changes in mammographic density was evaluated and compared among the groups. Results: There were no significant differences in age, parity, age at menopause, years after menopause, weight, height, and body mass index(BMI) among the groups. The risk of an increase in mammographic density after 1 year of treatment was significantly higher in CEE/MPA group(24/93, 25.8%), compared with tibolone(14/119, 11.8%) and raloxifene(1/42, 2.4%) group(p<0.05). Conclusion : This study showed that the changes in mammographic breast density related to postmenopausal HRT were dependent on the regimen of HRT. The continuous administration of progestogen as a component of the combined HRT seems to affect the breast density significantly.
최동호 ( Dong Ho Choi ),정재운 ( Jae Woon Jung ),윤광식 ( Kwang Sik Yoon ),진소현 ( So Hyun Jin ),최우영 ( Woo Young Choi ),최우정 ( Woo Jung Choi ),김상돈 ( Sang Don Kim ),임병진 ( Byung Jin Yim ),최유진 ( Yu Jin Choi ) 한국물환경학회 2010 한국물환경학회지 Vol.26 No.6
Runoff ratio of paddy fields for the application of Event Mean Concentration (EMC) method was studied. To measure actual runoff ratio of paddy fields, a field monitoring was conducted for 2008 ~ 2009 period. Long-term rainfall data of four cities in major river basins were analyzed and weighting factors were developed to consider temporal and spatial variation of rainfall distribution of Korean peninsula. The observed runoff ratio ranged 0.00 ~ 1.20 and arithmetic mean were 0.25, respectively. However, the representative runoff ratio for paddy fields was determined as 0.41 according to the method suggested by National Institute of Environmental Research (NI ER).
비점오염물질 저감을 위한 주암호 생태습지의 수생태학적 효율 평가
이상규(Sang-Gyu Lee),서동철(Dong-Cheol Seo),최익원(Ik-Won Choi),강세원(Se-Won Kang),서영진(Young-Jin Seo),임병진(Byung-Jin Lim),이준배(Jun-Bae Lee),김상돈(Sang-Don, Kim),허종수(Jong-Soo Heo),조주식(Ju-Sik Cho) 한국토양비료학회 2012 한국토양비료학회지 Vol.45 No.2
비점오염원 저감을 위해 설치된 주암호 생태습지의 수질 정화효율을 평가하기 위하여 시스템별 및 시기별 오염물질의 함량과 처리효율을 조사하였다. 유입원수의 BOD, COD, SS, T-N 및 T-P의 함량은 각각 0.20∼0.91, 1.24∼8.00, 0.6∼8.6, 0.04∼2.50 및 0.001∼0.685 mg L<SUP>-1</SUP> 범위로 나타났다. 주암호 생태습지 유입수의 대부분이 현행 오염물질 수질 기준을 초과하지 않은 상태로 유입되었지만 비점오염원이 많이 유입되는 특정 시기 (장마철)에는 높은 오염물질 함량을 나타내었다. 시기별로는 전반적으로 여름철에 유입원수의 영양염류의 유입이 다른 시기에 비해 높은 경향이었다. 전반적으로 C 시스템이 오염물질의 처리효율이 가장 높은 경향이었다. A 시스템의 습지들은 대부분 겨풀이 우점하고 있었으며 B 시스템의 습지들은 겨풀과 연꽃이 우점하고 있었다. C 시스템의 습지들은 겨풀, 수련 및 부들이 우점하고 있었다. 주암호 생태습지는 오염물질의 처리능이 전반적으로 안정화 상태에 도달하지 못한 것으로 판단되며, 특히 겨풀 및 물 참새피 등 식물교란종의 습지 내 침투로 인하여 습지의 수질정화효율이 전반적으로 낮았다. 따라서 본 연구결과로부터 조성초기 인공습지는 식생의 발달 여부가 수질의 안정화와 습지의 수생태학적 역할을 증대시키는데 중요한 역할을 하는 것으로 판단된다. To reduce non-point source pollutants in Juam Lake eco-wetlands, purification efficiencies of pollutants were investigated at three different systems. The constructed wetlands (CWs) consisted of A system, B system and C system. A system consisted of <SUP>1st</SUP> free water surface (FWS) CW, <SUP>2nd</SUP> FWS CW, <SUP>3rd</SUP> FWS CW, <SUP>4th</SUP> subsurface flow (SSF) CW and <SUP>5th</SUP> SSF CW. B system consisted of <SUP>1st</SUP> FWS CW, <SUP>2nd</SUP> FWS CW, <SUP>3rd</SUP> FWS CW, <SUP>4th</SUP> FWS CW and <SUP>5th</SUP> SSF CW. C system consisted of <SUP>1st</SUP> FWS CW, <SUP>2nd</SUP> FWS CW, <SUP>3rd</SUP> FWS CW, <SUP>4th</SUP> FWS CW and <SUP>5th</SUP> SSF CW. The concentrations of BOD, COD, SS, T-N and T-P in inflow ranged 0.20 ~ 0.91, 1.24 ~ 8.00, 0.60 ~ 8.60, 0.04 ~ 2.50 and 0.001 ~ 0.685 mg L<SUP>-1</SUP> from March to October in 2011, respectively. Removal rates of BOD, SS, T-N and T-P were high in Autumn, Spring, Spring and Summer, respectively. In A system, <SUP>1st</SUP> FWS CW, <SUP>2nd</SUP> FWS CW and <SUP>3rd</SUP> FWS CW were dominated by Leersia oryzoides. In B system, <SUP>1st</SUP> FWS CW, <SUP>3rd</SUP> FWS CW and <SUP>4th</SUP> FWS CW were dominated by Leersia oryzoides. In C system, <SUP>2nd</SUP> FWS CW and <SUP>3rd</SUP> FWS CW were dominated by Nymphaea teragona.