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Endothelin - 1 에 의한 돼지 관상동맥 수축에 미치는 17β - Estradiol 의 효과
정호경(Ho Gyeong Jeong),강병선(Byeong Sun Kang),김민구(Min Gu Kim),박병건(Byeong Gun Park),황진용(Jin Yong Hwang),서봉관(Byeong Sun Kang) 대한내과학회 1997 대한내과학회지 Vol.52 No.2
N/A Objectives: It is widely accepted that estrogen has favorable effects on cardiovascular diseases, especially in the postmenopausal women. Endothelin- 1(ET-I), released from the vascular endothelium, is a 21-amino acid peptide with strong vasoconstrictor activity. However, the effect of estrogen on the vasoconstriction to ET-1 has not been extensively studied. Methods: To investigate the effect of estrogen (175β-estradiol) on the vascular contraction to ET-1, porcine coronary artery(PCA) rings were suspended in organ chambers(37℃, 95% O2/5% CO2) for measurement of isometric tension change. Endothelium was removed mechanically if necessary. In acute experiments, vascular rings were preincubated for 15minutes with 3different concentrations of 170β-estradiol(10(-6), 10(-5), 10(-4)M) and concentration-contraction curves to cumulative doses of ET-1 were constructed. In the experiments after a longer exposure to 17β-estradiol, the vessels with endothelium were exposed in the 5% CO2 incubator to 3different concentrations of 17β-estradiol(10(-9), 10(-8), 10(-7) M) for 44-50 hours, and then concentrationcontraction curves to ET-1 were obtained. Results: Incubation for 15minutes with 170β-estradiol(10 -4)M) inhibited ET-1-induced contraction in the vessels with endothelium(area under the curve and maximal contraction, p<0.05 compared with control). This effect persisted regardless of the sex and the presence or absence of the endotheliurn. Incubation of the vessels far a longer time with 170β-estradiol(44-50 hours) resulted in the inhibition of maximal contraction to ET-1(p<0.05) by a lower concentration of 175β-estradiol(10(-7)M) than in acute experiments in male PCA rings, but an enhanced contraction to ET-1(area under the curve; p<0.05) by 10M of 175β-estradiol was observed in female PCA rings. Conclusion: Short-time incubation with 17Pβ-estradiol has an inhibitory effect on the contraction to ET-1 in PCA rings. This effect is independent of the presence of the endothelium and the sex of the pigs. A longer incubation with 17β-estradiol results in a similar inhibitory effect on male(but not female) PCA rings, suggesting that a sex-related difference may exist concerning the effect of 17β-estradiol on ET-1-induced contraction.
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(단보)국립공원공단의 전사적 데이터 관리 기반 및 정책에 관한 고찰
전세근(Se-Kun Jeon),강병선(Byeong-sun Kang),홍석진(Suk-Jin Hong) 국립공원연구원 2022 국립공원연구지 Vol.13 No.1
최근 제4차 국립공원공단 정보화전략계획 수립 결과물 및 관련 법령, 정책을 토대로, 현재 국립공원공단의 데이터 관리 수준을 파악하고자 한다. 데이터 프로파일링 기법을 이용하여 전사적 데이터 품질관리 수준을 확인한 결과, 데이터 표준이나 구조적으로 정합성을 확보하기 어렵고, 지침, 매뉴얼, 조직 및 예산 등 데이터 품질관리 기반이 부족한 실정이다. 국립공원공단의 전사적 데이터는 정확성(Accuracy), 일관성(Consistency), 최신성(Timeless), 완전성(Completeness)을 갖출 수 있도록 관리되어야 하고, 이를 실현하기 위하여 데이터 품질관리 프레임워크에 따라 이행계획을 수립해야 할 필요가 있다. Based on the results of the recent〝4th Korea National Park Service Information Strategy Plan〞 establishment and related laws and policies, we want to understand the current level of data management in Korea National Park Service. As a result of confirming the level of enterprise-wide data quality management using the data profiling technique, it is difficult to secure data standard or structural consistency, and the basis for data quality management such as guidelines, manuals, organization and budget is insufficient. The company-wide data of the National Park Service should be managed to ensure accuracy, consistency, timelessness, and completeness, and to realize this, an implementation plan is established according to the data quality management framework.
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정상 한국인에서 게이트혈액풀스캔을 이용한 좌심실 심기능지표들의 분석
정순일(Soon Il Chung),강재황(Jae Hwang Kang),박은숙(Une Sook Park),강병선(Byeong Sun Kang),임현옥(Hyeon Ok Lim),최동주(Dong Joo Choi),서봉관(Bong Kwan Suh),이근우(Keun Woo Lee) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1
N/A Background: The demand for refinement in noninvasive and quantitative assessment of left ventricular (LU) function is increasing. Purpose : To assess normal values of left ventricular functional parameters during both systole and diastole hy scintigraphic method using computerized triple-head gamma camera and to evaluate correlations between these parameters. Methods .' ECG gated blood pool scan with Tc#-Hurnan serum albumin was performed in 94 normal Korean;ubjects. Ejection fraction (EF), systolic parameters [peak emptying rate (PER), average emptying rate (AER), tirne to peak emptying rate (TPER)], and diastolic parameters [peak filling rate (PFR), average filling rate (AFR), time to peak filling rate (TPFR)] were obtained by analysis of LV time-activity curve, the correlation of these parameters to the age and sex, and the correlation between these parameters were evaluated. Results : 1) Mean value of ejection fraction in study subjects was 59.6 +- 5.25% and showed no significant correlation to age (r=0.08) and sex but showed most pronounced correlation to PFR (r=0.46, p<0.001), PER (r=0.41, p<0.001), AFR (r=0.34, p<0.001) and AER (r=0.28, p<0.01). 2) Mean values of systolic parameters were as follows: PER=3.22+ 0.50 end-cliastolic volume/sec, AER =2.22+0.45 end-diastolic volume/sec, TPER=103.5+29.30 msec. They showed no significant correlation to age and sex. 3) Mean values of diastolic parameters were as follows: PFR=2.71+0.51 end-diastolic volume/sec, AFR=1.830.44 end-diastolic volume/sec, TPFR=132.1+33.45 msec. They showed strong correlation to age <r=- 0.70, 0.64, 0.37, p<0.001). Conelwions . Left ventricular functional parameters in normal Korean subjects were obtained reliably by computerized scintigraphic method and may be applied to the evaluation of cardiac function in diseased patients.
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정순일,임정욱,강병선,천맹렬,최소영,정호경,박병건,박동열,심정우 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.2
Acute thyroid abscess is an uneommon type of neck infection. We experienced a case of staphylococcal thyroid abscess in 29 year old man, diagnosed by needle aspira~tion and culture of the aspirate. The patient had complained fever and slowly growing anterior neck swelling. Needle aspiration of the cold nodule prior to broad spectrum antibiotics was performed. After Surgical excision combined with antibiotics, he was discharged with elinical improvement. The laboratory diagnosis and clinical course was summarized and is reported with relevent references(J Kor Soc Endoerinol ll:207213, 1996).
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가성낭종을 동반한 만성 췌장염에서, 자연소실된 비정맥혈전증 1 예
이지훈,김기홍,박동열,김정열,이옥재,강병선,정호경,김민구,손미정,김영채 대한내과학회 1996 대한내과학회지 Vol.51 No.6
Splenic vein thrombosis is infreqently recognized as a cause of gastroesophageal varices and upper G-I bleeding. Extrahepatic portal hypertension constitute 5-10% of portal hypertension. Isolated obstruction of the splenic vein leads to isolated or segmental hypertension. The diagnosis of splenic vein thrombosis with gastroesophageal varices is important, since it can be cured by splenectomy. We report one cause of spontaneously resolved splenic vein thrombosis with gastroesophageal varices associateed with chronic pancreatitis with pseudocyst in 41-year old man. He suffered from epigastric pain for 4 months. UGI series and endoscopy revealed varices of gastric fundus and lower esophagus. Two years later, follow-up endoscopy showed no esophageal and gastric varices. On abdominal USG, no evidence of splenic vein thrombosis was observed.
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