벼 유전자 64,896종 DNA칩에 심었다

김민균,남백희,Kim, Min-Gyun,Nam, Baek-Hui 한국과학기술단체총연합회 2003 과학과 기술 Vol.36 No.10

추나(推拿) 관련 논문에 대한 연구

김민균,허동석,오민석,윤일지,Kim, Min-Kyun,Heo, Dong-Seok,Oh, Min-Seok,Yoon, Il-Ji 척추신경추나의학회 2007 척추신경추나의학회지 Vol.2 No.1

Objectives : To research the trend of the study related to Chuna(推拿) and to establish the direction of further studies into the Chuna(推拿). Methods : We reviewed and analyzed all theses published by Korean research institution. And these theses were classified by research institutions, published year, field of study, subject, research methods, thesis types, illness and symptoms. Results : The following results were obtained in this study. 1. Classified by the major field of study, oriental medicine accounted for 59 papers, followed by 18 in physical education and 2 in the science of nursing and medicine. 2. Upon classifying theses according to research method and thesis types, research related to clinical trial accounted for nearly half of all theses. It was followed by consideration of documents. 3. After 1998 deals with the effects of the Chuna on variable illnesses such as: ossified posterior longitudinal ligament, chronic coccyalgia, entrapment neuropathy, low birth weight infant, Bell's palsy, stress incontinence, paramenia, Parkinson disease, Bertolloti syndrom, TMJ (because of scoliosis) etc. 4. Two most widely cured illnesses using the Chuna therapy are scoliosis and HNP of L-spine. However, when considering the fact that several clinical tests and casuistics did not include research into Lumbago (including HNP of L-spine), it can be concluded that most of the Chuna therapies have been concentrated on Lumbago. Conclusion : As it can be seen in the above results, the possibility of curing illness through Chuna and the usefulness of Chuna have been shown factually and clinically through various consideration of documents, clinical trial & casuistics. Based upon such facts, it is regarded that further scientific research along with additional clinical approaches involving the Chuna should be performed.

주거관련 협동조합의 창업유형화 및 조성방안

김민균,오동훈,Kim, Min-Kyun,Oh, Dong-Hoon 한국벤처창업학회 2014 벤처창업연구 Vol.9 No.6

본 연구의 목적은 해외 사례 및 국내 유사 분야의 협동조합을 대상으로 활동현황을 파악하고, 국내에서 어떠한 형태의 주거와 관련되는 협동조합들을 창업할 수 있는지 이를 유형화하며, 이들을 성공적으로 조성하기 위한 필요한 요소들을 찾아 국내 주거관련 협동조합의 조성에 적합한 시사점을 도출하는 것이다. 주거관련 협동조합의 유형을 수행활동을 기준으로 주택신규공급 및 운영형, 기존주택유지관리 및 개선형, 주택설계 및 성능향상형의 세 가지로 구분하였다. 주택협동조합은 국가주택정책의 차원에서 간접적으로 접근할 수 있도록 해야 한다. 즉, 주택협동조합을 직접 조종하여 주택을 공급해야 한다는 차원보다는 자발적으로 일어나는 주택협동조합을 지원하고 간접적으로 방향을 유도하는 형태의 조치가 필요하다. 협동조합의 조직 형태가 절대적인 善이라고 할 수는 없다. 협동조합에 대한 지나친 보호나 지원정책은 오히려 민간시장영역에서 활동하는 기업체들에게 역차별이 될 수 있으며, 협동조합의 차원에서는 이러한 보호를 남용할 수도 있다. 협동조합이 기존의 경제체제를 완전히 대체할 수는 없겠지만, 보완적인 차원에서 자발적으로 노력하는 협동조합 자체의 움직임이 지역경제의 역동성을 촉진할 수 있다는 가능성에 주목할 필요가 있다. The purpose of this study is to draw the implication for building domestic housing-related co-operatives by understanding activities of housing-related co-operatives from case study and by suggesting the start-up typology for possible domestic housing-related co-operatives and requisites for building them. According to their activities housing-related co-operatives are categorized into three types which are housing supply and operation type, maintain and improve the existing housing type, and design and performance improvement type. National housing policy should be connected to housing co-operatives indirectly. That is, the policy direction ought to be not toward controlling housing co-operatives, letting them supply more houses directly, but toward supporting voluntary co-operatives, showing them the overall housing policy blueprint. Co-operatives cannot be a panacea. Too much protection or support for co-operatives could lead to a reverse discrimination against private companies, and the co-operatives might overuse this kind of prominent position. We need to focus on the possibility of the role of co-operatives as a facilitator for local economy rather than a perfect substitute for the existing economy system.

장려상-초고층건물

김민균,김소영,Kim, Min-Gyun,Kim, So-Yeong 한국건축구조기술사회 2007 건축구조 Vol.14 No.3

동축노즐 기반 바이오 프린팅을 이용한 자유형상 혈관 체외 모델 제작

김민균(M. G. Kim),강승원(S. W. Kang),이수연(S. Y. Lee),김서연(S. Y. Kim),남상균(S. G. Nam),김선진(S.-J. Kim),이희경(H. G. Yi) Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월

혈관 체외 모사를 위해 다양한 생체제조기술이 개발되어 온 가운데, Gao, et al.은 동축노즐 기반 바이오프린팅을 이용한 자유형상 혈관 제조 기술을 보고하였다. 이 기술은 두 재료를 동시에 압출해 프린팅하여 혈관을 원하고자하는 형태로 제작할 수 있는 특징이 있다. 따라서 본 연구에서는 동축노즐 기반 바이오프린팅을 이용한 자유형상 혈관 제조 기술을 이용하여, U-shape, Circular Shape, Loop Shape 등 다양한 영상을 가진 혈관 바이오프린팅 공정을 수립하고, 추후 조직과 혈관을 연결한 체외 모델 개발에 대한 적용 가능성을 확인하는 과정을 수행하였다. 14/18 G 동축 노즐을 이용해 두 헤드를 연결하였고, Bioink 로는 Shell 부분에 Collagen Based Bioink 를 사용하였다. Collagen은 향후 세포 배양을 위해 선택했으며, 낮은 기계적 특성을 보완하기 위해 Collagen : Alginate (3 : 2) Solution 을 제작하였다. Core 부분에는 Sacrificial Bioink 로 Pluronic F127 과 CaCl₂ 혼합한 CPF-127 을 사용하였으며, Alginate 의 가교 반응이 끝난 뒤 Washing 을 통해 제거했다. 적층으로 혈관의 내피를 프린팅한 후, 말아서 관형을 제작하는 기존의 프린팅 방식과는 달리, 동축 노즐과 Sacrificial Bioink 를 이용하여 관류가 가능한 혈관 구조를 한번에 프린팅이 가능했다. U 형태, Circle, Loop 형태 등 원하고자 하는 모양대로 프린팅이 가능했을 뿐 아니라, 공압에 따라 혈관의 두께 조정도 가능했다. 또한, Collagen Based Bioink 를 사용함으로써 다양한 Cell Culture 가 용이하며 경제적으로도 효율적으로 혈관 체외 모델을 제작할 수 있다. 바이오 프린팅 기술의 장점을 최대한 활용 가능하고 다양한 질병, 조직과 연결하여 복합적인 체외 모델 구현이 가능할 것이다.

월경성 기흉으로 내원한 폐의 자궁내막증

김민균 ( Min Gyun Kim ),김정훈 ( Chung Hoon Kim ),이사라 ( Sa Ra Lee ),주다혜 ( Da Hye Ju ),김성훈 ( Sung Hoon Kim ),채희동 ( Hee Dong Chae ),강병문 ( Byung Moon Kang ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.11

Endometriosis is a relatively common gynecologic disease. However thoracic endometriosis syndrome is exceedingly rare among various types of external endometriosis. We experienced a case of 35-year-old woman who presented with recurrent episodes of spontaneous right-sided pneumothorax that occurred during her menstrual periods. After the localization of the disease site by means of chest radiography and computed tomography of the thorax, a chest tube was inserted after which bullectomy and pleurodesis using doxycycline were performed. A hormonal treatment with gonadotropin-releasing hormone (GnRH) agonist for 12-months was also conducted. However, right-sided pneumothorax recurred two times after these procedures. Subsequently, surgical excision of diaphragmatic lesion along with pleurodesis was underwent. To prevent recurrence, we maintained long-term GnRH agonist administration with add back therapy using low dose estrogen-progesterone. Menstruation stopped, and the chest pain disappeared. During a 19-months follow-up period, pneumothorax did not recur. We report this case with a brief review of the concerned literatures.

재발성 또는 지속성 상피성 난소암에서의 Docetaxel 요법의 효용성 및 독성

주다혜 ( Da Hye Ju ),김용만 ( Yong Man Kim ),김민균 ( Min Gyun Kim ),김유진 ( Eu Gene Kim ),김대연 ( Dae Yeon Kim ),서대식 ( Dae Sik Seo ),김종혁 ( Jong Hyeok Kim ),김영탁 ( Young Tak Kim ),남주현 ( Joo Hyun Nam ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.11

목적: Paclitaxle-platinum 병합요법 치료 후, 재발하거나 반응이 없는 상피성 난소암에서 docetaxel 단독 및 병합 요법의 치료에 대한 효과 및 독성을 알아보고자 하였다. 연구 방법: 1989년 5월부터 2006년 12월까지 서울아산병원에서 재발성 혹은 지속성 상피성 난소암 환자 중 docetaxel 단독 요법 및 다른 항암제와의 병합 요법을 받은 40명의 환자를 대상으로 하였다. Docetaxel 요법은 docetaxel 75 mg/m2 단독 요법이나 docetaxel과 platinum (carboplatin AUC5 또는 cisplatin 75 mg/m2)을 1 일째 투여하는 병합 요법으로 하여 3~4주 간격으로 시행하였다. 치료 효과는 RECIST criteria와 CA-125 response criteria 정의에 따라 평가하였다. 약제 독성은 NCI Common Toxicity Criteria에 따라 평가하였다. 결과: 20명은 RECIST criteria를 기준으로, 20명은 CA-125 response criteria의 정의에 따라 평가하였다. 전체 반응률은 35% (14/40)이었고, 완전 반응은 11명 (27.5%)이었으며, 부분 반응은 3명 (7.5%)이었다. 40명의 재발성 난소암의 환자들의 평균 치료 반응 기간은 11.29개월 (4~20.7개월), 평균 병의 진행 기간은 6.91개월 (1~23개월)이었다. Platinum sensitivity에서 반응군에서는 38.7%, 저항군에서는 22.2%의 반응률을 보여 통계적으로 유의하지 않았으나 (p=0.776) 반응군에서 더 높은 반응률을 보였다. 한편 이전 3회 이상의 치료를 받은 군에서 그렇지 않은 군보다 통계적으로 유의하게 낮은 반응률을 보였다 (p=0.022). 가장 흔한 약제 독성은 탈모와 위장관계 독성이었으며, 가장 심각한 약제 독성은 골수 억제 반응이었다. 결론: 초회 치료로 paclitaxel-platinum 병용 요법을 사용 한 재발성 또는 지속성 상피성 난소암 환자에서 docetaxel은 효과와 독성 면에서 2차 치료약제로 고려할 만한 약제이다. Objective: The aim of this study is to determine the efficacy and toxicity of docetaxel in patients with recurrent or persistent epithelial ovarian cancer, previously treated with paclitaxel and platinum combination chemotherapy. Methods: Forty patients with recurrent or persistent epithelial ovarian cancer, had been treated with docetaxel combination chemotherapy at Asan Medical Center from May 1989 to December 2006. They received docetaxel (75 mg/m2) only or docetaxel (75 mg/m2) and platinum (carboplatin AUC5 or cisplatin 75 mg/m2) on day 1. The administration was repeated every 3 or 4 weeks. The response of patients was evaluated with CA-125 response criteria and RECIST criteria. The toxicities were defined according to the NCI common toxicity criteria. Results: Twenty patients had been evaluated by RECIST criteria and twenty patients had been evaluated by CA-125 response criteria. The overall response rate was 35% (14/40). Eleven patients were belonged to complete response (CR), and three patients were belonged to partial response (PR). The mean response duration (RD) was 11.29 months (4 to 20.7 months) and the mean time to progression (TTP) was 6.91 months (1 to 23 months). The response rate in the platinum-sensitive patients was 38.7% but in the platinum-resistant patients was 22.2%. The platinum-sensitive patients showed more favorable response rate, but that was not significant statistically. Heavily treated group, more than three prior regimens were used, had poor outcome. The common toxicities were alopecia and gastrointestinal toxicities (anorexia and nausea). Bone marrow suppression was the most serious drug toxicity, however, it was tolerable. Conclusion: The docetaxel is a considerable 2nd line chemotherapy with acceptable efficacy and toxicity in patients with recurrent or persistent epithelial ovarian cancer previously treated with paclitaxel and platinum combination chemotherapy.

신조어에 나타난 된소리 현상에 관한 연구 - 합성명사를 대상으로 -

김민균 ( Min Kyun Kim ) 문창어문학회 2004 문창어문논집 Vol.41 No.-

유방암에서 맞춤치료의 현황

김민균(Min Kyoon Kim),한원식(Wonshik Han) 대한종양외과학회 2013 Korean Journal of Clinical Oncology Vol.9 No.1

Cancer therapy is moving definitely towards personalized therapy that maximize the benefits for the right selected patients with cost savings. The paradigm of personalized therapy in breast cancer is applying specific drugs to the specific molecular targets by better understanding of molecular biology of breast cancer that has been switched from previous giving the same treatment to presumed homogeneous patients based on histology. In the last several years, many next generation sequencing (NGS)-based studies have been carried out to provide a comprehensive molecular characterization of cancers, to identify novel genetic alterations contributing to oncogenesis, cancer progression and metastasis. These efforts have yielded significant achievements for breast cancers also. In this paper, we review the recent advances in NGS-based cancer genomic research as well as current challenges for its clinical application, and discuss the future directions in the research for the advanced achievement and cooperative works.

골다공증을 동반한 골절 환자 치험 2례

김민균 ( Min Kyun Kim ),황재필 ( Jae Pil Hwang ),김현수 ( Hyun Soo Kim ),홍서영 ( Seo Young Hong ),허동석 ( Dong Seok Heo ),윤일지 ( Il Ji Yoon ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2007 한방재활의학과학회지 Vol.17 No.4

Objectives : There are a few case reports on the treatment of fracture in patients undergoing osteoporosis by herbal medication with acupuncture and physical therapy. We got a good results on two patients with fracture undergoing osteoporosis by herbal medication with acupuncture and physical therapy. Methods : Patients were hospitalized at Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dae-Jeon University, diagnosed as fracture with osteoporosis and treated mainly herbal medication ; Chungajihwang-tang(Q?nge?di?hua?ng-ta?ng), with acupuncture and physical therapy. This study was measured by radiography, BMD(Bone Mineral Density) and VAS(Visual Analog Scale) score. Results & Conclusions : Symptoms of patient such as fracture with osteoporosis were improved following the treatment. Gross synostosis on radiography, VAS score decreased and BMD value incresed in both two patient. So it is suggested that oriental medical treatment; herbal medication with acupuncture and physical therapy are effective in fracture in patients undergoing osteoporosis