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Henoch-Schönlein Purpura with Concurrent Cytomegalovirus Duodenitis
신새봄,최영진,이지은,곽봉기,김용희,하경선,강진형 대한감염학회 2017 Infection and Chemotherapy Vol.49 No.2
Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving the small vessels with distinct clinical features. The etiology of HSP is diverse, and viral infection is one of the many predisposing factors. Cytomegalovirus (CMV) infection mostly affects immune-suppressed patients, but rarely patients with normal immunity can also be affected. Authors experienced a case of HSP patient, with underlying small-cell lung cancer (SCLC) with CMV duodenitis. This is a rare case of HSP diagnosed in SCLC patient with predisposing factor of CMV infection.
ZnSO₄비내 점적으로 손상된 마우스 후각상피 및후구의 회복경과에 따른 면역조직학적 연구
김명원,문영화,김병국,곽봉기,박용진 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.4
Background and Objectives:The purpose of this study was to evaluate the time course of functional and anatomical recovery of the olfactory epithelium (OE) and olfactory bulb (OB) following intranasal instillation of 1% ZnSO4 in mice. Materials and Method:Two groups of mice, normal control group (intranasal instillation of normal saline, n=6) and experimental group (intranasal instillation of ZnSO4, n=18), were studied. Tissues of olfactory pathways were obtained at 1, 3 and 5 weeks after bilateral intranasal instillation of 1%, 100 μl ZnSO4 solution, and processed for immunohistochemistry using antisera, olfactory marker protein (OMP), proliferating cell nuclear antigen (PCNA) and tyrosine hydroxylase (TH) to evaluate the olfactory regeneration. For histological study, OE thickness stained with hematoxylin-eosin was analyzed. Results:At 1 week after ZnSO4 intranasal instillation, the lowest peak of OMP expression in OE appeared. Then the number of OMP-positive cells increased progressively at weeks. However, PCNA expression in OE showed quite the opposite. In the corresponding OB at 1 week, there was decrease of TH-positive cells and at 3 weeks, there was few TH-positive cells. At 5 weeks, there was increase in the number of TH-positive cells again. OE thickness was reduced to 20% of control OE at 1 week, and was significantly recovered to 80% of control OE at 5 weeks. Conclusion:Our results demonstrated that intranasal instillation of 1% ZnSO4 to mice produces a brief, reversible but essentially complete destruction of functional connection from the olfactory epithelium to the main olfactory bulb. (Korean J Otolaryngol 2006;49:395-401)
안면 신경 마비 환자의 측두골 자기공명영상 소견:벨마비 및 귀 대상포진의 비교
박시내,김현수,정소령,박경호,김범수,곽봉기,박준욱,이석은,여상원 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.7
Background and Objectives:Magnetic resonance imaging (MRI) is a valuable and important tool for use in diagnosing and investigating diseases affecting the facial nerve. However, there are few reports investigating the difference in the MRI findings of Bell’s palsy and Ramsay Hunt syndrome. in order to evaluate the difference in the clinical values regarding these two groups of facial nerve palsy syndrome. In this study, we observed the MRI findings to investigate the value of MRI and its clinical significance in those two different groups of facial nerve palsy. Subjects and Method:Fourty-eight patients of Bell’s palsy or herpes zoster oticus, who were admitted to Kangnam St. Mary’s Hospital from January 1998 to December 2003, were selected to assess the results of gadolinium enhanced MRI. The frequency and the site of the facial nerve enhancement and its correlation with electroneuronography (ENoG), the time interval of the palsy to MRI, and initial ESR levels were observed in both groups of facial nerve palsy. Results:On gadolinium enhanced MRI, 16 of 24 patients with Bell’s palsy and 22 of 24 patients with herpes zoster oticus had contrast enhancement in the meatal, labyrinthine segments and geniculate ganglion. The number of enhanced segments was significantly larger in the patients with herpes zoster oticus than in the patients with Bells palsy (p<0.05). There has been significant correlation between the number of enhanced segment of the facial nerve and the result of ENoG in the patients with herpes zoster oticus (p<0.05). Conclusion:Gadolinium enhanced MRI (Gd-MRI) studies may predict the extent of lesion within the course of the facial nerve and its clinical value as a prognostic factor could be suggested in patients with herpes zoster oticus.