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뜨임한 구조용강 SCM435의 경도 및 충격 흡수에너지에 대한 신뢰성 평가
윤서현,구세훈,남기우 한국산업융합학회 2019 한국산업융합학회 논문집 Vol.22 No.6
SM45C steel, which is widely used for mechanical structure, was carburized at 87 0℃ for 4 hours and tempered at 300℃ and 400℃ for 1, 3 and 6 hours. The tempered materials were evaluated for tensile test, hardness test and impact test. In particular, the hardness and the absorption energy were evaluate the reliability by the Weibull statistical analysis. 300℃-1h specimen is considered to be the best heat treatment condition in the tensile stress and the observation of fracture surface. 300℃-1h specimen showed larger shape and scale parameter than the other specimens, and Rockwell hardness variance was small and showed the best characteristics. 400℃-3h specimen showed larger shape and scale parameter than the other specimens, the dispersion of impact absorption energy is small, and showed excellent characteristics.
이원근,구세훈 경희대학교 산학협력기술연구원 2007 산학협력기술연구논문집 Vol.13 No.-
In this study, we extracted samples of soils and foods which we can contact easily, handled them and measured the concentration of gamma radiation with HPGe detector. And we compared its concentration with that of sites around the nuclear power plants. In result, the average concentration of ¹³⁷CS and ⁴⁰K on soils were <MDA¹⁾ in the most provinces. When compared with environmental radioactivity concentration around the nuclear power plants in 2005, these values were not out of the range of average concentration in Korea although there was little gap locally. Also, the gamma radiation concentrations of ¹³⁷CS, ⁴⁰K and ⁷Be from 17 kinds of foods in Gyeonggi province were not largely out of the range in the value in recent 5 years. When compared grains(rice) and culinary vegetables are compared with them of nuclear power plants, their concentration value were almost similar. Therefore, it was not a matter of grave concern.
송영조,유치호,구세훈,허경행,정성태 한국군사과학기술학회 2021 한국군사과학기술학회지 Vol.24 No.3
Hantaan virus(HTNV) causes hemorrhagic fever with renal syndrome(HFRS) with a case fatality rate ranging from <1 to 15 % in human. HantavaxⓇ is a vaccine against the Hantavirus, which has been conditionally approved by the Ministry of Food and Drug Safety(MFDS). However, only 50 % of volunteers had neutralizing antibodies 1 year following the boost. Effective antiviral treatments against HTNV infection are limited. Hantaviruses generally cause asymptomatic infection in adult mice. On the other hand, infection of suckling and newborn mice with hantaviruses causes lethal neurological diesease or persistant infection, which is different from the disease in humans. The development of vaccines and antiviral strategies for HTNV has been partly hampered by the lack of an efficient lethal mouse model to evaluate the efficacy of the candidate vaccines or antivirals. In this report, we established a lethal mouse model for HTNV, which may facilitate in vivo studies on the evaluation of candidate drugs against HTNV. The median lethal dose value of HTNV was calculated by probit analysis of deaths occurring within two weeks. Five groups of ten ICR mice were injected intracranially with serial 2-fold dilutions (from 50 to 3.125 PFU/head) of HTNV. Mice injected with HTNV began to die at 8 days post-infection. The lethal dose required to kill 50 % of the mice (LD50) was calculated to be 2.365 PFU/head.
항바이러스 효능을 가진 자연살해세포 치료제 플랫폼 개발
김동수,윤형석,이진희,연다영,유치호,구세훈,송영조,김정은,이승호,이용한,허경행,강정 한국군사과학기술학회 2024 한국군사과학기술학회지 Vol.27 No.1
. Various vaccines were rapidly developed during the COVID-19 pandemic to prevent and treat infections but global infections continue, and concerns about new mutations and infectious diseases persist. Thus, active research focuses on developing, producing, and supplying vaccines and treatments for various infectious diseases and potential pandemics. Natural killer(NK) cells, as innate immune cells, can recognize and eliminate abnormal cells like virus-infected and cancer cells. Hence, their development as anticancer and antiviral treatments is rapidly advancing. In this study, optimal short-term culture conditions were identified for allogeneic NK cells by simplifying the culture process through the isolation of NK cells(referred to as NKi cells) and eliminating CD3+ cells(referred to as CD3- cells). NK cells demonstrated reduced viral titer in injection of NK cells into SARS-CoV-2 infected ACE-tg mice increased survival. The study's findings could form the basis for an antiviral treatment platform that swiftly responds to new viral disease pandemics
항원 특이적 단일 기억 B 세포 분리를 이용한 신종 바이러스 대응 신속 항체 플랫폼 개발
석지윤,정수한,박아름,한예지,김정은,송영조,유치호,윤형석,구세훈,이승호,이용한,허경행,최웅 한국군사과학기술학회 2024 한국군사과학기술학회지 Vol.27 No.1
. The COVID-19 pandemic is not over despite the emergency use authorization as can see recent COVID-19 daily confirmed cases. The viruses are not only difficult to diagnose and treat due to random mutations, but also pose threat human being because they have the potential to be exploited as biochemical weapons by genetic manipulation. Therefore, it is inevitable to the rapid antibody-based therapeutic platform to quickly respond to future pandemics by new/re-emerging viruses. Although numerous researches have been conducted for the fast development of antibody-based therapeutics, it is sometimes hard to respond rapidly to new viruses because of complicated expression or purification processes for antibody production. In this study, a novel rapid antibody-based therapeutic platform using single B cell sorting method and mRNA-antibody. High immunogenicity was caused to produce antibodies in vivo through mRNA-antigen inoculation. Subsequently, antigen-specific antibody candidates were selected and obtained using isolation of B cells containing antibody at the single cell level. Using the antibody-based therapeutic platform system in this study, it was confirmed that novel antigen-specific antibodies could be obtained in about 40 days, and suggested that the possibility of rapid response to new variant viruses
최근 강원도 지역 군부대내 진드기 종분류 및 SFTS 바이러스 분포도 조사
박창보 ( Park Changbo ),정무영 ( Jung Muyoung ),김정윤 ( Jeongyun Kim ),김창연 ( Kim Chang Yeon ),정승관 ( Seunggwan-jeong ),황경율 ( Kyung-ryul Hwang ),구세훈 ( Sh Gu ) 국군의무사령부 2020 대한군진의학학술지 Vol.51 No.1
Objectives; The purpose of this study was to investigate and characterize the distribution of Severe fever with thrombocytopenia syndrome virus(SFTSV) in ROK military bases. Methods; To investigate the distribution, ticks were collected from 55 military bases within the operational area in Gangwon province. The SFTSV was detected by real time reverse transcription PCR and RT nested PCR. The nucleotide sequences and the phylogenetic tree were used in order to confirm and analyze SFTSV. Results; 5,959 ticks were collected from 55 military bases. 5,771 ticks(adult and nymph ticks) were Haemaphysalis longicornis(96.9%), 174 were Haemaphysalis flava(2.9%), and 9 were Ixodes nipponensis(0.15%). SFTSV was confirmed in eight military bases. Genetic and phylogenetic analyses of these sequences revealed that the tick-derived Korean SFTSV strain clustered into the genotype A and B. Conclusions; This findings suggest to build management system from tick collection and classification to SFTSV detection and preventive measures in preventive medicine unit and veterinary team(Division). Based on the collection of the information, the Army and the Armed Forces Medical Command are need to establish a plan of pest control and prevention of disease.