How general anesthetics work: from the perspective of reorganized connections within the brain

신터전,Kim Pil-Jong,버나드최 대한마취통증의학회 2022 Korean Journal of Anesthesiology Vol.75 No.2

General anesthesia is critical for various procedures and surgeries. Despite the widespread use of anesthetics, their precise mechanisms remain poorly understood. Anesthetics inevitably act on the brain, primarily through the modulation of target receptors. Even if the action is specific to an individual neuron, however, long-range effects can occur due to the tremendous interconnectedness of neuronal activity. The strength of this connectivity can be understood using mathematical models that allow for the study of neuronal connectivity dynamics. These models also allow researchers to develop hypotheses on the candidate mechanisms of action of different types of anesthesia. This review highlights the theoretical background associated with the study of the mechanisms of action of anesthetics. We propose a candidate framework that describes how anesthetics act on the brain and consciousness in general.

Modeling of Recovery Profiles in Mentally Disabled and Intact Patients after Sevoflurane Anesthesia; A Pharmacodynamic Analysis

신터전,한동우,노규정,구용서 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.6

Purpose: Mentally disabled patients show different recovery profiles compared to normal patients after general anesthesia. However, the relationship of dose-recovery profiles of mentally disabled patients has never been compared to that of normal patients. Materials and Methods: Twenty patients (10 mentally disabled patients and 10 mentally intact patients) scheduled to dental surgery under general anesthesia was recruited. Sevoflurane was administered to maintain anesthesia during dental treatment. At the end of the surgery, sevoflurane was discontinued. End-tidal sevoflurane and recovery of consciousness (ROC) were recorded after sevoflurane discontinuation. The pharmacodynamic relation between the probability of ROC and end-tidal sevoflurane concentration was analyzed using NONMEM software (version VII). Results: End-tidal sevoflurane concentration associated with 50% probability of ROC (C50) and γ value were lower in the mentally disabled patients (C50=0.37 vol %, γ=16.5 in mentally intact patients, C50=0.19 vol %, γ=4.58 in mentally disabled patients). Mentality was a significant covariate of C50 for ROC and γ value to pharmacodynamicmodel. Conclusion: A sigmoid Emanx model explains the pharmacodynamicrelationship between end-tidal sevoflurane concentration and ROC. Mentally disabled patients may recover slower from anesthesia at lower sevoflurane concentrationat ROC an compared to normal patients.

Therapeutic Implication of Botulinum Toxin B for Treatment of Muscle Hypertrophy from In Vivo Study

신터전,서광석,김현정,Shin, Teo-Jeon,Seo, Kwang-Suk,Kim, Hyun-Jeong The Korean Dental Society of Anesthsiology 2009 Journal of Dental Anesthesia and Pain Medicine Vol.9 No.1

배경: 보툴리눔 독소 A형은 강직성 질환을 비롯한 여러 질환의 치료제로 널리 사용되고 있다. 최근에 보툴리눔 독소 A형은 근육비대를 치료하기 위해 널리 이용되고 있다. 하지만 보툴리눔 독소의 근육비대의 치료효과에 대해서 알려진 바가 거의 없다. 본 연구는 토끼 정강뼈 근육에 보툴리눔 A, B형을 주입 후 시간경과에 따른 근육의 위축을 확인하여 근육비대의 치료에 보툴리눔 B형이 효과적인지 확인하고자 하였다. 방법: 36마리의 토끼를 4그룹으로 분류하였다(1 그룹: 생리식염수 주사: 2 그룹: 보툴리눔 독소 A, B - 2U, 3 그룹: 보툴리눔 독소 A, B - 5U, 4 그룹: 보툴리눔 독소 A, B - 10U). 정강뼈근육에 보툴리눔 독소 A, B형을 주입 후 1, 2, 4주에 정강뼈 근육의 부피를 측정하였다. 신경자극기를 이용하여 독소 주입 후 1, 2, 4주의 근육의 단일 수축을 확인하여 근육기능의 변화여부를 확인하였다. 결과: 보툴리눔 독소 B형을 주입시 통계적으로 유의하지 않지만 A형에 비해 근육 부피의 감소가 관찰되었다(P>0.05). 반면, 근육의 단일 수축은 보툴리눔의 용량에 관계없이 B형을 주입한 근육에서 더 높게 관찰 되었다. 결론: 보툴리눔 독소 B형을 주입한 경우 근육 기능의 회복속도는 빠른 반면 근육의 위축은 A형에 비해 더 오랫동안 지속되었다. 따라서 근육비대의 치료에 있어 보툴리눔 독소 B형이 A형보다 보다 더 효과적이라고 사료된다.

금관 수복치료 후 발생한 좌측 기관지 내로의 금관 흡인에 관한 증례보고

신터전,서광석,김현정,Shin, Teo-Jeon,Seo, Kwang-Suk,Kim, Hyun-Jeong 대한치과마취과학회 2010 Journal of Dental Anesthesia and Pain Medicine Vol.10 No.1

Foreign body aspiration (FBA) into the tracheobronchial tree could be life threatening requiringprompt intervention. Any objects placed in the oral cavity put patients at a risk of aspirating or swallowing the objects slipped or broken by physical injuries. Here, we report a case of 30 yr old patient with FBA during gold crown replacement was successfully treated with the use of the flexible bronchoscope. Case: A 30 yr old woman was admitted to Seoul National Dental Hospitalfor an amalgam restoration. She was scheduled to gold crown restoration for replacement of the damaged amalgam at #37 site. After performing crown lengthening procedure, the aspiration of gold crown occurred during the cementation of the crown. After aspiration, the patients complained of the subjective distress of respiration. Chest radiograph revealed that gold crown was enlodged to the left bronchus. Flexible fiberoptics was inserted to the bronchus to remove the aspirated crown. Fiberoptic assisted removal of the aspiratedcrown was successfully performed. After removal, there was no radiopaque material in the left bronchus on follow-up chest radiograph. Discussion: When aspiration of dental materials occurs, flexible fiberoptic can be used in the treatment of FBA. It is also very useful to take preventive management such as rubber dam, application of dental floss in dental procedure where there is high likelihood of FBA.

전신마취 하 임플란트 시술을 받은 환자에서 자가통증조절법 치료의 효용성 평가

신터전,서광석,박윤기,이정후,김현정,Shin, Teo-Jeon,Seo, Kwang-Suk,Park, Yun-Ki,Lee, Jung-Hoo,Kim, Hyun-Jeong 대한치과마취과학회 2009 Journal of Dental Anesthesia and Pain Medicine Vol.9 No.2

Background: Despite increasing popularity of dental implants, there is limited information on the pain experience associated with the surgical implant placement under general anesthesia. The aim of this study was to assess the characteristics of patient-reported pain and efficacy of patient controlled analgesia after implant surgery under general anesthesia. Methods: Total 39 patients who underwent implant surgery under general aensthesia were enrolled. In PCA group (n=30), patients received patient controlled analgesia (fentanyl 700 mg and ketorolac 150 mg) set to basal rate 1 ml/h, bolus 1 ml, and lockout interval 10 min. In control group (n=9), patients received ketorolac 30 mg intravenously when they feel painful. We evaluated pain intensity using VAS score at the end and after 12 hr of the operation and recorded the number of bolus injection as a surrogate of rescue therapy. We compared the VAS data, the frequency of complication between two groups. Results: The self reported pain was highest at 1 hous after surgery in both groups. However, the intensity was not severe (PCA group = 5.7, control group = 5.6), and decreased gradually thereafter. Total demand bolus number was less than 6 in nearly 65% patients. And there was no significant difference in the frequency of complications such as nausea, vomiting and dizziness between both groups. Conclusions: The Pain following the surgical placement of dental implants was generally mild and gradually decreased with time. There was no difference in complications between control group and PCA group.

소아 치과진정법 시행 시 진정심도 감시를 위한 Cerebral State Monitor의 임상적 유용성

신터전,현홍근,김영재,김정욱,장기택,이상훈,김종철,서광석,Shin, Teo-Jeon,Hyun, Hong-Keun,Kim, Young-Jae,Kim, Jung-Wook,Jang, Ki-Taeg,Lee, Sang-Hoon,Kim, Chong-Chul,Seo, Kwang-Suk 대한치과마취과학회 2014 Journal of Dental Anesthesia and Pain Medicine Vol.14 No.1

Background: It is imperative that adequate sedation level should be maintained for safe and effective dental sedation. Cerebral state index (CSI) is a empirically derived parameter calculated from the processed electroencephalography (EEG). We investigated whether CSI can be used as a sedation depth indicator. Methods: We continuously recorded CSI and bispectral index (BIS) values from 10 healthy children aged 3.6 yr undergoing dental sedation. We also evaluated sedation level using the Modified Observer's Assessment of Alertness/Sedation (MOAA/S). The correlation between CSI and BIS, or CSI and sedation score were sought a regression analysis. Results: There were good linearity between CSI values and sedation score. (r = 0.916, P < 0.001) The paired CSI and BIS values showed a significant correlation between the two values. (r = 0.895, P < 0.001) The difference between CSI and BIS values was not statistically significant at deep and conscious sedative levels. Conclusions: The CSI monitor can be easy to monitor sedation depth during dental sedation for children.

Surgical Invasiveness is Important for Determining Severity of Postoperative Pain after Oral & Maxillofacial Surgery

신터전,박윤기,서광석,한효조,김현정,Shin, Teo-Jeon,Park, Yun-Ki,Seo, Kwang-Suk,Han, Hyo-Jo,Kim, Hyun-Jeong The Korean Dental Society of Anesthsiology 2011 Journal of Dental Anesthesia and Pain Medicine Vol.11 No.1

배경: 술 후 통증은 술 후 합병증의 발생가능성을 증가시키며 생체기능의 회복을 방해한다. 술 후 통증을 효과적으로 조절하기 위해선 통증의 정도를 객관적으로 평가하는 것이 필요하다. 술 후 통증은 수술의 침습도와 관련이 높을 가능성이 많다. 본 연구에서는 수술 침습도의 정도와 술 후 통증의 정도 사이의 상관관계를 확인하고자 한다. 방법: 총 153명의 환자를 수술의 침습도에 따라 4개의 그룹으로 나누었다(그룹 1: 악성종양 수술 (malignancy surgery), 그룹 2: 양악수술(bimaxillary surgery), 그룹 3: 양성 종양수술(benign cancer surgery) 그룹 4: 임플란트 & 골절 수술(implant & frature)) 수술이 끝나갈 무렵 fentanyl 700 ${\mu}g$, ketorolac 1,500 mg (총 용적 120 ml)가 포함된 자가통증조절장치를 정맥로에 연결하였다. 술 후 통증의 정도는 시각통증등급(visual analogue scale)을 이용하여 측정하였고 자가통증조절장치의 총 사용시간, 투여된 진통제의 양, bolus 투여 총 횟수를 측정하였다. 결과: 술 후 시각통증등급은 술 후 1일부터 3일까지 그룹 1, 2 군에서 유의하게 높았다. 또한 시각통증등급 3점 이상의 통증을 호소하는 환자의 비율 역시 그룹 1, 2 군에서 유의하게 높았다. 진통제 총 투여용량 및 자가로 주입한 진통제의 양 역시 그룹 1, 2군에서 3, 4 군에 비해 유의하게 높은 것을 확인하였다. 결론: 본 연구결과 외과적 수술의 침습도가 술 후 통증의 정도를 결정하는데 있어 중요한 요소임 을 확인하였다.

Jaw Thrust Improves the Fiberoptic Laryngeal View during Fiberoptic Nasotracheal Intubation

신터전,서광석,김현정,Shin, Teo-Jeon,Seo, Kwang-Suk,Kim, Hyun-Jeong The Korean Dental Society of Anesthsiology 2010 Journal of Dental Anesthesia and Pain Medicine Vol.10 No.2

배경: 임상적으로 굴곡성 기관지 내시경을 이용 삽관 시행시 후두경으로 성문부위가 잘 드러나지 않는 환자의 경우 삽관 시행이 어려운 경우를 경험한다. 하지만 이에 대한 연구는 거의 없는 실정이다. 본 연구에서는 어려운 기도환자에서 굴곡성 기관지경 시행시 후두시야를 확보시 차이가 있는지 확인하고자 하였다. 방법: 전신마취 유도 후 Cormack - Lehane classification을 이용하여 기관 삽관의 어려움을 먼저 평가하였다. 기관지 내시경을 이용하여 내시경하 후두시야의 정도를 평가하였다. 후두경으로 기도 확보가 용이한 그룹(Cormack - Lehane grades 1, 2)과 어려운 그룹(Cormack - Lehane grades 3, 4) 간의 내시경하 후두 시야의 정도가 차이가 나는 지를 확인하였다. 결과: 후두경으로 기도확보가 용이하지 않을 경우에 기관지 내시경으로 후두 시야를 용이하게 (fiberoptic laryngeal view 1, 2) 확보하기가 어려웠다. 반면 하악을 전방으로 견인시 후두시야의 정도가 통계적으로 유의하게 개선되었다. 결론: 전방하악견인법 (jaw-thrust maneuver)은 기도확보가 어려운 환자에서 기관지 내시경을 이용한 기관내 삽관 시행시 시야를 개선시켜서 삽관을 용이하게 할 수 있을 것으로 생각된다.

Automatic Implantable Cardioverter Defibrillator (AICD)를 삽입한 환자에서 프로포폴, 레미펜타닐을 이용한 진정요법 하 제3대구치 발치 -증례보고-

신터전,서광석,김현정,Shin, Teo-Jeon,Seo, Kwang-Suk,Kim, Hyun-Jeong 대한치과마취과학회 2009 Journal of Dental Anesthesia and Pain Medicine Vol.9 No.2

The automatic implantable cardioverter defibrillator (AICD) has been widely used to treat recurrent malignant ventricular arrhythmia. Here, we case report 18 yr old patients implanted with Automatic implantable cardioverter defibrillator (AICD) who underwent surgical extraction under intravenous sedation and discuss the anesthetic implications for surgery.

치과영역에서 경구진정법의 활용

신터전(Teo Jeon Shin) 대한치과의사협회 2013 대한치과의사협회지 Vol.51 No.7

Sedation is frequently required to relieve anxiety in the field of dentistry. Among sedation techniques, oral sedation has been widely used because it is easy for administration and has a wide acceptability for dentists. This article discuss the pharmacology of oral sedatives and therapeutic considerations of these drugs, and finally how to manage apprehensive patients using oral sedation. Also, we recommend how pertinent drugs should be used to maintain an adequate level of sedation, not deep sedation