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지적장애를 가진 교통성 수두증을 동반한 뇌병변 환자 1예
김남열 ( Nam Yeol Kim ),고재상 ( Jae Sang Ko ),김세원 ( Se Won Kim ),이동화 ( Dong Hwa Lee ),김승현 ( Seng Hyeon Kim ),김근우 ( Geun Woo Kim ) 대한한방신경정신과학회 2013 동의신경정신과학회지 Vol.24 No.4
This study researches the effects of oriental treatments for brain lesions and communicating hydrocephalus of patients with mental retardations. We treated the patients with acupuncture and herbal medication ,and then followed up the results 3 times. After treatment, K-MBI is significantly increased but the MMSE-K is not. Although results indicate its significance to brain lesions, the oriental treatment is insufficient to cure mental retardation.
지식은폐의도와 지식전이의도의 영향요인에 관한 실증분석 -공기업 현장근로자와 사무실근로자의 비교분석-
김남열 ( Nam Yeol Kim ),전현규 ( Hyeon Gyu Jeon ),김민용 ( Min Yong Kim ) 한국지식경영학회 2017 지식경영연구 Vol.18 No.3
Most of the managers know that knowledge sharing has to be precede to create knowledge which has competitive advantage of organizations. Until now the study on knowledge management placed emphasis on knowledge creation and knowledge sharing but there is few study on knowledge hiding. This study investigates the factors implicate on knowledge hiding intention and knowledge transfer intention of front-line workers and office workers and the implication on job performance of knowledge hiding intention and knowledge transfer intention. We collected sample data from 100 front-line workers and 250 office workers and verified hypotheses using Multiple Linear Regression. The result described that factors affect active and passive knowledge hiding intentions and factors affect knowledge hiding intentions of front-line workers and office workers are different.
김경옥 ( Kyeong-ok Kim ),김천중 ( Cheon-jung Kim ),서상일 ( Sang-il Seo ),김남열 ( Nam-yeol Kim ),김근우 ( Geun-woo Kim ) 대한한방신경정신과학회 2017 동의신경정신과학회지 Vol.28 No.3
Objectives: The aim of this study was to investigate the clinical studies which focus on acupuncture`s effect on anxiety disorder. Methods: We selected clinical studies through six databases. We then examined the characteristics of the selected studies and conducted an assessment for Risk of Bias (ROB). Results: Seventeen randomized-controlled trials were selected to determine the effects of acupuncture on anxiety disorders. We found that the risk of bias in most studies was unclear. The intervention of 7 seventeen randomized-controlled trials (RCT) was basic acupuncture, 8 RCT involved electric acupuncture, 2 RCT consisted of acupuncture and Moxibustion. Four of the 7 basic acupuncture RCTs and 5 of the 8 electric acupuncture RCTs had a significant effect on anxiety factors for anxiety disorders. Conclusions: Acupuncture treatment for anxiety disorders was found to be effective compared to the controls, or there was no difference in effectiveness compared to the controls. However, the quality of the included studies was low, and there only were a small number of studies. Therefore, well-designed studies and a greater number of the studies are needed.
교통사고로 인한 외상 후 기질성 정신장애 환자 치험 1례
서상일 ( Sang Il Seo ),김남열 ( Nam Yeol Kim ),김대환 ( Dae Hwan Kim ),구병수 ( Byung Su Koo ),김근우 ( Geun Woo Kim ) 대한한방신경정신과학회 2015 동의신경정신과학회지 Vol.26 No.3
Objectives: This study evaluated the effect of oriental treatments and rehabilitation on a patient with organic mental disorder after head trauma caused by traffic accident. Methods: We treated the patient with acupuncture, herb-medication, oriental psychotherapy, and rehabilitation. MMSE-K, BDI, K-MBI, FIM were evaluated before and after treatment. Results: The results indicated that MMSE-K was maintained at 27 points; BDI was reduced from 16 points to 5 points; K-MBI was increased from 75 points to 99 points; and FIM was increased from 86 points to 115 points. Furthermore, the treatment resulted in reduced mental symptoms and improved work capacity. Conclusions: Oriental medical treatment has potential validity in improving symptoms of organic mental disorder.
신생 백서 척수후근절의 슈반세포 배양을 위한 Ara-C 분열억제제의 최적 효과에 대한 연구
김성민(Soung-Min Kim),이종호(Jong-Ho Lee),안강민(Kang-Min Ahn),김남열(Nam-Yeol Kim),성미애(Mi-Ae Sung),황순정(Soon-Jeong Hwang),김지혁(Ji-Hyuck Kim),장정원(Jeong-Won Jahng) 대한구강악안면외과학회 2004 대한구강악안면외과학회지 Vol.30 No.2
Schwann cell, one of important components of peripheral nervous system, interact with neurons to mutually support the growth and replication of embryonal nerves and to maintain the different functions of adult nerves. The Ara-C, known as an antimitotic agent, have been used to have high effectiveness in eliminating fibroblasts during Schwann cell culture period. This enrichment effect is also known to be cummulative with each successive pulse of Ara-C applied and is due to a progressive loss of fibroblasts. But the cytotoxicity by Ara-C is also cummulative and noticeable over the period. To determine the most effective application time and interval of Ara-C in the Schwann cell culture, we observed the Schwann cell purity and density with the Ara-C treatment in plain and three-dimensional culture from dorsal root ganglion of new born rat. By culturing dispersed dorsal root ganglia, we can repeatedly generate homogenous Schwann cells, and cellular morphology and cell count with mean percentages were evaluated in the plain culture dishes and in the immunostainings of S-100 and GFAP in the three-dimensional culture. The Ara-C treated cultures showed a higher Schwann cell percentage (31.0%±8.09% in P4 group to 65.5%±24.08% in P2 group), compared with that obtained in the abscence of Ara-C (17.6%±6.03%) in the plain culture after 2 weeks. And in the three-dimensional culture, S-100 positive cells increased to 56.22%±0.67% and GFAP positive cells to 66.46%±1.83% in G2 group (p<0.05), higher yield than other groups with Ara-C application. Therefore, we concluded that the Ara-C treatment is effective for the proliferation of Schwann cells contrast to the fibroblasts in vitro culture, and the first application after 24 hours from cell harvesting and subsequent 2 pulse treatment (P2 group in plain culture and G2 group in three-dimensional culture) was more effective than other application protocols.
말초신경재생을 위한 hNGF-$\beta$ recombinant Adenovirus의 제작 및 수종세포주에서 신경성장인자의 발현
고은봉,정헌종,안강민,김윤태,박희정,성미애,김남열,유상배,명훈,황순정,김명진,김성민,장정원,이종호,Gao, En-Feng,Chung, Hun-Jong,Ahn, Kang-Min,Kim, Yoon-Tae,Park, Hee-Jung,Sung, Mi-Ae,Kim, Nam-Yeol,Yoo, Sang-Bae,Myoung, Hoon,Hwang, Soon-Jung,Kim 대한악안면성형재건외과학회 2005 Maxillofacial Plastic Reconstructive Surgery Vol.27 No.5
Nerve growth factor(NGF) has a critical role in peripheral nerve regeneration. The aim of this study is to construct a well-functioning hNGF-$\beta$ recombinat adenovirus for the ultimate development of improved method to promote peripheral nerve regeneration with adenovirus mediated hNGF-$\beta$ gene transfection into Schwann cells. First PCR associated cloning of GFP-tagged hNGF-$\beta$ which was ligated into E1/E3 deleted adenoviral vector was performed and tranfected into E. coli to construct hNGF-$\beta$ recombinant adenovirus. After production of recombinat adenovirus in a large scale, its transfection efficiency, expression, and function were evaluated using cell lines or primarily cultured cells of HEK293 cells, Schwann cells, fibroblast(NIH3T3) and myocyte(CRH cells). GFP expression was observed in 90% of infected cells compared to uninfected cells. Total mRNA isolated from hNGF-$\beta$ recombinat adenoviru infected cells showed strong RT-PCR band, however, LacZ recombinant adenovirus infected or uninfected cells did not. NGF quantification by ELISA showed a maximal release of 18.865 +/- 0.31ng/mL at 4th day. PC-12 cells exposed to media with hNGF-$\beta$ recombinant adenovirus infected Schwann cell demonstrated higher levels of differentiation compared with controls. We generated hNGF-$\beta$ recombinant adenovirus and induced over expression of NGF successfully in nonneuronal and neuronal cells. Following these result, it is expected to develop an improved treatment strategy peripheral nerve regeneration using the hNGF-$\beta$ gene transfected cells.
ADHD 환자에게 미술치료와 한방치료를 병행하여 치료한 치험 3예
성원영 ( Won Young Sung ),유종호 ( Jong Ho Yoo ),황민영 ( Min Young Hwang ),김남열 ( Nam Yeol Kim ) 대한한방신경정신과학회 2014 동의신경정신과학회지 Vol.25 No.3
Objectives: Attention Deficit Hyperactivity Disorder (ADHD) is a psychiatric disorder, characterized by the primary symptoms of inattention and/or hyperactivity and impulsivity. The aim of this study is to investigate the clinical efficiency of the oriental medical therapy combined with art therapy in the treatment of ADHD. Methods: This study is clinical reports of 3 patients with ADHD who are being treated with the oriental medical therapy (Herb-med, acupuncture) and art therapy. K-ARS (Korean ADHD Rating Scale) was compared before and after 1 month of treatment. Results: The Oriental medical therapy including herb-med and acupuncture is effective in improving ADHD patients. Also, art therapy is effective in decreasing patients`` anxiety and tension and helpful for patients themselves to make an objective observation. Therefore, it is practically useful in the treatment of ADHD. Conclusions: The results show the oriental medical therapy in combination with art therapy is effective in the treatment of ADHD.