당뇨흰쥐의 콜라겐 감소 및 인간 피부 섬유아세포의 MMP-1 증가에 대한 목단피(牧丹皮)의 항피부노화 효과

김경진,김경준,Kim, Kyung-Jin,Kim, Kyung-Jun 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.1

Objective : Skin aging is commonly observed in patients with diabetes mellitus, which can be accessed by the amount of skin collagen and matrix metalloproteinase-1 (MMP-1). In the present study, anti-skin-aging effects of Root Cortex of Paeonia Suffruticosa Andrews (PSA), which has been widely used to treat diabetes mellitus, are investigated. Methods : Streptozotocin (STZ) was intraperitoneally injected to rats to induce diabetes. Body weights, feed intake, organ weights, blood glucose, and other biochemical index are determined in both normal and diabetic rats. In order to study the effect of PSA on skin aging, the amount of skin collagen was measured in diabetic rats after PSA treatments. Also, MMP-1 synthesis in UVB-irradiated human skin fibroblasts was investigated. Results : 1. When PSA was administered to STZ-induced diabetic rats, feed intake was significantly increased and blood glucose and total cholesterol were decreased in a dose-dependent manner. However, there are no differences in individual organ weights, GOT, and GPT. 2. A decrease of skin collagen in diabetic rats was significantly suppressed when PSA was treated. 3. PSA also inhibited MMP-1 synthesis in UVB-irradiated normal human skin fibroblasts, similar to retinoid, a well-known effective anti-skin-aging substance. Conclusion: PSA suppressed a collagen decrease in diabetic rats and inhibited MMP-1 synthesis in UVB-irradiated human skin fibroblasts. Therefore, the treatment of PSA is very effective to slow down the skin aging process.

좌심실형성부전증후군 환아의 치과치료를 위한 전신마취 시 강화 후두마스크를 이용한 기도 유지

김경진,신터전,현홍근,김영재,김정욱,장기택,이상훈,김종철,서광석,Kim, Kyung Jin,Shin, Teo-Jeon,Hyun, Hong-Keun,Kim, Young-Jae,Kim, Jung-Wook,Jang, Ki-Taeg,Lee, Sang-Hoon,Kim, Chong-Chul,Seo, Kwang-Suk 대한치과마취과학회 2013 Journal of Dental Anesthesia and Pain Medicine Vol.13 No.4

Despite the laryngeal mask airway (LMA) has been widely used in anesthesia, its use is rare in the field of dentistry. Placing LMA in the oral cavity may interrupt dental treatment. However, there are some circumstances in which LMA is more advantageous than tracheal intubation for managing the airway. Especially, the reinforced LMA has a flexible tube shaft, rendering it more accessible for dental treatment. We report a case of dental treatment of a 3-year-old patient with hypoplastic left heart syndrome combined with pulmonary hypertension using reinforced LMA for airway management under general anesthesia. We also discuss the considerations of utilizing the reinforced LMA for dental treatment.

이산대수 기반 Diffie-Hellman형 표준 키 분배 프로토콜의 안전성 분석에 관한 연구

김경진,김성덕,심경아,원동호,Kim, Kyung-Jin,Kim, Sung-Duk,Shim, Kyung-Ah,Won, Dong-Ho 한국정보처리학회 2002 정보처리학회논문지 C : 정보통신,정보보안 Vol.9 No.6

인터넷과 같은 첨단의 정보 전송 시스템이 발달함에 따라 네트워크 상에서 전송되는 메시지에 대한 기밀성을 제공하기 위해서 암호 시스템의 사용이 증가하고 있으며 그 중요성은 더욱 강조되고 있다. 안전한 암호 시스템을 구현하는 데 있어서 키 분배 프로토콜은 가장 필수적인 요소이며, 지금까지 여러 키 분배 프로토콜들이 표준으로 제안되었으나 이에 대한 엄밀한 안전성 증명은 아직까지 부족한 실정이다. 따라서 본 논문에서는 ANSI X9.42의 Diffie-Hellman형 표준 키 분배 프로토콜의 특징을 자세히 분석하고 이를 기반으로 여러 능동적 공격자 모델에 대한 프로토콜의 안전성을 증명하고자 한다 According to the wide-spread of information transmission system over network, the use of cryptographic system to provide the integrity of transmitted message over network is increasing and the importance of that is emphasized. Because the security of the cryptographic system totally relies on the key, key management is a essential part of cryptographic system. A number of key agreement protocols have been proposed to far, but their rigorous security analysis is still open. In this paper, we analyze the features of Diffie-Hellman based standard key agreement protocols and provide the security analysis of those protocols against several kinds of active attacks.

마판 증후군 소아 환자의 전신마취 하 치과치료

김경진,박소연,현홍근,신터전,김정욱,Kim, Kyung Jin,Bak, Soyeon,Hyun, Hong-Keun,Shin, Teo-Jeon,Kim, Jung-Wook 대한치과마취과학회 2013 Journal of Dental Anesthesia and Pain Medicine Vol.13 No.4

Multiple caries in a pediatric patient often requires dental treatment under general anesthesia, especially when the patient is suffering from a systemic disease. The patient was a 6-year-old boy with Marfan syndrome and needed extensive dental treatment. Marfan syndrome is an inherited disorder resulting from mutations in Fibrillin-1 gene. Patients are known to have mainly cardiovascular, ocular, and musculoskeletal problems. Although clinical symptoms of the syndrome are age-realted, thus hindering early diagnosis of the disease in young children, our patient had been confirmed by a gene study at a younger age. Medical history of the patient revealed moderate to severe mitral regurgitation and aortic root dilatation, which required mitral valve replacement surgery with a mechanical valve. As a result, the patient was taking warfarin post-operatively and changes in medication had to be made before the dental treatment. Also, prophyalctic antibiotics had to be given before the treatment for prevention of (to prevent the) infective endocarditis. With careful control of the medications and bleeding tendency, general anesthesia and the treatment were done successfully without any complications.

Ovalbumin으로 유발된 아토피피부염 모델 마우스에 대한 복합한약추출물 경구투여의 효과

김경진,김경준,Kim, Kyung-Jin,Kim, Gyung-Jun 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

Objective: This study was to evaluate whether herbal mixture (HM-A : Houttuynia cordata Thunberg, Rubus coreanus, Rehmannia glutinosa, Prunus yedoensis, HM-B : Houttuynia cordata Thunberg, Rubus coreanus, Rehmannia glutinosa, Angelica gigas nakai) supresses the development of atopic dermatitis in Balb/c mice sensitized by ovalbumin. Methods: Mice were sensitized by intraperitoneal injection of ovalbumin plus aluminum hydroxide hydrate, followed by epicutaneous sensitization for 6 weeks. After induced atopic dermatitis, HM-A and HM-B were orally administrated for two weeks(once a two days) as a 50 mg/kg concentration. After all mice were sacrificed at the end of the experiment, skin and blood were harvested. Results: Oral administration group was reduced the infiltration of eosinophils, mast cells and total T cells on the skin areas as well as blood analysis. Also, cutaneous expression of IL-4,13,17 decreased. Blood IgE level was decreased. Conclusion: These drugs could be potential candidates for the atopic dermatitis.

튜닝 브레이크 디스크의 성능평가 방법 개발

김경진,신재호,강우종,Kim, Kyung Jin,Shin, Jaeho,Kang, Woo Jong 한국자동차안전학회 2016 자동차안전학회지 Vol.8 No.3

Braking system is directly related to the safety of a vehicle and the brake discs are essential part of the braking system. Due to the repeated frictional forces and torque during braking, brake discs are always works at high temperature and high pressure. Furthermore, the brake disc is one of major tuning components in aftermarket, the braking performance of the brake disc should be evaluated for establishing the certification standards of tuning components. This paper proposes the test method to evaluate the performance of tuning brake discs.

염증치은의 PROSTAGLANDIN E와 F2${\alpha}$의 농도에 관한 연구

김경진,최상묵,Kim, Kyung-Jin,Choi, Sang-Mook 대한치주과학회 1982 Journal of Periodontal & Implant Science Vol.12 No.1

치은절제술후 periodontal pack이 치은치유에 미치는 영향

김경진,Kim, Kyung-Jin 대한치주과학회 1977 Journal of Periodontal & Implant Science Vol.7 No.1

로지스틱회귀모형의 평가를 위한 그래픽적 방법

김경진,강명욱,Kim, Kyung Jin,Kahng, Myung Wook 한국통계학회 2015 응용통계연구 Vol.28 No.6

대부분의 통계분석방법은 요약통계량에 의존하지만 그래픽적 방법을 이용하면 자료의 특성을 파악하기 쉽고 통계량만으로는 알아낼 수 없는 부분까지도 접근이 가능하다. 그래프를 통한 로지스틱회귀모형의 평가 방법으로 로그-밀도비를 통한 검토, 차원 검토, 주변모형산점도, 카이잔차산점도, CERES 그림을 알아보고 모의자료들을 통해 다양한 상황에서 그래픽적 방법들 어떠한 결과를 나타내지를 비교 검토한다. Most statistical methods are dependent on the summary statistic. However, with graphical approaches, it is easier to identify the characteristics of the data and detect information that cannot be obtained by the summary statistic. We present various graphical methods to assess the adequacy of models in logistic regression that include checking log-density ratio, structural dimension, marginal model plot, chi-residual plot, and CERES plot. Through simulation data, we investigate and compare the results of graphical approaches under diverse conditions.

신석기시대 망치형석기의 기능 연구

김경진(Kim, Kyung-jin),김소영(Kim, So-young) 중앙문화재연구원 2012 중앙고고연구 Vol.0 No.11

최근 서해중부지역에 위치한 인천 운서동·중산동유적, 시흥 능곡동유적 등의 신석기시대 유적에서 으스러짐에 의해 능이 발생한 특징적인 석기가 보고되고 있지만 그에 합당한 용어나 기능에 대한 연구는 아직 미비한 수준이다. 이러한 문제인식을 바탕으로 이 석기의 기능에 초점을 맞추어 ‘망치형석기’로 명명하고 형태기술과 사용흔분석을 통해 그 기능을 밝혀내고자 하였다. 망치형석기는 주로 신석기시대 주거지 내에서 갈돌, 갈판 등의 생활도구와 공반하고 망치 기능을 가지므로 일상생활에서 지속적으로 사용된 것으로 판단하였다. 석기의 제 작은 주로 석영맥암을 그대로 이용하여 사용하는 과정에서 형태가 잡혀갔으며 모양잡기(shaping)한 예는 드물었다. 또 손에 쥐기 적합한 크기와 무게를 지녔으며 능의 발달이나 마모정도에 의해 분류가 가능하지만 사용정도에 따른 차이로 판단되었다. 망치형석기의 기능에 대해서는 식량재료의 가공 또는 석기 제작에 사용되는 도구라는 가설이 주를 이루며, 이를 확인하기 위해 실험과 현미경 분석을 시도하였다. 망치형 석기는 도구의 뾰족한 부분과 능을 따라 사용에 의한 흔적과 도구의 변형이 집중되어 나타나며, 주로 깨짐과 으스러짐으로 형성되어 있었다. 실험에서 이 석기는 광물재료에 사용되었을 경우 실제 유물과 유사한 형태와 흔적을 보이며, 특히 석기의 모서리부 분을 도구 제작시 쪼는 방법으로 사용했을 때 실제 유물과 가장 유사한 흔적과 도구의 변형이 나타났다. 민족지학 자료와 실험 및 분석 결과 그리고 유적에서 공반 출토되는 유물 구성들을 토대로 운서동 망치형석기는 도구 가운데 갈돌, 갈판의 사용면을 다듬는 마무리 단계와 사용 중 많이 닳게 된 사용면을 재생하는 과정에서 사용하기 적합한 것으로 보이며, 주로 쪼는 작업방법으로 이용되었을 가능성이 높은 것으로 생각된다. The hammerstones that had particular characteristics of the crest formation caused by repetitive crushing were recently excavated in Neolithic sites which were located in the West Central regions. However, studies on the definitions of terminology or the functions of these stone tools are still insufficient. They were defined mainly as elements of grinding stone. For this reason, these tools were considered to have been used continuously in everyday life. The quartz veins primarily have been used in the production of the tools. Then, the shape of the tools was perfected while in use, rather than pre-made. They had the size and weight suitable for one-hand use. They were classified by the degrees of crest development. However, it is likely that these differences appear depending on the duration of use. There are two main hypotheses concerning the function of the hammerstone:the tool for the processing of food materials or the tool for the production of other stone tools. We have tried several experiments and microscopic analysis to confirm these hypotheses in this article. Usewear was formed intensively on the edges and the narrow part of the tools. Deformation of the tool surface due to the crushing and small chipping was identified. We also observed traces similar to those of archaeological tools that were used on the mineral materials with methods pecking. We assumed that the function of the hammerstone was to use in the manufacturing process or to retouch the grind stone using a method pecking on the ethnographic data, experimental data, and result of microscopic analysis.