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Endothelin - 1 에 의한 돼지 관상동맥 수축에 미치는 17β - Estradiol 의 효과
정호경(Ho Gyeong Jeong),강병선(Byeong Sun Kang),김민구(Min Gu Kim),박병건(Byeong Gun Park),황진용(Jin Yong Hwang),서봉관(Byeong Sun Kang) 대한내과학회 1997 대한내과학회지 Vol.52 No.2
N/A Objectives: It is widely accepted that estrogen has favorable effects on cardiovascular diseases, especially in the postmenopausal women. Endothelin- 1(ET-I), released from the vascular endothelium, is a 21-amino acid peptide with strong vasoconstrictor activity. However, the effect of estrogen on the vasoconstriction to ET-1 has not been extensively studied. Methods: To investigate the effect of estrogen (175β-estradiol) on the vascular contraction to ET-1, porcine coronary artery(PCA) rings were suspended in organ chambers(37℃, 95% O2/5% CO2) for measurement of isometric tension change. Endothelium was removed mechanically if necessary. In acute experiments, vascular rings were preincubated for 15minutes with 3different concentrations of 170β-estradiol(10(-6), 10(-5), 10(-4)M) and concentration-contraction curves to cumulative doses of ET-1 were constructed. In the experiments after a longer exposure to 17β-estradiol, the vessels with endothelium were exposed in the 5% CO2 incubator to 3different concentrations of 17β-estradiol(10(-9), 10(-8), 10(-7) M) for 44-50 hours, and then concentrationcontraction curves to ET-1 were obtained. Results: Incubation for 15minutes with 170β-estradiol(10 -4)M) inhibited ET-1-induced contraction in the vessels with endothelium(area under the curve and maximal contraction, p<0.05 compared with control). This effect persisted regardless of the sex and the presence or absence of the endotheliurn. Incubation of the vessels far a longer time with 170β-estradiol(44-50 hours) resulted in the inhibition of maximal contraction to ET-1(p<0.05) by a lower concentration of 175β-estradiol(10(-7)M) than in acute experiments in male PCA rings, but an enhanced contraction to ET-1(area under the curve; p<0.05) by 10M of 175β-estradiol was observed in female PCA rings. Conclusion: Short-time incubation with 17Pβ-estradiol has an inhibitory effect on the contraction to ET-1 in PCA rings. This effect is independent of the presence of the endothelium and the sex of the pigs. A longer incubation with 17β-estradiol results in a similar inhibitory effect on male(but not female) PCA rings, suggesting that a sex-related difference may exist concerning the effect of 17β-estradiol on ET-1-induced contraction.
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정상 한국인에서 게이트혈액풀스캔을 이용한 좌심실 심기능지표들의 분석
정순일(Soon Il Chung),강재황(Jae Hwang Kang),박은숙(Une Sook Park),강병선(Byeong Sun Kang),임현옥(Hyeon Ok Lim),최동주(Dong Joo Choi),서봉관(Bong Kwan Suh),이근우(Keun Woo Lee) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1
N/A Background: The demand for refinement in noninvasive and quantitative assessment of left ventricular (LU) function is increasing. Purpose : To assess normal values of left ventricular functional parameters during both systole and diastole hy scintigraphic method using computerized triple-head gamma camera and to evaluate correlations between these parameters. Methods .' ECG gated blood pool scan with Tc#-Hurnan serum albumin was performed in 94 normal Korean;ubjects. Ejection fraction (EF), systolic parameters [peak emptying rate (PER), average emptying rate (AER), tirne to peak emptying rate (TPER)], and diastolic parameters [peak filling rate (PFR), average filling rate (AFR), time to peak filling rate (TPFR)] were obtained by analysis of LV time-activity curve, the correlation of these parameters to the age and sex, and the correlation between these parameters were evaluated. Results : 1) Mean value of ejection fraction in study subjects was 59.6 +- 5.25% and showed no significant correlation to age (r=0.08) and sex but showed most pronounced correlation to PFR (r=0.46, p<0.001), PER (r=0.41, p<0.001), AFR (r=0.34, p<0.001) and AER (r=0.28, p<0.01). 2) Mean values of systolic parameters were as follows: PER=3.22+ 0.50 end-cliastolic volume/sec, AER =2.22+0.45 end-diastolic volume/sec, TPER=103.5+29.30 msec. They showed no significant correlation to age and sex. 3) Mean values of diastolic parameters were as follows: PFR=2.71+0.51 end-diastolic volume/sec, AFR=1.830.44 end-diastolic volume/sec, TPFR=132.1+33.45 msec. They showed strong correlation to age <r=- 0.70, 0.64, 0.37, p<0.001). Conelwions . Left ventricular functional parameters in normal Korean subjects were obtained reliably by computerized scintigraphic method and may be applied to the evaluation of cardiac function in diseased patients.
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