신경망 모델과 정신의학

고인송,Koh, InSong 대한생물정신의학회 1997 생물정신의학 Vol.4 No.2

Neural network models, also known as connectionist models or PDP models, simulate some functions of the brain and may promise to give insight in understanding the cognitive brain functions. The models composed of neuron-like elements that are linked into circuits can learn and adapt to its environment in a trial and error fashion. In this article, the history and principles of the neural network modeling are briefly reviewed, and its applications to psychiatry are discussed.

신경망 모델에서 시냅스 소실이 기억력에 미치는 효과

고인송,박정욱,최병걸,김창근,윤선희 대한신경과학회 2000 대한신경과학회지 Vol.18 No.1

신경정신질환의 컴퓨터모델 개발에 관한 연구

고인송,박정욱,Koh, In-Song,Park, Jeong-Wook 대한생물정신의학회 1999 생물정신의학 Vol.6 No.1

In order to understand the pathogenesis and progression of some synaptic loss related neuropsychiatric diseases, We attempted to develop a computer model in this study. We made a simple autoassociative memory network remembering numbers, transformed it into a disease model by pruning synapses, and measured its memory performance as a function of synaptic deletion. Decline in performance was measured as amount of synaptic loss increases and its mode of decline is sudden or gradual according to the mode of synaptic pruning. The developed computer model demonstrated how synaptic loss could cause memory impairment through a series of computer simulations, and suggested a new way of research in neuropsychiatry. 뇌공학 분야에서 개발된 연상기억의 능력을 가지는 Hopfield 신경망을 구성하고, 신경정신질환 중에서 시냅스의 손실과 관련이 되어서 생기는 치매와 일부 정신분열증의 모델로 변형시키기 위하여 인공신경망의 시냅스를 Hoffman의 시냅스 제거법칙과 무작위 방법에 따라 제거하면서, 그에 따른 기억능력의 변화를 관찰하였다. 구성된 컴퓨터모델에서 기억능력의 저하는 시냅스의 감소가 상당히 진행되어야 나타났으며, Hoffman의 시냅스 제거법칙에 따랐을 때는 80% 제거를 기점으로 급격하게 나타났으며, 무작위 제거시는 더 적은 시냅스 제거율인 40% 제거 때부터 점진적으로 나타나는 양상을 보였다. 컴퓨터 모델의 기억력저하 양상이 실제환자에서 관찰되는 기억력저하 양상을 설명할 수 있기 위해서는 증상이 발현되는 시점의 시냅스 소실의 정도는 얼마나 되는지, 또한 시냅스의 소실은 어떤 규칙에 의해 일어나는지 아니면 무작위로 일어나는지에 관한 생물학적 실험의 필요성이 부각되었다. 이와 같이 컴퓨터모델을 이용하여 모의실험을 하고 연구의 방향을 잡은 후에 생물학적 실험으로 검증해 나간다면, 매우 효율적인 이론과 실험의 공조체제를 이루어 신경정신질환의 이해를 도울 수 있을 것이다.

Extracting Bandpass Filters in Ocular Dominance Column Formation Models

고인송 국립보건연구원 1999 국립보건원보 Vol.36 No.-

유전체의학(Genomic Medicine)과 생명정보학(BioMedical Informatics)

고인송,Go, In-Song 한국과학기술정보연구원 2004 지식정보인프라 Vol.16 No.-

Phenylephrine이 토끼 유두근의 수축력과 활동전압에 미치는 영향

이영배,고인송,박종완,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1989 中央醫大誌 Vol.14 No.1

In order to clarify the receptor types and mechanisms underlying the positive inotropic effect of phenylephrie on the mammalian ventricular myocardium, the action potential, its first derivatives and isometric contraction of the rabbit papillary muscle were recorded using a free transducer and glass capillary microelectronics filled with 3M KCI, and results were analyzed. The results were as follows; l. In normal Tyrode solution, the contractile force was increased with increments of phenylephrine concentration and maximum effect was reached at the stimulation frequency of 1 Hz in 10^-5 M phenylephrine. 2. In 22 mM K^+-Tyrode solution, the maximum rate of rise (Vmax) of action potential, overshoot and the duration oction potential were significantly increased with increments of phenylephrine concentration (10^-6 ~ 10^-4 M). 3. The negative inotropic effect induced by verapamil was reversed by phenylephrine. 4. Phentolamine (3x10^-6 M) shifted the dose response curve for phenylephrine to the right more than propranolol (10^-6 M) did. The above results may be interpreted as follow; The positive inotropic effect of phenylephrine is caused by increase in slow inward current (Ca^2+influx into the myocardial cell), and is mediated through α- and β-adrengergic receptors in the rabbit pailary muscle

RNA-Seq for Gene Expression Profiling of Human Necrotizing Enterocolitis: a Pilot Study

정규환,고인송,김정현,정현섭,박태진,남소현,정수민,Cherry Ann Sio,김수영,정의석,이병국,김혜림,신은,정성은,최창원,김병일,정은영,신형두 대한의학회 2017 Journal of Korean medical science Vol.32 No.5

Necrotizing enterocolitis (NEC) characterized by inflammatory intestinal necrosis is a major cause of mortality and morbidity in newborns. Deep RNA sequencing (RNA-Seq) has recently emerged as a powerful technology enabling better quantification of gene expression than microarrays with a lower background signal. A total of 10 transcriptomes from 5 pairs of NEC lesions and adjacent normal tissues obtained from preterm infants with NEC were analyzed. As a result, a total of 65 genes (57 down-regulated and 8 up-regulated) revealed significantly different expression levels in the NEC lesion compared to the adjacent normal region, based on a significance at fold change ≥ 1.5 and P ≤ 0.05. The most significant gene, DPF3 (P < 0.001), has recently been reported to have differential expressions in colon segments. Our gene ontology analysis between NEC lesion and adjacent normal tissues showed that down-regulated genes were included in nervous system development with the most significance (P = 9.3 × 10−7; Pcorr = 0.0003). In further pathway analysis using Pathway Express based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, genes involved in thyroid cancer and axon guidance were predicted to be associated with different expression (Pcorr = 0.008 and 0.020, respectively). Although further replications using a larger sample size and functional evaluations are needed, our results suggest that altered gene expression and the genes' involved functional pathways and categories may provide insight into NEC development and aid in future research.

위 유문동근 K^+ - 경축에 미치는 Vanadate의 효과

김충수,고인송,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1988 中央醫大誌 Vol.13 No.3

Effects of vanadate on the spontaneous contraction and the high K^+-induced contracture of guinea pig’s pyloric antral smooth muscles were observed in the various Na^+ and/or Ca^+ of bathing solutions. Following results were obtained; 1. Basal tension and developed tension of the spontaneous activity were increased by vanadate and the membrane potential tended to be depolarized. 2. Phasic contracture increased, tonic contracture decreased as the outside K^+ concentration increased and the both components were increased by vanadate. 3. In the case of absence of K^+ and/or Na^+, the contracture were hardly developed and the spontaneous, rhythmic contraction were sustained. 4. Effects of vanadate on the K^+-contracture and the Ca^2+-sensitivity of the Phasit and tonic components were prominent in the presence of Na^+. The above results suggested that vanadate would increase the voltage-dependent calcium current in smooth muscle cells of the pyloric antrum.

The Effect of Increasing Control-to-case Ratio on Statistical Power in a Simulated Case-control SNP Association Study

강문수,최선희,고인송 한국유전체학회 2009 Genomics & informatics Vol.7 No.3

Generally, larger sample size leads to a greater statistical power to detect a significant difference. We may increase the sample size for both case and control in order to obtain greater power. However, it is often the case that increasing sample size for case is not feasible for a variety of reasons. In order to look at change in power as the ratio of control to case varies (1:1 to 4:1), we conduct association tests with simulated data generated by PLINK. The simulated data consist of 50 disease SNPs and 300 non-disease SNPs and we compute powers for disease SNPs. Genetic Power Calculator was used for computing powers with varying the ratio of control to case (1:1, 2:1, 3:1, 4:1). In this study, we show that gains in statistical power resulting from increasing the ratio of control to case are substantial for the simulated data. Similar results might be expected for real data.

Identification of genetic loci stratified by diabetic status and microRNA related SNPs influencing kidney function in Korean populations

조윤신,임지선,고인송 한국유전학회 2016 Genes & Genomics Vol.38 No.7

Chronic kidney disease (CKD) is characterized by a progressive loss of kidney function over a period of months or years. It is estimated that about 7.2 % of adults over the age of 30 have CKD worldwide. Although one of the major risk factors of CKD is family history, the heritability of CKD is not fully understood. It is also known that the diabetic condition is highly influential on the onset of CKD. To understand the genetic bases of CKD that remain unidentified, we performed genetic association analyses for kidney function-related traits such as blood urea nitrogen (BUN) and albumin in subjects stratified by diabetic status. In the discovery stage of the study, we used genome-wide scan data and clinical data in about 8800 subjects from the Korean Association Resource (KARE) project. Health2 study data comprising about 1800 subjects were used for the replication stage. Our two stage association analyses demonstrated that the LOC105374266 locus (rs9820070) showed strong evidence of association with BUN (P = 8.47 9 10-14) in nondiabetic normal subjects (n = *4300). To extend our knowledge of the genetic determinants influencing kidney function, we also analyzed the association between kidney function-related traits and microRNA related variants. For this analysis, miRNA related SNPs were selected from KARE and Health2 cohort genotype data. Our study suggests the potential relevance of miRNA to the kidney function (miR-518b for BUN; miR-146a and miR-1295a for albumin) in Korean populations.