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RISS 인기검색어
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- 저자 : 고순희(Soon Hee Koh) (검색결과 5 건)
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유재영(Jae Young Yoo),신호균(Ho Kyun shin),고순희(Soon Hee Koh),김종혁(Jong Hyouk Kim),송숙희(Sook Hee Song),김규태(Kyu Tae Kim),김학양(Ho Kyun Shin),김진한(Jin Han Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.4
Primary biliary cirrhosis is a relatively common liver disease with cholestasis in Western countries, especially in the middle aged women. The sex distributian of this disease between male to female was 1/9. 1n the Korean literatures, there were only 4 casea reported in female, not in male. We report a case of primary biliary cirrhosis with a review of literatures in a 62-year-old man whose serum bilirubin and alkaline phosphatase were persistently elevated.
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간장 및 담도 : 만성 B형 간질환 환자에서 각종 바이러스 증식 표지자의 출현동태
유재영(Jae Young Yoo),박충기(Choong Kee Park),김우중(Woo Joong Kim),김태빈(Tae Bin Kim),고순희(Soon Hee Koh),계세협(Sea Hyub Kae),신효균(Ho Kyun Shin),김연근(Yeon Keun Kim),임규성(Kyu Sung Lim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1
N/A We studied several viral replication markers of hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma to evaluate the clinical significance of thesemarkers in serum. The patients comprised of 43 males and 8 females, and ages from 17 to 64 (mean: 34) years. All patients were sero-positive for hepatitis B surface antigen (HBsAg). Histologically, 36 patients showed chronic active hepatitis and 15 showed hepatocellular carcinoma. The viral replication markers tested were hepatitis B e antigen (HBeAg), antibody to hepatitis B e antigen (anti-HBe), Immunoglobulin M antibody to hepatitis B core antigen (IgM anti-HBc), DNA polymerase and hepatitis B virus deoxyribonucleic acid (HBV-DNA). The results were summerized as follows. 1) The younger the patients, the higher was the positive rate of HBeAg; the older the patients, the higher was the positive rate of anti-HBe. 2) There was a reverse correlation between the age and the level of serum alanine aminotransferase (ALT); the younger the patients, the higher was the titer. But no correlation was noted between age and the level of serum aspartate aminotransferase (AST). 3) The histologic findings of the liver tended to be more severe in older patients. The patients with hepatocellular carcinoma were the oldest group. 4) The positive rate of HBeAg was higher in patients with chronic hepatitis than in patients with hepatocellular carcinoma. but there was no difference between these two groups in the positive rate of IgM anti-HBc. 5) The positive rate of HBV-DNA and DNA polymerase was 63% and 35%, respectively, and their titers were significantly low. 6) There was no significant correlation between the positive rate of HBeAg, IgM anti-HBc, HBV-DNA, and DNA polymtrase. On the basis of these findings, it is suggested that the natural history of chronic hepatitis B of Koreans might be different from that of Caucasians; the positive rate and the titers of the viral replication markers were lower in Koreans.
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관동맥 질환 환자에서 Lipoprotein ( a ) 농도와 당내인성과 관련성
두영철(Young Cheoul Doo),최조영(Jo Young Choi),장명국(Myung Kuk Jang),홍성훈(Sung Hun Hong),장명준(Myeong Jun Chang),고순희(Soon Hee Koh),한규록(Kyoo Rok Han),오동진(Dong Jin Oh),유규형(Kyu Hyung Ryu),고영박(Young Bahk Koh),이영(You 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A Objectives: A raised Lp (a) lipoprotein concentration is associated with coronary artery disease and impaired glucose intolerance has also been shown to be predictive of coronary artery clisease in some studies. It has been suggested that there is a significant association between impaired glucose tolerance and increased circulating Lp (a) lipoprotein concentration. The object of this study is to determine whether glucose intolerance and raised Lp (a) concentration are associated in subjects with coronary artery disease. Methods: The study group comprised 60 patients with coronary artery disease (M:20, mean age 56+/-13 year) and 70 control subjects without coronary artery disease (M:15, mean age 58+/-10 year). We compared the clinical variables, lipid profile including Lp (a), fasting glucose, and fasting insulin in subjects with coronary artery disease with impaired glucose tolerance and normal glucose tolerance, and in controls. Results: 1) Nine of 60 patients (15%) with coronary artery disease had glucose intolerance. There were no significant difference in the incidence of cardiovascular risk factors, body mass index, left ventricular mass index, the levels of lipid including Lp (a), and the levels of fasting glucose, insulin, and C-peptide except in the incidence of smoking (48% in patients with coronary artery disease vs 24% in normal control, p<0.05) between patients with coronary artery disease and normal controls. 2) Between coronary artery disease patients group with and without glucose intolerance, and normal controls, there were no difference in the level of Lp (a) concentration. Conclusion: The level of fasting glucose and concentration of Lp (a) were no difference in between patients with coronary artery disease and normal controls. There was no difference in concentration of Lp (a) in patients of coronary artery disease with and without glucose intolerance, and so suggest that raised Lp (a) lipoprotein concentration are not responsible for the association between impaired glucose tolerance and coronary artery disease.
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고순희,조미경,윤돈영,박영석,정기석,박근철,류지소,조현찬 대한내과학회 1992 대한내과학회지 Vol.42 No.5
철적아구성 빈혈은 조혈세포의 heme합성의 장애로 저색소성 빈헐, 철적아구 등을 특징으로 하는 질환인데 후천적 원인중 INH는 피리독신 의존성 효소의 길항작용을 하여 철적아구성 빈헐을 일으키는 것으로 알려져 있다. 저자들은 항결핵제로 INH를 사용한 19세 남자 환자에서 이차성 철적아구성 반혈 1예를 경험하였다. 환자는 2주간의 발열을 주소로 입원하였고 늑막삼출 소견이 있어 늑막생검을 하여 결핵성 늑막염 진단하에 INH, pyrazinamide를 포함한 항결핵제 투여를 시작하였다. 4개월후 노작성 호촙곤란과 전신허약을 호소하였고 이학적 소견상 빈혈 소견이 있어 말초혈액 검사및 골수생검을 실시하여 철적아구성 빈혈을 진단하였다. 항결핵제를 끊고 피리독신을 투여하여 철적아구성 빈혈소견은 없었졌고 후에 투여한 pyrazinamide는 철적아구성 빈혈을 일으키지 않았다. 따라서 INH에 의한 철적아구성 빈혈을 진단하였고 국내에서는 첫 예로써 보고하는 바이다. Sideroblastic anemias are diverse hypochromic disorders characterized by hypochromic anemia, ringed sideroblasts in the bone marrow, and ineffective erythropoiesis due to defective iron utilization within erythropoietic cells. Isonicotinic acid hydrazide (isoniazid, INH) is one of the secondary causes of the sideroblastic anemia. We experinced INH-induced sideroblastic anemia in a 19-year old boy with tuberculous pleurisy. The patient was admitted to our hospital because of fever for 2 weeks. The X-ray film of the chest showed pleural effusion on the left side. Tuberculous pleurisy was diagnosed by the pleural biopsy. After four months initiation of antituberculous medications he complained of exertional dyspnea and general weakness. Peripheral blood smear and bone marrow study with iron staining revealed typical sideroblastic anemia. He completely recovered by administration of pyidoxine and withdrawl of INH. Pyrazinamide that is a another possible cause of a sideroblastic anemia did not induce sideroblastic anemia or other hematologic changes in this patient. INH-induced sideroblastic anemia was diagnosed. This is the first case report of INH-induced sideroblastic anemia in Korea.
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