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현상환,정연우,황규찬,이국진,양일석,Hyun, Sang Hwan,Jeong, Yeon Woo,Hwang, Kyu Chan,Lee, Guk Jin,Yang, Il Suk 대한수의학회 2015 大韓獸醫學會誌 Vol.55 No.3
The number of wild animal species is gradually decreasing due to poaching, hunting and habitat loss. While several endangered animal species have been successfully preserved at the zoo, assisted reproductive technology (ART) must be applied to restore wild animals. In the case of critically endangered animals, somatic cell cloning is considered the most appropriate method of ART. Somatic cell cloning can be beneficial for the reproduction of endangered species with limited female populations. However, gene and cell banks, and understanding of reproductive physiology and optimization of ART for wild animals are urgently required for further activation of artificial reproduction of endangered species, which enlarges its application and maintains biodiversity. Care should also be taken to consider ethical and legal issues associated with somatic cell cloning for conservation of endangered animals.
아플라톡신을 간회 투여한 랫드의 간에서 CYP450 1A1, p53의 발현과 DNA adduct의 형성
이범준,이숙진,김태명,김대중,남상윤,현상환,강종구,홍진태,김철규,윤영원,Lee, Beom Jun,Lee, Sook Jin,Kim, Tae Myoung,Kim, Dae Joong,Nam, Sang Yoon,Hyun, Sang Hwan,Kang, Jong Koo,Hong, Jin Tae,Kim, Cheul Kyu,Yun, Young Won 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.4
Aflatoxins are produced mainly by Aspergillus flavus and Aspergillus parasiticus that grow in improperly stored cereals. Aflatoxin B1 ($AFB_1$) is a potent hepatocarcinogen in a variety of experimental animals including human beings. In spite of a high attention to the hepatocarcinogenecity of $AFB_1$, the relative toxicity of aflatoxins ($AFB_2$ and $AFG_1$) is not fully clarified. Sprague-Dawley male rats were orally administered with $AFB_1$, $AFB_2$, and $AFG_1$ at the dose of 250 ${\mu}g/kg$ (additionally including a dose of $1250{\mu}g/kg $ for $AFB_1$) body weight. Animals were then killed at 12, 24 or 48 hrs following aflatoxin exposure. Subsequently the immunohistochemical examination of p53, cytochrome p450 1A1 (CYP450 1A1), and glutathione-S-transferase placental form (GST-P) were performed. The level of the 8-OxodG in the liver was determined. Expressions of CYP450 1A1 and p53 were high in the liver of rats through 48 hrs after treatment of $AFB_1$ at the single dose of $250{\mu}g/kg $. This pattern was more clear as increasing doses. The treatment of $AFB_2$ and $AFG_1$ did not affect the expression of CYP450 1A1 but it caused weak expression of p53. The activity of GST were not found in the liver of rats treated with aflatoxins. The formation of 8-OxodG by $AFB_1$ increased in a dose-dependent manner up to 24 hrs after a single treatment of $AFB_1$ thereafter decreased to the level of control. The treatment of $AFB_2$ and $AFG_1$ did not affect the levels of 8-OxodG in the liver of rats with increasing time. These results in the present study indicate that $AFB_1$ among aflatoxins with low comparable levels is the most toxic as determined by early biomarkers such as CYP450 1A1, p53, GST-P, and 8-OxodG.
내용기반 이미지 검색 시스템에 대한 고찰과 설계 요건에 대한 연구
서재현,서상환,김흥식 인제대학교기초과학연구소 1998 자연과학 Vol.2 No.-
멀티미디어 데이터베이스의 내용기반 검색은 색인 기술을 요구한다. 전통적인 데이터베이스와는 달리 데이터 항목은 기본이 되는 데이터 타입들의 속성의 집합으로 나타내어지는데, 멀티미디어 데이터베이스에 있는 멀티미디어 객체는 특징들의 수집에 의해 표현되고, 객체 내용의 유사성은 문맥과 참조의 프레임에 의존하며, 객체의 특징은 다중양식 특징 측정에 의해 특성화된다. 내용기반 이미지 검색을 단계별로 3가지 큰 작업으로 나누어 보면 해당 이미지를 가장 정확하게 특징들을 추출하는 단계와 그 추출된 특징을 효과적이고 능률적으로 저장, 검색을 지원하는 단계와 다시 이미지의 유사성을 검출해 내는 단계로 요약된다. 본 논문에서는 기존에 연구된 이미지 특징 추출들을 연구 분석하고 이미지 내용 기반 검색에 적합한 다양한 특징 추출과 유사도 검색에서의 문제점과 이에 대한 적합한 설계요건에 대해 제시한다. Content-based retrieval of multimedia database calls for content-based indexing techniques. Different from conventional databases, where data items are represented by a set of attributes of elementary data types, multimedia objects in multimedia databases are represented by a collection of features; similarity of object contents depends on context ad frame of reference; and features of objects are characterized by multimodal feature measures. Try to divide content-based images retrieval systems into three large operation, it is consist of the following three phases; extracting features that can represent images the most exactly, storing the extracted features effectively and efficiently and support retrieval, detect similarity of images. In this paper we first investigated and analyse the existing image feature extraction methods and various features extraction that adequate for content-based image retrieval and problem of similarity retrieval, we also present design of suitable demand.
이연숙,서상환,서재현,김상균 인제대학교 1999 仁濟論叢 Vol.15 No.1
최근 다양하고 방대한 멀티미디어 데이터를 효율적으로 저장, 관리 및 검색할 수 있는 멀티미디어 데이터베이스 시스템이 정보화 사회의 핵심 기술로 대두되고 있다. 본 논문에서는 내용에 기반한 이미지 검색을 위해 최근 이미지 압축이나 신호 분석 등에서 많이 사용되고 있는 웨이브릿 변환(Wavelet Transform)기법을 사용하여 Wavelet 변환 영역에서 추출된 질감 특징을 영상 검색에 이용하는 내용기반 검색 시스템을 제안하고, 보다 효과적인 검색과 분류를 위해 신경망을 도입하여 설계하는 시스템을 제안한다. Recently, multimedia is appeared to be the core technology to store, manage and retrieve multimedia data efficiently. Efficient retrieval of image data is an important research issue in multimedia database. For content-based image retrieval, our searching method extracts the texture feature for each image automatically using wavelet transform. In this paper, we consider design of content-based image database retrieval using neural networks for effective retrieval and classification. Key words : content-based, wavelet, texture, neural-networks