폐의 신경내분비 종양의 세침흡인 세포검사 소견

고재수,Koh, Jae-Soo 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.1

The major categories of neuroendocrine tumors of lung are typical carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma. The histologic classification criteria of neuroendocrine tumors are well documented in the "WHO Classification of Tumors" based on mitotic figures and necrosis. Cytologic characteristics of neuroendocrine tumors are trabecular, acinar, and solid arrangement of tumor cells and occasional rosette formation. Nuclear chromatin patterns are characteristically described as "salt and pepper chromatin pattern". Many of cytologic classifications documented in the literature are before the "WHO Classification". In this review, the cytologic features of pulmonary neuroendocrine tumors are documented according to the WHO classification, and recent concepts of neuroendocrine tumors of lung are discussed.

담즙 세포학 표본 362건의 검색

고재수,하창원,명나혜,조경자,장자준,Koh, Jae-Soo,Ha, Chang-Won,Myong, Na-Hye,Cho, Kyung-Ja,Jang, Ja-June 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.2

A total of 362 bile samples from 104 patients with evidence of biliary tract obstruction were submitted for diagnostic cytology from January, 1989 to April, 1991. The patients were classified based on the obstructive cause, and the cytologic results were reviewed. 298 of the specimens were from patients with intrabiliary malignant structure, and 17 were from patients with extrabiliary malignant compression or benign biliary obstruction. Bile cytology was positive for carcinoma in 42 samples from patients with intrabiliary malignant stricture, and the diagnostic sensitivity was 14%. There were no false positive cases. We concluded that the cause of low sensitivity was degenerative change of cell due to prolonged sampling time. What is noteworthy was the high prevalence of Clonorchis sinensis eggs, being detected in 25 patients with intrabiliary malignancy, supporting the association between clonorchiasis and biliary tree malignancy.

다발성 골수종 1예의 체액 세포학적 소견

고재수,하창원,조경자,장자준,Koh, Jae-Soo,Ha, Chang-Won,Cho, Kyung-Ja,Jang, Ja-June 대한세포병리학회 1992 대한세포병리학회지 Vol.3 No.2

A case of multiple myeloma with massive pleural effusion is reported. A 53 year-old previous known multiple myeloma patient vistited our hospital complaining of cough with sputum. Radiologic study revealed multiple osteolytic bony lesions and left side pleural effusion. The effusion were bloody exudates containing numerous atypical plasma cells. The tumor cells showed pleomorphism, eccentric nuclei, prominent nucleoli, perinuclear halo, multincleation, and chromatin patterns of occasional cart-wheel appearance. The cytological examination of pleural fluid established the malignant nature of the effusion with multiple myeloma.

횡문근육종의 체액 세포학적 소견 - 3례 보고 -

고재수,하창원,조경자,장자준,Koh, Jae-Soo,Ha, Chang-Won,Cho, Kyung-Ja,Jang, Ja-June The Korean Society for Cytopathology 1993 대한세포병리학회지 Vol.4 No.1

Cytologic findings of pleural effusion in three cases of rhabdomyosarcoma are reported. Case 1 was a pleomorphic rhabdomyosarcoma which had devoped at the chest wall of an elderly male patient and caused pleural effusion. The cytologic features were consistent with pleomorphic rhabdomyosarcoma, that was, showing loose clusters, cellular pleomorphism, and abundant finely vesicular cytoplasm. Cases 2 and 3 were embryonal rhabdomyosarcomas in young adults. Primary site was the oral cavity in case 1, but unknown in case 2 and case 3. The effusion cytology was similar in these cases. Clustered or isolated small round cells with hyperchromatic nuclei and scanty cytoplasm were smeared. The cohesiveness of tumor cells was weak and the cells did not show linear arrangement or nuclear melding. Effusion cytology in a sarcoma patient would be diagnostic when the primary site and the type of sarcoma were already known. 저자들은 비교적 접할 기회가 흔치 않은 횡문근육종의 체액 세포학 3예를 경험하였기에 그 임상 소견과 함께 세포학적 소견을 간결히 기술하였다. 제 1예는 흉벽에 다형 횡문근육종이 있는 환자의 늑막 삼출액 소견으로서, 세포들은 느슨한 군집을 형성하거나 개별적으로 흩어져서 도말되었고 핵은 다형성이 심하였으며 다핵을 가지는 세포도 관찰되었고 과염색상을 보였다. 횡문근육종의 특이 소견인 가로무늬는 관찰되지 않았고 세포질은 미세 공포형이었다. 나머지 2예는 구강 원발성 및 원발 병소를 알수 없는 배형 횡문근육종으로서 이들의 늑막 삼출세포학적 소견은 서로 유사하였다. 군집을 형성하거나 개별적으로 흩어진 세포들은 작고 둥근 세포들로서 이들은 미미한 세포질과 과염색상의 핵을 가지고 있었으며 소 세포 암종에서 관찰되는 염주형 배열 또는 주물 현상은 인정되지 않았다. 육종의 체액 세포학은 원발 병소및 아형이 알려진 경우에 진단적이라고 여겨진다.

"Atypical Squamous Cells of Undetermined Significance"의 질적 분류와 조직 소견과의 비교

고재수,정진행,이승숙,조경자,Koh, Jae-Soo,Chung, Jin-Haeng,Lee, Seung-Sook,Cho, Kyung-Ja 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.1

To evaluate whether different qualifications of a cytologic diagnosis of "atypical squamous cells of undetermined significance(ASCUS)" predict a greater or lesser likelihood of tissue diagnosis of uterine cervix, we compared different cytologic qualifications of ASCUS with the tissue diagnosis. One hundred twenty-two consecutive Papanicolaou smears showing ASCUS in women who had undergone cervical biopsy within nearest 30 days were collected. The 122 smears were qualified as "favor reactive"(25%), "favor low grade squamous intraepithelial lesion (LSIL)"(24%), "favor squamous intraepithelial lesion(SIL)"(16%), "favor high grade squamous intraepithelial lesion(HSIL)"(16%), and "not otherwise specified"(19%). Squamous intraepithelial or invasive lesion was pathologically confirmed by cervical biopsy in 13%, of the "favor reactive", 27% in "favor LSIL", 70% in "favor SIL", 75%, in "favor HSIL", and 35% in "not otherwise specified" smears. There were significant associations between the favor reactive smear and the benign biopsy finding and between the favor SIL smear and the biopsy shewing a squamous intraepithelial or more severe lesion. Nevertheless, most of favor LSIL smears exhibit reactive process in tissue biopsy. Conclusively, qualified ASCUS stratifies women Into different risk groups for SIL. The cytopathologist should make the cytologic diagnosis of "ASCUS, favor LSIL" circumspectly.

호지킨 림프종과 역형성 대세포 림프종의 세침흡인 세포소견 비교

고재수,박선후,김민석,조수연,정수영,유한석,김정순,하화정,류백렬,이승숙,Koh, Jae-Soo,Park, Sun-Hoo,Kim, Min-Suk,Cho, Soo-Youn,Chung, Soo-Young,Ryu, Han-Suk,Kim, Jung-Soon,Ha, Hwa-Jung,Ryoo, Baek-Youl,Lee, Seung-Sook 대한세포병리학회 2006 대한세포병리학회지 Vol.17 No.2

To study the differentiating cytomorphological features of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) using fine needle aspiration cytology (FNAC), cytomorphological features of 16 patients with HL (n=8) or ALCL (n=8) were analyzed. In the initial cytological diagnosis prior to biopsy, HLs were properly diagnosed in 4 out of 8 cases (4 HL, 2 atypical, 2 benign), whereas all ALCL were diagnosed as malignancies. However, correct diagnosis of non-Hodgkin lymphoma (NHL) was made in only two ALCL patients (2 NHL, 1 HL, 1 sarcoma, 4 malignancy without specific type). Overall, the percentage of large abnormal cells ranged from 30% to 90% in ALCL except for one case, whereas it was less than 5% in all 8 HL. A spectrum of atypical cells was more characteristic of ALCL. In contrast, HL showed an sharp difference between reactive lymphoid cells and neoplastic ones (bimorphic pattern). Moreover, the emergence of kidney-shaped abnormal cells or wreath-like multinucleated cells was helpful in diagnosing ALCL. The combination of thesefeatures would be useful in differentiating HL and ALCL. Nevertheless, these two types of lymphomas cannot be definitely distinguished based on cytomorphological features alone. Therefore, the aim of FNAC would be to suggest a specific diagnosis and indicate the need for a biopsy.

모기질 세포종의 흡인 세포학 - 전이성 암종으로 오진된 2예 보고 -

고재수,하창원,조경자,장자준,Koh, Jae-Soo,Ha, Chang-Won,Cho, Kyung-Ja,Jang, Ja-June The Korean Society for Cytopathology 1993 대한세포병리학회지 Vol.4 No.1

35세 및 22세 여자의 경부에 생긴 종괴의 세침흡인 세포학적 검사에서 악성이 의심되는 병변 및 악성 병변으로 오진되었던 모기질 세포종 2예의 세포학적 소견을 기술한다. 핵 세포질의 비율이 높고 뚜렷한 핵소체를 보이는 기저양 세포, 농염성 핵을 가진 각화된 편평상피세포, 이물형 거대세포 및 괴사성 배경을 보였고, 후속하여 보았을 때 이러한 소견은 모기질 세포종의 특이적인 소견으로서 악성 종양으로 보기에는 염색질의 분포가 균질하고 핵들의 다형성이 없는 점이 악성 종양과는 구별되는 소견이었고, 모기질 세포종은 경부 종괴 및 여하한 부위의 피하 종괴의 세침 흡인에서 상기의 소견을 보일 때 감별 진단의 하나로서 고려해야한 양성 병변이다. We describe cytologic findings of two cases of pilomatrixoma which had been cytologically misdiagnosed as suspicious malignant and malignant lesions in 35 year-old and 22 year-old females who presented a palpable neck mass. The cytologic smears showed many basaloid cells with a high nuclear-cytoplasmic ratio, nuclear hyperchromatism and prominent nucleoli, keratinized squamous cells with pyknotic nuclei, foreign body giant cells, and chronic inflammatory cells in necrotic back-ground. Retrospective view of this aspiration smear revealed that these findings were characteristic features of pilomatrixoma, and the evenly distributed chromatin pattern as well as the lack of nuclear pleomorphism were considered to be the differential points from malignant neoplasm. Pilomatrixoma is a benign neoplasm which should be included in differential diagnosis if the fine needle aspiration cytologic smear of a neck mass or subcutaneous mass of any site showed these features.

가족기능성과 학교적응유연성의 관계에서 청소년 스마트폰 중독의 매개효과 검증

고재수(Jae-Soo Ko) 한국콘텐츠학회 2014 한국콘텐츠학회논문지 Vol.14 No.6

본 연구는 가족기능성과 스마트폰 중독이 학교적응 유연성에 미치는 영향과 스마트폰 중독이 매개효과를 가지는지를 알아보기 위해 구조방정식 모형을 사용하여 검증하였다. 조사대상자는 부산지역 초등 5, 6학년과 중학교 1, 2, 3학년을 대상으로 설문지를 통해 자료를 수집하였으며, 자료수집 기간은 2013년 3월 한 달 동안 이루어졌다. 연구결과, 가족기능성은 스마트폰 중독에 부적(-)영향을, 학교적응 유연성에는 정적(+)영향을 미치는 것으로 나타났으며, 스마트폰 중독은 가족기능성과 학교적응 유연성 간의 관계에서 부분매개 효과를 가지는 것으로 나타났다. 이러한 연구결과를 중심으로 청소년 스마트폰 중독에 대한 사회적 관심제고를 위한 방안과 함께 스마트폰 중독의 예방 및 치료적 개입을 위한 가정 및 학교에 대한 개입 방안을 제언하였다. This study aims to examine the effects of adolescents’ family function and School adjustment resilience on smartphone addiction through verification using the structural equation model. To attain the goal, the study collected data through a survey to elementary school fifth and sixth graders and middle school students living in Busan during March in 2013. The result of this study shows that family function exerts negative effects on smartphone addiction and positive effects on school adjustment resilience. And smartphone addiction is found to show partial mediating effect sin the relations between family function and school adjustment resilience. Based on the above results of this study, the paper suggests measures to enhance social interest in adolescent smartphone addiction and also methods to prevent smartphone addiction and intervene with families and schools for therapeutic intervention.

260K COLOR SMALLL TFT LCD DRIVER CHIP SET

고재수(Jae-Su Ko),이원효(Won-hyo Lee),김보성(Bo-Sung Kim),박원경(Kyoung-Won Park),홍순양(Soon-yang Hong) 대한전자공학회 2002 대한전자공학회 학술대회 Vol.2002 No.11

친환경 자동차, 대용량 조명장치 등에 적용이 가능한 전력변환장치(다상 교호 강압 컨버터)의 특성에 대한 연구

고재수 ( Jae Su Ko ),조은석 ( Eun Seok Cho ),이용근 ( Yong Keun Lee ) 서울과학기술대학교 과학문화전시디자인연구소 2014 한국과학예술융합학회 Vol.18 No.-

A step-down non-isolated Buck converter is a common and basic topology in the field. We analyzed the Characteristic of Multiphase Interleaved Buck Converter in DCM(Discontinuous Current Mode) and CCM(Continuous Current Mode) for law ripple and high efficiency1). Multiphase buck converter has more advantages than other topology. Input current of converter is divided into each converters because of the structure. it has features of decreasing input current ripple and increasing efficiency of converter. So we can reduce the size of Capacitor and Inductor2). It means that the size of system is also reduced3). The Time Reverse Recovery loss of diode was also affected4)5), the TRR loss was confirmed to be negligible in the 120kHz 8 Phase case despite the CCM situation. In this study, the effects of the loss factors were analyzed on the efficiency of the multiphase interleaving buck converter in DCM and CCM, and it would be helpful to design a more efficient converter by effectively controlling the factors of each loss. At least, we tested the performance of the analyzed system with PSpice.