유전 알고리즘을 이용한 ESS의 운용 최적화

구기범(Ki Beom Ku),정신규(Shin Kyu Jeong) 대한설비공학회 2015 대한설비공학회 학술발표대회논문집 Vol.2015 No.11

Energy Storage System (ESS) attracts a lot of attentions as one of building energy management systems. There are many applications of ESS. One of them is to decrease the energy consumption in peak time using ESS to prevent from blackout. In this study, an optimized ESS operation system using genetic algorithm (GA) is developed to decrease the cost of electricity. Hourly uses of energy(electricity) in a building is estimated by using EnergyPlus simulation and optimum charging and discharging schedule is determined using Genetic algorithm. To obtain optimum ESS capacity of given building, ROI and maximum profit in expectancy life were calculated by varying ESS capacity.

서포트 벡터 머신과 공정능력분석을 이용한 군 통신 쉘터의 EMI 차폐효과 안정 포인트 탐색 연구

구기범(Ki-Beom Ku),권재욱(Jae-Wook Kwon),진홍식(Hong-Sik Jin) 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.2

군 통신 쉘터는 내부에 통신 및 환경장비를 탑재하여, 네트워크 중심전에서 다양한 무기체계들의 통합적인 전투력 발휘를 위해 요구되는 정보의 송/수신 기능을 실시간 보장하고 전술환경의 생존성을 극대화시키는 장비이다. 쉘터 내부에 다양한 통신용 장비가 탑재되기 때문에 외부로부터의 전자기 공격에 대한 차페 성능을 반드시 보장해야한다. 본 연구에서는 데이터 마이닝 기법(서포트 벡터 머신)과 통계적 품질관리 기법(공정능력분석)을 이용하여 군 통신용 쉘터에서 차폐성능이 안정된 지점을 탐색하는 연구를 진행하였다. 안정된 지점의 탐색을 위하여 45대 쉘터의 EMI 차폐효과 측정데이터를 활용하였다. 먼저, 차폐효과가 안정되었다고 판단할 수 있는 기준을 세우고 서포트 벡터 머신으로 해당 기준에 부합하는 측정 포인트 집단과 그 외의 집단을 분리, 이 두 집단을 분류할 수 있는 분류 하이퍼플레인을 작성하였다. 그리고 공정능력분석을 이용하여 차폐효과 측정 데이터를 분석, 공정능력지수가 높은 측정 포인트와 서포트 벡터 머신의 하이퍼플레인으로 분류한 측정 포인트를 상호 비교함으로써 분류된 측정 포인트의 타당성과 차폐효과가 안정된 정도를 분석하였다. 분석 결과, 24개의 측정 포인트에서 안정된 차폐 성능을 보유하고 있음을 확인하였다. A military shelter for communication and information is necessary to optimize the integrated combat ability of weapon systems in the network centric warfare. Therefore, the military shelter is required for EMI shielding performance. This study examines the stable measurement points for EMI shielding effectiveness of a military shelter for communication and information. The measurement points were found by analyzing the EMI shielding effectiveness measurement data with data mining technique and process capability analysis. First, a support vector machine was used to separate the measurement point that has stable EMI shielding effectiveness according to set condition. Second, this process was conducted with process capability analysis. Finally, the results of data mining technique were compared with those of process capability analysis. As a result, 24 measurement points with stable EMI shielding effectiveness were found.

위암조직에서 p53 유전자의 돌연변이와 p53 단백질 발현

구기범(Ki-Beom Ku),박성훈(Seong-Hoon Park),정호영(Ho Young Chung),유완식(Wansik Yu),이명훈(Myung-Hoon Lee) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.4

Purpose: Variable changes occur in the progression from normal gastric epithelium to cancer, including many tumor, tumor suppressor and DNA repair genes, as well as growth factor and its receptors. The mutation and protein expression of the p53 gene may be useful prognostic factors, but their significance is still uncertain. Methods: Specimens from 296 gastric cancer patients, treated by a curative gastrectomy, between March 1999 and April 2001, at Kyungpook National University Hospital, were used. The p53 gene mutation was assessed using a polymerase chain reaction - single strand conformation polymorphism (PCR-SSCP) analysis, and the overexpression of tumor p53 protein using immunohistochemistry. The correlation between the results and clinicopathological parameters were then analyzed. Results: The mutation and protein overexpression of the p53 gene were shown in 61 (20.6%) and 124 (41.9%) tumors, respectively. Of the 61 cases with a p53 mutation, 43 (70.5%) showed overexpression of the p53 protein, and of the 235 without mutation of the p53 gene, 81 (34.5%) had no overexpression of the p53 protein, and also showed statistical significance (P<0.001). The mutation and protein overexpression of the p53 gene showed no significant differences according to age, gender, stage, location and gross type, but of the 138 intestinal and 128 of the diffuse types, 33 (23.9%) and 18 (14.1%) cases, respectively, showed p53 mutation (P=0.027); whereas, of the 150 well differentiated and 142 poorly differentiated tumors, 75 (50%) and 18 (33.8%), respectively, showed overexpression of the p53 protein. Also, of the 138 intestinal and 128 diffuse types, 71 (51.4%) and 43 (33.6%) showed overexpression of the p53 protein. There were no significant differences in the 5 year survival according to the mutation and protein overexpression of the p53 gene. Conclusion: The mutation and protein overexpression of the p53 gene, as assessed by PCR-SSCP and immunohistochemistry, respectively, showed a statistically significant correlation, but had little value as prognostic factors following a curative gastrectomy.

수술 후 조기 복강 내 화학요법을 시행받은 위암환자에서 p53 단백질 과발현과 생존율과의 관계

구기범(Ki-Beom Ku),박성훈(Seong-Hoon Park),권오경(Oh-Kyoung Kwon),정호영(Ho-Young Cheong),유완식(Wansik Yu) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.5

Purpose: In spite of curative surgery and early postoperative intraperitoneal chemotherapy, the prognosis of patients with gastric cancer involving the serosal surface is poor. The aim of this study was to analyze p53 protein overexpression in these patients and to clarify the usefulness of p53 mutation as a prognostic indicator. Methods: p53 protein overexpression was assessed by immunohistochemistry in 123 gastric cancer specimens. The correlation between p53 protein overexpression and clinicopathologic parameters and prognosis of the patients were analyzed. Results: Overexpression of p53 protein was identified in 67 (54.5%) tumors and was more frequent in differentiated tumors than in undifferentiated tumors (67.4% vs. 46.8%; P=0.026). However, there were no statistically significant differences in the frequency of p53 protein overexpression according to age, sex, depth of invasion, lymph node metastasis, distant metastasis, pathologic stage, and Lauren classification. There was no statistically significant difference in 5-year survival rate according to the p53 protein overexpression (P=0.565). Conclusion: Overexpression of p53 protein could not predict the effectiveness of early postoperative intraperitoneal chemotherapy. Therefore, it could not be used as a prognostic indicator in patients with advanced gastric cancer who underwent gastrectomy and early postoperative intraperitoneal chemotherapy.

유전알고리즘을 이용한 오피스 건물의 피크전력 감소를 위한 일일 예냉설정온도 최적화 연구

구기범(Ki Beom Ku),정신규(Shin Kyu Jeong) 대한설비공학회 2022 설비공학 논문집 Vol.34 No.1

In this paper, the peak electric power of an office building was reduced with a precooling strategy. Precooling was conducted two hours before work time. Set-point temperatures for precooling were optimized using a genetic algorithm to minimize daily peak electric power. Searching for optimized set-point temperature was conducted with an objective function that was developed with a multiple regression model. The regression model used dry-bulb temperature, relative humidity, and the set-point temperature as the input parameters, and set daily peak power of the building as the output parameter. Model data were collected from ‘EnergyPlus’, a building energy simulation program. The applied building was ‘Medium Office’ provided by EnergyPlus. Based on our results, there was a 0.71~5.64% reduction in daily building peak power with the application of the optimized precooling setpoint temperature. In addition, the reduction of electricity cost due to the reduction of peak electric power was observed.

활용 가능 기상 예보 인자를 이용한 건물 소비 전력 예측 모델 개발

구기범(Ki Beom Ku),정신규(Shin Kyu Jeong) 대한설비공학회 2015 대한설비공학회 학술발표대회논문집 Vol.2015 No.11

In this study, building energy prediction models were constructed using kriging model. 12 prediction models were constructed by monthly, and each model predicting daily building energy hourly. Kriging model was used for building energy modeling. Building energy model data were accumulated by EnergyPlus. As design variables, available weather forecasting factors from KMA were used. To obtain accurate building energy prediction value, this study used variogram to analyze correlation between building energy data. As the result of variogram analysis, a proper kriging correlation function was selected. Each model showed predictability of MBE 1~5%.

위암조직에서 p53 유전자의 돌연변이

구기범,박성훈,정호영,이명훈,유완식,Ku, Ki-Beom,Park, Seong-Hoon,Cheong, Ho-Young,Lee, Myung-Hoon,Yu, Wan-Sik 대한위암학회 2006 대한위암학회지 Vol.6 No.4

목적: 종양 억제, 세포 주기 조절 및 세포 고사의 기능과 연관 있는 유전자인 p53은 인간 종양에서 가장 흔히 발견되는 돌연변이 유전자로 알려져 있다. 위암에 있어서 p53의 돌연변이 정도와 생존율 등을 비교하여 각각의 상관관계와 예후 인자로써의 유용성에 대해 알아보고자 하였다. 방법: 1999년 3월부터 2001년 4월까지 경북대학교병원에서 위암으로 수술한 331명 환자의 조직을 이용하여, polymerase chain reaction single-strand conformation polymorphism 방법으로 p53 돌연변이를 확인하고, 환자의 임상 병리학적 인자와의 관계를 비교하였고, 환자의 생존율을 비교하였다. 결과: 전체 331명의 환자들의 조직 중 66예(19.9%)의 조직에서 p53 돌연변이가 관찰되었다. 이들 66예 중에서 exon 5에서 23예, exon 6에서 8예, exon 7에서 21예, exon 8에서 17예의 돌연변이를 보였는데, 이중 3예에서 2개의 exon에 돌연변이(exon 5와 exon 6, exon 6과 exon 7, exon 6과 exon 8)를 보였다 p53 돌연변이는 나이와 성별, 육안형, 병리학적 병기, 조직학적 분류, 종양의 위치에 따라서 차이는 없었으나, 장형 156예 중 36예(23.1%), 미만형 145예 중 19예(13.1%)로 유의한 차이가 있었고(P=0.007), p53 돌연변이에 따른 생존기간은 유의한 차이가 없었다(P=0.632). Exon 5는 장형(9.7%)에서 미만형(2.8%))보다 p53 돌연변이 빈도가 높았고(P=0.024), 림프절 전이가 있는 군에서 림프절 전이가 없는 군보다 p53 돌연변이의 빈도가 유의하게 높았다(25.0% vs 15.6%, P=0.034). 나머지 항목에서는 통계학적으로 유의한 차이가 없었다. 근치적 절제술을 시행한 예에서의 p53 돌연변이에 따른 생존율은 유의한 차이를 보이지 않았다(P=0.704). 결론: p53 돌연변이는 위암 환자의 예후인자로써 가치가 충분하지 않다. Purpose: p53 is one of the most commonly mutated genes in human tumors. The aim of this study was to analyze p53 mutation in gastric cancer and its correlations with the clinicopathologic variables to clarify the usefulness of p53 mutation as a prognostic factor. Materials and Methods: Specimens from 331 patients with gastric cancer who underwent a gastrectomy between March 1999 and April 2001 at the Kyungpook National University Hospital were used. p53 gene mutations were assessed by using a polymerase chain-reaction single-strand conformation polymorphism (PCR-SSCP) analysis. The correlations between p53 gene mutation and clinocopathologic parameters were analyzed. Results: p53 mutations were found in 66 (19.9%) tumors. Among those 66 cases, mutations were seen in 23 tumors at axon 5, in 8 at exon 6, in 21 at exon 7, and in 17 at exon 8. Two mutations were shown in 3 tumors. Thiriy-six (23.1%) of 156 intestinal-type tumors and 19 (13.1%) of 145 diffuse-type tumors showed p53 gene mutation (P=0.007). The frequency of p53 gene mutation didn't show any significant differences according to age, sex, stage, location, or gross type. Exon 5 mutations showed more frequently in intestinal-type tumors than in diffuse-type tumors (9.7% vs. 2.8%, P=0.024), and p53 mutation were more frequent in lymph nodes metastasis group than lymph nodes non-metastasis group with statistical significance (25.0% vs 15.6%, P=0.034). The five-year survival rate showed no statistically significant difference with p53 mutation (P=0.704). Conclusion: p53 mutations assessed by PCR-SSCP had little value as a prognostic factor after gastrectomy in patients with gastric cancer.

위암 환자의 골수에서 발견된 Cytokeratin 양성세포의 임상적 의의

신정혜,구기범,박성훈,정호영,배한익,유완식,Shin, Jung-Hye,Ku, Ki-Beom,Park, Seong-Hoon,Chung, Ho-Young,Bae, Han-Ik,Yu, Wan-Sik 대한위암학회 2006 대한위암학회지 Vol.6 No.4

목적: 암 환자의 골수에서 발견되는 cytokeratin 양성세포와 암의 재발과의 상관관계에 대해서는 알려진 바가 많지 않다. 이에 위암환자의 골수에서 발견되는 cytokeratin 양성세포가 위암 환자의 재발과 생존율을 예측할 수 있는지 알아보고자 하였다. 대상 및 방법: 1998년 6월부터 2000년 7월까지 경북대학교병원 외과에서 원발성 위암으로 수술받은 환자 419명을 대상으로 하였다. 수술 직전 장골능선에서 골수를 흡인하여 단핵구를 분리하고 항 cytokeratin 항체를 이용하여 면역세포화학적 염색을 하였다. 결과: Cytokeratin 양성세포는 219예(52.4%)에서 발견되었고, 위암의 침윤깊이(P=0.021), 병기(P=0.026)에 따라서 통계학적으로 유의한 차이가 있었으나, 암의 위치, 육안형, 림프절전이, 원격전이, 분화도에 따라서는 유의한 차이가 없었다. 골수의 cytokeratin 양성세포 유무에 따른 5년 생존율은 유의한 차이가 없었고(P=0.248), 재발여부, 재발부위도 유의한 차이가 없었다. 결론: 위암 환자의 골수에서 cytokeratin 양성세포 유무는 예후인자로 사용되기 어렵고 재발양상을 예측하기도 어렵다. Purpose: Controversy still exists over in the prognostic significance of microscopic tumor cell dissemination in patients with cancer. This study evaluated the prognostic implication of isolated tumor cells in the bone marrow of patients with gastric cancer. Materials and Methods: Four hundred nineteen (419) patients who underwent surgery for gastric cancer between June 1998 and July 2000 were enrolled in the study. Bone marrow aspirate was obtained from the iliac crest before removal of the primary tumor. Mononuclear cells were isolated and stained with AE-1/AE-3 PAN-CYTOKERATIN. Results: Cytokeratin-positive cells were found in the bone marrow of 219 patients (52.3%). The incidence varied significantly with the depth of invasion (P=0.021) and the stage (P=0.026). The five-year survival rate of patients with cytokeratin-positive cells was 74.1% and that of patients without cytokeratin-positive cells was 81.1%(P=0.2481). There were no significant differences in the recurrence rate and the site of recurrence according to whether or not cytokeratin-positive cells were present in the bone marrow. Conclusion: The presence of cytokeratin-positive cells in the bone marrow of patients with gastric cancer did not predict outcome and recurrence. Therefore, it cannot be used as a prognostic factor.

엔진 발전기 추가 적용을 통한 軍 지휘 · 지원차량의 광대역 전자파 방사 노이즈 개선

서석호(Suk Ho Seo),구기범(Ki Beom Ku),김지훈(Ji Hoon Kim),오대산(Dae San Oh) 한국산학기술학회 2020 한국산학기술학회논문지 Vol.21 No.9

현재 운영되고 있는 군 지휘 · 지원차량은 상용차량의 일부를 개조하여 제작되었으며, 군에서 필요한 통신장비 운용환경을 확보하기 위하여 통신실 내부에 별도의 컨버터를 장착하는 전원공급시스템이 적용되었다. 하지만, 이러한 전원공급시스템은 전자파 방사 노이즈를 발생시켜 차량에서 무전교신 시 잦은 잡음과 통신감도 저하 등의 문제점이 발생되었다. 이를 개선하기 위해, 엔진에 발전기를 추가 장착하여 통신장비에 필요한 전력을 공급받도록 전원공급시스템을 변경하였다. 추가 장착된 발전기는 통신장비가 운용되는 통신실과 완전히 분리된 엔진 룸에 위치하도록 설계되어 전원공급시스템에서 발생되는 전자파 방사 노이즈에 의한 영향을 감소시켜줄 것으로 기대되었다. 개선된 시스템의 효과를 검증하기 위하여 기존 차량과 신규 전원공급시스템이 적용된 차량에 대하여 광대역 방사시험을 각각 수행하였고 측정 결과를 비교하였다. 시험 결과 신규 전원공급시스템이 적용된 차량의 광대역 방사 노이즈는 국내 자동차 안전기준에 모두 만족하였으며, 기존 차량 대비 일부 주파수 구간을 제외한 대부분의 구간에서 감소함을 확인할 수 있었다. 특히, 차량 우측면의 수직편파 170~225 ㎒ 구간에서 최대 10.751 ㏈㎶/m 감소하였다. The military tactical vehicle currently being operated is manufactured by improving the parts of commercial vehicles. In addition, the power supply system is applied by installing a separate converter inside the communication room to secure the operating environment of communication equipment. On the other hand, due to electromagnetic radiation noise, there are problems in frequent noise and deterioration in communication sensitivity during wireless communication in vehicles. To improve these, an advanced power supply system is applied, which is also equipped with an alternator to receive power required for communication equipment reducing broadband electromagnetic radiation noise. An additionally installed alternator, which is located in the engine room, is separated from the communication room where communication equipment is operated and is expected to reduce the effect of electromagnetic radiation noise generated from the power supply system. To verify these, a broadband radiation test was performed on a previous and advanced one. As a result, the broadband radiation noise of vehicles with an applied advanced power supply system satisfied all of the domestic vehicle safety standards and reduced in most of the sections except for some frequencies compared to previous typed vehicles. In particular, broadband radiation noise was decreased by up to 10.751 ㏈㎶/m in the vertical sections in 170 to 200 ㎒ on the right side of the vehicle.

뇌혈관질환 환자에 대한 청심연자탕(淸心連子湯), 도담탕(導痰湯), 혈부축어탕(血府逐瘀湯), 보신익뇌탕(補腎益腦湯)의 간기능과 신기능 안전성 평가 : 후향적 연구

김민화,조임학,남이랑,김마리아,구기범,이세연,권정남,이인,홍진우,윤영주,김소연,한창우,박소정,최준용,신현규,Min-hwa Kim,Im-hak Cho,I-rang Nam,Maria Kim,Ki-beom Ku,Se-yeon Lee,Jung-nam Kwon,In Lee,Jin-woo Hong,Young-ju Yun,So-yeon Kim,Chang-woo Han 대한한방내과학회 2023 大韓韓方內科學會誌 Vol.44 No.3

Objectives: As Korea transitions into an aging society, the incidence of cerebrovascular disease is expected to increase. Herbal medicine is commonly used in Oriental medicine to treat cerebrovascular disease. However, there is insufficient clinical evidence to actively support the safety of herbal medicine in clinical practice. Therefore, the aim of this study was to determine the toxicity and safety of four herbal medicines (Cheongsimyeonja-tang, Dodam-tang, Hyeolbuchukso-tang, and Boshiniknai-tang) in patients with cerebrovascular disease. Methods: This study used electronic medical records to analyze patients admitted to an oriental medicine hospital from April 1, 2017, to December 31, 2020. Liver and renal function values at the time of admission and discharge were compared. Results: A total of 25 patients were included in this study. We found no significant differences in various variables, such as complete blood count, liver-renal function test, and urine, before and after the administration of the four herbal medicines. Additionally, no significant adverse events related to herbal medicine were observed. Conclusions: This study confirmed the safety of the four herbal medicines in patients with cerebrovascular disease who were hospitalized in a single Oriental medicine hospital.