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헤파린 투여 중 칼슘 투여가 혈액응고 기전에 미치는 영향
김일룡,김근형,김병선,윤영민,이경갑,Kim, Il-ryong,Kim, Gon-hyung,Kim, Byungsun,Yun, Young-min,Lee, Kyoung-kap 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.3
This study was performed to investigate the effects of calcium administration on the blood coagulation mechanism through APTT in the calf. Five male calves (70~90 kg) were used in this experiment. In the control group, heparinized normal saline (1 IU/kg/min) had been infusing into the jugular vein for 100 minutes. For the analysis of calcium effects on the APTT, the same solutions had been infusing during the first 40 minutes, subsequently the solution including calcium gluconate (3.3 mg/ml/min) had been infusing for 60 minutes. Blood samples were serially collected every 10 minutes for the APTT and platelets count and every 20 minutes for the calicum level during the infusion. In the calcium-treated group, after 70 minutes the APTT ratio (APTT heparin/APTT baseline) was higher than the therapeutic range. APTT was significantly increased at 50, 60 and 70 minutes in the calcium-treated group as compared to the control group (p<0.01). In the control group, calcium level was decreased significantly after heparin infusion (p<0.01). The platelet count was gradually decreased without significant variation in the both control and calcium-treated groups. These results suggested that APTT is slightly increased in combined heparin and calcium administration.
임계결손된 토끼 요골에서 인체 유래 탈회골기질의 골치유 효과
김종민 ( Jong Min Kim ),( Jun Sik Son ),채희열 ( Hee Youl Chai ),지형진 ( Hyeong Jin Ji ),김대중 ( Dae Joong Kim ),강성수 ( Seong Soo Kang ),김근형 ( Gon Hyung Kim ),최석화 ( Seok Hwa Choi ) 한국조직공학과 재생의학회 2011 조직공학과 재생의학 Vol.8 No.2s
This study was designed to evaluate the effect of pure demineralized cortical bone source (CBS), and CBS and non-demineralized cancellous bone sources (CCBS) on bone healing process. Twenty-one male New Zealand White rabbits were used in this study. The rabbits were anesthetized with zoletil (15 mg/kg, IM) and xylazine (5 mg/kg, IM). An osteoperisteal segmental defect was created on the middle portion of three times as long as the diameter of the diaphysis for creation of critical-sized defect. Rabbits received bilateral segmental radial defect of 15 mm. The created defects were filled in rabbits with human-drived deminerallized bone matrixes (DBM) such as CBS and CCBS. Evaluation consisted of radiographs after surgery and sacrifice, three-dimensional micro-computed tomography (micro-CT) and histopathology. Complications after implantation with CBS and CCBS were not identified. Comparison of the scoring of the radiographs or micro-CT images revealed no significant difference in defect bridging between CBS and CCBS. Bone remodeling of critical-sized radial bone defect was completed at 13 weeks after DBM implantation. In conclusion, the results of this study indicate that DBM may be used in clinical trials for healing of bone defect.